ライフサイエンスコーパス: the discovery of

1 The discovery of 1 and the characterization of NanA have

2 l testing of 62 screening candidates yielded the discovery of 10 new agonist chemotypes with sub-micr

3 The discovery of 2-dimensional (2D) materials, such as C

4 These efforts have culminated in the discovery of 4-({5-[4-fluoro-1-(2H-indazol-6-yl)-1H-

5 ility loci; however, this does not equate to the discovery of 40 Alzheimer's disease genes.

6 ance the permeability, which directly led to the discovery of 7 (BMS-986202) as a clinical Tyk2 inhib

7 of enriched features which ultimately led to the discovery of a 1 nM inhibitor of thrombin.

8 Here, we present the discovery of a 16-mer cyclic peptide that binds to C

9 Herein, we describe the discovery of a candidate-quality dimethylpyridone be

10 upervised learning approach could facilitate the discovery of a comprehensive set of chromatin intera

11 The discovery of a diverse microbial community in smecti

12 Here, we report the discovery of a family of endoplasmic reticulum (ER)

13 Recently, the discovery of a gaseous debris disk with a compositio

14 h a distinctly prostrate growth habit led to the discovery of a gene category that participates in th

15 We report the discovery of a Janus nanomolecule, Au(191)(SPh-tBu)(

16 Here, we report on the discovery of a large family of warfarin-like compoun

17 of different Euphorbia plants and regarding the discovery of a marine natural product, revealing bio

18 We present the discovery of a microbial inhibitor combo consisting

19 We report the discovery of a mitoribosome-associated quality contr

20 the shift of this paradigm, we present here the discovery of a new and distinct heavy-atom QMT react

21 onia ligand of (TMP)Ru(NH(3))(2), leading to the discovery of a new catalytic C-N coupling to the par

22 We report the discovery of a new superprotonic compound, Cs(7)(H(4

23 These mechanistic insights assisted the discovery of a new Ti(salen) catalyst, which substan

24 Here, we report the discovery of a novel chemical series of non-bile aci

25 The hit-to-lead optimization led to the discovery of a novel chemotype series exemplified by

26 t that GaMF1 presents an attractive lead for the discovery of a novel class of anti-tuberculosis F-AT

27 structure-activity relationship, leading to the discovery of a novel DBO, ANT3310, which uniquely ha

28 Here, we described the discovery of a novel E3 ligase von Hippel-Lindau-rec

29 -based colorimetric readout of this assay to the discovery of a novel monoclonal antibody (mAb) sandw

30 We present the discovery of a novel radical cation formed through o

31 Herein, we report the discovery of a novel series of reversible and select

32 Here, we report the discovery of a novel, transcriptionally independent

33 The discovery of a pan-genotypic hepatitis C virus (HCV)

34 The resulting 680 genome sequences led to the discovery of a pan-susceptible ST313 lineage (ST313

35 Peptide scan analyses led to the discovery of a peptide containing methyl lysines rec

36 Here, we report the discovery of a pharmacological treatment that thins

37 In this report we describe the discovery of a potent and selective DYRK1A inhibitor

38 The discovery of a potential biomarker opens up new rese

39 SAR studies have enabled the discovery of a predictive 3DQSAR model.

40 Here, we report the discovery of a previously uncharacterized virus gene

41 Finally, the discovery of a prominent innate lymphoid cell-2 clus

42 Here we report the discovery of a rudimentary synthetic molecular assem

43 f the 2-sulfonylpyridine reactive group with the discovery of a selective covalent modifier of adenos

44 Herein, we report the discovery of a series of JAK1-selective kinase inhib

45 spectively, is identified, which accelerates the discovery of a series of new oxide perovskite cataly

46 Herein, we describe the discovery of a series of oxadiazole ketones, which u

47 We previously described the discovery of a small molecule, (+)SW033291, that bin

48 This scenario is now rapidly changing with the discovery of a spectrum of genomic defects that hija

49 Here we report on the discovery of a ternary silicon titanium nitride with

50 t a medicinal chemistry campaign that led to the discovery of ABBV-744, a highly potent and selective

51 Despite the discovery of acesulfame and PFAS in most OSPW sample

52 The effort described herein culminated in the discovery of ACT-1004-1239 (28f).

53 c code expansion and provides a pipeline for the discovery of additional orthogonal pairs and a found

54 The discovery of air-breathing structures in eurypterids

55 BTZ scaffold as a useful starting point for the discovery of allosteric MGL inhibitors.

56 his process on a synthetic scale, leading to the discovery of an Amadori-type rearrangement of dopega

57 We describe the discovery of an archaeal virus, one that infects arc

58 Here we report the discovery of an articulated and very well-preserved

59 Specifically, the discovery of an intracellularly active complement sy

60 Furthermore, the discovery of an intratumoral microbiome and the eluc

61 set of natural-product-derived cores led to the discovery of an uncharged macrocyclic inhibitor of t

62 The discovery of an unexpected high-concentration doping

63 idirectional circuits.SIGNIFICANCE STATEMENT The discovery of anterograde transneuronal spread of AAV

64 netic research are highlighting pathways for the discovery of anti-ageing interventions that may be a

65 iabetes has recently been recognized through the discovery of antibodies and T-cell reactivity agains

66 based screen in Saccharomyces cerevisiae for the discovery of antifungal inhibitors of GPI-anchoring

67 ral-host interactions that should facilitate the discovery of antiviral drugs for this important zoon

68 e autophagy pathway is a viable strategy for the discovery of autophagy-specific probes and therapeut

69 an greatly simplify diagnosis and accelerate the discovery of bacterial tick-borne pathogens.

70 The S. tora reference genome will accelerate the discovery of biologically active anthraquinone biosy

71 The discovery of borospherenes unveiled the capacity of

72 oscapulohumeral dystrophy (FSHD) have led to the discovery of candidate therapeutics, and it is impor

73 rs and photo-electrochemical devices, and to the discovery of catalytic pathways beyond two electrons

74 ypic and genetic heterogeneity, complicating the discovery of causative genes.

75 Ds for the treatment of RRMM, culminating in the discovery of CC-92480, a novel protein degrader and

76 his was acknowledged only later though, upon the discovery of CD31's 2 intracytoplasmic tyrosine resi

77 The discovery of CD4(+) T cell subset-defining master tr

78 regulation during CAR-T therapy, leading to the discovery of cellular factors associated with durabl

79 0, DOI: 10.1021/acs.jmedchem.0c01342) report the discovery of CG416 and CG428 as two potent small-mol

80 based, PheWAS-guided approach can accelerate the discovery of clinically relevant disease phenome and

81 The discovery of clonal hematopoiesis (CH) in older indi

82 The discovery of colorectal (CR) cancer stem cell (CSC)

83 ents with nanometer resolution, facilitating the discovery of complex and dynamic protein networks.

84 , permeability, and low efflux culminated in the discovery of compound 1, which exhibited target enga

85 This led to the discovery of compound 41, a highly potent, selective

86 oral phramacokinetics properties resulted in the discovery of compound 41, which showed improved toxi

87 This led to the discovery of compound BAY 1214784, an orally availab

88 ssing the ongoing antibiotic crisis requires the discovery of compounds with novel mechanisms of acti

89 itational constant by Henri Cavendish(1) and the discovery of Coulomb's law.

90 t effective against CSCs, which necessitates the discovery of CSC-specific biomarkers and drug target

91 The discovery of current mutational processes for predic

92 The discovery of D1-mGlu5 functional heteromers mediatin

93 Here, we report the discovery of dechloroacutumine halogenase (DAH) from

94 The discovery of drivers of cancer has traditionally foc

95 n related to Wallerian degeneration in mice; the discovery of 'druggable' enzymes, including SARM1 an

96 in the progression of liver diseases and in the discovery of drugs for the treatment of these disord

97 Until the discovery of DUX4 and its causal role in FSHD, most

98 Several recent developments-including the discovery of dwarf galaxies associated with the Mage

99 The discovery of efficient organocatalysts is generally

100 This approach resulted in the discovery of eight new proline-containing cyclic non

101 ructure-activity relationship studies led to the discovery of enantiomerically pure 39 endowed with a

102 The discovery of eukaryotic giant viruses has transforme

103 wever, are inherently problematic because of the discovery of excessive false positive (FP) mutations

104 ased method implemented in R, that automates the discovery of expressed non-coding RNAs and UTRs from

105 Here we report the discovery of extensive endochondral bone in Minjinia

106 The discovery of fall armyworm, a native of the Western

107 The discovery of fibroblast growth factor 23 (FGF23), wh

108 We also report the discovery of first-in-class dual bromodomain-kinase

109 The discovery of flat electronic bands with topological

110 The discovery of fluorescence two centuries ago ushered

111 The discovery of FRB 200428 implies that active magnetar

112 Accelerated timelines necessitate the discovery of fully human antibodies as biotherapeuti

113 Since the discovery of functionally competent, energy-consumin

114 Since the discovery of garnet-type LLZO in 2007, there has bee

115 ome-wide association studies has facilitated the discovery of gene-environment interactions (GxE).

116 These findings indicate the potential for the discovery of genetic factors influencing haemodynami

117 Whole-exome sequencing (WES) has facilitated the discovery of genetic lesions underlying monogenic di

118 int of entire ecosystems (MeE) to facilitate the discovery of global bioactivity hotspots.

119 Previously, we reported the discovery of GNF6702, a selective inhibitor of the k

120 important part of the software stack used in the discovery of gravitational waves(1) and in the first

121 lustrate the potential of NGLs to accelerate the discovery of GSL ligands of GBPs.

122 hms has led to important insights, including the discovery of guidance rules that attacking predators

123 Here we report the discovery of hierarchical controls on the inorganic

124 Here, we report the discovery of high-magnesium calcite [CaMg(CO(3))(2)]

125 evelop a new algorithm, MOCHI, to facilitate the discovery of HIMs based on network motif clustering

126 The discovery of hydrogen-induced electron localization

127 These findings highlight the discovery of IACS-13909 as a potent, selective inhib

128 The discovery of impaired hippocampal synaptic plasticit

129 Despite the discovery of ipRGCs nearly two decades ago, there is

130 gh-throughput sequencing technologies led to the discovery of isomiRs, which are miRNA sequence varia

131 es, a structural optimization program led to the discovery of isosteric 7-hydroxy-5-oxopyrazolo[4,3-b

132 The discovery of JAKs and STATs and their roles in cytok

133 The discovery of keratinocyte-sensory neuron synaptic-li

134 e Ron Duman, we provide a historical note on the discovery of ketamine and its putative mechanisms.

135 tion of genome-scale metabolic models toward the discovery of key metabolic pathways.

136 With the discovery of lateral budding in 'Kolteria novifilia'

137 of 268 unrelated individuals of P. deltoides The discovery of lignin regulators began with the quanti

138 y, including novel ligand identification and the discovery of loss-of-function mutations associated w

139 Initial efforts resulted in the discovery of M4K2009, an analogue of the previously

140 CTSRs can, therefore, aid in the discovery of major regulatory mechanisms and allow r

141 The discovery of many E. chaffeensis proteins crucial fo

142 y propagated crop can be accelerated through the discovery of markers and candidate genes that could

143 r substantial additional insights, including the discovery of mechanisms that trigger and propagate k

144 The glymphatic concept along with the discovery of meningeal lymphatic vessels have, in re

145 Since the discovery of metal nanoparticles (NPs) in the 1960s,

146 The discovery of methane (CH(4)) accumulation in oxic ma

147 nces), particularly the perfluorinated ones, the discovery of microbial defluorination under common a

148 These findings will help efforts towards the discovery of microbial-derived repellent/oviposition

149 The discovery of MISTR circuitry highlights the use of e

150 The present focus is on the discovery of molecules that may regulate the activit

151 hus propagating information that can lead to the discovery of molecules, metabolic pathways, and ecos

152 nificance of genetic variants and to utilize the discovery of molQTLs in precision medicine.

153 tein-coupled receptors, has directly enabled the discovery of most drugs developed to modulate recept

154 cise as a valuable experimental platform for the discovery of much-needed novel therapeutic targets i

155 monas aeruginosa LpxC as guides, resulted in the discovery of multiple chemical series based on (i) i

156 Since the discovery of mycobacterial T7SSs about 15 y ago, gen

157 The discovery of MYD88 and CXCR4 mutations in WM has fac

158 basis of PD mimetic-induced Parkinsonism and the discovery of neuroprotective agents.

159 The discovery of new antiviral therapies is imperative t

160 a significant source of inspiration towards the discovery of new bioactive compounds based on novel

161 The discovery of new biomarkers will lead to improved di

162 inst membrane proteins, which could catalyze the discovery of new candidates for antibody-based thera

163 esistance to the current antimalarial drugs, the discovery of new drug candidates is a major global h

164 , a scarcity of molecular tools has hindered the discovery of new drug targets.

165 tlas in neuroinflammatory disease and report the discovery of new druggable pathways.

166 diffraction studies up to 27 GPa, we report the discovery of new high-pressure polymorphs of the fel

167 of these photosynthetic organisms, including the discovery of new molecular pathways governing the li

168 offer the opportunity in future studies for the discovery of new physiological roles of MK-4.

169 h as silsesquioxane, is a fruitful arena for the discovery of new reactivity.

170 cycle will provide unique opportunities for the discovery of new reactivity.

171 mpared with previous analyses(3-15), enabled the discovery of new signatures, the separation of overl

172 s to understand mechanisms of binding and in the discovery of new SLPs.

173 The discovery of new solid-state electrolytes (SSEs) can

174 in the course of disease progression, while the discovery of new therapeutic interventions has been

175 of the sequence space and to applications in the discovery of new therapeutics.

176 type of skin gammadelta T cells will improve the discovery of new therapies.

177 s help to deepen our understanding and guide the discovery of next-generation water harvesting materi

178 The discovery of non-native kelp washed up on Antarctic

179 icient in silico-guided approach that led to the discovery of novel allosteric RORgammat inverse agon

180 ents a promising noncovalent lead series for the discovery of novel antituberculosis agents.

181 eCLIP peak co-occurrences across RBPs enable the discovery of novel co-interacting RBPs.

182 approached in the clinic and laboratory for the discovery of novel gene variants.

183 As proof-of-concept for the discovery of novel P2X receptor agonists, here we de

184 r Waals materials provide a new platform for the discovery of novel physics and effects.

185 entific and translational efforts, including the discovery of novel protein biomarkers of disease.

186 ER), a RiPP genome mining algorithm aimed at the discovery of novel RiPP classes.

187 midst the global rise in metabolic syndrome, the discovery of novel signaling roles for metabolites,

188 abling systematic identification of BGCs and the discovery of novel SMs.

189 wo neonatal disorders, holding potential for the discovery of novel targets to treat BPD and ROP.

190 te genes for future studies in connection to the discovery of novel trichome specific promoters.

191 A second major novelty is the discovery of numerous derived CRISPR-Cas variants, o

192 The third highlight is the discovery of numerous families of ancillary CRISPR-l

193 Since the discovery of ocular dominance plasticity, neuroscien

194 evelop a two-step rational design method for the discovery of oligomer-specific antibodies.

195 Conversely, it also allows for the discovery of optimal human GRI dynamics not captured

196 Here we report the discovery of our clinical candidate S64315, a select

197 Here we report the discovery of over 300 new imine reductases and the p

198 dy (mAb) technology is an excellent tool for the discovery of overexpressed cell surface tumour antig

199 These results are then applied to the discovery of p53-like binders to MDM2, and to a fami

200 The discovery of PBIs with supramolecular structures bey

201 der Fleming's original fungal isolate behind the discovery of penicillin, now classified as Penicilli

202 e could be a potential untapped resource for the discovery of phage-derived therapeutic proteins.

203 screening has great potential to accelerate the discovery of phenotypic negative regulatory elements

204 This work has led to the discovery of potent and effective SHP2 degraders, ex

205 ), the development of which will be aided by the discovery of potent and selective antibodies against

206 We previously reported the discovery of potent and selective families of GRK in

207 p study of 2-arylvinylquinolines, leading to the discovery of potent, low nanomolar antiplasmodial co

208 Finally, a road map for the discovery of potential new glioma drug targets is su

209 Here we report the discovery of pressure-stabilized divalent ozonide Ca

210 The discovery of previously unknown N(2)-fixing (diazotr

211 These findings hold great promise for the discovery of previously unknown tumor antigens for c

212 Here, we report the discovery of prophages in cultured SAR11, the ocean'

213 This work culminated with the discovery of PROTAC 23, which we demonstrated to be

214 -phenotypic approach presents a strategy for the discovery of protective mechanisms in fibroblast-ric

215 The discovery of protein inhibitors of CRISPR-Cas system

216 syltransferase that synthesises amylose, and the discovery of PROTEIN TARGETING TO STARCH1 (PTST1) th

217 ged from our analyses provide a resource for the discovery of proteins that impact the expression of

218 This resulted in the discovery of pyrazolopyrimidine 3, which was optimiz

219 Since the discovery of quantum beats in the two-dimensional el

220 require large sample cohorts, cis-X enables the discovery of regulatory noncoding variants in indivi

221 First, the discovery of relatively regular activity patterns in

222 proach and avoidance responses, facilitating the discovery of rewarding behavior in the many novel co

223 In 2006, the discovery of RNAi was awarded the Nobel Prize in Med

224 Since the discovery of roaming as an alternative molecular dis

225 '-O-methyl RNA and hexitol nucleic acids and the discovery of RTs for the orphan XNA chemistries D-al

226 The discovery of safe, general, and practical procedures

227 Herein, we report the discovery of second-generation GluN2C/D-selective NM

228 natural product chemical space, accelerating the discovery of selective lead compounds.

229 om new material and the holotype, leading to the discovery of several new morphological features, suc

230 This review documents the discovery of several polypeptide ligands and their c

231 We report the discovery of several thematically unified, remarkabl

232 The discovery of single-phase multiferroic materials and

233 This Perspective reviews recent advances in the discovery of small molecule inhibitors of p97, their

234 Since the discovery of SOCE, many inhibitors have been identif

235 The discovery of spin-polarized correlated states in ele

236 around 20% of all patients with lung cancer, the discovery of stratified medicine options for tobacco

237 ce of chromosome-scale phased assemblies for the discovery of structural variants (SVs), including th

238 hes to expand our antibiotic arsenal through the discovery of structurally distinct antibacterial mol

239 The discovery of such conditions could lead to novel sou

240 al methods have been developed to facilitate the discovery of such non-classical secreted proteins; h

241 vanced breast cancer for three decades until the discovery of tamoxifen.

242 There has been huge progress in the discovery of targeted cancer therapies in recent yea

243 n approach and ethos that have resulted from the discoveries of the last few decades.

244 The discovery of the Asgard archaea, which harbor close

245 ed by Rolf Kemler and Masatoshi Takeichi for the discovery of the cadherin family of Ca(2+)-dependent

246 The discovery of the clinical development candidate MRTX

247 The discovery of the clustered regularly interspaced sho

248 search orchestrated by Randy Schekman led to the discovery of the coat protein complex II (COPII).

249 The GUV-based assay has led to the discovery of the critical role of phosphatidylserine

250 We discuss the discovery of the DNA methylation-based biomarkers fo

251 Furthermore, we report the discovery of the first known CntA inhibitors and sol

252 highlight issues and perspectives raised by the discovery of the first pharmaceutical strongly affec

253 f catalytic luciferase enzymes, coupled with the discovery of the genes and pathways that encode diff

254 ompounds mediate their effects, which led to the discovery of the mammalian endocannabinoid system.

255 This study concludes the discovery of the MbA biosynthetic pathway and provid

256 In this minireview, we highlight the discovery of the monofunctional glycosyltransferases

257 Herein we report the discovery of the most potent and selective UCHL1 pro

258 In addition, the discovery of the new RE-hpt-MOF-1 and RE-ken-MOF-1 f

259 n accelerated first-principles screening for the discovery of the next generation of functionalized m

260 Inspired by the discovery of the nonselective aminotransferase inact

261 The discovery of the opposing functions of BRCA1 and the

262 The discovery of the PHD-HIF-pVHL system revolutionized

263 Since the discovery of the pioneering bimetallic {MnII4[MIV(CN

264 selectivity, and oral bioavailability led to the discovery of the potent, highly selective, orally av

265 ge-scale TF-binding in vivo, making possible the discovery of the potential interaction and cooperati

266 Until the discovery of the rapid acting antidepressant (RAAD)

267 The discovery of the rapid-acting antidepressant effects

268 els and the experimental work that led up to the discovery of the remarkable, singular Soai reaction.

269 ion in lambda, the study of which began with the discovery of the Rho transcription termination facto

270 The discovery of the role of the PD familial genes PTEN-

271 The discovery of the spin-orbit-entangled exciton in ant

272 In the three decades since the discovery of the Wallerian degeneration slow (Wld(S)

273 Our results suggest a new path for the discovery of therapeutic molecules by demonstrating

274 ay or combinatorial chemistry approaches for the discovery of therapeutic peptides, we present a meth

275 This is a brief account of the discovery of these mutants and how they led to the i

276 Here, we present the discovery of thieno[3,2-d] pyrimidine SGC-STK17B-1 (

277 etwork that was specifically associated with the discovery of this embedded structure.

278 A strategic screening approach led to the discovery of this novel ligand, which was successful

279 tform represents an interesting strategy for the discovery of this type of inhibitors.

280 merging sequencing technologies have enabled the discovery of thousands of SVs, uncovering informatio

281 rly detection of lung cancer might result in the discovery of thyroid incidentalomas.

282 orm shallow CNNs as well as k-mer methods in the discovery of tissue-specific sites bound in vivo.

283 The discovery of TMEM173/STING-dependent innate immunity

284 These studies culminated in the discovery of TNO155, (3S,4S)-8-(6-amino-5-((2-amino-

285 etic manipulation in vivo and may facilitate the discovery of treatments for diabetes.

286 robial biosynthesis platforms can facilitate the discovery of tropane alkaloid derivatives as new the

287 Previously, we described the discovery of tropifexor (LJN452), the most potent no

288 Thus, we present the discovery of two components of c-di-AMP signaling in

289 We describe, date, and contextualize the discovery of two hominin crania from Drimolen Main Q

290 Here we report the discovery of two homologous groups of pericyclases t

291 In this study, we present the discovery of two new class-level lineages of free-li

292 Here, we report: the discovery of two previously unknown surface glycan b

293 his work is to describe a novel platform for the discovery of tyrosinase inhibitors, based on (a) one

294 have recently emerged as effective tools for the discovery of Ub chain-specific interactors in proteo

295 This strategy may also be employed for the discovery of unconventional spherical assemblies in

296 f plasma cells and plasmablasts could enable the discovery of useful antibodies for therapeutic or re

297 sorder can be combined effectively to enable the discovery of variants not identified by studying eit

298 Furthermore, the discovery of wild plants that do not produce amylose

299 2, 1896, the local press in Malaga reported the discovery of X-rays, relating various news items abo

300 The discovery of XP advances our knowledge of these impo