ライフサイエンスコーパス: the concept that

1 Our results support the concept that (18)F-NaF is a feasible option in imagi

2 observational study, these findings support the concept that 2LCTX + BSC is associated with an OS be

3 us, in patients with traumatic brain injury, the concept that 90 mm Hg represents a unique or importa

4 The study supports the concept that a better understanding of the factors t

5 In conclusion, our data support the concept that a dichotomous functional organization,

6 Our findings support the concept that a maternal T1D environment improves neo

7 The concept that a minority of group A streptococcus (GA

8 Simplified model systems(3-6) have led to the concept that a single fixed saturation concentration

9 Here, the concept that a structure can guide desirable biologi

10 Experimental evidence supports the concept that Abeta multimers can act as seeds and st

11 e findings of this study are consistent with the concept that abnormal AAT protein conformation and i

12 This contrasts with the concept that accumulation of myeloid cells at ischem

13 Together, these results support the concept that activating Stat1 in the presence of JAK

14 These data support the concept that activation of ERBB family members is su

15 Included in this rubric is the concept that activation of the inflammasome, a molec

16 Recent evidence supports the concept that AD can also recognize other comorbiditi

17 Our data support the concept that adipocyte G(i) signaling is essential f

18 Our findings support the concept that age-related reduction of LC structural

19 Growing in vivo evidence supports the concept that airway smooth muscle produces various i

20 the mechanism of SIT and we will put forward the concept that allergens may be viewed as 'protoxins'

21 In addition, it reinforces the concept that allogeneic HSCT offers optimal eradicat

22 These findings introduce the concept that allostery in proteins could have its or

23 cles tested and provide indirect support for the concept that ALS may specifically affect muscle grou

24 f autoimmune diseases, providing support for the concept that alterations in immune regulation contri

25 alternatively spliced exons, consistent with the concept that altered splicing might be a common mech

26 SPI1 by affecting HilD stability, supporting the concept that altering the stability of this regulato

27 These results reinforce the concept that alternate activation profiles control M

28 These findings support the concept that an amplification process occurs along t

29 Together, these results support the concept that aneuploidy-inducing gene deficiencies c

30 f anti-Caspr2 antibodies are consistent with the concept that anti-brain antibodies present in women

31 rmal neurobehavioral development and support the concept that antibiotics and other environmental che

32 These data advance the concept that apoptotic cells are not inert cells wai

33 These new insights herald the concept that astrocytes represent a diverse populati

34 r, the preclinical and clinical data support the concept that autoimmune CD8 T cells play an importan

35 Overall, this study supports the concept that autoimmunity is a causative parameter t

36 der the possibility of iterated development, the concept that behavioral and life history trajectorie

37 Together, the data support the concept that beta cell killing occurs sporadically d

38 Our results support the concept that beta-blocker drugs may improve the surv

39 e results lead to a paradigm shift away from the concept that binding of the anti-beta2GP1 autoantibo

40 Evidence from multiple studies supports the concept that both glomerular filtration and proximal

41 ive in driving acrosomal exocytosis supports the concept that both NAADP-gated cascades match local N

42 etected in these cells further substantiates the concept that BRCA2 abrogation triggers cell-intrinsi

43 vaginal bacterial species between women and the concept that BV is sexually transmitted.

44 The concept that c-kit expression in the adult heart ide

45 tion during progression of T1D and reinforce the concept that candidate genes for T1D may affect dise

46 rpinning the vision of precision medicine is the concept that causative mutations in a patient's canc

47 expressing anti-stress DCT molecule supports the concept that CAV1 functions as a tumor suppressor in

48 These findings support the concept that CD44 mediates several of its effects on

49 These findings support the concept that celiac disease is associated with neuro

50 The concept that certain aggregation-prone proteins can

51 These findings provide strong support for the concept that changes in diet and gut environment are

52 These findings support the concept that choroidal vascular degeneration, predom

53 ailed to improve patient outcomes, promoting the concept that clinically important oxidative stress m

54 on compared to Atxn1154Q/2Q mice, supporting the concept that cognitive deficits in SCA1 arise from a

55 ative of subpial cortical pathology supports the concept that common CSF-mediated factors might play

56 Our analysis reinforces the concept that compartmentalisation influences Ras sig

57 e mechanism of TRIM5 restriction underscores the concept that core uncoating and reverse transcriptio

58 These data support the concept that cross-talk between the Wnt/beta-catenin

59 ncipient gynoecial primordium and strengthen the concept that cytokinin regulates auxin homeostasis d

60 These findings provide molecular support for the concept that defective inflammation resolution contr

61 Our findings support the concept that defined bacterial products can be explo

62 also provide additional evidence supporting the concept that desensitization and internalization are

63 The concept that dietary changes could improve the respo

64 'Differential placebo effects' is the concept that different types of placebos (e.g. inert

65 These findings reinforce the concept that disruption of the functions of PML-NB p

66 omain was the most specific, consistent with the concept that domain insertions drive the evolution o

67 Findings challenge the concept that durable polymers are key in VLST format

68 e, our research group is currently exploring the concept that dysbiosis-associated expansion of Enter

69 Our findings support the concept that dysregulated eIF2alpha phosphorylation,

70 el in responders to antidepressants supports the concept that dysregulation of brain arousal is a pos

71 Overall, this study supports the concept that early assessment of urinary antimicrobi

72 The results support the concept that Ebola virus infection is self-contained

73 ote phagocytosis of apoptotic cells, support the concept that EBOV relies on apoptotic mimicry to inv

74 Our results support the concept that EC Kir2 channels boost vasodilatory sig

75 The concept that EGFR oncogene inhibitor drugs could be

76 These results support the concept that EGFRt represents a promising approach t

77 Recently, the concept that endogenous stem/progenitor cells could

78 These data support the concept that endothelial dysfunction due to high cir

79 enesis/vasculogenesis, providing support for the concept that ENOX1 represents an antiangiogenic drug

80 combined effects of POPs on ALS and supports the concept that environmental exposures play a role in

81 These findings support the concept that eosinophils might act as antigen-presen

82 We investigated the concept that erythrocyte membrane microparticles (MP

83 ctural analysis and DFT calculations support the concept that Eu(2+) ions preferably occupy RbO(6) an

84 The concept that excess superoxide production from mitoc

85 The concept that exposure in utero to maternal anti-brai

86 These data are compatible with the concept that FGF21 functions physiologically as an i

87 Our data support the concept that FIH-1 may interact with Notch2 and repr

88 Transcriptomic data support the concept that functional, rather than compositional,

89 These results are supportive of the concept that G-quadruplex small molecules such as CM

90 data obtained for this ecosystem, supporting the concept that general models are applicable to predic

91 Fundamental to network analysis is the concept that genes underlying the same phenotype ten

92 lity and proliferation increase; this led to the concept that glia are required for maintenance of th

93 reduced TNF-alpha synthesis, which supports the concept that glycerophosphoinositol inhibits the de

94 nesthetized mice with electrodes, supporting the concept that glymphatic influx and intracranial lymp

95 with theoretical considerations, has led to the concept that granule cells encode afferent input as

96 These findings establish the concept that H3K4me defines the transcriptional stat

97 These results challenge the concept that haploinsufficiency is a unifying mechan

98 sed in examining RBPs and their networks and the concepts that have been developed.

99 The concept that hemostatic responses might be linked to

100 sults in a small sample, they are a proof of the concept that HER2-targeted imaging can identify addi

101 Support for the concept that herpes simplex virus type 1 (HSV1), whe

102 climate change concerns, this work supports the concept that high rice yields can be achieved with m

103 polarization (PHIP) was used to demonstrate the concept that highly polarized, catalyst-free fluids

104 This study explores the concept that homologous recombination DNA repair is

105 This work reinforces the concept that hosts and members of their associated m

106 The concept that hypnozoites give rise to relapses in Pl

107 The results support the concept that Id-specific Th cells may trigger the de

108 proof-of-principle data are compatible with the concept that IL-6 trans-signaling is relevant to AAA

109 Emerging evidence supports the concept that immune cells become activated and enter

110 These data support the concept that immunisation of devils with DFTD cancer

111 This reveals loss of AC and supports the concept that in asthma, biological processes underly

112 These results support the concept that in vivo, cumulative signals from the mi

113 The concept that individuals with the same disease and a

114 These findings support the concept that inflammasome activation is connected to

115 Excitingly, the concept that inflammation may be the core of cardiov

116 to the term "colitis-associated cancer" and the concept that inflammation promotes colon tumorigenes

117 hat result in premature telomere shortening, the concept that inhibiting telomerase might be a succes

118 These findings support the concept that inhibition of apoB synthesis traps lipi

119 Collectively, these results support the concept that inositol-1,4,5-trisphosphate type 3 rec

120 mprehensive assessment of fatness reinforced the concept that intraabdominal fat compartment is stron

121 The results of this study remark the concept that IOP is a dynamic parameter and that int

122 Our data support the concept that IPF fibroblasts acquire a cell-autonomo

123 In conclusion, our data support the concept that Jak2-Stat5a/b signaling promotes metast

124 a key regulator of metastasis and establish the concept that K14(+) epithelial tumor cell clusters d

125 Drug design is built on the concept that key molecular targets of disease are is

126 Our findings support the concept that localized, acquired SIgA deficiency in

127 We discuss the validity and limitations of the concept that low dose cardiovascular polypills, alre

128 Previous observations supporting the concept that maintenance of the intestinal epitheliu

129 These findings are consistent with the concept that male fetuses are more aggressive with r

130 These data support the concept that medication adherence is modifiable via

131 More broadly, this work supports the concept that microbial colonization status may influ

132 synthesize bioactive metabolites, supporting the concept that microbial dark matter harbors diverse p

133 t of alpha-synuclein pathology, and supports the concept that microglia play an integral role in the

134 t and rhesus monkey, yet are consistent with the concept that microglia regulate NPC function in the

135 otubule dynamics in neurite outgrowth led to the concept that microtubules directly drive plasma memb

136 These findings support the concept that microvascular dysfunction precedes and

137 The concept that mitochondria are highly dynamic is as w

138 eloped an innovative approach by introducing the concept that mitochondrial targeting peptides (MTP)

139 This supports the concept that MM41 (and by implication other quadrupl

140 -terminal region of the protein, and support the concept that modulating mutant HTT conformation migh

141 This method is based on the concept that most energy required for neuronal commu

142 & CLINICAL RELEVANCE: These findings support the concept that mother's milk has a distinct antifood a

143 The concept that motor disorders of the gallbladder, cys

144 These results all support the concept that mRGC degeneration is a contributor to c

145 o eruption, supporting and further extending the concept that Msx2 controls formation of mineralized

146 y TDP-43, VCP and SOD1 mutations, supporting the concept that multiple ALS genes interact in a regula

147 The findings of this study do not support the concept that myocardial viability is associated with

148 These results are consistent with the concept that Nanog-negative cells may contain subpop

149 The premise of this review is the concept that ncRNAs, like many large proteins, have

150 in neurons and cortical circuits, supporting the concept that neonatal gene therapy may prevent the f

151 de direct biologic and molecular support for the concept that neuroendocrine transdifferentiation in

152 T and the severity of MDE is consistent with the concept that neuroinflammation in specific regions m

153 These results support the concept that nitrate-rich vegetables may reduce the

154 Overall, this study supports the concept that NK cells accumulate in EBOV-infected ti

155 ved in human metastatic melanoma, supporting the concept that NLRC4 expression controls tumor growth.

156 In contrast, the concept that NLRs can inhibit innate immunity is sti

157 Recent studies have raised the concept that non-alcoholic fatty liver disease (NAFL

158 rapidity of some of the GC effects, however, the concept that non-genomic actions may contribute to G

159 Finally, these data confirm the concept that normal stroma function is essential for

160 to immunosuppression, these findings support the concept that Notch inhibitors could be attractive fo

161 inflammatory response persists, underscoring the concept that NTHi induces dysregulation of normal in

162 This study supports the concept that nTS astrocyte transporters influence sy

163 The concepts that obesity is merely a consequence of ove

164 ecular analysis of OCBs and strongly support the concept that OCBs are not merely the terminal result

165 In agreement with the concept that once infection is established high leve

166 clinical and genetic overlap and challenges the concept that one phenotype is attributable to one si

167 Taken together, these data refute the concept that ongoing HIV replication is common with

168 Overall these findings reinforce the concept that orthogonal E-cadherin-based signaling p

169 These data corroborate the concept that osteoblasts modulate the inflammatory r

170 the absence of this epitope, substantiating the concept that other antigens can be sufficient for pa

171 Our data support the concept that passive antibody and sulfasalazine coul

172 CD8(+) T cell reactivities, which reinforces the concept that peptide length is a key determinant of

173 iew the experimental evidence which supports the concept that peptides derived from chloroplast prote

174 in younger cohorts and were consistent with the concept that periodontitis is associated with pertur

175 Overall, our findings support the concept that perturbations in host-microbiota intera

176 original genetic association and supporting the concept that pharmacological inhibition of ADAMTS7 s

177 urvival of intestinal stem cells and support the concept that pharmacological quiescence is a potenti

178 We also propose the concept that phosphatidylserine recognition receptor

179 A robust body of evidence supports the concept that phosphodiesterase 10A (PDE10A) activity

180 Here, we describe the concept that PI16, a protein of unknown function mai

181 I3K inhibitors and summarize data supporting the concept that PI3Kdelta inhibitors initially develope

182 Of importance, our data challenge the concept that PI3Kgamma is required for insulin secre

183 In this study we propose the concept that pollen grains can be engineered for use

184 ese results provide an empirical example for the concept that population-based linkage analysis is a

185 d away from the direction of movement favors the concept that posterior parietal cortical mechanisms

186 Our findings support the concept that PPG value <12 mm Hg after TIPS placemen

187 These data support the concept that presynaptic boutons have a robust highl

188 derstanding of prion replication and support the concept that prion replication can be separated from

189 The concept that proteins and small RNAs can move to and

190 The results support the concept that "proteostasis" mechanisms, such as intr

191 TP-mediated biochemical events and reinforce the concept that PTPs are indispensable and specific mod

192 a result of poor stromal ecology, supporting the concept that purely tumour epithelium-centric metric

193 ces arrhythmia susceptibility and reinforces the concept that RA plays a critical role in the pathoph

194 Our results lead to the concept that reduced Ca(2+) buffering enables fast a

195 This preclinical study supports the concept that reduced toxicity with similar efficacy

196 These results bring forward the concept that reversing Arc abnormalities could provi

197 This study offers strong support to the concept that rhinitis and asthma represent the manif

198 Furthermore, we present the concept that RNA modifications can impair RNA-depend

199 , and reporter and mutation analysis support the concept that RORgamma regulates the transcription of

200 thesis of therapeutic hNGF but also supports the concept that salivary gland from TG animals is an ef

201 d among different biological systems, and so the concept that scaffolding complexes might not always

202 is massively enlarged, which is in line with the concept that SCYL1 regulates Golgi integrity.

203 ecies-level vertical inheritance, supporting the concept that secondary metabolites represent functio

204 Our data support the concept that secretion of host peptides results in a

205 CS1 transporters, and in particular, forward the concept that selective channel-like gates might cont

206 Our findings reinforce the concept that sentinel nodes act as pivotal sites for

207 The study does not therefore support the concept that severe asthma is associated with cortic

208 ctional studies in vivo and in vitro support the concept that Shank3 is critical for synaptic plastic

209 These results further support the concept that SM proteins in general are part of the

210 The concept that SNF5 is a coactivator for MYC, however,

211 These observations support the concept that some DOCK8-immunodeficient patients hav

212 These data support the concept that specific amino acid sequence modificati

213 upon prolonged serum deprivation, supporting the concept that ST6Gal-I confers a survival advantage.

214 Pneumocystis CONCLUSIONS: These data support the concept that stimulation of preexisting immunologica

215 Therefore, our data support the concept that store-operated Ca(2+) channels in hPECs

216 Our data support the concept that strategies aimed at enhancing hepatic b

217 Results of this study support the concept that stress-induced activation of KOR by end

218 ectively, these pre-clinical data help prove the concept that subcutaneous and subconjunctival inject

219 The concept that surface chemistry at the (sub)nanometer

220 These results support the concept that syntaphilin-mediated immobilization of

221 The concept that T lymphocytes are positively selected i

222 We investigated and validated the concept that target drug concentrations associated w

223 results of this study establish the proof of the concept that targeted HNPs can enhance the therapeut

224 of HER2-positive breast cancer, highlighting the concept that targeted therapies are successful when

225 nt-derived GBM stem-like cells, thus proving the concept that targeting aldehyde dehydrogenase might

226 tor of PI3K/AKT signaling; they also support the concept that targeting KDM5B is a novel and effectiv

227 induction of apoptosis, and strongly support the concept that targeting MCC dependence on these molec

228 Our results are consistent with the concept that Tbr2(+) neural precursor cells were pre

229 Our results strongly support the concept that TEIPPs derive from ubiquitous, nonmutat

230 Our results extend the concept that telomere length affects risk of lung ca

231 t nature of the truncated tau and supporting the concept that TFEB-mediated lysosomal exocytosis prom

232 our findings provide additional support for the concept that the anatomic and genetic etiological ba

233 Further, our results indicate proof of the concept that the assay can be used to detect Histopl

234 These results support the concept that the balance of TIMP3 and ADAM17 activit

235 Our results are consistent with the concept that the beneficial action of PI3Kgamma abla

236 These data substantiate the concept that the continuity of SC endothelium is an

237 he replicon to replicate, further supporting the concept that the correct positioning of both the bet

238 fined in the mathematical sense, and support the concept that the defining mechanism is a stable grou

239 These results support the concept that the Drg1-Dvl interaction regulates apic

240 Based on the concept that the droplet state is stabilized by the

241 We also found evidence supporting the concept that the effects on microphthalmia-associate

242 These observations support the concept that the emergence of human-adapted S. enter

243 egulation and cell cycle control, supporting the concept that the established GABAergic dysfunction i

244 These findings support the concept that the folding trajectory of SERT is sampl

245 The concept that the full effects of CPCs require repeat

246 Operating under the concept that the GFD benefits only individuals with

247 ere we provide an experimental validation of the concept that the HD dialytic removal of PBUTs can be

248 All in all, these results support the concept that the implantation of encapsulated GDNF-s

249 Together, our results support the concept that the interface between LD and cardiac mi

250 Our work challenges the concept that the KLRG1(+)CD127(low) population is do

251 ifferent frequencies and provide support for the concept that the locomotor central pattern generator

252 Our data support the concept that the major autophosphorylation site (Thr

253 These results support the concept that the measured behavior of glaucomatous V

254 Our results confirm the concept that the monosynaptic projection between HC

255 Our data suggest the concept that the multi-PDZ-domain adaptor protein GR

256 The intent of this review is to develop the concept that the multifaceted therapeutic effects of

257 studies have provided increasing support for the concept that the nucleolus represents a multilayered

258 over the primary linoleate products enhances the concept that the oxidations disrupt corneocyte membr

259 These findings have attested to the concept that the paracellular pathway is physiologic

260 These studies support the concept that the perithrombus endothelium is the pre

261 Collectively, a solid basis is provided for the concept that the probability of cyst formation is de

262 el that captures these features, building on the concept that the ribbon under the imposed deformatio

263 aging profile, providing further support for the concept that the separation between them should be a

264 Our results support the concept that the TCR can continue to signal after it

265 The evidence to date supports the concept that the thrombotic manifestations of severe

266 e basis of a H-tunneling mechanism that uses the concept that the tunneling of a heavier isotope requ

267 l)-S-phenylglycine t-butyl ester, supporting the concept that the two compounds act at the transcript

268 ausing acute disease, thereby giving rise to the concept that the virome is a component of the microb

269 Thus, our results support the concept that the ZO-1 shuttle from the cell junction

270 The data support the concepts that the exRNA/RNase1 system participates i

271 tive T cell immunity to melanoma and support the concept that therapeutic vaccination, as an adjunct

272 This innovation might be the concept that there are subtypes of early and interme

273 The concept that there is a single "cochlear amplificati

274 there is limited genetic evidence to support the concept that these boundaries restrict the search sp

275 They support the concept that this dietary lifestyle can act as a ris

276 This study tested the concept that this female advantage associates with a

277 are assembled into the acrosome, challenging the concept that this organelle is strictly derived from

278 Our findings do not support the concepts that this phase is devoid of markers of dis

279 , and at a behavioural level this has led to the concept that tics result from a failure of inhibitio

280 This leads to the concept that tissue regeneration required stimulatio

281 Here we discuss the concept that TNTs/TMs fill an important niche in the

282 Together, our study supports the concept that transcriptional suppression of KV2.1 by

283 icity and tissue regeneration and introduces the concept that transient therapeutic delivery of senes

284 Pharmacogenomics (PGx) is the concept that treatments can be modified to account f

285 of TNFalpha promoter activation, supporting the concept that TRIF-dependent signalling plays an impo

286 These findings support the concept that TSLP plays a role in the development of

287 Taken together, our findings support the concept that tumor or precursor cells of BLS-type DL

288 ental models of breast cancer, we reinforced the concept that tumor-infiltrating gammadeltaT17 cells

289 The concept that tumor-initiating cells can co-opt the s

290 y distinct genomic alterations, highlighting the concept that tumors can dysregulate key pathways thr

291 The concept that type I interferons (IFN-I) are essentia

292 on of key computational predictions supports the concept that understanding the molecular complexity

293 An important emerging area is the concept that unregulated [Ca(2+) ]i signals in cells

294 This finding supports the concept that uptake and efflux at monoamine transpor

295 Our results are in line with the concept that very high levels of specific humidity,

296 Overall, these data develop the concept that VgrGs are indispensable components for

297 Our findings support the concept that viral load drives the severity of RSV d

298 This has been used to support the concept that viral reactivation in HCMV carriers rou

299 ice sites disrupting splicing and introduces the concept that VWF splicing is affected by shear stres

300 Overall, these findings are consistent with the concept that "what doesn't kill me makes me stronger