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1       Conical intersections corresponding to the presumed 1,2-hydrogen shift and 1,2-alkyl shift to g
2 ned, however, in part because only 40-60% of the presumed 700-1,000 proteins involved in mitochondria
3                                              The presumed ability of these CD4-based BiKEs to bind al
4 riants involving the His-509-Glu-514 dyad as the presumed acid-base catalyst.
5 rotein kinases, and the second N terminal to the presumed activation loop located between subdomains
6      Distal chemical shift changes involving the presumed active site cover imply indirect conformati
7                                       One of the presumed advantages for using VSV as an oncolytic vi
8 n reflecting affective negativity) simulated the presumed affective state of the target person.
9 +) breast cancer (BCa) treatment is based on the presumed aggressiveness and likelihood of cancer rec
10  hydrophobic patch in the domain opposite to the presumed ALK4 binding site.
11 azosin was given with phenylephrine to block the presumed alpha-1 agonist effect of phenylephrine.
12 ered viruses suggested that the structure of the presumed alpha-helical structure and positioning of
13                        Biotic pollination is the presumed ancestral condition, but this key element o
14 al phenomena, a significant mismatch between the presumed and actual scale of ecological data may ari
15 ical scans, and the spatial concordance with the presumed and invasively defined seizure onset zone w
16 ght be exactly the ones to benefit most from the presumed antiarrhythmic properties of ranolazine.
17 as unevenly distributed, particularly around the presumed apex of the cone.
18  providing approximately 14-fold coverage of the presumed approximately 1.48-Gb genome.
19 lder mono- and bis-cycloadducts derived from the presumed aryne intermediates in high yield.
20 alse-negative rate that was close to that of the presumed background rate of latent tuberculosis infe
21 ation flow between the brain and spinal cord-the presumed basis of ensuing clinical impairment.
22 tion between height and waist circumference: the presumed benefits of being taller are waist-dependen
23                                              The presumed benefits of valve surgery remain unproven d
24 nion based on its orientation with regard to the presumed binding mode of aristolochene.
25 ABA(A) receptors, and point mutations around the presumed binding pocket were introduced into GLIC an
26                                              The presumed biogenesis of these RNAs involves a non-can
27                                     Although the presumed biological function of RNAP pausing is to a
28 ities of the WH2 domains do not reconstitute the presumed biological function of the full-length prot
29  in catalytic efficiency for the excision of the presumed biological target (paired with T) relative
30  and determinant of free leptin index (FLI), the presumed biologically active form of leptin.
31 ng expansion strategy designed to complement the presumed biosynthesis of this complex meroterpene.
32  in minimal medium or with added methionine, the presumed biosynthetic methyl donor.
33 pected apparent size of the event horizon of the presumed black hole, suggesting that the bulk of Sgr
34 immediately adjacent to the tnaC stop codon, the presumed boxA and rut sites, contributed most signif
35                                              The presumed broad tropism of poxviruses has stymied att
36 d with a particulate steroid suspension, and the presumed but not proven mechanism is embolization an
37                   This model identifies that the presumed C-terminal transmembrane helix is buried wi
38                  Surprisingly, we found that the presumed cancer-promoting gene TCF7L2 functions inst
39 ecretase activity without altering levels of the presumed catalytic component (PS) of the enzyme may
40 the H296A mutant, in which the side chain of the presumed catalytic His is removed, had a 6-fold drop
41                         Binding of Sr(2+) to the presumed catalytic Pb(2+) site in the precatalytic l
42 formed aggregates, whereas an E72Q mutant in the presumed catalytic residue is much less active.
43 ino acids in the signature, one of which was the presumed catalytic tyrosine, resulted in a 1,000-fol
44                             The bacterium is the presumed causal agent of huanglongbing (HLB), one of
45                  Searching for host nests is the presumed causal factor influencing cowbird Hp size,
46 sociated with a peripheral component in that the presumed causative agent, PrPSc, also accumulates in
47            Extensive strut malapposition was the presumed cause for ScT in 1 case.
48 psy, which revealed Exserohilum rostratum as the presumed cause of death.
49             In many cases, the microbiota is the presumed cause of the variation.
50         The normal germinal centre B cell is the presumed cell of origin for both BL and diffuse larg
51 ressed in interstitial cells of Cajal (ICCs)-the presumed cell of origin for GIST-as well as in haema
52  chains and also failed to properly localize the presumed cell wall hydrolase, GbpB.
53                                              The presumed cellular targets of brain stimulation do no
54 ha-/- mice despite the continued presence of the presumed cervical cancer precursor cell type, reserv
55  and NCOs are strongly modulated in trans by the presumed chromatin remodelling protein PRDM9, and in
56                The tetrad Arg-Ala-Lys-Arg is the presumed cleavage site in the gPr73env precursor, an
57       In those cases, UHR OCT suggested that the presumed clinical diagnosis was incorrect and favore
58 igmaU activity caused by disruption of rsuA, the presumed cognate anti-sigma factor of sigmaU.
59     RitR is phosphorylated in vitro by StkP, the presumed cognate kinase of PhpP, and the site on Rit
60 g helix alpha4' in the C-terminal domain, of the presumed common ancestor of cytosolic GSTs (i.e. glu
61 t the exact mode of uPAR/uPA interactions or the presumed conformational changes that accompany uPA/u
62 ongener patterns similar to those of salmon, the presumed contaminant source.
63 o reconcile this transient mRNA profile with the presumed continuing "need" for TTP protein, for exam
64                  Cortex of posteromedial HG, the presumed core of human auditory cortex, represented
65  of a seed molecule, a stabilized version of the presumed critical nucleus, removes the kinetic barri
66 e inhibitor occupies both the glutamate- and the presumed cysteine-binding site and disrupts the prev
67                          A receptor in which the presumed cytoplasmic signaling C-terminal tail of FP
68 ns that were transmitted account for 6.8% of the presumed de novo mutations in the children.
69 icide or when binding at the sodium channel, the presumed destination of the neurotoxin.
70 ancer death associated with screening during the presumed detectable preclinical phase was 0.26 (95%
71                                   In humans, the presumed detrimental role of a heightened blood CRP
72 d electrical stimulus was increased, despite the presumed disappearance of an SDP in the post-AP peri
73 3 Mb deletion whose proximal region contains the presumed disease-associated gene TBX1 (T-box 1).
74 s is now widely discounted, owing largely to the presumed distinct embryonic origins of these structu
75                      Hence, although lacking the presumed DNA binding domain, CHT7 modulates the expr
76 n's disease (PD) is still controversial, yet the presumed dopamine toxicity is partly responsible for
77 press wild-type and mutant forms of Lamin C (the presumed Drosophila A-type lamin), in an otherwise w
78  result, the electrostatic environment along the presumed electron transfer path is substantially dif
79  were performed with dihydroxyacetone (DHA), the presumed endogenous substrate for FSA, as well as hy
80 n with a sister history of breast cancer and the presumed enrichment of shared environmental and gene
81 quency oscillations sources (80-200 Hz) with the presumed epileptogenic zone and the resected cortex
82 c) ovules (41-89%) in tetraploid F1s despite the presumed equal genetic contribution from the diplosp
83 s recorded in the LL firing maximally within the presumed ethological ITD range.
84  distinct lesion was seen endoscopically but the presumed etiology was an unidentified vascular malfo
85                                      Despite the presumed evolutionary advantages associated with ful
86  the broad molar mass distribution (MMD) and the presumed existence of different end group functional
87 he binding site, in which re-entrant loop 2, the presumed extracellular gate for the substrate bindin
88 combined test localizations were compared to the presumed EZ and to the postsurgical outcome.
89 n linked the laboratory-confirmed cases with the presumed first fatality of the outbreak in December
90 r storage polysaccharide in this species and the presumed food of H. hampei.
91 r led to a possible catalytic cycle based on the presumed formation of an acylborate intermediate.
92      Injection of a peptide corresponding to the presumed fourth intracellular loop of the transporte
93 with large complex carbohydrates, reflecting the presumed function of DPE2 in vivo.
94                                     Based on the presumed function of homologous genes involved in th
95                                       So, is the presumed functional hierarchy in FEF an intrinsic pr
96 unwind DNA suggest that these two members of the presumed functional replisome may act synergisticall
97 ion of Arg18 is more optimally positioned at the presumed gamma-phosphate location of ATP, close to t
98 nterneurons, what might be of importance for the presumed gating function of PRC in normal and diseas
99 ighlight the stage-specific requirements for the presumed "general" coregulators Sin3a and Sin3b in i
100                                              The presumed ground state of a nematic fluid confined in
101                  In the process of reviewing the presumed healthy PGP-10 genomes, we find numerous li
102                     Several formulations for the presumed heme-Fe{N(2)O(2)}(n-) intermediates have be
103 yces cerevisiae Mcm7 protein is a subunit of the presumed heteromeric MCM helicase that melts origin
104                                              The presumed hexaploidization event occurred after the A
105 ppreciable activation of alpha4beta2 nAChRs, the presumed high-affinity nAChRs in rodent brain.
106 on, this receptor is the only GPCR for which the presumed higher order oligomeric state in native mem
107                                    Moreover, the presumed Hox target genes are predominantly situated
108                                              The presumed hydrazine-FeMo-cofactor adduct displays a r
109 lly observed adduct (OEP)Co(II) (NO.BF(3) ), the presumed hyponitrite intermediate (P(.+) )Co(II) (ON
110                  One negative outcome can be the presumed identification of peptides that do not exis
111 ated is used as a metric of plausibility for the presumed identification.
112                           This suggests that the presumed immune tolerance in chronic HBV infections
113                                   Because of the presumed importance of ChBF regulation for maintenan
114 eparin (LMWH) during PCI has been limited by the presumed inability to monitor its anticoagulant effe
115 aracterized the distribution of ferroportin, the presumed intestinal iron exporter, and have evaluate
116  were mutated to cysteine, one at a time, in the presumed intracellular end of the first transmembran
117 nnecting TM1 to TM2 (Leu(277)-Arg(287)), and the presumed intracellular end of TM2 (Ala(288)-Ala(291)
118 ments suggest that the effective charge near the presumed intracellular mouth of the pore is critical
119                                              The presumed involvement of paired box gene 5 (PAX5) in
120 oline substitution at residue 419 (A419P) of the presumed ion channel TRPML3.
121 d with each other and that were aligned with the presumed isofrequency axis of the central nucleus of
122                                              The presumed junction between the precursor and the proc
123 ans-5-OH-TBOH to dehydrate at all pH values, the presumed kinetically controlled yield of 17alpha-TBO
124                      We investigated whether the presumed lack of transmission of serotype 11E is con
125                          As a consequence of the presumed lack of ZMPSTE24 activity, prelamin A, the
126                                              The presumed [LCo-H](+)-intermediate, especially when L
127 se and SM1 presumably competes with enolase, the presumed ligand, for binding to a putative midgut re
128  share several conserved residues, including the presumed ligands for the Mg(2+) and a catalytic hist
129 to epoxidize linalool, a model substrate for the presumed linear polyketide intermediate in monensin
130 c surface of the endoplasmic reticulum (ER), the presumed locale of channel synthesis.
131          After responsive animal sampling in the presumed location of exposure, cattle and/or buffalo
132                                     Based on the presumed location of K33 at or near the luminal doma
133 ) is located near the end of each S6 domain, the presumed location of the activation gate.
134 e neuroimaging techniques were compared with the presumed location of the epileptogenic zone (PEZ) as
135 pted, with one component blue shifted due to the presumed loss of an H-bond donor and the other red s
136 stood but is expected to be large because of the presumed low tolerance of deep-sea taxa to environme
137                          The effect of RT in the presumed low-risk luminal A-like tumors was excellen
138 s share the same centric fusions relative to the presumed macropodid ancestral karyotype, but can be
139 ologically relevant behavioural responses of the presumed, magneto-receptive American lobster and the
140 oning, we showed that the largest subunit of the presumed maize Pol IV is involved in paramutation, a
141 expectedly high frequency in regions lacking the presumed mammalian "targets," suggesting that mammal
142                                              The presumed maternal inheritance in angiosperms allows
143                                              The presumed mechanism behind this association suggests
144                                              The presumed mechanism for this effect is inhibition of
145 acological treatment options with respect to the presumed mechanism of action and its role in DCI.
146             Despite the therapeutic promise, the presumed mechanism of action of donor cell populatio
147         Inhibition of pro-survival pathways, the presumed mechanism of CAL-101, does not explain this
148   In two additional specimens, simulation of the presumed mechanism of fifth metatarsal bone fracture
149 in process variables (variables that reflect the presumed mechanism of treatment), and monitoring dif
150  why intraspecific competition should not be the presumed mechanism underlying density-dependent habi
151 elected biomarkers, which is consistent with the presumed mediation hypothesis.
152 alkaline treatment, which is consistent with the presumed membrane localization.
153 from the microanalytical results; otherwise, the presumed metal-core composition would have been (mu(
154 verexpression is difficult to reconcile with the presumed mitochondrial matrix localization for endog
155                                              The presumed mode of action is via blockade of axonal vo
156 a) is highly expressed in adipose tissue and the presumed molecular target for antidiabetic thiazolid
157 e pentameric form of PLB, despite the use of the presumed monomeric I40A mutant.
158 ase with a synthetic pentaketide analogue of the presumed monomeric polyketide precursor of elaiophyl
159 ects required significantly higher titers of the presumed more virulent FSS13025 Cambodia (ZIKV(C)).
160 romuscular junction (NMJ), only about 32% of the presumed motor axon terminals in the ventral horn ex
161                              We propose that the presumed multiple effects of Nampt/PBEF/visfatin may
162 stent vegetative state, less apprehension of the presumed mysteries of legal proceedings, and greater
163  CD9 levels may serve to distinguish between the presumed MZ precursor B cell population in the splee
164 rotein may serve as an additional marker for the presumed MZ precursor population of splenic B cells.
165 e presented rearrangement reaction, in which the presumed N-acylated intermediate reacts intramolecul
166 ysteines engineered to positions external to the presumed narrow region (e.g., 334, 335, and 337 in T
167 orm intramolecular G-quadruplexes, which are the presumed natural substrates for the G-quadruplex hel
168                                Thus, despite the presumed need to recognize a similar range of antige
169 quadruplex DNA structures in genomic DNA and the presumed need to resolve these structures for DNA re
170                The assay's specificity among the presumed negative American donor samples was 100% (9
171 atency increases in firing to a danger cue - the presumed neural substrate for fear output - signal t
172 an unexpected relationship between AP180 and the presumed non-neuronal homologue CALM.
173                                              The presumed nonenzymatic hydrolysis of N-propargylimino
174 e that have not been dated by tuning them to the presumed Northern Hemisphere signals.
175                            Here, we examined the presumed nucleosome remodeling activity of Lsh on ch
176  copy-number plasmid carrying POL30, despite the presumed occurrence in the mutant of sliding clamp a
177 of alternative social organizations involves the presumed odorant-binding protein gene Gp-9 in fire a
178                                  To decipher the presumed oncogenic mechanism of miR-125b, we used tr
179 enes encode neomorphic proteins that produce the presumed oncometabolite 2-hydroxyglutarate (2-HG).
180  were randomly assigned within 6 weeks after the presumed onset of infection to receive hyperimmune g
181 ice, and levels within the intestinal tract (the presumed origin of the gas) were four times greater
182                                              The presumed origin of the infection seemed to be enviro
183                                              The presumed palaeotetraploidy of the American paddlefis
184 sum of pancreatic tissue area to the left of the presumed pancreatic transection site.
185 for most caridean shrimps and corresponds to the presumed Pancrustacean ground pattern.
186  anomalies were considered in the context of the presumed pathogenetic mechanism related to the neuro
187                                  Only one of the presumed pathogenic mutations in the VSX1 gene, Asp1
188                                    Curves in the presumed penumbral regions (n = 8) showed varied mor
189 e reaction required for the isomerization of the presumed peroxynitrite intermediate to the product,
190 tron microscopy specimen protocol shows that the presumed phospholipid bilayer membrane ribbons that
191 her active sites but mirrors the geometry of the presumed phosphoryl transfer transition state.
192 ) nor peptidyl transferase center (PTC) RNA, the presumed physiological RNA substrate, favor oligomer
193 n of the lever arm in a crystal structure of the presumed poststroke conformation of myosin VI.
194 not K-Cl cotransporter 2, are colocalized at the presumed postsynaptic sites.
195 monstrates that both prostate carcinomas and the presumed precursor lesion (high-grade prostatic intr
196                       Barrett's esophagus is the presumed precursor lesion for this cancer.
197 on as a biomarker for infection persistence, the presumed precursor of HPV16-associated oropharyngeal
198 g prostatic intraepithelial neoplasia (PIN), the presumed precursor of human prostate cancer.
199  fide CCD, and is able to cleave zeaxanthin, the presumed precursor of saffron apocarotenoids, both i
200 d the adjacent epithelium from cystadenomas, the presumed precursor of SBTs.
201 have been identified, with cholesterol being the presumed precursor.
202 t to the site of vascular injury do not play the presumed preeminent role in supporting prothrombinas
203 sory regions (Kloosterman et al., 2019), but the presumed prefrontal signature of a conservative-to-l
204 temporal tip, accounting for half or more of the presumed premorbid volume, was unlikely to have cont
205  There was a high level of agreement between the presumed preoperative diagnosis and intraoperative d
206 ting carnivorous predators in green tissues, the presumed primary function of terpenoid volatiles rel
207     The amino-terminal 290 residues of UL44, the presumed processivity factor of human cytomegaloviru
208                                        PF-8, the presumed processivity factor of Kaposi's sarcoma-ass
209                             The structure of the presumed product-bound state reveals that binding in
210 1) in primary human germinal center B cells, the presumed progenitors of HRS cells, upregulates disco
211 -negative/stx(2)(+) E. coli O157:H7 strains, the presumed progenitors of stx(1)(+)/stx(2)(+) E. coli
212 d IGF-I deprivation required the survival of the presumed progenitors.
213 rcept of the aura changed corresponding with the presumed propagation from the V1 to the V2 region of
214                                          And the presumed protective effect of obesity on osteoporosi
215 rly because longstanding hypotheses, such as the presumed protective effects of fruits, vegetables, a
216 ve to determine the type of parkinsonism and the presumed proteinopathy using specified criteria.
217 gional differences in neuronal properties of the presumed pyramidal cells were found between PrL and
218 eaction is inhibited by molecular oxygen via the presumed quenching of the photoexcited triplet state
219                                   Because of the presumed radical nature of the process, hindered ami
220                               In both cases, the presumed receptor is cryptochrome, a protein thought
221                                  To identify the presumed receptor proteins, two-hybrid screening was
222                            This mechanism is the presumed recognition step for the vesicular packagin
223               To date, little is known about the presumed redox activity of VIMP, its structure and h
224 hinery revealed similarities among sugars at the presumed reducing termini of these oligosaccharides.
225 otype T cells that includes cells expressing the presumed regulatory T cell marker, Foxp3.
226                 The Mcm2-7p heterohexamer is the presumed replicative helicase in eukaryotic cells.
227 though 90% of isolates from the environment, the presumed reservoir for the majority of P. aeruginosa
228 lizes as stationary dots at the cell cortex, the presumed result of offloading in our model, as does
229 cated in three regions: the AUG start codon, the presumed ribosomal binding site region, and a region
230 rship interests have never been established, the presumed right of researchers and institutions to co
231 rs are usually surgically removed because of the presumed risk of complications.
232 e although these residues were far away from the presumed RNA binding site in the crystal structure o
233 equence space would have been crucial during the presumed RNA world and confers selective advantage i
234 tion is inconsistent with published data and the presumed role of ABCC6, we performed experiments to
235                                        Given the presumed role of alpha cells to detect brisk transie
236                                              The presumed role of an overactive protein arginine deim
237                                    Following the presumed role of grid cells in vector navigation, we
238                                 Furthermore, the presumed role of mTOR in hypertrophy is derived from
239                        This might underscore the presumed role of the cerebellum as a state estimator
240                                              The presumed role of the primate sensorimotor system is
241  also for abiotic and biotic processes with, the presumed, same formal chemical degradation mechanism
242 sidered to remain constant during G1, due to the presumed scaling of its production rate with cell si
243 elated maps had a degree of concordance with the presumed seizure onset zone for all patients.
244 nd the maps had a degree of concordance with the presumed seizure onset zone in 10 patients.
245 elated maps had a degree of concordance with the presumed seizure onset zone in six of eight patients
246 er was localizable at sub-lobar level within the presumed seizure onset zone in six patients.
247 ally significant haemodynamic cluster within the presumed seizure onset zone was between 1.1 and 3.5
248  that extracellular Mg(2+) signalled through the presumed sensor histidine kinase, CsrS.
249 tern of activity was the opposite of that of the presumed serotonergic cells.
250 -magnetic layers is typically ignored due to the presumed short range of such proximity effects.
251 cture of a cysteinyl-flavin covalent adduct, the presumed signaling species that leads to phototropin
252 amma-methylene-diphosphonate (GMP-PCP) (i.e. the presumed signaling-active state) and show that it is
253                            We then confirmed the presumed site of AP and low-threshold Ca(2+) spike i
254  was traced with microsatellite markers from the presumed site of domestication to distant regions of
255  located at the preautophagosomal structure, the presumed site of double-membrane vesicle formation.
256 trafficking of coat protein to mitochondria, the presumed site of FHV assembly, and that this traffic
257 and decorrelation from the receptor array to the presumed site of odour learning, the mushroom body.
258 ssociated with ribosomal function, including the presumed site of peptidyl transferase activity in th
259         In 2012, a skeleton was excavated at the presumed site of the Grey Friars friary in Leicester
260 y integrated in the brain's central complex, the presumed site of the sun compass.
261 te circuitry in the brain's central complex, the presumed site of the sun compass.
262 bic channel of dihydroorotate dehydrogenase, the presumed site of ubiquinone binding during oxidation
263 sociated with puberty, self-evaluations, and the presumed social reorientation during the transition
264 ng adherence, drug susceptibility results of the presumed source case (if known), safety, cost, and p
265          The ventral tegmental area (VTA) is the presumed source of dopamine in the dorsal hippocampu
266 resumably chaotrope-induced deceleration and the presumed, square root-dependent ionic strength-induc
267                                 With FISH as the presumed standard testing method, the positive and n
268 ax than do K15- basal cells, consistent with the presumed stem cell nature of K15+ basal cells.
269 mediately adjacent to the first or closer to the presumed stimulus of interest.
270             Tonically active neurons (TANs), the presumed striatal cholinergic interneurons, could be
271 r type of protecting group), a compound with the presumed structure of the natural product serratin w
272           A fluorogenic peptide representing the presumed subtilase recognition site in AtRALF23 was
273 normal thalamic RSNs lend further support to the presumed subtle thalamic injury in patients with MTB
274                Studies are needed to confirm the presumed superiority of this method for diagnosing A
275 ral insertions led to elevated expression of the presumed target flanking genes.
276 ency at the rat serotonin 5-HT(2A) receptor, the presumed target for hallucinogenic agents, and a rec
277 n several RNA data sets, and the function of the presumed target gene was explored using an RNA inter
278                  Much has been learned about the presumed target of acute stroke therapy, the ischemi
279                                      Whereas the presumed target of this inhibitor was rhodesain (als
280 s as the peptide moves on the access path to the presumed target, the inner membrane.
281 nvestigate the localisation and magnitude of the presumed tau Positron Emission Tomography (PET) trac
282 es such as tris(chlorophenyl)methane (TCPM), the presumed TCPM metabolite tris(chlorophenyl)methanol
283 ring the simulations shift the operators and the presumed termini of the loop.
284    This concept has been tested by replacing the presumed tetrahedral carbon of a thermolysin substra
285 tance to the active-site zinc ion, mimicking the presumed tetrahedral transition state.
286                                  The role of the presumed Th17 cytokine IL-26 in antibacterial host d
287 moters is well known to silence genes and is the presumed therapeutic target of methylation inhibitor
288                          While the cages are the presumed thermodynamic sink, we experimentally demon
289 cination (ie, they had antibody levels above the presumed threshold for herd immunity).
290  showed a gradient in dendritic length along the presumed tonotopic axis.
291 ent in temporal processing properties across the presumed tonotopic axis; neurons in the MSO and the
292                                              The presumed totipotency of plant cells leads to questio
293                           This suggests that the presumed transglycosidases Dfg5 and Dcw1 of cdc1-314
294  investigation into the nature and causes of the presumed underuse of epilepsy surgery and the elabor
295      We extend the basic models to show that the presumed unidirectional nature of the amplification
296 arliest tetrapods and raises questions about the presumed vertebral architecture of tetrapodomorph fi
297                                     Owing to the presumed weak influence of single genes on disease p
298 hereas an 8-bp deletion in the third exon of the presumed wild-type normal allele causes a frame-shif
299 uring early juvenile development but only in the presumed XX female genotype.
300 gical variant of UL, may account in part for the presumed yet rare malignant transformation of UL to

 
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