ライフサイエンスコーパス: the responsible

1 roductively focus efforts toward identifying the responsible Ag, and implementing more effective ther

2 The responsible agent, Kaposi's sarcoma-associated herpe

3 ent antibodies can be helpful in identifying the responsible agent.

4 Yet seldom have the responsible agents and their respective genes been i

5 nt neuronal network oscillations, identifies the responsible aggregation state of Abeta and proofs th

6 ilies, a transcription-altering mutation was the responsible allele.

7 search and establish objectives that promote the responsible and sustainable development of nanotechn

8 oman who referred to our clinic for identify the responsible antigen of anaphylaxis.

9 3 NC1 (Col4alpha3NC1) has been identified as the responsible autoantigen, it remains unknown how auto

10 amounts of sensitizing hapten suggests that the responsible B cells have increased IgM receptor gene

11 ith imaging provides possible identities for the responsible bacteria.

12 ubsequently provide evidence indicating that the responsible BFA-sensitive ADP ribosylation factor-GT

13 rogenic acid and cryptochlorogenic acid were the responsible biomarkers for the separation of the ste

14 ear envelope ruptures during interphase, but the responsible biophysical processes remain unclear.

15 oducer of deimino-antipain was sequenced and the responsible biosynthetic gene cluster was identified

16 very of the pyonitrins and identification of the responsible biosynthetic gene clusters revealed an u

17 urce, showing that dendritic cells (DCs) are the responsible cell type for production of type I IFN,

18 However, the responsible cellular and molecular components have n

19 Probing the responsible cellular mechanisms pinpoints a disturba

20 ization, indicating that oxidative stress is the responsible cellular stimulus.

21 e-chain determinants different from those of the responsible cephalosporins and have negative pretrea

22 human insulin promoter fragment, pointing to the responsible cis element.

23 and much progress has been made in defining the responsible cis elements and transcription factors.

24 years, research has concentrated on defining the responsible cis-elements in the untranslated regions

25 The responsible clinician determined administration of s

26 The responsible clinician determined the administration

27 To schedule the blocked examinations, the responsible clinician was required to personally log

28 possible with successful treatment targeting the responsible clone.

29 blocking mAb further established factor H as the responsible cofactor.

30 We sought to determine the responsible components of black tea and elucidate th

31 at allergic patients may lose sensitivity if the responsible compounds are avoided.

32 rrespective of the underlying mechanisms and the responsible compounds, phenolic mango peel extracts

33 r must occur between cofactor and substrate, the responsible conformational change again being that w

34 h challenges in diagnosis, identification of the responsible constituents, treatment, and prevention.

35 acy monitoring and mass trapping efforts, if the responsible cues are identified.

36 by Cln3 or later S- or M-phase cyclins, but the responsible cyclin interface was unknown.

37 The responsible CypD residues for this activity were map

38 w here that secretory vesicle cathepsin L is the responsible cysteine protease of chromaffin granules

39 for presentation to developing T cells, but the responsible DC subsets remained poorly defined.

40 omic nervous system balance in HRV patterns, the responsible deeper physiological, clinically relevan

41 y CNVs, and copy number gains in particular, the responsible dosage-sensitive gene(s) have been hard

42 s several neurobehavioral abnormalities, but the responsible dosage-sensitive gene(s) remain undefine

43 s a major role in glioblastoma pathogenesis, the responsible downstream mechanisms remain less clear.

44 related behaviors in humans and rodents, but the responsible downstream receptors remain poorly under

45 , is critical to limbic epileptogenesis, but the responsible downstream signaling pathways are unknow

46 ghly effective when the specific allergen is the responsible driver for the symptoms.

47 phenomenon, large-scale studies dealing with the responsible drivers are rare.

48 cutaneous eruption is suspected, identifying the responsible drug(s) is a complex clinical challenge.

49 alosporins and positive skin test results to the responsible drugs underwent serum specific IgE assay

50 itizes IRS1 to degradation, and a screen for the responsible E3 ligase identified Fbxo40 as mediating

51 conditionally deleting the Rnf40 subunit of the responsible E3 ligase in mice.

52 e for ubiquitin in this degradation pathway, the responsible E3 ligase is unknown.

53 l in elucidating the mammalian ERAD pathway, the responsible E3 ligase or ligases remain unknown.

54 Dictyostelium, and further identification of the responsible E3-ligase may provide a novel therapeuti

55 In addition, the responsible elastic elements must be able to stretch

56 and the E-boxes in the promoter region were the responsible element.

57 ced activation of spinal cord microglia, but the responsible endogenous TLR2 agonist has not been ide

58 that the nonfibrillized P-tau is most likely the responsible entity for the disruption of microtubule

59 cells implicate the Src family kinase Lck as the responsible enzyme and its activity in this process

60 ciently cleansed from the nucleotide pool by the responsible enzyme in Escherichia coli MutT and its

61 up-regulated by enhanced gene expression of the responsible enzyme N-acetylglucosaminyltransferase I

62 served in zygotes and primordial germ cells, the responsible enzyme(s) have been elusive.

63 igopeptidase B (OPB; Clan SC, family S9A) as the responsible enzyme.

64 s to folate monoglutamates by the cloning of the responsible enzyme; ii) identification of the cDNA r

65 ases involved in histone ubiquitination, yet the responsible enzymes and the function of histone ubiq

66 H2B ubiquitination and histone methylation, the responsible enzymes and the functions of H2A ubiquit

67 Although the responsible enzymes are thought to be fairly well ch

68 The responsible enzymes-ALG3, ALG9, ALG12, ALG6, ALG8 an

69 e assembly of ubiquitin chains is managed by the responsible enzymes.

70 7 cells, indicating that catecholamines were the responsible exercise factors.

71 The responsible exoribonuclease is Usb1, which removes n

72 produced ROS in the regenerating liver were the responsible factor for TSP-1 induction.

73 To identify the responsible factor, we tested several candidate tyro

74 The responsible factors are not fully understood, but TG

75 We put a hypothesis that one of the responsible factors is the presence of gastrointesti

76 wn stream of the muscarinic receptors may be the responsible factors.

77 e identified the PE_PGRS47 protein as one of the responsible factors.

78 high collinearity between variables might be the responsible for high uncertainty values in the predi

79 The responsible gene acts as a tumor suppressor, and tum

80 en less robust in identifying and validating the responsible gene and/or genetic variants.

81 We provide evidence that the responsible gene at LGS1 codes for an enzyme annotat

82 A study was undertaken to identify the responsible gene defect underlying late onset spinal

83 Identification of the responsible gene for SCA26 ataxia will provide furth

84 ation sequencing method, we excluded CASK as the responsible gene for the remaining family.

85 Myosin VIIa has been identified as the responsible gene for USH type 1B, and a number of mi

86 Lgn1, has been mapped to chromosome 13, but the responsible gene has not been identified.

87 Ltxs1, has been mapped to chromosome 11, but the responsible gene has not been identified.

88 n of risk and genetic mapping has identified the responsible gene in a few mendelian cases.

89 inked to three loci: 2p21 (GLC3A), for which the responsible gene is CYP1B1, and 1p36 (GLC3B) and 14q

90 lE7 was not identified, implying either that the responsible gene is essential for cell viability, or

91 next-generation sequencing (NGS) to identify the responsible gene mutation in the family.

92 ociated with trisomy 21 (Down syndrome), but the responsible gene or genes on chromosome 21 have not

93 henotypes followed by genotyping to discover the responsible gene or mutation.

94 -dependent retinal diseases, suggesting that the responsible gene regulates retinal aging, and its im

95 The identification of the responsible gene will provide new insights into the

96 The responsible gene(s) therefore resides in an interval

97 netic and physical mapping efforts localized the responsible gene(s) to a well-defined region on huma

98 mutants defective in IT formation and cloned the responsible gene, ERN1, encoding an AP2/ERF transcri

99 We cloned the responsible gene, trafficking protein, kinesin bindi

100 ne locus for SSNS, as a first step to detect the responsible gene, was thus identified.

101 The responsible gene, WASP, has multiple domains, each w

102 To identify the responsible gene, we sequenced the exomes of five in

103 identify the transcription factor, Usf1, as the responsible gene.

104 smooth muscle myosin heavy chain (myh11) as the responsible gene.

105 s a starting point for the identification of the responsible gene.

106 genetic form of polymicrogyria and localize the responsible gene.

107 cholesterolemia were ruled out by sequencing the responsible genes (LDLRAP, LDLR, PCSK9, APOE and APO

108 ns can arise through several mechanisms, but the responsible genes and pathways are poorly understood

109 dence is well established; identification of the responsible genes has proved challenging.

110 s it is absent from humans and disruption of the responsible genes has shown a lethal phenotype for E

111 However, few of the responsible genes have been identified, and little i

112 ured from primary cilia of kidney cells, but the responsible genes have not been identified.

113 The identification of the responsible genes may lead to insights into the path

114 n persons with schizophrenia and then mapped the responsible genes onto transcriptome profiles of nor

115 uman disease loci may help identification of the responsible genes, and is thus a topic of considerab

116 To identify the responsible genes, we mapped virulence in F(1) proge

117 two genetic loci, within which we identified the responsible genes: one locus contains a known xylose

118 compare closely related strains to identify the responsible genetic determinants.

119 Identification of the responsible genetic factors will greatly enhance the

120 Identification of the responsible genetic locus in those mutants significa

121 al component in linking phenotypic traits to the responsible genetic variation in the genomes of plan

122 trait-associated genetic markers to discover the responsible genetic variation.

123 However, the inhibitory function of the responsible group 3-like ILCs was not dependent on t

124 oliferation in crypt stem cell compartments, the responsible growth factors regulating this continuou

125 ent specificities limited our exploration of the responsible HDAC member to HDAC1, HDAC2, or HDAC3.

126 e E3 ligase that mediates the proteolysis of the responsible HDACs (see the related article beginning

127 However, the responsible histone acetyltransferase enzymes are ye

128 Many chemicals were identified by GC-MS, but the responsible individual compounds could not be exactl

129 induction of transplantation tolerance, but the responsible inflammatory mediators have not been ide

130 ecular levels permits mechanistic studies of the responsible interactions relevant to the inherited h

131 The responsible interplanetary meteoroids were initially

132 e timely adoption of innovative methods, and the responsible interpretation of research findings.

133 logical, no clinical counter-measures target the responsible intracellular pathways.

134 However, the responsible intracellular signaling pathways trigger

135 These will support the responsible introduction of surgical innovations.

136 ubiquity of this common excitable property, the responsible ion channels have not been identified.

137 specific function, our algorithm identifies the 'responsible' isoform(s) of a gene and generates cla

138 functionalities and experimentally validated the 'responsible' isoforms using data from mammary tissu

139 The responsible justice department and ethics committee

140 However, the responsible kinase has remained elusive.

141 own to be a phosphoprotein in vivo; however, the responsible kinase(s) have not been determined.

142 y targets S451 and we have identified Akt as the responsible kinase.

143 ic treatment modalities, which may eliminate the responsible malignant clone.

144 tering a "bottom-up" stewardship approach to the responsible management of risks from engineered nano

145 Elucidating the responsible meal components and receptors could aid

146 ignaling, imposed by nuclear plakoglobin, is the responsible mechanism for the pathogenesis of ARVC.

147 ist around the acetylene bridging unit to be the responsible mechanism generating a partial to an alm

148 The responsible mechanism involves an increased nuclear

149 The responsible mechanism is the breakdown of the aforem

150 menon is due to an expansion of T cells, but the responsible mechanism is unknown.

151 bone loss induced by ovariectomy (ovx), but the responsible mechanism is unknown.

152 one loss induced by estrogen deficiency, but the responsible mechanism is unknown.

153 n cellular stress and apoptosis, were likely the responsible mechanism of action.

154 nephropathy and retinopathy in diabetes, but the responsible mechanism remains unclear.

155 ine is a potent elicitor of GLP-1 secretion, the responsible mechanism remains unclear.

156 Analysis of the responsible mechanism using neutrophils from beta2 n

157 Cellular origin of excess adipocytes, the responsible mechanism(s) and the basis for predomina

158 To delineate the responsible mechanism, we generated transgenic mice

159 tal evidence for understanding the nature of the responsible mechanism.

160 parasympathetic fibers by mepivacaine may be the responsible mechanism.

161 inkage between polar and tropical regimes as the responsible mechanism: the interplay of northward mi

162 abolism but there is limited appreciation of the responsible mechanisms and molecular components with

163 ptual framework to help the understanding of the responsible mechanisms and, when available, an updat

164 The responsible mechanisms are multifarious, but effects

165 d as a risk factor for beta-amyloidosis, but the responsible mechanisms are not clear.

166 The responsible mechanisms are not completely understood

167 ardial infarction and thrombotic events, but the responsible mechanisms are not fully understood.

168 stimulation protects cells from anoikis, but the responsible mechanisms are not well known.

169 However, the responsible mechanisms are not well understood.

170 the ischemic myocardium from infarction, but the responsible mechanisms are unclear.

171 atic nucleus (SCN) have been implicated, but the responsible mechanisms have not been clearly delinea

172 Although the responsible mechanisms have not been well defined, n

173 ntial risk of neoplastic transformation, but the responsible mechanisms have not yet been established

174 Fs) and U937 human monocytic cells; however, the responsible mechanisms have not yet been fully estab

175 The responsible mechanisms involve cis-trans interaction

176 Clues to the responsible mechanisms may lie with the discovery of

177 The responsible mechanisms of restless legs syndrome are

178 plication results in chronic-phase AIDS, but the responsible mechanisms remain controversial.

179 However, the responsible mechanisms remain elusive.

180 EAK1 is known to promote cell migration, but the responsible mechanisms remain unclear.

181 gression of cardiovascular disease, although the responsible mechanisms remain unclear.

182 tation are well studied in maize (Zea mays), the responsible mechanisms remain unclear.

183 e processing and oncogenic ability, although the responsible mechanisms remain unknown.

184 ression is increased in tissue ischemia, but the responsible mechanisms remain unknown.

185 However, the responsible mechanisms remain unresolved.

186 The responsible mechanisms, however, are not well unders

187 The responsible mechanisms, however, remain unclear and

188 To investigate the responsible mechanisms, we studied the regulatory ef

189 and turnover rates are useful in elucidating the responsible mechanisms.

190 ratum corneum integrity/cohesion, as well as the responsible mechanisms.

191 d aging in cancer survivors and to determine the responsible mechanisms.

192 icity and mechanical durability, and reveals the responsible mechanisms.

193 The responsible meningococci belong to a highly virulent

194 The responsible metabolic lesion appears to involve a po

195 ereby implicating hexosamine biosynthesis as the responsible metabolic pathway.

196 The responsible methyltransferase (MT) is fused with an

197 dification has been hindered by ignorance of the responsible methyltransferase.

198 ver, for the majority of these methylations, the responsible methyltransferases (MTases) remain unkno

199 biochemical activity with identification of the responsible microbes and enzymes.

200 ver been shown in a longitudinal design, and the responsible milk components are still unknown.

201 The responsible miRNAs function by suppressing multiple

202 However, the responsible mitochondrial lysine-specific methyltran

203 de useful platforms from which to search for the responsible modulators.

204 n the last two decades has aimed to decipher the responsible molecular and cellular mechanisms for re

205 early events in muscle differentiation, but the responsible molecular mechanisms are unknown.

206 lain this fundamental biological phenomenon, the responsible molecular mechanisms have not been deter

207 in response to mechanical loading; however, the responsible molecular mechanisms remain largely unkn

208 To begin dissecting the responsible molecular mechanisms, we set out to iden

209 e of maintaining HSCs ex vivo long-term, but the responsible molecular players remain unknown.

210 netic mosaics, present evidence that Slit is the responsible molecule.

211 This provides the basis for identifying the responsible molecules and developing strategies to a

212 tion and endocrine inhibition, implying that the responsible molecules are not unique to pancreatic m

213 in the fourth to fifth postnatal weeks, but the responsible molecules are unknown.

214 vities have been recorded in many cells, but the responsible molecules have not been identified.

215 Map-based identification of the responsible mutation identified a G-->A transition,

216 s were formed of neuroserpin aggregates, and the responsible mutations in neuroserpin were identified

217 nsmitted during the Korean outbreak and that the responsible mutations were compatible with robust in

218 f identifying families with XLID and finding the responsible mutations, as well as the determined and

219 nced their host attachment genes to identify the responsible mutations.

220 The responsible neuronal circuitries show lifetime plast

221 learning because it is difficult to identify the responsible neurons when a mistake is made.

222 eview important disease symptoms and some of the responsible neuropathology.

223 The responsible non-ribosomal peptide-polyketide hybrid

224 n or loss of sensation and to CPSP, although the responsible nuclei have not been identified.

225 Optogenetic activation or inhibition of the responsible olfactory neural circuit promotes the lo

226 y, we identify the Yersinia urease enzyme as the responsible oral toxin.

227 found in mammalian cells, including kidney, the responsible organ for osmolyte regulation, posing th

228 the conclusion that heat-processing was not the responsible parameter for that distortion, but the s

229 and laboratorians to continue the search for the responsible pathogen.

230 However the responsible pathogenic mechanisms are still far to b

231 or to this threat, but little is known about the responsible pathogens.

232 So far, the responsible pathophysiological mechanisms are poorly

233 uce morbidity and mortality requires knowing the responsible pathophysiologies and the therapeutic ad

234 ted the role of ceramide versus caspase, and the responsible pathway for ceramide generation in ultra

235 o define the final steps in this pathway and the responsible peptidases, we fractionated by size the

236 We hypothesized that the responsible permeability barrier to CO(2) resides in

237 physician's error, ranging from confronting the responsible physician to changing providers to pursu

238 to the intervention group (n=1238), in which the responsible physician was alerted by another hospita

239 patients to an intervention group, in which the responsible physician was alerted to a patient's ris

240 se guidelines, the committee recognizes that the responsible physician's judgment remains paramount.

241 epression and a decrease in return visits to the responsible physician.

242 er kg) was administered at the discretion of the responsible physicians who were aware of local and i

243 integrin alpha(IIb)beta(3) in platelets, but the responsible PKC isoforms and mechanisms are unknown.

244 For each quantitative trait locus, the responsible polymorphism is rare among a diverse set

245 ciated with 2 main haplotypes in VKORC1, but the responsible polymorphisms remain unknown.

246 hich pigments have been discolored, what are the responsible processes, and which (environmental) con

247 quencing of the encoding gene indicates that the responsible processing enzyme is a member of the pro

248 cells to activation induced cell death, and the responsible products had the features of ganglioside

249 s in brain inflammation and injury, although the responsible prostaglandin receptors have not been fu

250 hought, raising questions on the identity of the responsible protease(s).

251 by incubation with synovial fluid, although the responsible proteases could not be identified.

252 This study was undertaken to identify the responsible proteases.

253 loci more frequently than to loci for which the responsible protein coding gene is known, thus sugge

254 r cellular phenotype and the inactivation of the responsible protein due to the off-target effect of

255 The simulations identify the responsible protein residues, the arginine finger al

256 The responsible protein was identified as a P450 monooxy

257 data regarding the structure and function of the responsible protein, ATP7B, and the importance of it

258 The responsible proteins for the transport of 5-azacytid

259 arly years was to select a function, isolate the responsible proteins, and locate the corresponding g

260 However, the responsible quality control (QC) mechanisms remain p

261 report the in vitro reconstitution of TbtI, the responsible radical S-adenosyl-methionine (rSAM) C-m

262 the cause and determine, in cooperation with the responsible radiologist, whether these doses are jus

263 The responsible receptors and signaling pathways are inc

264 The responsible regions of Dmp1 gene were located in the

265 nthesis of their membrane phospholipids, but the responsible regulatory mechanisms are incompletely u

266 To delineate the responsible regulatory motifs, luciferase reporter c

267 The responsible residue is usually identified by site-sp

268 To find the responsible residue, all cysteines, Cys(7), Cys(379)

269 volatile hexanoic acid and characterize how the responsible sensory receptor (the variant ionotropic

270 from cell membranes and, if so, to identify the responsible sheddase and determine whether activatio

271 lpha, providing a strong incentive to define the responsible sheddases.

272 chimeras, hSkM1P1 and hH1P1, indicated that the responsible sialic acids are localized to the hSkM1

273 sive research, many parts and subroutines of the responsible signal transduction networks have been i

274 and pik3r1 genes indicating class IA PI3K as the responsible signaling pathway.

275 sic investigations of oil spills aim to find the responsible source(s) of the spill.

276 However, the responsible soy component or components and the magn

277 We identified the responsible species and the produced toxins as well

278 ed and demonstrated that the four genomes of the responsible ST-41 strains clustered closely on a sub

279 More data are needed to inform next steps in the responsible stewardship of this process, from the pe

280 The identification of the responsible substitutions and elucidation of the und

281 sease; however, the differentiation state of the responsible T cells is unclear.

282 but the underlying mechanisms of action and the responsible target genes are largely unknown.

283 However, the responsible trans-factors and the mechanism by which

284 and identified nuclear factor Y (NFY) to be the responsible transcription factor as assessed by over

285 indicated that an ATF4/c-Jun heterodimer was the responsible transcription factor.

286 ial gene expression, because the identity of the responsible transcription factors (TFs) often cannot

287 diagnosis and treatment require excision of the responsible tumor.

288 istry testing, and difficulty in identifying the responsible tumor.

289 nstrate that elevated NEDD4 is implicated as the responsible ubiquitin E3 ligase for HSF1 degradation

290 high prevalence of cognitive impairment but the responsible underlying pathological mechanisms are u

291 e availability of effective antibiotics, and the responsible use of antibiotics.

292 how the pharmaceutical industry can support the responsible use of antimicrobials.

293 the reproductive setting is needed to inform the responsible use of these technologies to decrease th

294 well-informed public discussions to explore the responsible use of this currently theoretical techno

295 an only be removed effectively by correcting the responsible valvular lesion.

296 Both the responsible variant and the molecular mechanism caus

297 action of the familial risk, perhaps because the responsible variation arises by somatic mutation (SM

298 Identification of gG as the responsible vCKBP was achieved by repeating similar

299 However, the responsible virus - SARS-CoV-2 - gains entry to host

300 5), and possibly both, due to an increase in the responsible Wee1 and Myt1 kinases.