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2 step- and atom-economical protocol allowing the synthesis of 1,4-diazepanes and also tetrahydro- and
3 constitutes a mild and efficient method for the synthesis of 1,4-dihydroquinoline derivatives from s
4 toribosome) and associated proteins regulate the synthesis of 13 essential subunits of the oxidative
6 elial and mast cell interactions, leading to the synthesis of 15-Oxo-ETE, may contribute to the dysre
11 provides an efficient and scalable route for the synthesis of 3-diarylmethine substituted dihydropyrr
13 action has a broad scope, as demonstrated by the synthesis of 35 different ketones bearing a wide var
15 ce the groundbreaking discovery in 2018 that the synthesis of a bottleable nucleophilic aluminyl anio
19 corporation at both early and late stages of the synthesis of a drug(6,7), these processes are often
20 thetic DNA transcription templates regulates the synthesis of a fluorescence-activating RNA aptamer.
21 utility of this reaction was demonstrated in the synthesis of a furan with sensitive functionalities.
23 pecific annulation of dihydrocholesterol and the synthesis of a key intermediate of englitazone illus
24 s (HCV) during virus entry, but also enabled the synthesis of a labelled tool compound that retained
25 n nitrogen has been optimized and applied in the synthesis of a library of chromophore-amino acid con
27 s context, we have envisioned the design and the synthesis of a new class of chimeric catalytic entit
28 this method provides an efficient route for the synthesis of a new class of optically active 2-spiro
32 Fs), we demonstrate a versatile approach for the synthesis of a novel composite material PEDOT:CNF wi
33 The current research article was reported the synthesis of a novel poly(3-hydroxy butyrate)-b-poly
35 ic solvents has been successfully applied in the synthesis of a poly-[n]-catenane composed of interlo
37 of this novel approach were demonstrated by the synthesis of a series of [2]-, [3]-, and [4]rotaxane
40 itionally, the rearrangement was utilized in the synthesis of a stereochemically-defined bis-tetrahyd
41 ermed "superchanneling." In superchanneling, the synthesis of a substrate-linked poly-Ub chain can oc
43 ent as well as atom-economic methodology for the synthesis of a wide array of organic molecules, but
44 d scope of the coupling partners, it enables the synthesis of a wide range of 1,3-C-disubstituted BCP
46 lity of this method has been demonstrated in the synthesis of acylsilanes bearing different silyl gro
47 iboswitches during translation initiation or the synthesis of alarmones, which drastically alter cell
49 idic environment was exploited to accomplish the synthesis of alkenes using a one-pot, two-step exper
55 in research laboratories and industries for the synthesis of amines as well as pharmaceuticals, agro
56 toacid analogues provide a natural route for the synthesis of amino acids by transamination with glyc
57 e modified by mutating genes responsible for the synthesis of amylose and amylopectin in the endosper
59 Different phenols reacted smoothly, enabling the synthesis of an array of alpha-triphenylmethylamines
60 ose analog, 5-azidoribose (5-AR), as well as the synthesis of an inactive control derivative, 1-azido
62 was investigated, including applications to the synthesis of anti-1,2-diols and anti-1,2-amino alcoh
63 or lack of systemic COX-1 activity decreased the synthesis of anti-aggregatory PGI(2) and PGD(2) at n
67 the synthesis of oxetanes and cyclobutanes, the synthesis of azetidines via intermolecular aza Pater
68 yrroline ring has been probed for utility in the synthesis of BChl a by preparation of a hybrid macro
69 multicomponent cascade reaction approach for the synthesis of beta-keto sulfones by exploiting differ
70 one-pot, metal-free, double cyclization for the synthesis of bicyclic 2-pyridones as peptidomimetics
74 This approach represents a rare example of the synthesis of biologically active compounds exclusive
75 eusable Pd catalyst reflected its utility in the synthesis of biologically important AMP-activated pr
76 hetic procedure was previously developed for the synthesis of bisphosphinates starting from acyl chlo
78 -1355, a well-known glucansucrase catalyzing the synthesis of both high- and low-molar-mass alternans
79 c acids and esters play an important role in the synthesis of C(sp(3))-rich medicines, agrochemicals,
82 an important organic intermediate, used for the synthesis of chemicals like ethylbenzene, cumene, cy
83 bonds at fully substituted carbon centers in the synthesis of chiral 2,2-disubstituted benzomorpholin
84 -mediated methodology has been developed for the synthesis of chiral 2-aryl-ferroceneamides from chir
86 mide products are suitable intermediates for the synthesis of chiral vicinal diamines as has been ver
89 pene or butenes, which are indispensable for the synthesis of commodity chemicals, is an important en
93 and the application of titanium catalysis to the synthesis of complex organic small molecules, natura
94 is study reveals an alternative sequence for the synthesis of compounds that contain the pyrrolodiket
95 n with a copper precursor, (P-Se)+Cu, and 2) the synthesis of copper phosphide, Cu(3) P, nanoparticle
96 se and amino acids (e.g., arginine) to drive the synthesis of critical macromolecules for uncontrolle
100 he organozinc reagents, thereby allowing for the synthesis of cyclic and acyclic tetrasubstituted dou
101 rticular biotechnological interest, e.g. for the synthesis of cyclic peptides for drug design or for
105 betaOHB oxidation in mitochondria boosts the synthesis of cytosolic aspartate (Asp) and NAA, whic
106 tions highlight the utility of the method in the synthesis of densely functionalized small molecules
107 RM2 subunits, is the rate-limiting enzyme in the synthesis of deoxyribonucleoside triphosphates (dNTP
110 at can be useful synthetic intermediates for the synthesis of diverse bioactive molecules such as glu
111 multicomponent tandem assembly procedure for the synthesis of diverse C4-quaternary 3,4-dihydroquinaz
112 ism and redirected metabolic pathways toward the synthesis of diverse primary and secondary metabolis
113 We present a stabilization method involving the synthesis of DNA brick nanostructures with dendritic
115 there exist few radiolabelling protocols for the synthesis of either, inhibiting the development of P
117 c cells and potentially in mycobacteria, but the synthesis of enantiomerically pure InoAz analogues v
121 erns of the genes involved in glycolysis and the synthesis of FAs, 2-MAG, TAG, and membrane lipids co
122 However, its potential use as a catalyst for the synthesis of fine chemicals, pharmaceuticals and agr
126 oliation and modified Hummer's technique for the synthesis of free-standing borophene are also discus
127 vailable, our findings open a new avenue for the synthesis of functional and tunable polyelemental na
128 s unactivated internal alkenes to streamline the synthesis of functional molecules from basic feedsto
129 l frameshift errors are often deleterious to the synthesis of functional proteins and could therefore
130 e, used as an initiator, was tracked through the synthesis of Glu-PLGA by both (13)C NMR and enzymati
133 alpha reaction that forms (12)C affects(1,2) the synthesis of heavy elements in the Ga-Cd range in pr
135 iphatic and aromatic ester precursors and to the synthesis of heterocycles including BODIPY fluoropho
136 We describe an unprecedented methodology for the synthesis of heterometallic titanium frameworks by m
138 d copper nanomaterials and paves the way for the synthesis of high-nuclearity copper nanoclusters.
139 d conditions and broad scope, and allows for the synthesis of highly functionalized azetidines from r
140 ly simple and efficient one-pot protocol for the synthesis of highly functionalized thiazolidin-4-one
142 hthalene) (DMAN), although its synthesis and the synthesis of its derivatives can be problematic.
143 tiation is regulated by HetR which activates the synthesis of its own inhibitory morphogens, diffusio
148 glycan strands from the membrane to complete the synthesis of mature peptidoglycan is a long-standing
150 s, in particular polyols, are well-known for the synthesis of metal nanoparticles, often acting as re
154 C-H amination of the tetralone substrate in the synthesis of (-)-microthecaline A, 2) the use of pho
156 ped to install phosphorus bonds directly: 1) the synthesis of molecular P(4) Se(3) and subsequent rea
160 t targeting transcription selectively limits the synthesis of mRNAs involved in tumor growth without
165 fers an efficient and practical approach for the synthesis of N(beta)-substituted alpha,beta-diamino
167 a recent methodological study investigating the synthesis of N-alkoxyazomethine ylides, an unexpecte
168 t normal embryonic development by disrupting the synthesis of NAD, a key factor in multiple biologica
169 ogether, the application of isoimpratorin in the synthesis of nano-metallic electro and photocatalyst
170 e are able to redirect 89% of acyl-CoAs from the synthesis of neutral lipids to alka(e)nes and reach
175 so demonstrated its potential application in the synthesis of new mechanofluorochromic materials with
177 pyrazine chemistry and can be applied toward the synthesis of novel drug-like molecules with favorabl
178 ular mechanism of thermally stable proteins, the synthesis of novel polymer materials that undergo ul
179 hate monoesters to diesters may have enabled the synthesis of nucleic acids, perhaps opening a way in
180 Here we present our results to evaluate the synthesis of Omomyc using three complementary strate
182 ate metal-ion coordination opens the way for the synthesis of other molecular knot topologies and to
183 We hope that these findings will lead to the synthesis of other porous liquids whose guest-uptake
185 hough this approach is commonly employed for the synthesis of oxetanes and cyclobutanes, the synthesi
187 anic framework Bi-BTC successfully catalyzed the synthesis of para-xylene from bio-based 2,5-dimethyl
191 boxylic acid-phosphoric acid anhydrides, for the synthesis of peptidyl-RNAs, peptides, RNA oligomers
192 he boron-chalcogen mixture (BCM) method, for the synthesis of phase-pure uranium chalcogenides based
194 ies involving lipid metabolism, specifically the synthesis of pigments and oxylipins, and the metabol
195 to repurpose it for novel functions, such as the synthesis of polymers containing non-natural buildin
198 The development of an efficient method for the synthesis of polysubstituted isoindolinones from 1,3
199 d are archetypal specialty chemicals used in the synthesis of polyvinyl-co-unsaturated acids resins,
200 ked alkyne equivalents (MAEs) are needed for the synthesis of polyyne polyrotaxanes, as insulated mol
202 and represents a new and powerful method for the synthesis of porous solids with tailored functionali
204 d-response plant growth restriction requires the synthesis of potent mediators called jasmonates (JAs
206 rthermore, metabolic reconfiguration towards the synthesis of protective metabolites of those fruits
207 motica that drive cell expansion, as well as the synthesis of protein, cell wall and cell membrane co
208 lent ways to enhance memory is by regulating the synthesis of proteins controlled by the translation
209 r vesicle clusters (IVCs)-serve as sites for the synthesis of proteins targeted for secretion as EV-a
212 to generate retinoic acid (RA) and supports the synthesis of RA from type II alveolar ECs to suppres
214 t and coordination (ACC) strategy to achieve the synthesis of rare-earth single erbium (Er) atoms sup
215 Early activation of the network linked to the synthesis of reactive oxygen species was associated
217 of the components of nucleotides-either via the synthesis of ribose and the canonical nucleobases an
218 y enzyme CndF is PLP-dependent and catalyzes the synthesis of (S)-2-amino-6-oxoheptanoate 3 that is i
219 Furthermore, undiscovered genes involved in the synthesis of secondary metabolic biosynthetic gene c
225 e natural product-ribosome structure enabled the synthesis of simplified analogues that retained both
230 The plant hormones jasmonates (JAs) control the synthesis of specialized metabolites through complex
231 dition, n-3 PUFAs serve as the substrate for the synthesis of specialized proresolving mediators, whi
232 ound PF-06446846 (PF846) selectively inhibit the synthesis of specific proteins, by stalling translat
234 his observation was additionally verified by the synthesis of stable CO and 2,6-xylylisocyanide (XylN
238 development has created a paradigm shift for the synthesis of stereodefined acyclic molecules though
240 yzed, convenient, and expedient strategy for the synthesis of styrene and naphthalene derivatives wit
246 In this article, a high-yield method for the synthesis of sulfonyl 9-fluorenylidenes is described
247 ith carbon and nitrogen nucleophiles enables the synthesis of sulfoximines and sulfonimidamides in a
249 ent to the conventional methods employed for the synthesis of TAEs, and would be a valuable tool for
250 Here we report a strategy that simplifies the synthesis of terpenes by inverting the order of natu
252 t obstruction of pilus retraction stimulates the synthesis of the cell-cycle regulator cyclic diguany
254 a double-stranded DNA sensor that catalyses the synthesis of the cyclic dinucleotide cyclic GMP-AMP,
255 reaction was also established and applied to the synthesis of the first example of the pyrrolo[1,2-a]
257 are the predominant pathways responsible for the synthesis of the most abundant phospholipids, phosph
258 e glycosyltransferase activities involved in the synthesis of the N-glycan of the viral major capsid
262 cribe a catalytic, multicomponent method for the synthesis of the privileged polyketide 1,3-dienyl-6-
263 f esterified cutin monomers, are involved in the synthesis of the procuticle during cell division and
264 enerated, the pyrimidines persist throughout the synthesis of the purine deoxyribonucleosides, leadin
267 ALOSE-6-PHOSPHATE SYNTHASE1 (TPS1) catalyzes the synthesis of the sucrose-signaling metabolite trehal
271 he optimized conditions have finally allowed the synthesis of these extremely promising heterocycles
274 For 1As this overcomes prior difficulties in the synthesis of this classical arsonium-ylide that have
278 e of the most straightforward approaches for the synthesis of three-dimensional, chiral heterocyclic
279 outline five activities that can accelerate the synthesis of trait data across the Tree of Life, the
286 uccinimide removal by Pd(II) was applied for the synthesis of two ubiquitin activity-based probes (Ub
287 on mesoporous silica since the early 1990s, the synthesis of two-dimensional (2D) silica nanostructu
291 ce, the current strategy may be suitable for the synthesis of various complex natural and unnatural c
292 nuous, scalable, and solvent-free method for the synthesis of various naphthalic imides and perylene
293 d a metal-free, mild, and novel protocol for the synthesis of various triarylmethanes (TRAMs) in mode
295 tereoselective method has been described for the synthesis of versatile alkaloid-type azetidines from
297 er as an environmentally benign solvent, and the synthesis of vitamin B(12) component on the gram sca
298 tion to diverse acrylate monomers, including the synthesis of well-defined di- and triblock copolymer