ライフサイエンスコーパス: the known

1 rved eggs or eggshell for the first third of the known 315 million year history of amniote evolution.

2 y was based on the Wittig-Horner coupling of the known A-ring phosphine oxide with the corresponding

3 These effects are consistent both with the known actions of LSD on serotonin receptors and with

4 we have investigated the additive impact of the known adult glioma susceptibility loci on the pediat

5 We validated our methods by reproducing the known affinities between VEGF-A(165a):VEGFR1 and VEG

6 1.0 pM and 10 pM respectively, and validated the known affinity VEGF-A(121):VEGFR2 as K(D) = 0.66 nM.

7 nally in Korea appears to be more similar to the known African viruses than to any other Asian viruse

8 In addition to the known Al(IV) at the framework bridging acid site (BA

9 ds for both the T(C) and the H(C2) among all the known alloy superconductors composed of only transit

10 ethod provides a complementary approach over the known alpha-substitution-based methods for accessing

11 his dataset has also significantly increased the known amount of heterogeneity between P. vivax schiz

12 The ground truth was provided by the known anatomical connections predicting hippocampus

13 This review focuses on describing the known and emerging CVD biosensing technologies for a

14 In addition, the known and potent immunomodulatory effects of these a

15 trait loci SNPs in cancer patients more than the known and random motifs.

16 and protein turnover.IMPORTANCE We extended the known annotation space for the NCLDV by 46%, reveali

17 a soluble trimeric and multimeric variant of the known anti-cancer TNF-related apoptosis-inducing lig

18 Consistent with the known anti-inflammatory influence of the peripheral

19 , and this association is likely mediated by the known APOL1 association with chronic kidney disease.

20 cation but also enhance our understanding of the known arsenal of defence systems.

21 In addition to the known association between Met46, Arg179 and Arg258 s

22 Given the known association between podocyte loss and irrevers

23 Given the known association of microglial activation with adva

24 Owing to the known association of socioeconomic status (SES) on P

25 The internal cluster concentration maps onto the known attractive glass line of sticky colloids at lo

26 growth assays, and pretreatment with MnP or the known autophagy inhibitor 3-methyladenine abrogated

27 stimulation of autophagy might help explain the known benefits of unsaturated FAs in countering the

28 s been prepared in multigram quantities from the known bicyclic diketone 7 in four steps without the

29 Among all of the known biological carcinogens, Epstein-Barr virus (EB

30 Here, we summarize the known biological functions, target substrates, and e

31 deficiency and MPD was not predicted through the known biology and has remained an enigma.

32 Herein, we discuss the known biology of IL-23 at the human enthesis and hig

33 Contrasted to the known bloom-forming species U. prolifera growing at

34 and higher GTPase, similar to the effect of the known bottom capper protein MciZ.

35 rentiated" (SU) neurons and assigned them to the known brain lineages.

36 Thereby, these methods complement the known Buchwald-Hartwig coupling methods for N-arylat

37 r early onset of several cancer types beyond the known cancers.

38 ray-scale US and optoacoustic US features of the known cancers.

39 rbons (PAHs) including naphthalene (NAP) and the known carcinogen benzo(a)pyrene (BaP), sulfur dioxid

40 e topology of the phase diagram evolves from the known case of (4)He, as the system is made more (and

41 examine whether (i) CSD methods can discover the known causal relationships from observational clinic

42 ugh a novel mechanism that is independent of the known CD8(+) T cell-based antiviral responses or cha

43 mple spike ephaptic signaling, combined with the known CF divergence, allowed a single inferior olive

44 depending on the substrate employed, unlike the known change in crystal orientation.

45 f OLPVR1 reveals remarkable differences from the known channelrhodopsins and a unique ion-conducting

46 predicts new highly-charged anions by using the known charged clusters as building blocks.

47 ry organic aerosol (SOA) particles relies on the known chemical composition of the particles.

48 Together, these findings expand the known chemical space of monocot terpenoid metabolism

49 Here, we present the cryoEM structure of the known CI assembly intermediate CI* from Vigna radiat

50 The physical origin of the formation of the known classes of lipidic lyotropic liquid crystallin

51 ermia agents and as a cytotoxic agent due to the known cobalt ion toxicity, allowing the achievement

52 enerate a single unified model that captures the known cognitive-behavioural variations in SD and map

53 effect of 5.9 million SNPs, including 57% of the known common SNPs, on enhancer and promoter activity

54 stematic errors, which was not possible with the known composite pulses in NMR.

55 This is reminiscent of the known conductance regulation by neuromodulators in c

56 t that PACKMAN is robust enough to reproduce the known conformational changes and is able to predict

57 istical tests, GeoNet detected 0.2% to 2% of the known contamination incidents (Na +/- Cl) in streams

58 Consistent with the known control of the Set3 histone deacetylase comple

59 The simulation starts with the known coordinates of the noncovalent complex.

60 n of the Ragulator subunit LAMTOR4, revealed the known core mTORC1 regulatory signaling complexes and

61 Dedicated post-processing exploiting the known CPMG spikelet frequencies allowed to probe the

62 Here, we review the known cross-subfamily RTK heterointeractions and the

63 plex [{Th(Tren(TIPS) )(mu-ORb)}(2) ] (6) and the known cyclometallated complex [Th{N(CH(2) CH(2) NSiP

64 the dynamics of GC B cell development beyond the known dark zone and light zone compartments, we perf

65 ach is profoundly limited by the sparsity of the known data, the annotation bias often found in the l

66 egular consumption of probiotics may improve the known deterioration of periodontal health in navy sa

67 t correlation between the measured score and the known diagnosis of the patients.

68 To adjust the age difference, which reflects the known difference in clinical and radiologic courses

69 This perspective outlines many of the known DILI mechanisms and assessment methods used to

70 a network diffusion approach, starting from the known disease genes in a heterogenous network constr

71 ons of TET proteins in DNA demethylation and the known distribution of 5hmC at transcribed genes and

72 tsia and Arsenophonus were found, increasing the known diversity in these groups.

73 genomes and metagenomes continue to increase the known diversity of Bacteria and Archaea; however, wh

74 These findings expand the known diversity of inorganic metabolisms that suppor

75 The known diversity of tetrapods of the Devonian period

76 Our work expands the known diversity of uncultured gut bacteria, which pr

77 An exciting possibility is that the known, DM-mediated coupling between chirality and cr

78 ensitivity analysis, varying the strength of the known effect of G6PDd on anaemia, showed that this b

79 Our observations are in good agreement with the known effects of cholesterol on the area-compressibi

80 Consistent with the known effects of Hamp up-regulation, SREBP-1a-overex

81 It offers a mechanistic underpinning for the known effects of iron availability in humans.

82 Instead of strictly fitting the known elements, BNNR is designed to tolerate the noi

83 Our approach leverages the known equivalence between the driving forces for sin

84 This early immigration preceded the known establishment of housecat populations in the r

85 erate fetal growth, which is consistent with the known estrogenic properties of o,p'-DDT and p,p'-DDT

86 The known event and condition chronology correlate with

87 f follicular (TFH) cells potentially driving the known expansion of B lineage cells in the CSF in MS.

88 : see text] bonding quantified by exploiting the known exposed surface planes, terminations, and coor

89 heart, and brain in rodents-consistent with the known expression of the biotin transporter-and there

90 These results show how the known family of 2D crystals can be extended beyond t

91 biosynthesis enables cancer cells to bypass the known fatty acid desaturation pathway that is depend

92 The strongest signal resides in the known flowering gene E2, verifying the effectiveness

93 In contrast to the known FM metallic phase in stoichiometric Sr(2) FeRe

94 putative molecular defect underlying most of the known folate-sensitive fragile sites in the genome.

95 with greater than 90% reduced expression of the known FoxO transcriptional targets, glucose-6-phosph

96 dative stress and mTOR signalling underwrite the known function of T cell subsets in patients with SL

97 he thrombospondin type 1 region, contrasting the known function of the Furin-like domains in Wnt sign

98 putative computational modules that reflect the known functional domains of the pharynx.

99 neage morphology is described in relation to the known functional domains of the VNS neuropil and bas

100 te biology, and these advances have expanded the known functions of mitochondria contact sites in exc

101 ive euchromatic compartment, consistent with the known functions of TET proteins in DNA demethylation

102 Consistent with theoretical models and the known functions of the dentate gyrus-CA3 circuit, ac

103 d bile acid metabolism, findings that expand the known functions of the FA pathway and may provide me

104 key ham, and cheese, demonstrated that 10 of the known fungisporin-related metabolites and three of t

105 t is, with a mass ratio q of 0.7 to 0.8)(5), the known Galactic population of merging double neutron-

106 or agonistic modulators (SEGRAMs) as none of the known GC-induced debilitating side effects were obse

107 differentially expressed genes, we validated the known genes and pathways in septic shock and identif

108 The known genetic architecture of blood pressure now com

109 Our findings increase the knowledge of the known genetic diversity of smacoviruses and highligh

110 energy balance sensing, which is upstream of the known genetic networks for branching and architectur

111 minimum contig length needed to cover 50% of the known genome (NG50) up to 25 Mb and phased ~99.5% of

112 ccuracy of the assembly using the reads from the known genomes.

113 o alleviate phosphate limitation and expands the known geographic extent and taxonomic affiliation of

114 nd that these compounds are more potent than the known GGT inhibitor 6-diazo-5-oxo-l-norleucine and a

115 functional class of glycopeptide antibiotics-the known glycopeptide antibiotic complestatin and a new

116 d were not significant after conditioning on the known GWAS-identified variants.

117 s of fluorescent probes were designed around the known hA(2A)AR selective antagonist preladenant (SCH

118 The known harms associated with treatment include advers

119 Here we review the known hazards of human spaceflight, how spaceflight

120 oronary microvasculature was found to follow the known helical organization of cardiomyocytes in the

121 si-ordered' NTR states that can give rise to the known heterogeneity and plasticity of HSPB1.

122 Despite the known heterogeneity of type 2 diabetes and variable

123 Given the known heterogeneity within the autistic population,

124 Our findings show that the known high-risk CNVs are not only associated with sc

125 eparate clades, which is more in accord with the known history of the virus in Africa.

126 o model the infection dynamics incorporating the known host ecology.

127 Hair cell-specific expression of the known HSP70 receptor TLR4 was required for the prote

128 Atomic models of 103 of the known human AT1R polymorphisms were constructed usin

129 oximately 17.51 nm is likely associated with the known icosahedral CBPV satellite (CBPVS).

130 binds more tightly, which is consistent with the known importance of glutamylation for spastin microt

131 Despite the known importance of the transcription factors ATOH1,

132 tries are rapidly increasing, which reflects the known increase in IBD prevalence in these countries.

133 Even at extreme levels of some of the known inducers of the transition, there is a certain

134 The effects observed with the known inhibitor compounds in animal models are descr

135 Finally, the known inhibitor of TPX2, the importin-alpha/beta het

136 transition provides additional insights into the known inhibitory role of light in hypocotyl developm

137 These findings coupled with the known insensitivity of CD8(+) T cells to corticoster

138 in endothelial function and maybe a link for the known interaction of periodontitis and coronary hear

139 This unbiased approach recovered most of the known intestinal stem cells/enteroblast and EE marke

140 CSe(-) , AsCS(-) , and AsCSe(-) , as well as the known ion NCSe(-) were investigated in the gas phase

141 In addition to the known JBTS-associated proteins CEP104 and CSPP1, we

142 f C(2) -C(4) alkyl alcohols, based solely on the known kinetics of the elementary steps of the cataly

143 rontal cortex, respectively, consistent with the known KOR distribution in primate brains.

144 This study expands the known landscape of FGF signalling and identifies man

145 rotation in space, and translation in time, the known laws of physics are not universally invariant

146 n the aqueous phase of an oil/water mixture, the known levels of toxicity for individual PAHs, a toxi

147 tly solved structures of alphaSN fibrils and the known ligand preference of CR4, we hypothesize that

148 ill a mystery, but we present in this review the known ligands and receptors associated with itch.

149 with this collection highlight and reinforce the known limitations of serologic testing in early LD,

150 In this review, we summarize the known literature of liver transport proteins with a

151 prostate cancer datasets are correlated with the known marker genes and enriched in cancer-relevant K

152 rs of the form [Formula: see text], based on the known material [Formula: see text], using density fu

153 oteasome inhibitors without interfering with the known mechanism of action of these LRAs.

154 ng mechanisms; second, this work will detail the known mechanisms of hydrogen sulfide in the mitochon

155 e range of tactile experience and engage all the known mechanisms of texture coding-scanned across th

156 e a LD-nuclear signaling axis that underlies the known metabolic benefits of MUFAs and PLIN5.

157 Among the known methodologies, carbonylation reactions represe

158 Many of the known methods to synthesize aryl trifluoromethyl eth

159 le barnacles (coronulids) accurately reflect the known migration routes of their host whales.

160 Utilizing this approach, we have identified the known molecular chaperones that interact with human

161 Partitioning was consistent with the known molecular function of the individual cloned ge

162 The known molecular functions of pseudouridine, which in

163 This minireview summarizes the known molecular mechanisms of iron, zinc, and B vita

164 Our analysis extends the known motifs of protein-adenine interactions in the

165 DB28 and NV18.1 compete with the known MR1 ligands, 5-OP-RU and acetyl-6-FP, for MR1

166 on-specific molecular pathway lies alongside the known mRNA translation-dependent processes necessary

167 uction, we show that L8 is a sister clade to the known MTBC lineages.

168 eometry for grasping in the PMC that matches the known multifocal parietal maps of grasping represent

169 protein with similar or better proximity to the known native structure than several state-of-the-art

170 The statistical matching of the known nearly Gaussian incoming Gibbs state at the AD

171 surgery, all nodules were benign, confirming the known negative predictive value of HTNs with regard

172 Given the known neurochemical changes in the serotonergic syst

173 Our datasets almost completely account for the known neuronal diversity of the Drosophila optic lob

174 Given the known neuroreparative actions of IL-33 in experiment

175 , in Caco-2 cells transcellular transport of the known OATP2B1 substrate atorvastatin was changed in

176 H-preferring, phosphonate, in agreement with the known OGDH dependence of beta-oxidation.

177 ial biofilm on the oil films predominated by the known oil degrading bacteria Oleispira, Alkanindiges

178 Finally, we establish that the known oncoprotein and hexose deglycase, fructosamine

179 s, reveal that T4L in solution mainly adopts the known open and closed states in exchange at 4 us.

180 etylases 1 and 2 (HCAC 1/2), which is one of the known ORF36 functions.

181 embryo Me31B interactome and compared it to the known ovary interactome.

182 terns of mtDNA levels in the liver reflected the known oxygen tension gradient.

183 These new genomes greatly expanded the known pangenomes of many oral clades, including the

184 th a variety of neurological conditions with the known pathogenic genes excluded.

185 Notably, all but one of the known pathogenic point mutations map to XPGcat, and

186 In striking agreement with the known pathophysiology we find feedforward excitatory

187 We also review the known pathways in which DNA replication, transcripti

188 onths lag) temperatures, possibly reflecting the known patterns of short and long cycle typhoid trans

189 onsider the possibility that the founders of the known pedigree may themselves be inbred and compute

190 butions to the population and model drift on the known pedigree.

191 Compatible with the known PGC-1alpha functions in reactive oxygen specie

192 ges, some of which are highly divergent from the known phage families.

193 es of the radiation depart considerably from the known phenomenology of HHG.

194 The catalog expands the known phylogenetic diversity of bacteria and archaea

195 bservations, while remaining consistent with the known physics of the system.

196 t and a logical parsimonious explanation for the known physiological effects of NPA on plant growth,

197 pathogens plus plant symbionts, lack all of the known pimelate synthesis genes and instead encode bi

198 Based on the known planar nature of energetically favorable domai

199 lants, showing that this pathway splits from the known plastidial arogenate pathway at chorismate, in

200 (3)-Na-Mn(II)(ptac)(3)] (1) was derived from the known polymeric structure of [NaMn(II)(acac)(3)](inf

201 tions of their polymerization, by analogy to the known polymerization of Mes-P=CPh(2).

202 The docking results did not match the known pose and affinity of Olmesartan.

203 ood extractives was also modeled, confirming the known positive effect of ethanol and temperature on

204 P2X4 by ~twofold, similar to potentiation by the known positive modulator ivermectin.

205 The purpose of this report is to review the known prevalence and potential importance of coronar

206 offers a convenient practical alternative to the known procedures.

207 ed, with similar safety profiles compared to the known profiles of each agent alone.

208 nous anaesthesia were generated according to the known prognostic factors (extent of resection, methy

209 ity for phosphorylated EGFR, consistent with the known promiscuity of SH2 domains.

210 ntracortical inhibition can account well for the known properties of direction selectivity in carnivo

211 These results add piezoelectricity to the known properties of monolayer hBN, which makes it a

212 ting of residues not recognized by either of the known proteases plants use to macrocyclize peptides,

213 , we discuss the properties and diversity of the known proteins mediating cell-cell fusion and highli

214 Based on the comparison of the known PSI structures, we propose that PSI in B. brau

215 c's epitope which may partially overlap with the known PTH (1-34) binding site.

216 PRJ in cells, reduces the phosphorylation of the known PTPRJ substrate epidermal growth factor recept

217 mRNA processing in Synechocystis and expand the known range of organisms possessing small RNAs deriv

218 he uncertainty in positions can cover all of the known ranges of bond lengths and bond angles for a g

219 ormation, a pathway expected by analogy with the known reactivity of HNO with thiol.

220 This is directly analogous to the known reactivity of Ni(II) complexes with R*, a step

221 energy and is therefore not competitive with the known rearrangements to phenyldiazirines, ring expan

222 s can be presented for degradation by any of the known receptors, whereas those targeted to the prote

223 is a maximum when electrons are injected at the known redox potential of the protein.

224 n error was assessed by the distance between the known reference site and the estimated site.

225 were consistently within +/-1.5% relative to the known reference values.

226 The phenylthio acids were usually made by the known regioselective reaction of alpha,beta-epoxy ac

227 ression profile of a human disease and (iii) the known relationship between Food and Drug Administrat

228 The known relationship between the gestational age at ma

229 Our results show that the known relationship between the physical strength of

230 epresent candidate biological substrates for the known relationships between SES and cognition.

231 sess the accuracy of the method by comparing the known relative concentrations of isomeric carbohydra

232 The known repertoire of junction-regulating genes is inc

233 d agricultural importance, greatly expanding the known repertoire of stable protein complexes in plan

234 additional TA systems reported here expands the known repertoire of TA systems in M. tuberculosis.

235 Our eY1H-derived network greatly expands the known repertoire of TF-cytokine gene interactions an

236 hallmark A:T->C:G transversions conformed to the known replication errors because of oxidized guanine

237 rituximab recognition, and in agreement with the known requirement of CD20 to form clusters to elicit

238 ingle-bottom graphene/QD devices, overcoming the known restriction that the diffusion length imposes

239 hose treated with cisplatin only contrary to the known results.

240 Unlike in the known rhodopsins, in HeRs the N termini face the cyt

241 The structure is unique among the known rhodopsins. Structural and functional data and

242 ional analyses demonstrated that in addition the known role in synthesizing beta-citraurin, CCD4b is

243 ntional alphabeta T cells; however, based on the known role of gammadelta T cells as immune sentinels

244 We validate the known role of HRI-mediated translational stimulation

245 In accordance with the known role of SAAs in regulating Th17 cell effector

246 Given the known role of the coatomer protein complex I, we spe

247 Consistent with the known roles of ILF3 in immune response, epithelial-m

248 iation for VP1 and VP2 proteins belonging to the known RVA genotypes and (ii) correlate intergenotypi

249 d if/how the VP1 and VP2 proteins encoded by the known RVA genotypes differ from each other in their

250 Safety results were consistent with the known safety profile of binimetinib; the most common

251 ncies of adverse events were consistent with the known safety profile of denosumab, which showed long

252 Adverse events were consistent with the known safety profile of intravitreal aflibercept.

253 observed adverse events were consistent with the known safety profile of vandetanib.

254 This chemistry expands the known scope of pyridazine/pyrazine chemistry and can

255 ells along the gastrointestinal tract yields the known segmental specificity of this organ and may co

256 at temporal processing should be imbued with the known selectivity found within non-temporal neurons.

257 The basal-like phenotype is consistent with the known sensitivity of LELC-B to chemotherapy and sugg

258 In addition to the known severe complications associated with the disea

259 Additionally, we show that L(pro) cleaves the known SG scaffold proteins G3BP1 and G3BP2 but not T

260 n (e.g. KCNC1, GABRE), including a subset of the known shared markers between RA and human laryngeal

261 sitive effects on metabolic syndrome without the known side effects of potent rexinoids.

262 cestral ISG repertoire that includes most of the known signaling components of the IFN system.

263 Results show that the known SO(2) concentrations ranging from 10 to 300 pp

264 ion of the exocyclic bond by comparison with the known solution (= crystal in all cases) conformation

265 nctional differences can be accounted for by the known spatial gradients of cochlear dimensions, with

266 3/NR1F1 appears to function independently of the known SPE-44 gene regulatory network, revealing the

267 hese uncultured genomes substantially expand the known species repertoire of the collective human gut

268 d for all three approaches and compared with the known specifications in the calibration phantom.

269 sured ratios of the MS ion responses against the known spiked-in ratios (CVs < 8% for calibration sta

270 y GEM, with SI traceability based in part on the known spontaneous emission lifetime of the probed 6

271 t bacteriophage Mini is distantly related to the known ssDNA phages and belongs to an unclassified ss

272 in fast oscillatory brain signals parallels the known stability of fMRI-based intrinsic FC architect

273 an undamped stiffness 100 times larger than the known static stiffness.

274 septic patients is facilitated by reviewing the known stimuli that activate the PCT family of genes.

275 s these types of characteristics, and all of the known structures achieve their separation performanc

276 le frequencies and presence of exceptions to the known Sub1A-1 association in the genotype panel.

277 hat the latter would be exceeded for 1.5% of the known surface water exposure concentrations worldwid

278 st, 10,184 molecules structurally similar to the known sweeteners were identified in the database.

279 cell carcinoma (ESCC) models, reciprocal to the known synthetic lethal interaction.

280 rticular, we describe the molecular basis of the known target protection systems, emphasizing that ta

281 Our study broadens the known target specificity of GNAT toxins beyond the e

282 reg1a nor N-BUTX-Ptr1a affects ion channels, the known targets of their toxin scaffolds, but binds to

283 t degraders without culture bias and expands the known taxonomic distribution of sulfolane biodegrada

284 Unique among the known ternary transition-metal borides, the LiNiB st

285 In addition to the known Th and U complexes, our calculations include c

286 rotein (RBP) nucleolin, which interacts with the known TNT-inducing protein MSec, is essential for TN

287 The known top PD-associated variant (3' variant rs356182

288 thus aiding viral replication by preventing the known toxic effects of Zta overexpression.IMPORTANCE

289 and maintained information, consistent with the known tuning curves for these features.

290 In this review, we will discuss the known types of mitophagy observed in mammals, recent

291 mations to PDEs based on actual solutions to the known underlying equations.

292 computationally efficient implementation of the known variable selection method that we call the Aut

293 This differs from the known virulence mechanisms of mammalian rhabdoviruse

294 d, as well as a novel activating mutation in the known virulence regulator gene saeS (Ala106Thr).

295 7 viral populations (>=5 kb), which augments the known viruses from ETSP by 10-fold.

296 In view of the known wide variation in operational models for PET/C

297 Finally, families can overrule the known wishes of the deceased, which can mean prevent

298 It initially cataloged the known X-linked, autosomal recessive and autosomal do

299 In addition to the known Y-shaped conformation, we also observed an unu

300 ically by the combination of the two through the known Zn-cysteine finger redox trap effect.