ライフサイエンスコーパス: theca cell

1 rotein and mRNA levels are increased in PCOS theca cells.

2 pression and intrinsic abnormalities in PCOS theca cells.

3 ression profile that is distinct from normal theca cells.

4 rian surface epithelium, granulosa cells and theca cells.

5 NA when added to the medium of cultured PCOS theca cells.

6 defined a stable molecular phenotype of PCOS theca cells, 2) suggested new mechanisms for excess andr

7 strong mRNA labeling for BMP-4 and -7 in the theca cells and BMP receptor types IA, IB, and II in the

8 Oocyte growth is supported by theca cells and granulosa cells, which establish dynamic

9 he first genetic evidence for the origins of theca cells and reveal a multicellular interaction criti

10 n and insulin resistance persist in cultured theca cells and skin fibroblasts, respectively, from wom

11 g in the development and function of ovarian theca cells and the pathophysiologic effects of hyperins

12 anisms for excess androgen synthesis by PCOS theca cells, and 3) identified new candidate genes that

13 subfamily C member 3) were identified in GC, theca cells, and oocyte.

14 omatic cell types, including follicle cells, theca cells, and ovarian stromal cells.

15 A hallmark of PCOS is excessive theca cell androgen secretion, which is directly linked

16 l interactions between ovarian granulosa and theca cells as an approach to cHRT.

17 ciated with the persistence of steroidogenic theca cells, but this connection is poorly understood.

18 Here we show that theca cells derive from two sources: Wt1(+) cells indige

19 r development by antagonizing the actions of theca cell-derived BMPs.

20 Only mural granulosa cells and theca cells express large numbers of LH receptors, and L

21 In this environment, theca cells form, oestrogen is produced and germ cells a

22 Our previous studies demonstrated that theca cells from PCOS ovaries maintained in long term cu

23 Our analysis revealed that PCOS theca cells have a gene expression profile that is disti

24 ved in excess androgen synthesis by the PCOS theca cells in order to identify candidate PCOS genes.

25 Using theca cells isolated and propagated from normal cycling

26 osa cells, reach preantral stages containing theca cell layers by 2 weeks.

27 mutant stromal cells consist of a luteinized theca cell lineage at various differentiation stages inc

28 lls, the identification of mutant luteinized theca cells may add crucial evidence in understanding th

29 Thus, theca cells may contribute significantly to the inhibin

30 in expression to Leydig cells of the testis, theca cells of the ovary, and cells of the adrenal corte

31 ocytes and interstitial cells of the testis, theca cells of the ovary, cerebral cortical neurons, and

32 results suggest that GT198 mutant luteinized theca cells overexpressing CYP17 are common in ovarian c

33 in impaired granulosa cell proliferation and theca cell recruitment as well as fewer primordial folli

34 Knock-down of DENND1A.V2 in PCOS theca cells reduced androgen biosynthesis and CYP17A1 an

35 orced overexpression of DENND1A.V2 in normal theca cells resulted in a PCOS phenotype of augmented CY

36 we report the unexpected finding that bovine theca cells show abundant INHA expression and 'free' inh

37 overexpressing steroidogenic enzyme CYP17, a theca cell-specific marker.

38 ocated in the cytoplasm as well as nuclei of theca cells, suggesting a possible role in gene regulati

39 tly greater amounts of androgens than normal theca cells, suggesting an intrinsic abnormality.

40 is showing that treatment of cultured bovine theca cells (TC) with BMP6 significantly (>twofold; P <

41 activated medullary follicles recruit fetal theca cells to establish a two-cell system for sex-stero

42 Reelin, which is expressed in theca cells, triggers a signal in granulosa cells via ap

43 genes with increased mRNA abundance in PCOS theca cells were aldehyde dehydrogenase 6 and retinol de

44 , turn over most granulosa cells, but retain theca cells which expand in number together with interst

45 Human granulosa and theca cells, which express endogenous SF-1, contained mo