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2 s comprised of a variety of cancer diatheses that manifest a spectrum of distinct biologic potentials
4 exists another class of important positions that manifests a wide range of functional outcomes upon
6 al nocturnal hemoglobinuria (PNH), a disease that manifests after clonal expansion of hematopoietic c
7 lting in chronically deactivated macrophages that manifest an impaired ability to control pathogens.
8 e show (i) there is a set of 255 transcripts that manifest an increase in translational efficiency du
10 with a CD8 T-cell IL-15-transgenic leukemia that manifests an autocrine IL-15/IL-15Ralpha pathway pr
11 have produced the first novobiocin analogues that manifest anti-proliferative activity against severa
13 be diketo acid inhibitors of HIV-1 integrase that manifest antiviral activity as a consequence of the
14 ports suggest that animals produced with ART that manifest apparent epigenetic defects typically do n
15 it a delayed onset of neurologic dysfunction that manifests around the child's first birthday and pro
18 g disease, cells experience various stresses that manifest as an accumulation of misfolded proteins a
19 axias are autosomal dominant channelopathies that manifest as attacks of imbalance and incoordination
20 rs result in tissue-level control mechanisms that manifest as biological oscillators, such as observe
21 tion is driven by changes in gene expression that manifest as changes in cellular phenotype or functi
22 s as well as cause direct pathologic effects that manifest as clinical disease such as HIV-associated
26 se LBNP, disrupt MSNA firing characteristics that manifest as fused integrated bursts before the onse
27 currently being used to investigate diseases that manifest as global disturbances of brain function.
28 induces highly dynamic [Ca(2+)]cyt signaling that manifest as hundreds of discrete [Ca(2+)]cyt spikes
29 es can have nontargeted heterologous effects that manifest as increased protection against nonvaccine
30 a group of fatal neurodegenerative disorders that manifest as infectious, sporadic, or familial and a
31 onstellation of neurodevelopmental disorders that manifest as intellectual disability, epilepsy, auti
32 ess substantial microscale internal stresses that manifest as intergranular and intragranular residua
33 proteins modulate diverse downstream effects that manifest as interindividual differences in efficacy
34 of biologically relevant genetic alterations that manifest as intratumor heterogeneity, these aggrega
36 aging for diagnosis of malignancy in lesions that manifest as microcalcifications at mammography.
37 These DSA elicit cycles of injury and repair that manifest as multilamination of the peritubular capi
38 t alterations in CNS physiology and function that manifest as neurologic and psychiatric diseases.
39 This lends further support that lung cancers that manifest as NSNs have an indolent course and can be
44 acterized by unwanted, repetitive behaviours that manifest as stereotyped movements and vocalizations
46 enes causes neurodevelopmental abnormalities that manifest as the fractionation of mental abilities t
47 ible to the untoward effects of osteoporosis that manifest as thinner, more porous alveolar bone, PDL
48 pors induces structural and chemical changes that manifest as toposelective hydrogenation of alternat
49 development, disruptions in motor behaviors that manifest as unproductive swim attempts, and spontan
50 to be effective for treating variant angina that manifested as a non-respiratory tract symptom of as
51 n of the pancreas by gut-derived lymphocytes that manifested as a pancreatic insulitis with beta-isle
52 formed consent was obtained, 50 lung cancers that manifested as a solid nodule on computed tomographi
53 +)) mice showed developmental irregularities that manifested as adult-onset glomerulosclerosis and pr
54 treatment generated oxidative genome damage that manifested as an accumulation of oxidized bases in
55 of LASY aggravated the inflammatory response that manifested as an increase in both basal and TNF-alp
56 ependence of release after block of activity that manifested as an increase in probability of release
57 nic mice correlated with an atopic phenotype that manifested as blepharitis and pulmonary inflammatio
58 rus-infected cells produce paracrine signals that manifested as intercellular calcium waves (ICWs), o
59 S. aureus conferred responsiveness to IL-20 that manifested as modification of actin polymerization
60 e, GAT1 and SGLT1 exhibited charge movements that manifested as pre-steady-state current transients.
61 2 months, had significant cutaneous disease that manifested as red violaceous plaques of the cheeks,
62 arly increase in vesicular glutamate release that manifests as a fourfold increase in the frequency o
64 ectra were represented in Kubelka-Munk units that manifests as a linear dependence of spectral peak h
65 ase type II, is a lysosomal storage disorder that manifests as a progressive myopathy, secondary to m
67 ous defect in hematopoietic progenitor cells that manifests as abnormal myeloid and B-lymphoid develo
68 d to the genetic liability for schizophrenia that manifests as altered reconfiguration of brain netwo
69 a substrain (B10.Q-H2-(q)/SgJ) of B10.Q mice that manifests as an acute susceptibility to infection b
70 PFC functional connectivity in schizophrenia that manifests as an unmodulated persistence of an HF-DL
71 ant role in progression to chronic rejection that manifests as bronchiolitis obliterans syndrome (BOS
72 e causative agent of amebiasis, an infection that manifests as colitis and, in some cases, liver absc
73 idence of optic nerve or retinal dysfunction that manifests as decreased contrast sensitivity, even w
74 ndent latent modulation of GABA(A)R function that manifests as delayed-onset uncoupling may be releva
75 due to an excess of neural progenitor cells that manifests as early as embryonic day 9.5 in developm
77 en characterized by a robust B-cell response that manifests as increased intrathecal immunoglobulin G
78 il to detect or else conflate generalization that manifests as increased learning rate with generaliz
79 syndrome (WAS) is a primary immunodeficiency that manifests as increased susceptibility to many patho
80 versely, breakdown of medial immunoprivilege that manifests as more intense leukocytic infiltrates, l
81 ome should be redefined as one of starvation that manifests as obesity in a food-rich environment.
82 eloma is a malignant disease of plasma cells that manifests as one or more of lytic bone lesions, mon
83 nes may represent a rudimentary relationship that manifests as out-of-phase oscillation of Fgf and Wn
84 xample, the AhR regulates PAH immunotoxicity that manifests as pre-B cell apoptosis in models of B ce
85 onse in the developing embryonic mouse brain that manifests as pro-inflammatory cerebrospinal fluid (
86 ct caused by the Human Papilloma Virus (HPV) that manifests as profoundly altered phonatory and upper
87 a (PHN) is a common complication of shingles that manifests as prolonged excruciating pain, which has
88 siological evidence of "hidden hearing loss" that manifests as reduced neural output from the cochlea
89 ed focal dystonia is a neurological disorder that manifests as repetitive involuntary spasms and/or a
90 ome is an inherited and irreversible disease that manifests as retinitis pigmentosa (RP) and bilatera
91 that appeared in a colony of FVB/N mice and that manifests as severe ataxia appearing at around 12 d
92 rare hereditary disease of heme biosynthesis that manifests as severe photosensitivity and hepatotoxi
95 n limited by public and political opposition that manifests as structural barriers to HIV prevention,
96 y, Leber congenital amaurosis type 4 (LCA4), that manifests as the loss of vision during the first ye
97 demonstrate a reduced efficacy of inhibition that manifests as triggering of seizures at room tempera
98 tory condition of the gastrointestinal tract that manifests as ulcerative colitis and Crohn disease.
102 Our data highlight a complexity to binding that manifests at higher temperatures and can be explain
103 ological mesenchymal progenitor cells (MPCs) that manifest autonomous fibrogenicity in xenograft mode
107 ptide-MHC-II molecules become effector cells that manifest better recall responses, and Tregs with ca
108 le increases in CBF throughout the forebrain that manifested bilaterally, albeit with an ipsilateral
110 en fluorescent protein tagged to 37 alanines that manifests both toxicity and inclusion formation in
111 rophage responses in a dose-dependent manner that manifested by an increased TNF-alpha and IL-12, but
112 somatic expression of CaV2.1 splice variants that manifest CDF and progressive dendritic targeting of
113 r array of isotopologs along the fibril axis that manifests clearly identifiable vibrational transiti
114 trinsic mechanism for human vascular disease that manifests clinical complications in sickle cell dis
115 endent roles in the complex immune responses that manifest clinically as asthma and other allergic di
116 terorgan and intraorgan vessel heterogeneity that manifest clinically in a disparate response of diff
117 and leads to mucosal damage and inflammation that manifests clinically as antibiotic-associated diarr
118 liferation and loss of functional liver mass that manifests clinically as ascites, encephalopathy, an
120 hotoreceptors and retinal pigment epithelium that manifests clinically as pigmentary retinopathy.
121 antigen load drives an inflammatory response that manifests clinically as TBM-IRIS in most, but not a
122 lly affected by the type I collagen mutation that manifests clinically in their heterozygous offsprin
123 ptured prevalent mixed-lineage intermediates that manifested concurrent expression of haematopoietic
124 genital, autosomal recessive retinal disease that manifests cone dysfunction, reduced visual acuity a
127 gene are associated with cornea plana (CNA2) that manifests decreases in vision acuity due to the fla
129 imeric recombinant bovine-human PIV3 viruses that manifest different levels of attenuation in rhesus
130 genes could be causative for human diseases that manifest distinctive combinations of tissue-specifi
132 rast, female-predominant autoimmune diseases that manifest during the acute phase, such as Graves' di
133 provokes neutrophil-induced vascular leakage that manifests during the physical movement of neutrophi
136 ce in the N74D reverse transcription complex that manifests early after infection and prior to intera
137 ough a number of mutants have been described that manifest ectopic organ fusion, little is known abou
138 lar FLIP long transgenic (c-FLIP(L)-Tg) mice that manifest elevated caspase activity have greatly red
139 and causes decelerations in statural growth that manifest gradually over time.To illustrate an appro
141 t deficient in lysosomal cysteine cathepsins that manifests hallmarks of human lysosomal storage dise
144 6 (59.5%) of NPDR and 28 (70.0%) of PDR eyes that manifested improvement at 1 year maintained improve
145 myriad of genetic and biochemical processes that manifest in a final common pathway of physical impa
146 nic traumatic encephalopathy-like conditions that manifest in a singular manner throughout the white
149 ecipitating neurodevelopmental abnormalities that manifest in adults and/or G1/S cell-cycle dysregula
150 ssociated with inherited cobalamin disorders that manifest in both severe homocystinuria and methylma
152 s caused by internal wave-induced upwelling, that manifest in distinct daily temperature minima.
153 es in function among costimulatory molecules that manifest in distinct pathologies of allograft rejec
154 isorders are complex heterogeneous syndromes that manifest in dysfunctions across multiple brain regi
158 hyperproliferation and autoimmune phenotypes that manifest in mice lacking E3 ubiquitin ligases such
159 the evolutionary stage for later refinements that manifest in modern humans as language-based convers
160 variants have divergent molecular properties that manifest in selective initiation of brain hyperexci
162 t will also discuss common systemic diseases that manifest in the shoulder as well as disorders of th
165 ore cystic component; and distant metastases that manifest in unusual sites (disseminating phenotype)
166 t, patient mutations Ala236Gly and Arg477Lys that manifest in XLT without progressing to WAS do not d
168 273R RdRp in vitro was increased by 2-3-fold that manifested in a 2-3-fold increase in the diversity
169 reatment elicited a highly specific response that manifested in elevated levels of metallothionein is
170 ospital complaining of persistent chest pain that manifested in the evenings and early mornings.
171 e retinopathy (AIR) is a treatable condition that manifests in acute and progressive vision loss in p
172 mune alteration in T1D patients and siblings that manifests in an exaggerated CD4(+)Tem response and
174 ct of 4-aminobutyric acid (GABA) degradation that manifests in humans as 4-hydroxybutyric (gamma-hydr
175 ut a description of real sensory computation that manifests in improved behavioural performance.
176 er (ASD) is a behaviorally defined condition that manifests in infancy or early childhood as deficits
177 wo different signals results in a new signal that manifests in late flowering, low protein oxidation
178 aining the shared cerebellar motor phenotype that manifests in mutants of the mGluR1 and GluRdelta2 s
182 an autosomal-dominantly inherited condition that manifests in the second half of life and is genetic
183 compounds from the thiosemicarbazone family that manifest increased growth inhibitory activity in mu
184 IRPalpha-deficient (Sirpalpha(-)/(-)) mouse, that manifests increased erythropoiesis as well as heigh
186 ed to direct effects of climate from effects that manifest indirectly through species turnover across
187 l lymphoma is a form of non-Hodgkin lymphoma that manifests initially in the skin and disseminates sy
188 cardinal vein into a second arterial vessel that manifests intact arterial gene expression, interseg
189 fect and the easy accessibility of the cells that manifest it have made it a favorite tool of biochem
190 mbrane protein 1 (LMP-1) is a viral oncogene that manifests its oncogenic phenotype through activatio
191 d with intracellular C. neoformans residence that manifested itself in impaired cell cycle completion
192 sorders was diminished autonomic flexibility that manifested itself throughout the day, accompanied b
193 ds constraints to the optimization procedure that manifests itself as an imposed structure on the obs
194 lated loss of accommodation of the human eye that manifests itself as inability to shift focus from d
195 ing and the toxicity of the infectious agent that manifests itself as progressive vacuolar neurodegen
196 i into a multifactorial developmental output that manifests itself as root system architecture (RSA).
197 reducible imprecision in such climate models that manifests itself as structural instability in clima
198 f the CEC system engender migration behavior that manifests itself in a relatively narrow elution win
201 yndrome is an X-linked hematopoietic disease that manifests itself in platelet deficiency and a compr
202 , first a rapid swelling of axonal processes that manifests itself in relative impedance above contro
203 ween vibrations of the beta-sheet, a process that manifests itself in the 2D IR spectrum as a frequen
205 s varies with the motor context, a mechanism that manifests itself in the phase-locked entrainment of
206 ed by overall disruption of the folded state that manifests itself in three ways: (1) dramatically re
208 report and explain an ice removal mechanism that manifests itself simultaneously with freezing, driv
213 aterials in the form of emergent excitations that manifest like point charges, or magnetic monopoles.
214 e studies have produced novobiocin analogues that manifest low micromolar activity against several ca
215 eneration of a murine Ptpn14 gene trap model that manifested lymphatic hyperplasia with lymphedema.
216 TPs, the RNA primer is extended in a process that manifests most of the properties of in vitro transc
219 Auxetics comprise a rare family of materials that manifest negative Poisson's ratio, which causes an
220 est and lethality by E11 of Hif1a-/- embryos that manifested neural tube defects, cardiovascular malf
221 ic and organic components to yield materials that manifest new functionalities unattainable in tradit
222 concentrations may cause subclinical effects that manifest only when triggered by a stressor, suggest
223 nd quantified a form of bacterial chemotaxis that manifests only as an emergent property by measuring
224 ty can enact lasting transcriptional control that manifests only during a unique period of the lifesp
225 Many plant pathogens cause disease symptoms that manifest over days as regions of localized cell dea
227 es are used here to derive a molecular clock that manifests persuasive evidence that Nrf2 orthologues
228 ys were seen in all SLE B lymphocyte subsets that manifested phenotypic features of immature, mature,
231 n female presented with gingival enlargement that manifested postpartum and was most likely related t
232 Non-noviosylated coumermycin A1 analogues that manifest potent antiproliferative activity resultin
233 t a robust model of cutaneous carcinogenesis that manifests precancerous lesions and SCCs resembling
234 se depletion and multiple deletions of mtDNA that manifest predominantly as a myopathy usually beginn
236 liferations composed chiefly of plasma cells that manifest primarily in the lungs, but may occur in v
237 erize a series of transgenic FUS mouse lines that manifest progressive, mutant-dependent motor neuron
238 sts identified longitudinal bacterial series that manifested progressive changes in liquid media grow
240 e developed a transgenic mouse model of OPMD that manifests progressive muscle weakness accompanied b
241 ve been several descriptions of mouse models that manifest select immunological and clinical features
242 cycline contains ionizable functional groups that manifest several species with charges at different
247 conformations of the vicinal difluoro motif that manifest stabilizing hyperconjugative interactions
248 Van der Waals materials and heterostructures that manifest strongly bound exciton states at room temp
250 se) into G6Pase-deficient (G6Pase(-/-)) mice that manifest symptoms characteristic of human GSD-1a.
253 for the design of protein-mimetic oligomers that manifest the folding encoded in natural amino acid
255 and demonstrate novel graphene metasurfaces that manifest the potential to dynamically control the p
257 ntified, we generated a knockout mouse model that manifested the phenotype and studied the mechanisms
258 the design and isolation of a peptide binder that manifests the most subtle kind of discrimination of
259 ancer cell lines and serve as lead compounds that manifest their activities through Hsp90 inhibition.
260 nduced by antagonistic epithelial morphogens that manifest their pattern-generating actions mechanica
261 rnal-effect and five paternal-effect mutants that manifest their phenotypes at the time of, or after,
262 tly, we identified numerous genetic variants that manifested their regulatory effects exclusively on
263 normal behavior and of diseases of the brain that manifest themselves as behavioral abnormalities.
265 difficult to ascribe causality to processes that manifest themselves at the level of the entire orga
267 ve been predicted to form a molecular system that manifests this peculiarity under natural conditions
268 ts in the N-linked glycosylation pathway and that manifest through impaired neuromuscular transmissio
269 e DacA null mutant presented a growth defect that manifested through an increased lag time, produced
271 transgenic ablation of brown adipose tissue that manifests typical metabolic complications of obesit
275 lecular C-H silylation of unactivated arenes that manifests very high regioselectivity through steric
276 of inflammation --> damage --> inflammation that manifests via organ-specific inflammatory switching
277 ygosity (ROH) are important genomic features that manifest when an individual inherits two haplotypes
278 ygosity (ROH) are important genomic features that manifest when identical-by-descent haplotypes are i
281 ract are types of extragenital endometriosis that manifest with nonspecific symptoms, but their detec
284 surface-positive cells underwent activation that manifested with cell proliferation and/or up-regula
285 r-Willi syndrome (PWS) is a complex disorder that manifests with an array of phenotypes, such as hypo
287 eye disease (TED) is a degenerative disease that manifests with detrimental tissue remodeling, myofi
288 etween SkM AMPK signaling and insulin action that manifests with diet-induced obesity, as insulin act
289 osis Complex (TSC) is a rare genetic disease that manifests with early symptoms, including cortical m
290 ecessive disorder caused by an MCM8 mutation that manifests with endocrine dysfunction and genomic in
291 managing neurogenic orthostatic hypotension that manifests with falls or cognitive impairment, but w
293 inuria (PNH) is a rare clonal blood disorder that manifests with hemolytic anemia, bone marrow failur
294 (PNH) is a rare bone marrow failure disorder that manifests with hemolytic anemia, thrombosis, and pe
295 mplex (TSC) is a multisystem genetic disease that manifests with mental retardation, tumor formation,
296 -onset, inherited neurodegenerative disorder that manifests with personality changes, movement disord
297 ular AMD, while its role in nonexudative AMD that manifests with progressive retinal pigment epitheli
298 C) is an autosomal dominant genetic disorder that manifests with seizures, autism, and cognitive defi
299 e changes in the physician-patient encounter that manifested within 2 weeks of EHR transition and the