1 As far as we know, this is
the first study about characterization of the oxidized p
2 This is
the first study about removal of lead (Pb(II)) from ener
3 This is
the first study analyzing both prevalence and new onset
4 This is
the first study analyzing CTC and DTC status in 1 cohort
5 We present
the first study and comparison of the performance of mag
6 In
the first study arm, the efficacy of CPX NS (1, 3, 5 mg/
7 This is
the first study attempting to identify the bioactive com
8 This is
the first study characterising the genetic structure of
9 As
the first study concentrated in the transposition activi
10 This is
the first study demonstrating a biologically relevant, p
11 This is
the first study demonstrating a regulatory role of miR-4
12 To our knowledge, this is
the first study demonstrating inflammation within the ne
13 To the best of our knowledge, this is
the first study demonstrating Se transference during met
14 astomys coucha as preclinical model, this is
the first study demonstrating seroconversion against dif
15 This is
the first study demonstrating that BPSS2242 is responsib
16 In summary, this is
the first study demonstrating the beneficial effects of
17 To our knowledge, this is
the first study demonstrating the influence of trait str
18 To the best of our knowledge, this is
the first study demonstrating the potential of a liquid
19 enzyme (LpxR), and to our knowledge, this is
the first study describing it as a potential vaccine can
20 This is
the first study describing the role of pUL47 in both vir
21 This is
the first study describing ToF-SIMS imaging for probing
22 The first study enrollment occurred on November 18, 2015
23 To our knowledge, this is
the first study examining and quantifying the associatio
24 nal secretion.SIGNIFICANCE STATEMENT This is
the first study examining the mechanism of mutant huntin
25 This is
the first study examining transcriptomes of multiple hip
26 t role from AtMPK9 To our knowledge, this is
the first study implicating a function for a TDY MAPK in
27 These are
the first studies in any cell type demonstrating that la
28 Therefore, we report
the first studies in humans demonstrating that pharmacol
29 Here, we report
the first studies in this field capable of distinguishin
30 This is
the first study in a middle-income country in the Asia a
31 This is
the first study in an under evaluated population of recu
32 This is
the first study in children with steroid-resistant NS wh
33 nsmission has been reported in mice, ours is
the first study in nonhuman primates to demonstrate infe
34 This is
the first study in plants that reveals novel functional
35 ealthy participants were obtained as part of
the first study in the Canadian Biomarker Integration Ne
36 This is
the first study in the field to show that risk communica
37 This is
the first study in which changes in work-loop shape deta
38 This is
the first study in which mycotoxins and other microbial
39 As far as we know, this was
the first study in which precise editing of an oncogenic
40 To our knowledge, this is
the first study in which the time course of hospitalizat
41 To the authors' knowledge, this is
the first study in which the uptake and time-dependent a
42 The first study included 126 kidney transplants performe
43 This is
the first study introducing an Aspergillus strain for be
44 To the best of our knowledge, this is also
the first study investigating the effect of AMPs on airw
45 This is to our knowledge
the first study investigating the human cerebellar elect
46 In
the first study,
male 12-week-old Wistar-Kyoto rats were
47 In
the first study,
nasal specimens and either nasopharynge
48 In one of
the first studies of human pancreatic islets with a dise
49 We report
the first study of a gas-phase reaction catalyzed by hig
50 This is
the first study of adherence to follow-up recommendation
51 UNICORN was
the first study of an off-label protocol using whole blo
52 This is
the first study of anaphylaxis-related mortality coming
53 In
the first study of HTLV-1 disease associations based on
54 This is
the first study of its kind demonstrating that donor age
55 To our knowledge, this is
the first study of its kind to investigate chemolithotro
56 To the best of our knowledge, this is
the first study of its kind to investigate inter-donor v
57 As
the first study of its kind, this study comprehensively
58 In
the first study of its kind, we investigate whether and
59 This is
the first study of POT guided by intravascular ultrasoun
60 This is
the first study of the biological effects of LCs on pulm
61 time mass spectrometry (DART-MS)-we present
the first study of the chlorination chemistry that occur
62 In this work, we report
the first study of the mechanical stability of the BapA
63 Here we report
the first study of the neutron radiation tolerance of tw
64 This is
the first study of the oxidation of limonene with HOCl a
65 Herein we report
the first study of the oxygen reduction reaction (ORR) c
66 This is
the first study of the persistent health impacts of THC
67 Here, we present
the first study of the seasonal variation in composition
68 This is
the first study of the use of MOFs for biofouling contro
69 To our knowledge, we present
the first study on a multispanning protein incorporated
70 This is
the first study on chronic algal toxicity to combine syn
71 This is
the first study on NO(*)-related molecular changes and S
72 Here, we present
the first study on oxidative damage of human telomere G-
73 This is
the first study on the nanoencapsulation of Danube fish
74 Presented here, is
the first study on the vocalisations of long-finned pilo
75 In
the first study,
paired associative stimulation (PAS) wa
76 To the best of our knowledge, this is
the first study predicting gammai for bisolute adsorptio
77 This is
the first study presenting morphogeometric and volumetri
78 This is
the first study presenting wide range of elements in gre
79 This is
the first study providing evidence for the hypothesis th
80 This is, to our knowledge,
the first study providing in vivo human evidence that DA
81 To the best of our knowledge, this is
the first study regarding detailed investigation of hepa
82 This is
the first study reporting excretion of sTAM receptors in
83 This is
the first study reporting fatty acid profiles and distri
84 This is
the first study reporting Hereditary Myotonia in pigs an
85 To our knowledge, this is
the first study reporting that a member of the TRIM fami
86 This is
the first study reporting that cardiac enzymes and infla
87 This is
the first study reporting the distinct cellular protein
88 Furthermore, we present
the first study revealing AFP glycopeptide signatures of
89 This is one of
the first studies showing that nutritional dietary plans
90 This is one of
the first studies showing the potential of using earth o
91 We present
the first study showing differences in faecal VOC profil
92 This is
the first study showing regulation of let-7 targets in i
93 This is
the first study showing that Abeta reduction at early di
94 This is
the first study showing that ADR variants are susceptibi
95 6.50 x 10(-8) for rs4950(.) This represents
the first study showing that CHRNB3/A6 are highly associ
96 This is
the first study showing that metabolomic profiling of ur
97 This is, to our knowledge,
the first study showing that the TPH2 genotype may modul
98 CASSIOPEIA is
the first study showing the clinical benefit of daratumu
99 In
the first study,
sixteen beef cattle were implanted with
100 The first study-
specific co-primary outcome (Auditory Co
101 This is
the first study suggesting that the poor stroke recovery
102 To our knowledge, this is
the first study supporting the notion that Native Americ
103 Here, we provide
the first studies targeting a key protein-protein intera
104 RTANCE To the best of our knowledge, this is
the first study that compares intra-individual evolution
105 This is
the first study that defines the antiviral capacities of
106 This is
the first study that demonstrates that (*)OH in Co(2+)-a
107 To the best of our knowledge, this is
the first study that demonstrates the role of RNA-bindin
108 To our knowledge, this is
the first study that demonstrates the therapeutic effica
109 This is
the first study that describes EAV full-length genomic e
110 To the best of our knowledge, this is
the first study that describes the use and reaction mech
111 This is
the first study that directly compares temperature adapt
112 This is
the first study that documented the occurrence of anthro
113 This is
the first study that evaluates ERC-related infectious co
114 To our knowledge, this is
the first study that evaluates the functional and clinic
115 As far as we know, this is
the first study that has investigated the targeting of Z
116 This is
the first study that has successfully sequenced the comp
117 Overall, this is
the first study that identified novel unsaponifiable com
118 This is
the first study that makes complementary use of solvent
119 This is
the first study that provides an overview of the global
120 This is
the first study that underscores the direct implication
121 We present findings from
the first study that used NA to examine the relationship
122 To our best knowledge, this is
the first study that uses whole-exome sequencing for the
123 To our knowledge, this is
the first study that utilizes both machine learning and
124 For
the first study,
timed-pregnant B6C3F1 mice were exposed
125 To our knowledge, this is one of
the first studies to examine (13)C(6)-glucose utilizatio
126 This is one of
the first studies to find diet-mediated tolerance.
127 tocols.SIGNIFICANCE STATEMENT This is one of
the first studies to use a repeated-measures imaging pro
128 This is
the first study to analyse community DNA (targeting meio
129 be continued and improved.IMPORTANCE This is
the first study to analyze global country level HIV-1 di
130 This is
the first study to analyze spatiotemporal trends in part
131 This is also
the first study to apply MHRA to questions of relatednes
132 This is
the first study to apply next-generation sequencing tech
133 To our knowledge, this is
the first study to assess and report the mismatching bet
134 This is
the first study to assess DNAm GrimAge in PTSD patients.
135 We describe
the first study to characterise accumulated consequences
136 This is
the first study to characterize the function of SLC22A15
137 Our research is
the first study to characterize whole-genome expression
138 To our knowledge, this is
the first study to compare intellectual trajectories bet
139 This is
the first study to compare metal levels before disease o
140 This is
the first study to compare the two dominant approaches t
141 To our knowledge, this is
the first study to comprehensively analyze all 10 (struc
142 To our knowledge, this is
the first study to comprehensively evaluate the associat
143 ding accuracy.SIGNIFICANCE STATEMENT This is
the first study to conduct a network-level analysis of t
144 This is
the first study to confirm prominent hyaluronan exudates
145 To our knowledge, this is
the first study to date of place of birth and incident d
146 This is
the first study to date providing a comparison of the CT
147 To our knowledge, this is
the first study to define the immunotherapeutic differen
148 To our knowledge, this is
the first study to define the role of HIPK2 in cardiac b
149 This is
the first study to delineate that a history of migraine
150 This is
the first study to demonstrate a cognitive role related
151 This is
the first study to demonstrate a link between maternal T
152 This is
the first study to demonstrate an association with acidi
153 This is
the first study to demonstrate anti-CS17 antibodies prov
154 This is
the first study to demonstrate associations between the
155 This is
the first study to demonstrate decreased fatty acid desa
156 To our knowledge, this is
the first study to demonstrate functional boundaries of
157 This is
the first study to demonstrate increased uptake of both
158 This is
the first study to demonstrate interpersonal difficultie
159 This is
the first study to demonstrate invasion of human-RPEs, b
160 ine mucin as the model mucin system, this is
the first study to demonstrate strong interactions betwe
161 To the best of our knowledge, this is
the first study to demonstrate that diabetes activates B
162 To our knowledge, this is
the first study to demonstrate that skeletal muscle atro
163 In conclusion, this is
the first study to demonstrate that uterine PVAT plays a
164 This is
the first study to demonstrate the applicability of an u
165 To our knowledge, this is
the first study to demonstrate the clinical utility of p
166 To the best of our knowledge, this is
the first study to demonstrate the crucial role of react
167 This is
the first study to demonstrate the feasibility of using
168 This is
the first study to demonstrate the potential clinical ut
169 This is
the first study to demonstrate usefulness of the HDRA fo
170 This is
the first study to detect an acute DNA damage response i
171 at synonymous sites could be strong, this is
the first study to detect and quantify strong selection
172 This is
the first study to determine the occurrence of NPSs incl
173 This is
the first study to determine the stability of reference
174 o the best knowledge of the authors, this is
the first study to develop a novel rat model of polymicr
175 iatal brain areas in both disorders, this is
the first study to directly compare the glutamate concen
176 such increases in dopamine post-DBS, this is
the first study to do so using MS methodologies.
177 This is
the first study to elucidate the mechanism of hepatic up
178 This is
the first study to emulate PCB exposures in a school and
179 This is
the first study to establish the immunomodulatory proper
180 This is
the first study to evaluate associations between neighbo
181 This is
the first study to evaluate elamipretide in heart failur
182 This is
the first study to evaluate pulmonary critical care fell
183 Conclusions: This is
the first study to evaluate the association between peri
184 This is
the first study to evaluate TMS-associated changes in co
185 As
the first study to examine microplastics ingestion follo
186 This was
the first study to examine multiple forms of psychopatho
187 This is
the first study to examine PRS, composed of variants tha
188 In
the first study to examine systematically associations b
189 To the best of our knowledge, this is
the first study to examine the transition-metal resonanc
190 To our knowledge, this is
the first study to experimentally validate previous nucl
191 Here, we present
the first study to explicitly evaluate the role of micro
192 This is
the first study to explore how surgeons decide among man
193 This is
the first study to explore the role of Scx in cortical b
194 e best of our knowledge, the present work is
the first study to focus on the screening of umami pepti
195 To our knowledge, this is
the first study to fully assess compliance with the Fina
196 and epilepsy.SIGNIFICANCE STATEMENT This is
the first study to fully characterize the contribution o
197 To our knowledge, this is
the first study to have evaluated the association betwee
198 This is
the first study to identify a surgeon volume threshold (
199 This is
the first study to identify computational impairments du
200 This is
the first study to identify contact lenses and more spec
201 This is
the first study to identify cross neutralizing scFv mono
202 This is
the first study to identify genetic variants contributin
203 This is
the first study to identify pathogenic variants in NAXD
204 This is
the first study to identify PTEN as a potential downstre
205 This is
the first study to identify racial differences in the br
206 This is
the first study to identify the transcriptome signatures
207 To our knowledge, this is
the first study to indicate that frequent fish consumpti
208 Moreover, this is
the first study to indicate that volatile organic compou
209 This proof-of-principle analysis is
the first study to integrate large, diverse biomarker da
210 It is
the first study to investigate activation patterns acros
211 As
the first study to investigate and identify the cancer c
212 This is also
the first study to investigate and show an association o
213 To our knowledge, this is
the first study to investigate signal contrast and camou
214 To our knowledge, this is
the first study to investigate the association of collag
215 n To the best of our knowledge, CONKO-005 is
the first study to investigate the combination of chemot
216 This is
the first study to investigate the impact of a second fi
217 To our knowledge, this is
the first study to investigate the long-term association
218 This is
the first study to investigate the synergistic effect of
219 This is
the first study to investigate the usefulness of the VHS
220 This is
the first study to isolate the metabolic and structural
221 As
the first study to localize the differential cortical co
222 y used in laboratory toxicity tests, this is
the first study to measure concentrations of persistent
223 NAMs at the mGlu(5) receptor, which is also
the first study to measure ligand binding kinetics and n
224 The first study to measure metabolomic urinary cancer bi
225 This is
the first study to our knowledge to calibrate a model of
226 To our knowledge, this is
the first study to produce a global estimate of the need
227 This is
the first study to provide a comprehensive overview of t
228 This is
the first study to provide a systematic characterization
229 In conclusion, this is
the first study to provide evidence for a link between e
230 To our knowledge this is
the first study to provide policy makers with synthesize
231 This is
the first study to provide the intimate structural basis
232 This is
the first study to quantify PFAAs in marine mammals from
233 To our knowledge, this is
the first study to quantify the consequences of climate
234 dia with polymorphism at FBX011, but this is
the first study to report association with the locus TGI
235 To our knowledge, this is
the first study to report global prevalence of obstructi
236 This is
the first study to report identification of major coenzy
237 To our knowledge, this is
the first study to report such long-term growth of HBECs
238 This is
the first study to report that appendectomy is associate
239 This is
the first study to report that common genetic variation
240 This is
the first study to report the complete mineralization of
241 This is
the first study to report the distribution of melamine a
242 As such, this is
the first study to report the widespread occurrence of g
243 This is to the best of our knowledge
the first study to report within an RCT a differential c
244 This is
the first study to reveal relationships between ventrome
245 This is
the first study to reveal the importance of metabolites,
246 To the best of our knowledge, this is
the first study to reveal the role of EBV-miRNA-BART12 i
247 This is
the first study to show a complex formation between iron
248 This is
the first study to show a unique, nutrient-deplete metab
249 To our knowledge, this is
the first study to show expansion of virus-specific CAR
250 This is
the first study to show quantitatively that binocular ey
251 ed (ASL) magnetic resonance imaging, this is
the first study to show regional reductions in cerebral
252 This is
the first study to show that altered connectivity betwee
253 To our knowledge, this is
the first study to show that attention recruits two spat
254 To our knowledge, this is
the first study to show that CBFA2T3 down-regulation is
255 This is
the first study to show that chronic cadmium exposure, e
256 This is
the first study to show that early cardiac remodeling nu
257 This is
the first study to show that greater genetic predisposit
258 This is
the first study to show that HHP treatment triggers de n
259 To our knowledge, this is
the first study to show that highly intermittent schedul
260 To our knowledge, this is
the first study to show that pembrolizumab interferes wi
261 This is
the first study to show that probability of rhythm viola
262 es EGFR at T654 to promote metastasis and is
the first study to show that the phosphorylation of this
263 INTERPRETATION: CALM is
the first study to show that timely escalation with an a
264 This is
the first study to show the effectiveness of H3N3 COBRA
265 To our knowledge, this is
the first study to show the expression of LPL from the v
266 This is
the first study to show the value of genetic diagnostic
267 This is
the first study to substantiate an association between P
268 This is
the first study to suggest a mechanism by which LPS stim
269 We believe this is
the first study to suggest that an extracellular water i
270 This is
the first study to suggest that congenital CMV infection
271 This is
the first study to suggest the activation of plant defen
272 This is
the first study to systematically investigate the strate
273 We report here
the first study to systematically seek and collate servi
274 This is
the first study to test for parental age effects on offs
275 This is
the first study to use an hPSC-derived reporter line to
276 ohort of patients included and because it is
the first study to use an inverse periosteal-fascial sut
277 This is
the first study to use causal inference to measure the i
278 This is
the first study to use cells derived from skeletal muscl
279 This is
the first study to use chemometric methods to differenti
280 This is
the first study to use CMR to assess independent prognos
281 m hNSPC cultures by DEP sorting, making this
the first study to use electrophysiological properties f
282 This is
the first study to use general practice data to examine
283 This report summarizes
the first study to use MALDI-IMS to analyze drug penetra
284 This is
the first study to use matched analyses to investigate t
285 This is
the first study to utilize perfusion bioreactors as a to
286 This is
the first study to validate and calibrate current-flow m
287 This is
the first study to visualize Pb dynamics in the lung and
288 This is
the first study,
to our knowledge, of the prevalence of
289 This is
the first study,
to our knowledge, to provide a direct l
290 This is
the first study,
to our knowledge, to suggest a prevalen
291 This is
the first study,
to propose the use of the S. repens for
292 Herein we report
the first studies toward these molecules, resulting in a
293 The first studies towards estimation of charge transfer
294 This is
the first study translating metabolomic data to develop
295 velty effects.SIGNIFICANCE STATEMENT This is
the first study using functional magnetic resonance imag
296 Here we report
the first study utilizing targeted next-generation seque
297 At
the first study visit after cataract surgery, BCVA was i
298 Since
the first studies were undertaken, these approaches have
299 This is
the first study where behavior of monoanion and dianion
300 Ss obtained from 2 of the 75 participants in
the first study yielded positive results for SARS-CoV-2