ライフサイエンスコーパス: the postulated

1 The postulated 1,2-phenyl shift as origin for the side r

2 1,2-benzo[d]isoxazole has been used to trap the postulated a-oxo gold carbene intermediate involved

3 The postulated actin-binding region of MARCKS, which inc

4 bimetallic singly bridged iron(III)-dimer as the postulated active catalytic species.

5 CMV protease provides a better definition of the postulated active site cavity and reveals an elastas

6 d that two conserved aromatic amino acids in the postulated active site region could be altered witho

7 mutant L483Y, known to lack desensitization, the postulated active state of the LBD dimer is indeed t

8 er than that for endogenous adenosine due to the postulated additional endothelial dilator.

9 s of expression are clustered on one side of the postulated alpha-helical structure.

10 ur rows of bristles on the scutum resembling the postulated ancestral one.

11 delocalization depends on the degradation of the postulated anchor protein(s) by the McsA-McsB-(ClpC

12 mmunoprecipitation experiments, we confirmed the postulated APP-FE65 and the LRP-FE65 interaction.

13 y a physical interaction between RNase P and the postulated archaeal exosome, a connection that has n

14 l data suggest these nuclei might constitute the postulated attractor-path integration mechanism, and

15 ts with primary biliary cirrhosis (PBC), but the postulated autoimmune mechanisms behind these condit

16 A first clinical assessment of the postulated autoimmunity showed that fibromyalgia sub

17 Consistent with the postulated autoinhibitory role of the JMD Tyr-559 an

18 eling studies and the successful trapping of the postulated azomethine ylide and azaquinone methide i

19 re specifically, red wine) represents one of the postulated beneficial components of the traditional

20 roism spectrum of Jun a 3 is consistent with the postulated beta-sheet core.

21 bserved location thus would be favorable for the postulated binding of E7 to phosphatidylethanolamine

22 switches in this system, are consistent with the postulated biological function of the SdiA protein a

23 within the highly conserved CHAE sequence of the postulated C-terminal deaminase catalytic domain des

24 atous plaque through a biological mechanism, the postulated capability to reduce or inhibit restenosi

25 ucture, in complex with citric acid bound in the postulated carbamoyl phosphate binding site, was det

26 n routes A and B appeared to be possible for the postulated carbene mechanism.

27 d N170 in addition to concerted movements in the postulated carboxyl binding pocket that might allow

28 tations are important enough as to attenuate the postulated cardiovascular benefits of the MedDiet.

29 P NMR and HRMS analyses, which shed light on the postulated catalytic cycle.

30 The postulated catalytic mechanism involves stabilizatio

31 that any temperature-dependent alteration of the postulated cell matrix does not significantly affect

32 The postulated cellular mechanisms underlying the positi

33 We demonstrate that the postulated central binding domain surrounding layer

34 for hydroxyls on the lunar surface, and (ii) the postulated chondritic lunar water is not retained in

35 However, the postulated clear functional separation of rhythm- ve

36 DP-glucose dehydrogenase rather than through the postulated competing pathway leading from glucose 6-

37 rring during CPR in OHCA patients, including the postulated contribution of CC and non-CC related pat

38 complex has been studied in connection with the postulated contribution of short hydrogen bonds to b

39 A study of reaction orders supports the postulated cooperative catalysis.

40 05 and 1.10 angstroms unambiguously identify the postulated covalent carbinolamine and Schiff base in

41 However, lysine 155 is not required for the postulated covalent enzyme-substrate imine intermedi

42 We also apply mitoRNAi to directly determine the postulated crosstalk between individual respiratory

43 hilicity of the functional group involved in the postulated cyclodecarbonation reaction and on solven

44 ergic inhibition in the PFC and suggest that the postulated deficit in GABAergic function in schizoph

45 The effect of the postulated deltaE(t) on fluctuations in the radiativ

46 th phosphoglycolohydroxamate, an analogue of the postulated DHAP ene-diolate intermediate.

47 The postulated differences in stimulant effect between c

48 The postulated direct conversion of chemical energy into

49 a point inverse density weights derived from the postulated distance metric.

50 The functional role played by the postulated disulphide bridge in gamma-aminobutyric a

51 In addition, they formally prove the postulated downstream relationship of BMP4 with resp

52 e classified in 3 main families according to the postulated effect of exogenous boosting: 1) progress

53 The postulated effect of p65 on the JNK-mediated death-s

54 The postulated effect on orbital overlap may account for

55 and explained through the complex balance of the postulated electronic delocalizations.

56 cortin (Ucn), a Crh-related neuropeptide and the postulated endogenous ligand for Crhr2, is a potenti

57 In this review, we discuss the postulated evolutionary etiologies for sexual dimorp

58 Microarray analyses have led to the postulated existence and identification of numerous

59 ata support the idea that the Y5 receptor is the postulated 'feeding' receptor, and may provide a new

60 ng mode would place the C5 hydroxyl group of the postulated final intermediate distal to Fea and virt

61 on of Fl(red) with molecular oxygen restores the postulated Fl(N5[O]) via an unknown pathway.

62 O) from HNO dimerization would not only test the postulated formation pathway but also offer an easil

63 Since the postulated function of HilD at the hilA promoter is

64 The postulated function of the Asp274-His32 diad is to h

65 The Mb diffusion data indicate that the postulated gel network in the cell must have a minim

66 Membrane-associated fragments within the postulated globular extracellular N-terminal domain

67 putative GTP-binding site is consistent with the postulated guanine specificity of the protein.

68 In this paper, we discuss several of the postulated harms cited in academic and lay publicati

69 xual phenotype in sib pairs, we predict, for the postulated HD gene, a male thetamax as high as .254,

70 Overall, our findings support the postulated health benefits of fish consumption.

71 irudin-like region within the alpha subunit, the postulated high affinity binding site, direct bindin

72 The postulated high frequency and continent-wide geograp

73 1,2-dioxetanedione supports its viability as the postulated high-energy intermediate in the well-know

74 The results suggest that the postulated homeostatic function of 5-HT2CR editing i

75 omic library of Mycobacterium bovis BCG with the postulated homologous domains from mycocerosic acid

76 wheel', with central or visceral obesity as the postulated hub of the wheel.

77 The postulated ICA expansion and the subsequent increase

78 and one quinone (4-OBzl-1H-indole-6,7-dione, the postulated immediate precursor of the final blue dye

79 tion of primary accretion of the planets and the postulated impact origin of the Moon.

80 nt mutant, it should be possible to test for the postulated important roles for sulfolipids in the pa

81 peripheral blood leukocytes consistent with the postulated inflammatory function.

82 However, the postulated influence of pathogens on the filling of

83 In the postulated initiation pathways DHP can act as either

84 instability, but the nature and magnitude of the postulated instability is a matter of conjecture.

85 the four stereoisomers of beta-Me(2')Nal in the postulated interaction site of the peptide inhibitor

86 this modelling framework we address whether the postulated interactions of the pathways and species

87 ) from singlet dioxygen (1O2*) and water via the postulated intermediacy of dihydrogen trioxide (H2O3

88 The electronic structure of the postulated intermediate is believed to lie between t

89 Further support for the postulated intermediates in the chemically challengi

90 nd chemical mechanisms and indicate which of the postulated intermediates in the latter will be detec

91 e, has repeatedly been proposed, but none of the postulated intermediates occurring after addition of

92 e PILs can select folding pathways featuring the postulated intermediates so that they are fully popu

93 in excellent agreement with model spectra of the postulated intermediates, supporting the proposed me

94 e extracted and compared to model spectra of the postulated intermediates.

95 ecular dynamics simulations, thus confirming the postulated intramolecular mechanism in atomic detail

96 athogenesis seems to be multifactorial, with the postulated involvement of the circulating fibrocytes

97 a useful reagent for experimentally probing the postulated involvement of virion surface proteins in

98 The trifluoromethanide anion is the postulated key intermediate in nucleophilic trifluor

99 the numerical and geometrical primitives of the postulated language could be detected, both in isola

100 statistical model to rank the performance of the postulated laws.

101 and with a bisubstrate inhibitor that mimics the postulated linear reaction intermediate.

102 Second, the postulated link between primary tumor size and emiss

103 At selected positions within the postulated lipid surface of the AChR, tryptophan sub

104 Our previous amino acid substitutions at the postulated lipid-exposed transmembrane segment M4 of

105 challenges in avoiding crystallization near the postulated liquid-liquid critical point have focused

106 alphaCys222 is located in the postulated M1 transmembrane domain and predicted to

107 se fluorinated substrates is consistent with the postulated macrocyclization mechanism(s) en route to

108 Here, we show that the postulated macrotransposon can excise and reinsert e

109 enzyl cyanide as the second nitrile supports the postulated mechanism as well as the structure of der

110 To prove the postulated mechanism based on the participation effe

111 These findings, together with the postulated mechanism for S1PL activity, reinforce th

112 The postulated mechanism for the double-strand DNA break

113 In addition, the postulated mechanism has been explicitly demonstrate

114 The postulated mechanism is the activation of anorexigen

115 at is tethered to Ser195, in accordance with the postulated mechanism of action of this class of inhi

116 dynamic (PD) biomarkers were consistent with the postulated mechanism of action.

117 These results are consistent with the postulated mechanism of AGT repair that involves DNA

118 ith subsequent revascularization may support the postulated mechanism of chromosome 9p21 for promotin

119 Our findings provide support for the postulated mechanism of O2(.-) activation at class I

120 The postulated mechanism of the cardiotoxicity is genera

121 Finally, the postulated mechanism was investigated and supported

122 re chlorophyll-a samples are consistent with the postulated mechanism.

123 We also address the postulated mechanisms and the clinical implications

124 This review will also discuss the postulated mechanisms associated with these drug-ind

125 One of the postulated mechanisms for the function of these prot

126 revealed a working mechanism of PSS1 akin to the postulated mechanisms of the membrane-bound O-acyltr

127 he C-terminal domain of the protein close to the postulated membrane-binding surface.

128 three molecules suggest a means for testing the postulated metabolic pathway.

129 ctional theory (DFT) calculations shows that the postulated Mn oxo active species, [Mn(O)(tpp)(Cl)] (

130 For example, the postulated mobile surface charges could be on an int

131 We found no evidence for the postulated moderation effect in any study.

132 roximately 20 A from D1-Glu65 and D2-Glu312, the postulated network of hydrogen bonds must extend for

133 f the problem of serial order in behavior is the postulated neural representation of all serial eleme

134 Finally, a potential catalytic mechanism for the postulated noncatalytic PLA(2)-like proteins is anti

135 sis of the DNA polymerase is consistent with the postulated nonthermophilic phenotype of these crenar

136 rous tubal intraepithelial carcinoma (STIC), the postulated origin for high-grade serous cancer.

137 The postulated origins of the microwave-specific effect

138 cts of Stevens-type [1,2]-alkyl shift within the postulated oxonium ylide intermediate.

139 e we study an alternative possible cause for the postulated ozone drop: a nearby supernova explosion

140 a provide the first biochemical evidence for the postulated participation of the alpha-amino group in

141 To clarify the postulated pathway as mentioned in the literature, t

142 The postulated pathway of cGMP-dependent protein kinase

143 The postulated pathways involve initial proton abstracti

144 lation to the risk of in situ breast cancer, the postulated penultimate stage preceding invasive brea

145 electron demand created by rearrangement of the postulated peroxy intermediate.

146 hole at pH 10, which could be interpreted as the postulated pH-gating mechanism of AQP0-mediated wate

147 However in the same system the postulated Phe/Arg (i, i + 4) cation-pi interaction

148 ated isomerization product of CTC (iCTC) and the postulated photooxygenation product, bearing two oxy

149 In addition, we verify association of the postulated pore-forming protein CsoS1D with the carb

150 A cosmid containing the postulated pps gene cluster was identified by screen

151 rrier protein (ACP) to 3-methylcrotonyl-ACP, the postulated precursor of the cyclopropane ring of cur

152 nsight provides an intuitive explanation for the postulated presence of (Coulombically) univalent Mg(

153 se performed in rat and correlated well with the postulated presence of PV-1 in the endothelial diaph

154 The postulated principal mechanism underlying the benefi

155 he transition from the cleavage-competent to the postulated product release/transfer state may involv

156 visual cortex (V1) and hippocampus adhere to the postulated properties of the SR after visual sequenc

157 sight may help explain the interplay between the postulated protective and pathogenic roles of PrP in

158 Thus, our findings do not support the postulated protective role of enzalutamide in treati

159 would be more stable toward hydrolysis than the postulated protonated imine in the enzymatic reactio

160 ) in the presumptive R7 cell and constitutes the postulated R1/6-to-R7 signal required in combination

161 The postulated radical mediated mechanism is supported b

162 directing conformational changes controlling the postulated rate-limiting product release step, even

163 The results were compatible with the postulated reaction mechanism, in which NAD(+) initi

164 im of proving the biochemical feasibility of the postulated reaction, we have heterologously expresse

165 The postulated reactive intermediate, a terminal alpha-o

166 ounds synthesized by us and others confirmed the postulated reactivity.

167 The postulated relation between silicone breast implants

168 a stronger quantitative basis for addressing the postulated relation, we applied several techniques o

169 The postulated relationship between the two proteins inv

170 The postulated relationship has not been proven, however

171 ticeable ictal behavioral changes challenges the postulated requirement for normal thalamocortical ac

172 nm in venous erythrocytes, incompatible with the postulated reservoir function of SNO-Hb.

173 We question whether the postulated revenge and forgiveness systems constitut

174 ossible link between prebiotic chemistry and the postulated RNA world is discussed.

175 pY are not identical to those of dsRBDs, as the postulated RNA-binding site in pY does not coincide

176 e findings of this study are consistent with the postulated role for caveolin as a regulator of cellu

177 n the CRM1 RNA export pathway analogously to the postulated role for Dbp5p in yeast mRNA export.

178 ur findings suggest that CLC-2 does not play the postulated role in fluid transport at the basolatera

179 These results support the postulated role of altered aversive conditioning in

180 protein levels of PHAVOLUTA, consistent with the postulated role of AMP1 in miRNA-controlled translat

181 Lp(a) and vascular accumulation, supporting the postulated role of apo(a) LBS in this potentially at

182 This function would be consistent with the postulated role of BRCA1 as a caretaker gene in pres

183 cell-substrate attachment is consistent with the postulated role of caveolin-1 in positively regulati

184 Consistent with the postulated role of CES-1 as an antiapoptotic transcr

185 This result is consistent with the postulated role of Cys-276 as a catalytic residue an

186 Focusing on the postulated role of epigenetic factors in the aetiopa

187 clin D1 gene expression has implications for the postulated role of ERbeta as a modulator of the prol

188 The results also confirm the postulated role of His-178 in binding the phosphate

189 The postulated role of infection in the causation of chi

190 this and other studies significantly weaken the postulated role of rivers as major drivers of Amazon

191 nes that have lost the mutant allele support the postulated role of SAMD9L in the regulation of cell

192 others discussed below are in agreement with the postulated role of the adjacent aspartates in the ca

193 In accordance with the postulated role of the caveolin-1 scaffolding domain

194 aemodynamic changes such as diaschisis or to the postulated role of the cerebellum in motor skill lea

195 The postulated role of the invariant Glu-235 is to ion p

196 e interaction with the receptors, similar to the postulated role of the N-terminal domain of CheR.

197 There is a considerable controversy about the postulated role of the Thr(671)-Leu(690) (peptide A)

198 e observed in normal cells may be related to the postulated role of this DNA repeat in position effec

199 ease with aging, an unexpected finding given the postulated role of this enzyme in repairing age-dama

200 dence induced by 4-hydroxyestradiol supports the postulated role of this metabolite in hormone-associ

201 ns the door for long-term studies to address the postulated role of this morbillivirus in the develop

202 This is consistent with the postulated role of this residue as essential for mai

203 hippocampus is of particular interest due to the postulated role played by neurogenesis in memory.

204 mas-disrupted mutant should allow testing of the postulated roles of mycosides in pathogenesis.

205 An anatomical basis was sought for the postulated roles of nitric oxide (NO) as a labile tr

206 and M. leprae, it should be possible to test the postulated roles of these unique lipids in tuberculo

207 ies with respect to the structure as well as the postulated roles of this metalloenzyme in host-patho

208 f human SRAP and found that it does not have the postulated RRM (RNA recognition motif).

209 Here, we show that the postulated sensory Loop of the MEM domain plays an i

210 in integrating serine/threonine kinases into the postulated signaling pathways activated by hematopoi

211 oterozoic plate velocities that substantiate the postulated slowdown.

212 mucoid qualifies as a preferential probe for the postulated small pore system, our results are discus

213 challenging period, possibly orchestrated by the postulated social homeostasis system.

214 er Company Holdings (TEPCO) (17,000 points), the postulated source of the leakage was (1) leaks from

215 midzone MAPs may be one molecular basis for the postulated spindle matrix.

216 Changes of the DB sequence without affecting the postulated stem structure led to drastic losses of t

217 structures, thus confirming the presence of the postulated stem-loop, while all the bases in the loo

218 ) endometrial epithelial cells (EECs) assume the postulated stem/progenitor cell niche within the hum

219 regulation with DnaK structures obtained in the postulated stimulating state S with biochemical test

220 ay involve conformational changes other than the postulated switch to a genu-linear state.

221 Mutations in the postulated target site alter viral sensitivity to in

222 tudies provide a three-dimensional model for the postulated ternary cleavable complex of topoisomeras

223 yl donor is critical in the establishment of the postulated ternary complex for stereocontrol.

224 We present solid evidence to validate the postulated theory that links C(dilute)(*) to molecul

225 after dose escalation was 331 ng/mL, within the postulated therapeutic range.

226 ound at all the nucleophilic 3' ends used in the postulated transesterification step.

227 e-5'-phosphate decarboxylase in complex with the postulated transition state analog, 6-hydroxyuridine

228 s: PB2-T1 ends at Pro466, on the boundary of the postulated transmembrane domain, and PB2-T2 ends at

229 A model of the postulated TSOX adduct suggests that it is stabilize

230 The postulated units express the spontaneous dynamics of

231 her, these results suggest that, contrary to the postulated universal corepressor role, CtIP activate

232 esterase-triggered thiocarbamates that block the postulated unproductive deprotonation-based pathway

233 differentiation in a manner consistent with the postulated UPB1 function.