ライフサイエンスコーパス: the intended

1 The intended 2-year course was achieved in 69% of patien

2 was found to direct photoadduct formation to the intended 5'-TpA base step next to the PNA-binding si

3 stopped the trial for futility after 644 of the intended 900 participants were enrolled.

4 functional contribution of their homologs to the intended action.

5 ed to work with the immune system, enhancing the intended activation of antigen presenting cells (APC

6 00 neurons in the motor cortex, we predicted the intended activity of several of the paralysed muscle

7 ies to probe the optimal molecular design of the intended ADCs as targeted cancer therapies.

8 methods are easily implemented and preserve the intended alpha level and power.

9 ation of IgG antibodies with specificity for the intended analyte.

10 Comparing the intended and final postoperative refractions calcula

11 vocalizations, detects discrepancies between the intended and heard vocalization, and contains inform

12 as patients for whom the difference between the intended and postoperative refractive errors was mor

13 When the differences between the intended and postoperative refractive errors were ca

14 The intended and postoperative refractive outcome and di

15 -driven approach is a useful way to detangle the intended and unintended mechanisms of drug action ac

16 The method worked well for the intended application in image data management.

17 open, extended frameworks can be tailored to the intended application through crystal-structure desig

18 rtunity to achieve enhanced functionality in the intended application.

19 take from several hours to days depending on the intended applications.

20 Infusion of Nlxz into the intended area reduced food intake by 42.3% below bas

21 d tomography demonstrated dose delivery into the intended area.

22 s a visually specified reference command for the intended arm/hand position trajectory with respect t

23 uided chemoablation with acetic acid enabled the intended arrhythmic substrate, whether deep or super

24 The intended audience for this statement includes health

25 The intended audience is both quantum chemists who seek

26 The intended audience is physicians and other emergency

27 The intended audiences include researchers, government p

28 that the intended cue for future action and the intended behavior could be decoded from distinct pos

29 oviders, governments, and the people who are the intended beneficiaries of development programming.

30 ndary should be further increased to provide the intended benefits for the people living near the por

31 under what circumstances triage would confer the intended benefits.

32 hopeful monster" differed significantly from the intended (betaalpha)(8)-barrel fold by an extra beta

33 ilt into existing scaffold proteins matching the intended binding site geometry with high accuracy.

34 take and compare it with the distribution of the intended biologic target (as visualized with immunoh

35 series was used to demonstrate inhibition of the intended biological target, resulting in apoptosis a

36 een the functional molecules on the MNPs and the intended biological targets.

37 looked a valuable resource, the expertise of the intended biologist users.

38 through an external circuit to interact with the intended biosystem whereas electrons are transported

39 The intended care patterns varied widely across indicati

40 as bound in the active site, interacted with the intended catalytic base in a catalytically relevant

41 The intended change was considered major in 176 of 382 (

42 ent virus, and each of the viruses expressed the intended chemokine in a dose-dependent manner.

43 he causal mechanisms and interactions within the intended clinical context is needed to develop inter

44 g development time compared with waiting for the intended clinical outcomes.

45 unction with duration of effect suitable for the intended clinical use in acute coronary syndromes.

46 The results did not allow the intended comparison due to an unanticipated effect o

47 into structures with high shape fidelity to the intended computer-aided design.

48 The DPV and EIS responses with the intended concentrations of the sequence were linear

49 tion show that the designed protein folds to the intended configuration, tying itself in a knot in th

50 The solution structure confirmed the intended connectivity and stereochemistry of the oli

51 legislation as written is not likely to have the intended consequences, as it fails to adequately shi

52 a unique, reliable, and valid assessment of the intended construct.

53 liable score measuring all key dimensions of the intended construct; and/or lacked adequate psychomet

54 The key building blocks (6, 7, and 8) for the intended construction of the originally proposed str

55 some scenarios, it is difficult to simulate the intended contact of materials used in food packaging

56 other assessed asthma parameters, reflecting the intended controlled status of the trial subjects.

57 s in group II (76.6%) were within +/-0.5D of the intended correction and 23 eyes (76.6%) in group I a

58 nd 94% (15) eyes were within 1.0 diopters of the intended correction.

59 es in group II (50%) were within +/-0.25D of the intended correction.

60 Multivariate analysis showed that the intended cue for future action and the intended beha

61 to off-target sites and poor availability at the intended delivery site.

62 criptional rewiring may confer bacteria with the intended desirable properties, such approaches may a

63 optic flow to redirect self-movement toward the intended destination.

64 whether the dicistronic vector produces only the intended dicistronic mRNA.

65 Lack of efficacy in the intended disease indication is the major cause of cl

66 As with a variety of patterns of mismatch to the intended DNA target.

67 four patients received three inoculations at the intended dose levels, which elicited antibodies able

68 s, continuing to receive imatinib at 100% of the intended dose.

69 All patients received the intended doses of proton radiotherapy.

70 wn to mimic inhibition of HMG-CoA reductase (the intended drug target) with the same lipids and metab

71 roxy-3-methylglutaryl-CoA reductase (HMGCR), the intended drug target.

72 he dimeric diaminopyridazine 2a corroborates the intended duplex mode of assembly.

73 lonies propagated without selection harbored the intended edits, of which more than one-half were hom

74 d hypercholesterolemia per se may counteract the intended effect of aromatase inhibitors.

75 of action behind treatment toxicity reflects the intended effect on the treatment target, the toxicit

76 lf-report data also were obtained to confirm the intended effects of script-driven imagery.

77 Palliative sedation with the intended end point of unconsciousness (PSU) is a mor

78 ex (PPC) have previously been used to decode the intended endpoint of a reach, providing the first ev

79 s such as the chicoric acids do not act upon the intended enzymatic target but behave as entry inhibi

80 uction and colony size phenotypes indicating the intended exploration of design space.

81 RH3 adopted the intended fold, which has not been observed previousl

82 ed entirely by apolar side chains conform to the intended fold.

83 When the intended foot placement changes during a step, eithe

84 ogels the ability to participate actively in the intended function of the carrier system rather than

85 he mode of secretion seems to be tailored to the intended function of the secreted molecule.

86 gonists, and antagonists in order to achieve the intended functional activity at a GPCR of therapeuti

87 in high yield in Escherichia coli and share the intended functional and structural properties with K

88 eta-catenin promoted endogenous HCC carrying the intended gain-of-function mutations.

89 ng and its relation with the environment and the intended genetic improvement.

90 mited dilution to isolate cell colonies with the intended genomic manipulation.

91 eurons provide multimodal representations of the intended goal of a forthcoming action, encoding a be

92 Patients could be enrolled irrespective of the intended goal of pump support (bridge to transplanta

93 s with advanced heart failure, regardless of the intended goal of support (bridge to transplantation

94 The intended goal of surgical correction of SUI and POP

95 pump or the axial-flow pump irrespective of the intended goal of use (bridge to transplantation or d

96 y of reward were decoded simultaneously with the intended goal.

97 te action outcomes and their deviations from the intended goals and to adjust behavior accordingly.

98 t VLPFC may host an abstract "vocabulary" of the intended goals pursued by primates in their natural

99 ts reconsideration to ensure it is achieving the intended goals.

100 stem is effective and efficient in achieving the intended goals.

101 y that one enantiomer of a compound bound to the intended HCV NS5B polymerase target whereas the mirr

102 ors and how to modify them and for assessing the intended health, livelihood, and environmental benef

103 We found that the polypill showed the intended immediate and sustained release profiles ba

104 In 361 patients with the intended implant (189 HM3 and 172 HMII), 65 strokes

105 epithelial defect overlying the Intacs body, the intended implantation depth measured by high-magnifi

106 ted 13 novel receptor variants stabilized in the intended inactive state among which two exhibit an a

107 evels that compete for these antibodies over the intended individual acetylation sites.

108 To extract the intended information from these regulated genes, bio

109 s that are highly unexpected on the basis of the intended layer sequencing.

110 and actions are represented independently of the intended limb in PPC and PMd.

111 Implantation success (1 valve in the intended location) was 98.3%.

112 d addition of an herbicide-tolerance gene at the intended locus in a significant number of isolated e

113 Other than the intended Lys/amino terminal iTRAQ labeling, such mod

114 The intended management before and changes as a conseque

115 ssified as either treatment or nontreatment, the intended management change for each cancer type was

116 (18)F-DOPA PET/CT changed the intended management of 41% of patients with brain tu

117 ct of (18)F-sodium fluoride PET (NaF PET) on the intended management of cancer patients with osseous

118 e-specific membrane antigen (PSMA)-11 PET on the intended management of patients with biochemically r

119 nificant impact of (68)Ga-DOTATATE PET/CT on the intended management of patients with NETs (50% of ch

120 nstrates a substantial impact of DOTATATE on the intended management of patients with neuroendocrine

121 When the intended management plan before PET was treatment, a

122 According to Q3 responses, the intended management was implemented in 160 of 206 (7

123 ore effortful processing needed to interpret the intended meaning of an utterance.

124 h which native speakers are able to identify the intended meanings of common polysemous words.

125 kage assays, and electron microscopy support the intended mechanism of action, which leads to prefere

126 n antisense sequences and thereby may affect the intended mechanism of action.

127 tervention affects the tumor burden process, the intended mechanism through which it is hoped that mo

128 , indicating that it kills cancers cells via the intended mechanism.

129 operation on the inferior rectus rather than the intended medial rectus muscle, and inattention and/o

130 f therapy for relapsed NSCLC did not achieve the intended median survival of 6 months.

131 which allows listeners and readers to infer the intended message (speaker meaning) from the coded me

132 res display semantic information relevant to the intended message [4-6].

133 minishes the amount of ZnCl(2) available for the intended metathesis reaction to take place.

134 therapy, with a significant interaction with the intended method of revascularization (P<0.0001).

135 Randomization was stratified by the intended method of revascularization, coronary arter

136 The intended mode of action of adjuvants is to simultane

137 Even when K(+) channel block is the intended mode of action, block of related channels i

138 This novel assay to measure the intended molecular pharmacodynamic effect of decitab

139 ding of the interaction between the GNPs and the intended molecular target is critical for the develo

140 reflecting an inverse model, rather than by the intended motion of the visual cursor (forward model)

141 hen auditory feedback does not correspond to the intended motor gesture.

142 urse of motor pre-programming and release of the intended movement by an acoustic startle stimulus.

143 ists of implanted electrodes that can record the intended movement of a paralyzed part of the body, a

144 le lengthening and to detect departures from the intended movement trajectory.

145 the body, a computer algorithm that decodes the intended movement, and an assistive device such as a

146 ghly specific in silencing the expression of the intended mutants without affecting wild-type p53.

147 tion requires a guide RNA targeting close to the intended mutation, whereas heterozygous introduction

148 ed that over 2/3 (24 of 35 designs, 69%) had the intended new site specificity, and that 14 of the 15

149 certificate of need regulation is achieving the intended objectives and whether those objectives sho

150 UCL, +1.00+1.18x148) with a difference from the intended of -0.18+0.35x7 (95% LCL, -1.91+1.22x38; 95

151 ieve minimal off-targeting while maintaining the intended on-target activity.

152 specifically block infection, independent of the intended on-target effect.

153 arable to (or higher than) those observed at the intended on-target site.

154 sequence space of microRNA seeds instead of the intended on-target space of protein-coding genes.

155 henotypic effects of siRNAs are unrelated to the intended "on-target" mechanism, defined by full comp

156 The intended operations were aborted in all patients fol

157 The intended operations were all subsequently performed,

158 ation and is agnostic to genetic ancestry of the intended or contaminating sample.

159 ks (MOFs), metal centres can coordinate with the intended organic linkers, but also with solvent mole

160 nger at Observable and Related outcomes than the Intended outcome when the Communicator used speech.

161 Deviation from the intended path was on average <10%.

162 ssessment of interpretation and impact among the intended patient group.

163 se event profile, and severity of illness of the intended patient population.

164 ion of an object drug and consequently alter the intended pharmacologic response and potentially lead

165 nsiderable pre-existing SOC stocks will have the intended policy and climate change mitigation outcom

166 reaction involving the oxime did not provide the intended polyheterocyclic fenestrane.

167 ination of risk of bias and applicability to the intended population and setting.

168 ppeared not to have severe renal impairment, the intended population for this dose.

169 ad modest and relatively targeted effects on the intended populations.

170 The intended primary end point was the change in interst

171 specific neuronal subtypes that approximate the intended primary mammalian cells on both the RNA and

172 hesions from the surface of the heart before the intended procedure can begin, thereby substantially

173 roup B, the median time to the initiation of the intended procedure was 1.6 hours; periprocedural hem

174 conditions the cells will experience during the intended process and measure the appropriate physiol

175 ot always the case, with multiple species of the intended product being produced due to amino acid mi

176 ce a vast range of molecular structures, but the intended product must be known at the outset.

177 ia an electrophilic intermediate that may be the intended product.

178 t terms used to frame the exercise, 3) state the intended purpose for any proposed set of criteria, a

179 e importance of these six domains depends on the intended purpose for the criteria (clinical care, ba

180 The intended purpose of analytical methods is directly r

181 Abuse-deterrent formulations can have the intended purpose of curtailing abuse, but the extent

182 ly for low-risk studies, may no longer serve the intended purpose of protecting human participants, a

183 ce of these domains of usefulness depends on the intended purpose, of which there are four broad cate

184 oefficients were found to be less suited for the intended purpose, other methods can provide a suitab

185 to inform on their usefulness with regard to the intended purpose.

186 The intended rats for cancer treatment received two succ

187 is ultimately contingent on the response of the intended receiver, and there are differential effect

188 a wide array of songs to attract a mate, and the intended receivers must differentiate these calls fr

189 If unheard by the intended receivers, calls are not beneficial to the

190 re (100%); maintained the ability to bind to the intended receptor; formed a minimal amount of aggreg

191 rs: gender, the relationship of the donor to the intended recipient and the presence of ambivalence a

192 In the event that the intended recipient dies after the donor graft has be

193 l communication in pairs of chimpanzees when the intended recipient was within 10 m of the signaller.

194 een procured and cannot be transplanted into the intended recipient, and if informed consent has been

195 smooth muscle cells that were allogeneic to the intended recipient, using a biomimetic perfusion sys

196 hen seeded with cells that were derived from the intended recipient--either endothelial progenitor ce

197 he type of pretransplant crossmatch used for the intended recipient.

198 The intended reduction in antibiotic duration ranged fro

199 Hill-RBF 2 had more eyes within +/-0.25 D of the intended refraction (76 out of 127 eyes [59.84%]) co

200 >/=20/40, and 81.8% of eyes were +/-0.5 D of the intended refraction.

201 eratometric meridians were used to calculate the intended refractive error.

202 Treating the intended refractive outcome as a spherocylinder impr

203 a bridge with two carbon atoms should enable the intended regiocontrol within the DNA duplex structur

204 Although the intended regioselectivities were not observed, unusu

205 The intended remdesivir treatment course was 10 days (20

206 h may be a product of tissue (heart) or that the intended response was transient.

207 licy recommendations and guidelines that are the intended result of collecting the data in the first

208 t from consensus PPR motifs selectively bind the intended RNA in vivo, and we use this property to de

209 52%) of studies, authors were unclear about the intended role of the test, and in 3% (95% CI: 0%, 6%

210 mination in peripheral vision at the goal of the intended saccade.

211 The intended sample size was 900 patients.

212 Only 56% of the intended sample size was recruited.

213 slow recruitment after enrolling only 25% of the intended sample size, leaving it severely underpower

214 ne may be informed by assessing gaps between the intended scope of practice of residents and actual s

215 tion-specific nucleotide biases that obscure the intended signal and reduce the effectiveness of thes

216 ptors, which is crucial for translation into the intended signaling outputs.

217 that proofreading can remain effective when the intended signaling pathway exhibits high levels of r

218 rvened on, with Melody valve implantation at the intended site in all patients.

219 ve high levels of the activated cytotoxic at the intended site of action.

220 structure reveals that Ca.CD2 binds Ca2+ at the intended site with the designed arrangement, which v

221 These RNAi lines expressed the intended small interfering RNAs in the anther and sh

222 quent catalytic amplification magnifies only the intended SNV targets.

223 Although this was not the intended strategy of the task, it was nonetheless an

224 ask what modifications are necessary to form the intended structure and what potential this approach

225 mize a self-assembly reaction to ensure that the intended structure is kinetically accessible.

226 nating or directing groups incorporated into the intended substrate has helped address these limitati

227 TNFR1) that normally regulates expression of the intended target (ICAM-1).

228 ctivity (disruption of DNA-LEF-1 binding) at the intended target and site (inhibition of intracellula

229 ven guideline is memorable and actionable by the intended target audience.

230 ctors can be saturated, and genes other than the intended target can be silenced.

231 tive axons across the injured spinal cord to the intended target establishing a critical step for neu

232 When the structure of the intended target is available, one approach is to use

233 gen receptor ligand-binding domain (AR-LBD), the intended target of androgen deprivation therapies in

234 achment to and entry into host cells, and is the intended target of antibody therapeutics.

235 mposed on bacterial populations that are not the intended target of antimicrobial therapy.

236 Each primer set detected 20 cDNA copies of the intended target per sample and had no reaction with

237 HCV RDTs should be evaluated in the intended target population, as sensitivity can be im

238 aged 0.78 diopters (0.49-1.07) of error from the intended target refractive outcome.

239 87% of the captured sequence originated from the intended target region with sequencing coverage fall

240 g opportunities to study genomic data beyond the intended target regions.

241 Specific amplification of the intended target requires that primers do not have ma

242 at the developed inhibitors do interact with the intended target site.

243 screen, can bind to the survivin protein at the intended target site.

244 rsor center-out task, tuning to direction of the intended target was well captured by a log-linear co

245 target appearance could be used to classify the intended target with an accuracy of 95% in one parti

246 e the same fluorescence as one equivalent of the intended target, and detection works reliably over a

247 development: it can influence recognition of the intended target, pharmacokinetics, and off-target ef

248 c eye movements consistently fail to land on the intended target, saccade accuracy is maintained by g

249 stent with an acute inactivation of mGluR8a, the intended target, two findings confounded this interp

250 Besides the intended target, unexpected drug off-target interact

251 howed affinity/activity for GPCRs other than the intended target, which could be partly attributed to

252 t the compounds are cell-permeable and reach the intended target.

253 t differ by as many as five nucleotides from the intended target.

254 e-conferring kinase domain (KD) mutations in the intended target.

255 njected into the DCN to guide graft axons to the intended target.

256 assignment of positive clinical response to the intended target.

257 d with chemical structure or the identity of the intended target.

258 l folate intake without adequately impacting the intended target.

259 cretion of soluble cytolytic proteins toward the intended target.

260 movement in paralysed animals by focusing on the intended targets of movement rather than their inter

261 oligomeric SOD1 species in the spinal cord, the intended targets of the immunization strategy.

262 DT) display poor chemical selectivity toward the intended targets, and uptake by cells most likely ar

263 nction of many transmembrane proteins beyond the intended targets.

264 d and their joint velocities decomposed into the (intended) task-relevant and the (spontaneous) task-

265 es in gene expression may sensitize cells to the intended tetracycline-controlled loss or gain of fun

266 within 5 +/- 3 d was well tolerated and had the intended therapeutic effect.

267 digm in understanding drug action focuses on the intended therapeutic effects and frequent adverse re

268 Randomization was stratified according to the intended timing of nonculprit-lesion PCI (either dur

269 tion was consistently observed regardless of the intended timing of nonculprit-lesion PCI (P = 0.62 a

270 river lines display excision activity beyond the intended tissue or cell type, and these data are fre

271 ency with which a drug accumulates to act on the intended tissue.

272 eliver sufficient nanoparticle quantities to the intended tissues.

273 Readthrough of these RNAs into the intended transcriptional unit potently stimulated re

274 ignificantly affects the comparison, as does the intended transportation application.

275 A total of 407 patients received the intended treatment and were available for primary ou

276 The intended treatment duration was 14 days.Main Outcome

277 ebo; all randomly assigned patients received the intended treatment), 205 non-responders, and 235 ine

278 In analysis based on the intended treatment, mean +/- SD length and LAZ for t

279 Fe horizontal lineO unit (r = 1.661(2) A) in the intended trigonal bipyramidal geometry enforced by t

280 uld be useful, particularly one aligned with the intended ultimate outcome of this scientific effort:

281 at the use of such materials may not achieve the intended uniformity among laboratories measuring CMV

282 onolayers (i) comprised, almost entirely, of the intended unit cell, (ii) exhibiting patterned domain

283 rther comparison under conditions simulating the intended use combined with the criterion of long-ter

284 The intended use of a magnetic material, from informatio

285 The intended use of case definitions should be considere

286 d dual target plasmid pRSETMON-02 is fit for the intended use of quantifying MON 810 maize and is a b

287 uate accuracy and precision are achieved for the intended use of the material.

288 l factors need to be considered: (1) What is the intended use of the TBT?

289 Cohort D, which represented the intended use population that reflected the U.S. Food

290 do not perfectly reflect the composition of the intended use population, (2) potential biases that c

291 Study designs should account for the intended use when choosing the study population, set

292 al showed to be sufficiently homogeneous for the intended use, and storage at -20 degrees C for 5 mon

293 f a specific characterized cultivar based on the intended use, fresh consumption or processed product

294 s on its place and date of production and on the intended use.

295 le to choose the desired pumpkin variety for the intended use.

296 rmous clinical trials are required to define the intended-use and to verify the specification.

297 and the risks and benefits of a treatment in the intended-use patient population.

298 The intended users of this action plan are clinicians, p

299 ents for optimal selectivity and efficacy in the intended vascular bed.

300 To produce a word, the intended word must be selected from a competing set