ライフサイエンスコーパス: the specificity of

1 The specificity of (18)F-FLT PET/CT was higher than that

2 ensitivities of 216Dx and UA are comparable, the specificity of 216Dx was higher than that of UA.

3 The specificity of 3D sequences improved when multiplana

4 The specificity of (68)Ga-FOL was assessed in a blocking

5 lue > 19 U/ml has a sensitivity of 96.3% and the specificity of 85.5%.

6 The specificity of (99m)Tc-duramycin for apoptosis was a

7 In addition, we sought to determine whether the specificities of a less cross-reactive anti-Zaire eb

8 ntrolled ECL is a simple approach to improve the specificity of a basic [Ru(bpy)(3)](2+) film based s

9 Substitutions at this position change the specificity of a diverse panel of environmental TraA

10 With the threshold matched to the specificity of a normal clinical read (56.3%), DL ha

11 e the flexibility of chemical synthesis with the specificity of a programmable DNA-binding protein by

12 Uncertainty about the taxonomic status and the specificity of a species commonly prevent its consid

13 Calcium plays a key role in determining the specificity of a vast array of signalling pathways i

14 CD studies demonstrated the specificity of A-ZIP53 as it did not interact with b

15 The specificity of ABCG37 for individual coumarins was f

16 elements within adjacent loci and safeguard the specificity of action of promoters and enhancers tow

17 a, given their vast structural diversity and the specificity of adsorbate interactions afforded by th

18 ontractile injection systems while revealing the specificities of AFP.

19 The study confirms the specificity of AIT.

20 e its role, along with the MHC, in directing the specificity of allorecognition.

21 lete a large serological survey to elucidate the specificity of antibodies against contemporary H3N2

22 Competition assays revealed a difference in the specificity of antibodies induced by the two rPfMSP2

23 f responses across mice give us insight into the specificity of antiviral CD8(+) T cell responses.

24 ocessing speed were also performed to assess the specificity of any associations to executive functio

25 The specificity of AR extends to the regions flanking th

26 recall and item recognition and suggest that the specificity of associative recall through re-encodin

27 vealing the structure features important for the specificity of ATR inhibitors.

28 three regulatory mechanisms contributing to the specificity of ATXR5/6.

29 The specificity of AuNP-MIP sensor was further investiga

30 With the goal of better understanding the specificity of B-cell responses and the role of immu

31 he enzyme and to draw further conclusions on the specificity of beta-porphyranase and more particular

32 -binding site on TGF-beta2 and shed light on the specificity of BG for select TGF-beta-type GFs and t

33 complexity, formulas were derived to measure the specificity of biological groups and the specializat

34 d dynamic range of these assays benefit from the specificity of bioluminescent resonance energy trans

35 y of electrochemical signal transducers with the specificity of biomolecular recognition strategies.

36 The specificity of blood-fluid level for OAC-ICH was 99.

37 The specificity of both assays was 100% (95% CI, 91.8% t

38 Against the composite reference standard, the specificity of both assays was higher (95.7% [92.0 t

39 The specificity of both CT and (18)F-FDG PET/CT is low b

40 The specificity of both RDTs was >99%.

41 field strength scanner, taking into account the specificity of both settings in the context of trans

42 Conclusion OA/US increases the specificity of breast mass assessment compared with

43 The specificity of breath H(2) remained high (100%) when

44 The specificity of brilliant lymph nodes, hyper-attenuat

45 It provides a structural basis for the specificity of CB-5083 toward the D2 domain, offers

46 Previous studies of the specificity of CBEs have identified off-target DNA e

47 However, the studies reported here show that the specificity of CD4(+) T cells elicited by protein-ba

48 cell development, recent advances regarding the specificity of chemokine signaling, and novel techni

49 The specificity of clinical assessment was 81% (CI, 65%

50 e of artifact correction logic would improve the specificity of clinical event detection without comp

51 , cloning and peptide screens to demonstrate the specificity of clonally expanded TCRs in the cerebro

52 The specificity of coiled-coil dimer pairing is mainly b

53 Few studies have explored the specificities of contextual modulations of the proce

54 The specificity of 'continuous' area under the curve (AU

55 The specificity of cortical activation can be considered

56 rect for this copy number effect, increasing the specificity of CRIPSR screens to identify essential

57 sidering the role of allosteric signaling in the specificity of CRISPR-Cas9, this work poses the mech

58 To evaluate the specificity of current definitions used to identify

59 ntrosome in controlling the capacity but not the specificity of cytotoxic killing.

60 rstanding these phenotypes will also improve the specificity of diagnoses of prodromal degenerative b

61 These data strongly suggest that the specificity of different classes of ClpP peptidase s

62 Taking advantage of the specificity of different endoglycosidases and isotop

63 We used a set of natural peptides to explore the specificity of dissolved extracellular wastewater pe

64 nd rapid gene fusion strategy which expliots the specificity of DNA ligase and the speed of isotherma

65 enlighten the roles of the two metal ions in the specificity of DNA polymerases.

66 To confirm the specificity of DNA-damage related modulation, severa

67 Here, we systematically analyzed the specificity of DNMT1, revealing a pronounced influen

68 ime intervals from symptom onset and studied the specificity of each assay in pre-coronavirus disease

69 Consequently, the specificity of each candidate peptide marker was con

70 rent CESA proteins and hence what determines the specificity of each CESA class.

71 Our results help explain the specificity of Eco 6S RNA for Esigma(70) and show ho

72 We further assessed the specificity of effects by examining brain dysconnect

73 d as there was a lack of correlation between the specificities of Env-specific IgA and IgG (in milk,

74 veloped to assist investigators in exploring the specificity of epigenomic features across selected t

75 ther, our data demonstrate that TMM dictates the specificity of ERfs for the perception of different

76 in late schizonts, possibly associated with the specificity of erythrocyte invasion.

77 These restrictions leave unexplored the specificity of esterases for aliphatic esters.

78 t artifact correction significantly improved the specificity of event detection without decreasing se

79 However, little is known about the specificity of extracellular peptidases derived from

80 To determine the specificity of FMRP for the RREs, we performed quant

81 Though much is known about the specificity of Galpha subunits, the specificity of G

82 duce a conformational change contributing to the specificity of gamma-secretase.

83 wn about the specificity of Galpha subunits, the specificity of Gbetagammas activated by a given GPCR

84 We then show that hp-sgRNAs increase the specificity of gene editing using five different Cas

85 To discover regulatory elements driving the specificity of gene expression in different cell typ

86 a rapidly implementable strategy to improve the specificity of genome editing for most genomic loci.

87 itive and scalable approach to understanding the specificity of genome editors.

88 le for stereoelectronic effects in dictating the specificity of glycan recognition by proteins.

89 To further elucidate the specificity of H2A.Z, we determined its genomic loca

90 atelet function assays significantly improve the specificity of heparin-induced thrombocytopenia diag

91 Both Asf1 and Vps75 can increase the specificity of histone acetylation by Rtt109, but ne

92 ng the Hoxa1 and TALE genes, indicating that the specificity of HOXA1 during development may be regul

93 zed three imaging parameters that may affect the specificity of HS-27 based diagnostics - time betwee

94 kidney biopsies from patients with IgAN and the specificity of IgG in immunodeposits has not been te

95 e by modulating the activity or multiplexing the specificity of IgGs to recognize more than one antig

96 approaches provide a general way to enhance the specificity of imaging in neurobiology.

97 This approach extends the specificity of immunocapture to metal affinity magne

98 It provides a useful model in which to test the specificity of in vivo binding of the putative tau l

99 he modification of tail-region substituents, the specificity of inhibition for SphK1 and SphK2 could

100 g of the integration products, revealed that the specificity of integration is primarily directed by

101 as negative controls, thereby demonstrating the specificity of interaction between PAS1 and toluene.

102 The specificity of interaction between PvTRAg38 and basi

103 The specificity of interim PET/CT based on RIW criteria

104 Evaluating the selectivity and the specificity of ion localization and regulation acros

105 The specificity of IPCA was 0.96 for clinical images and

106 To define the specificity of IQGAP1 for the control of PI3K signal

107 To test the hypothesis that the specificity of iron occupancy in the N vs C lobe inf

108 reathing motions of adjacent layers revealed the specificity of isotope engineering in a layered mate

109 ial phosphorothioate oligodeoxynucleotide in the specificity of its biological effect.

110 ot understand the ligand specificity of D14, the specificity of its interaction with SMXL7, nor the s

111 We demonstrate that according to the specificity of its tailspikes TSP2, TSP3, and TSP4,

112 evolution, and we provide clear evidence of the specificity of its targets and timing and of the ben

113 To corroborate the specificity of JT010, it was investigated whether th

114 Ba(2+) ion in the selectivity filter boosts the specificity of K(+) binding relative to Na(+) in the

115 The results demonstrate that the specificity of KMTs is highly sensitive to the side

116 tivity within premotor circuits, but whether the specificity of learning depends on structured change

117 ll binding without significantly influencing the specificity of ligand binding.

118 The specificity of ligand requirements provides insight

119 Here, to evaluate the specificity of lipid interactions of an anti-MPER bn

120 ion in nanoscale topography (DNA-PAINT), and the specificity of locked nucleic acid (LNA) probes for

121 Using these clones, we demonstrate the specificity of LtxA for cells expressing LFA-1.

122 doCEST MRI is a promising tool for improving the specificity of lung cancer diagnosis.

123 te contributions is critically important for the specificity of many proteases, but this balance is n

124 The specificity of MEcPP is further confirmed by the lac

125 dy measured the extent of age differences in the specificity of memory representations using a false

126 ve synapses is thought to be detrimental for the specificity of memory storage.

127 Thus, the specificity of mEndoG for 5hmC and junctions derives

128 of the enzyme on the nucleosome, explaining the specificity of methylation to H3K36.

129 eventing off-target embolization, increasing the specificity of microsphere delivery, and reducing th

130 Furthermore, the specificity of milk IgA differed from that of system

131 TRT combines the specificity of molecular and sometimes physical targ

132 oth maternal and zygotic genes can ascertain the specificity of morphant phenotypes.

133 The specificity of MrfAB suggests that these proteins ar

134 The specificities of MRI versus CT (0.91 versus 0.92) an

135 Additionally, the specificity of mutant proteins, with variants of ami

136 However, the specificity of N. gonorrhoeae NAATs may be suboptima

137 The specificities of NAAT, ChromID plus PM CDM, and Chro

138 t question whether such entities can achieve the specificity of natural enzymes and receptors.

139 -hybrid assays, we also gained insights into the specificity of NFU1 for the maturation of chloroplas

140 d using assays from Quanterix and Roche, and the specificity of NT1 for AD versus a nonspecific marke

141 The specificity of nucleic acid amplification tests (NAA

142 ognition helix that could be used to predict the specificity of other FOX family members.

143 Coupling the specificity of OTR with the speed and sensitivity of

144 Because the specificity of our approach for prion detection and

145 The specificity of our biosensor is validated by compari

146 ct, which greatly enhances the stability and the specificity of our Cre expression.

147 ized in vitro and in vivo assays to validate the specificity of our novel M2e-MAbs and to explore the

148 g agent latrunculin B (Lat B), demonstrating the specificity of our optimized labeling method.

149 d, partly due to difficulties in determining the specificity of P-TEFb toward the various heptad repe

150 a few CRISPR-Cas variants, such as type I-E, the specificity of PAM selection resides with Cas1-2, wh

151 The specificities of PET and SPECT were similar in large

152 lecular approaches that can be used to probe the specificity of pHLA-targeting molecules, aiding the

153 nt peptide hormone maturation are scarce and the specificity of processing enzyme(s) is largely unkno

154 al but not cerebellar binding, demonstrating the specificity of (R)- (11)C-Me-NB1 binding to the huma

155 rticles (FRNPs) that synergistically combine the specificity of Raman spectroscopy with the versatili

156 addition to sequence motifs, in determining the specificity of RBP binding and m(6)A modification.

157 The specificity of receptor type and mechanism of intera

158 ry representations, remains unclear, as does the specificity of regions involved.

159 the G-protein cycle itself may contribute to the specificity of response regulation in plants by affe

160 Furthermore, these results illustrate the specificity of retinal connections, which cannot be

161 the 2 legs opposite one another, can explain the specificity of Rev for the RRE.

162 ible method to rapidly and reliably evaluate the specificity of RGEs, Cas::gRNA pairs, and gain insig

163 structural motifs to trigger and/or maintain the specificity of RNA-driven phase separation.

164 challenge for the field will be to elucidate the specificities of Rpn11, Usp14, and Uch37 in greater

165 s flanking the nascent TMD and thus explains the specificity of SecA recognition.

166 ribe a technology (BiSeqS) that can increase the specificity of sequencing by at least two orders of

167 chemoproteomic approach can provide clues to the specificity of serine hydrolases by using a panel of

168 The specificity of serine/threonine kinases is partly de

169 ies that deliver cytotoxic cargo targeted by the specificity of shell components.

170 ation may exist, which likely contributes to the specificity of signal-response coupling.

171 Using a microbiological reference standard, the specificity of SILVAMP-LAM was 90.9% (95% CI 87.2%-9

172 The specificity of skin snips for onchocerciasis diagnos

173 ecificity of its interaction with SMXL7, nor the specificity of SMXL7 function.

174 tions, were not affected by tDCS, confirming the specificity of stimulation effects to movement sensa

175 ar emphasises how little we understand about the specificity of strigolactone signalling with respect

176 The specificity of structural OCT alone was 97.5% for gr

177 However, mechanisms contributing to the specificity of such interactions remain poorly under

178 Although considerable research suggests that the specificity of synapse formation is supported by com

179 In this study, we redirected the specificity of T cells to SLAMF7 through expression

180 synthetic fusion proteins that can redirect the specificity of T cells toward designated antigens.

181 The specificity of taccalonolide binding to beta-tubulin

182 utations by gene editing approaches, we test the specificity of TALENs by disrupting the H2A.B multi-

183 ADS domain protein complexes plays a role in the specificity of target gene regulation.

184 reads improves downstream results, improving the specificity of taxonomic assignments and of k-mer-ba

185 e human SQLE structure to further understand the specificity of terbinafine, an approved agent target

186 activity likely plays a role in establishing the specificity of thalamocortical connectivity and the

187 s glycan-modified trimers and then dissected the specificities of the antibody responses.

188 atching the sensitivity of the radiologists, the specificities of the DL systems were significantly h

189 The specificities of the ELISAs were 83% (IgA), 98% (IgG

190 Thus, we aimed to clarify the specificities of the NHR domains.

191 spite abundant VlsE, prompted us to identify the specificities of the protective rabbit antibodies an

192 olute-binding protein (Bal6GBP) that governs the specificity of the ABC transporter encoded by the sa

193 as higher than Affirm (75.9%; P = 0.023) and the specificity of the Affirm assay (98.8%) was higher t

194 k for schizophrenia and depression confirmed the specificity of the Alzheimer's disease polygenic ris

195 The specificity of the Amy13K CBMs provides a molecular

196 atives allowed the first precise analysis of the specificity of the antibody responses to this extrem

197 For BV, the specificity of the Aptima IVD assay (86.3%) was high

198 The specificity of the assay was successfully verified a

199 The specificity of the assay with respect to other prote

200 the absence of acute xeno-GVHD, highlighting the specificity of the assay, and shows a robust respons

201 restricted inclusion of non-CP-CRE to assess the specificity of the assays.

202 al analyses were performed to further assess the specificity of the association between migraine and

203 The current understanding of the specificity of the bacterial class I release factors

204 th sensitivity set at 85% for a triage test, the specificity of the best 3-antigen model was 34% (95%

205 We also demonstrated the specificity of the beta(2)-m variant in determining

206 We report that Salmonella enterica increases the specificity of the broadly conserved proteases Lon a

207 controls the sensitivity and a major part of the specificity of the CAR or TCR construct, regardless

208 c CD4(+) T cell memory, we hypothesized that the specificity of the CD4(+) T cell response was a crit

209 The specificity of the cobas assay for M. genitalium ran

210 These data affirm the specificity of the combined effect of the first pass

211 Furthermore, we demonstrate the specificity of the compounds toward the de novo pyri

212 In the H18A/H19A mutant the specificity of the copper/zinc binding sites is lost

213 g the simplicity of RNA biotin labeling with the specificity of the CRISPR/Cas9 system.

214 The specificity of the CRP detection by the proposed str

215 This study also stressed that the specificity of the current surveillance strategy in

216 The specificity of the deep learning algorithm was 44 of

217 knee meniscus fibrocartilage, demonstrating the specificity of the degradative effect of E2.

218 s do not extend to sexuality biases, showing the specificity of the effect.

219 bstitutions within variable region A altered the specificity of the Env-receptor interaction.

220 findings elucidate the structural basis for the specificity of the epoxidation reaction catalyzed by

221 The specificity of the evaluated MAbs, P1B1 and P4W2 wer

222 e ecological context of the symbiosis, while the specificity of the exchange mechanism underlies mole

223 tic and interpretable information reflecting the specificity of the HLA-DR molecules investigated, su

224 llow-up analyses were conducted to determine the specificity of the identified opioid abstinence netw

225 quent T-cell recognition of target cells and the specificity of the immune response.

226 DAMTS13-His(6) immobilization and to confirm the specificity of the immunoassay for detection of anti

227 y increased sensitivity without compromising the specificity of the immunoassay.

228 The specificity of the immunosensor is also very high, a

229 scape provides a blueprint for understanding the specificity of the interaction between ACE2 and S an

230 The specificity of the interaction between the TCR heter

231 Importantly, the specificity of the L240F TUBB mutant for microtubule

232 We confirmed the specificity of the LAMP assay using 41 serotypes of

233 y of Gtfs and S. mutans biofilms, signifying the specificity of the lead compound.

234 cell RNA-Seq data for a case of melanoma and the specificity of the ligand-receptor interactions and

235 ation of Smk1 on Y209 also appears to modify the specificity of the MAPK by suppressing Y kinase and

236 eous detachment from the hippocampus reduces the specificity of the memory.SIGNIFICANCE STATEMENT Thi

237 earch has failed to convincingly demonstrate the specificity of the mu rhythm, meaning that it is unc

238 We finally show that the specificity of the nanobodies for the target protein

239 the clinical features of disease to increase the specificity of the new criteria for underlying PSP p

240 e, enabling pharmacological interrogation of the specificity of the offspring response.

241 The specificity of the OSA was 91.5%.

242 nction, the level of partner dependence, and the specificity of the partnership.

243 t modes of action were tested to investigate the specificity of the phenotype.

244 (PMEIs; 76 members in Arabidopsis) questions the specificity of the PME-PMEI interaction and the func

245 Although this interaction defines the specificity of the pollen rejection response, the id

246 evertheless, in the current study, we tested the specificity of the previously discovered actin-bindi

247 e disorders provide a basis for re-examining the specificity of the prospective association of manic

248 The specificity of the protease heavily impacted the num

249 We further refined the specificity of the proteins identified by combining

250 knockout of Oga, was also scanned to assess the specificity of the radioligand for its target enzyme

251 or transmission of avian IAVs into humans is the specificity of the receptor-binding protein, hemaggl

252 of lower-affinity clones, thereby promoting the specificity of the response.

253 sium or magnesium attraction thus clarifying the specificity of the response.

254 isothermal titration calorimetry, explaining the specificity of the riboswitch.

255 The specificity of the scoring function that we use is d

256 nd sodium pyruvate were implemented to prove the specificity of the sensor towards hydrogen peroxide.

257 Furthermore, to test the specificity of the sensor, samples from tuberculosis

258 gaps regarding the fate of seeds in soil and the specificity of the soilborne fungi that are their mo

259 nisms underpinning disease manifestation and the specificity of the subunits mutated are incompletely

260 ane pores, while accompanying domains define the specificity of the target of the toxicity.

261 raged locomotor characteristics must reflect the specificity of the task and the neurological states.

262 detected has a low fluorescence efficiency, the specificity of the technique allows API traces havin

263 We determined the specificity of the tracer for activated T cells in v

264 The specificity of the UAD-2 assay was achieved by captu

265 These enzymes largely determine the specificity of the ubiquitination reaction.

266 plosives which can then be identified due to the specificity of the unique SERS response obtained.

267 treatment of various diseases, depending on the specificity of the used Abs.

268 Rohingya individuals to ensure it reflected the specificities of their refugee experience and cultur

269 ment, each allergist will need to understand the specificities of these treatments and their expected

270 However, findings on the specificity of these alterations in patients with Al

271 at and contain the commensal microbiota, yet the specificity of these antibodies remains elusive.

272 in an enantiospecific manner that parallels the specificity of these complexes with duplex DNA.

273 However, the specificity of these effects is unknown.

274 cellular processes, but the rules governing the specificity of these interactions are poorly underst

275 We demonstrate the specificity of these membrane interactions and the d

276 is FIT-PNA on fresh tumor tissue emphasizing the specificity of these molecular sensors.

277 At the heart of the specificity of these novel strategies is the recogni

278 However the specificity of these reagents remains a concern, esp

279 adaptive immunity operate sequentially, and the specificity of these responses depends on the initia

280 leoprotein (RNP) complex that is critical to the specificity of these small molecules for SMN2 over o

281 The specificity of these viral protein-FND conjugates to

282 the MCR-1 and MCR-2 genes, to further prove the specificity of this assay.

283 ) necessary to produce pyocyanin, supporting the specificity of this biomarker.

284 s E2 Ub in an open conformation and explains the specificity of this cognate RBR E3/E2 pair.

285 hanges in WT binding of (18)F-AV45 undermine the specificity of this effect.

286 egion of interest analyses further supported the specificity of this finding (ANOVA P = 0.02; pairwis

287 mpared with younger HC, which argues against the specificity of this finding in AD.

288 While the specificity of this marker remains to be demonstrate

289 We next validated the specificity of this model to study empathic processe

290 As further illustration of the specificity of this phenomenon, serum collected from

291 Further analyses investigated the specificity of this prediction.

292 The specificity of this transport was highlighted by the

293 abilities were significantly correlated with the specificity of TMS propagation patterns across DAN a

294 The specificity of trend-based analysis was matched to t

295 e sequence and structural elements governing the specificity of TRUB1, achieving near-perfect predict

296 The specificity of variant-metabolite associations were

297 DNA-binding protein CLAMP are key players in the specificity of X chromosome binding.

298 combined results support the hypothesis that the specificity of YbaK toward Cys-tRNAPro is determined

299 we have developed an approach for improving the specificity of zinc finger nucleases (ZFNs) that eng

300 To gain more insights into the specificity of ZnPP occurrence, a SEC-HPLC-UV-fluore