ライフサイエンスコーパス: theophylline

1 sible with an adenosine receptor antagonist (theophylline).

2 r the related methylxanthine present in tea, theophylline.

3 icatechin gallate, caffeine, theobromine and theophylline.

4 ta-agonists, and 1.05 (CI, 0.99 to 1.10) for theophylline.

5 reases in gene expression in the presence of theophylline.

6 s in COPD patients treated with low doses of theophylline.

7 injection of the nonselective Ado antagonist theophylline.

8 re all significantly reduced by about 22% by theophylline.

9 was reversed by coadministration of systemic theophylline.

10 retory responses to glucose and glucose with theophylline.

11 f the clinically important drugs digoxin and theophylline.

12 ontaining rolipram, milrinone, zaprinast, or theophylline.

13 c hammerhead ribozymes that are activated by theophylline.

14 Oral terbutaline plus aminophylline or theophylline.

15 recur during outpatient treatment with oral theophylline.

16 group 3,825 recipients of sustained-release theophylline.

17 insulin secretion stimulated by glucose and theophylline.

18 f adenosine receptors with 8-(p-sulfophenyl) theophylline.

19 ccumulation of lipophylic substances such as theophylline.

20 nosine receptor antagonist 8-(p-sulfophenyl)-theophylline.

21 adenosine receptor blocker 8-(p-sulfophenyl)theophylline.

22 nts and induction of the mutant phenotype by theophylline.

23 study drug, and again after the infusion of theophylline.

24 infusion, and the effects were diminished by theophylline.

25 sulin/C-peptide in response to D-glucose and theophylline.

26 t N(6)-cyclohexyladenosine or the antagonist theophylline.

27 n recovery and can be ameliorated ex vivo by theophylline.

28 ith higher affinity to 3-methylxanthine than theophylline.

29 Theophylline (1,3-dimethylxanthine) exhibited an effect

30 denosine A1 receptor antagonists (50 mumol/L theophylline/1 mumol/L 8-cyclopentyl-1,3-dipropylxanthin

31 Theophylline 10(-5) M significantly increased lymphocyte

32 ine receptor blockade with 8-(p-sulphophenyl)theophylline (10 mg kg-1, i.v.) or cyclooxygenase inhibi

33 letely abolished in the presence of 8-phenyl theophylline (10(-5) M), a nonselective adenosine recept

34 nosine receptor antagonist 8-(p-sulfophenyl)-theophylline (100 micromol/L) or by the protein kinase C

35 lxanthine (155 M(-1)), 1,3-dimethylxanthine (theophylline, 157 M(-1)), 1,3,7-trimethylxanthine (CAF,

36 uM resveratrol, +/-1 uM curcumin, +/-5 mg/L theophylline, +/-1uM prednisolone and cytokines, and SIR

37 7-2.74], antileukotrienes 4.83 [1.63-14.34], theophylline: 2.46 [1.23-4.91], and oral corticosteroids

38 Administration of theophylline (20 mg/kg, i.v.) had no effect on NMDA-depe

39 inhaled steroids (38%), cromolyn (35%), and theophylline (23%).

40 Adding rolipram (100 microM) or theophylline (3,000 microM) to the STH used for flushing

41 The overall binding constants of DNA-theophylline = 3.5x10(3) M(-1), DNA-theobromine = 1.1x10

42 y the non-selective ADO receptor antagonist, theophylline (30-500 nmol) administered i.t.

43 A1/A2-receptor antagonist [8-(p-sulfophenyl)theophylline, 4 mg/kg intravenous] to determine the pote

44 Theophylline (5.0 micromol/kg, i.p.), a centrally active

45 K(I) values for the antiasthmatic xanthines, theophylline (7.8 microM) and enprofylline (6.4 microM),

46 iers, namely, nicotinic acid, valproic acid, theophylline-7-acetic acid, and choline, were synthesize

47 /kg, i.p.) on EEG, whereas 8-(p-sulfophenyl)-theophylline (8-PST, 150.0 micromol/kg, i.p.), a periphe

48 ive adenosine A1 antagonist 8-(p-sulfophenyl)theophylline (8-SPT) or the adenosine A2 antagonist 3,7-

49 In the presence of 8-(p-sulfophenyl)theophylline (8-SPT), an antagonist of A1 and A2 adenosi

50 osine receptor antagonist, 8-(p-sulfophenyl) theophylline (8-SPT).

51 adenosine receptor antagonist 8-sulphophenyl theophylline (8-SPT, 20 mg kg-1, i.v.) virtually abolish

52 mals receiving intravenous 8-(p-sulfophenyl)-theophylline) (8-SPT), a non-selective adenosine recepto

53 One small molecule, theophylline, 8-[(benzylthio)methyl]-(7CI,8CI) (TPBM), i

54 Theophylline, a competitive inhibitor of cAMP phosphodie

55 Theophylline, a drug known to inhibit several classes of

56 Theophylline, a non-selective phosphodiesterase (PDE) in

57 -12 % during an infusion of either saline or theophylline, a non-specific adenosine receptor antagoni

58 The effect of dilazep was blocked by theophylline, a nonspecific adenosine receptor antagonis

59 is tyrosinephosphorylated in the presence of theophylline, a phosphodiesterase inhibitor that creates

60 annin, the immunosuppressant, rapamycin, and theophylline, a phosphodiesterase inhibitor, promote mar

61 and for a range of other analytes including theophylline, a therapeutic drug, at a concentration as

62 tivity, clinical studies have suggested that theophylline acts as an antitussive agent.

63 8-(p-Sulfophenyl)theophylline administration abolished the cardioprotecti

64 Neither theophylline alone nor caffeine alone (each at 10 mg/kg/

65 Theophylline also improved the increase in perfusate PO(

66 Through this mechanism, theophylline also reverses corticosteroid resistance, an

67 -week, open-label clinical trial, intranasal theophylline (an epithelial membrane transport and proto

68 .), is the main cause of Captagon addiction; Theophylline, an antagonist that blocks adenosine recept

69 CBB5 also oxidized theophylline and 1- and 3-methylxanthines to 1,3-dimethy

70 as sole carbon and nitrogen sources but also theophylline and 3-methylxanthine.

71 s increased 76-fold by the administration of theophylline and 8-bromo-cAMP to increase cAMP levels.

72 re facilitated by functional synergy between theophylline and amphetamine.

73 tly prevented by the ADO receptor antagonist theophylline and blockade of NO production by L-NA (100

74 Enzymes involved in theophylline and caffeine degradation were coexpressed w

75 Thus, the theophylline and caffeine N-demethylation pathways conve

76 nonselective adenosine receptor antagonists, theophylline and caffeine, were examined, using the rat

77 an also be achieved by low concentrations of theophylline and curcumin, which act as HDAC activators.

78 that could reverse this resistance, such as theophylline and nortriptyline.

79 HDAC2 expression, which can be achieved with theophylline and phosphoinositide 3-kinase delta inhibit

80 p300) or activators of histone deacetylase (theophylline and resveratrol) and were increased by the

81 nhibitors, 1-methyl-3- isobutyl xanthine and theophylline and rolipram, a specific PDE IV inhibitor.

82 ntained the pharmaceuticals ketoconazole and theophylline and several previously untested chemicals,

83 tween episodes, patients may be treated with theophylline and terbutaline, which clinical experience

84 of the general adenosine receptor antagonist theophylline and the A1 antagonist 8-cyclopentyl-1,3-dip

85 lecular interactions between Amphetamine and Theophylline and their important GPCRs targets, includin

86 Two aptamers that recognize theophylline and thiamine pyrophosphate were embedded in

87 The effect of 10(-5) M theophylline and, in survivors, change in I(max) during

88 Drugs (caffeine, theophylline) and hormones (vasopressin, aldosterone) kn

89 metabolites (theobromine, paraxanthine, and theophylline) and microbial metabolites (hippuric acid a

90 with ICS, 53.3% LTRAs, 64.1% anti-IgE, 10.7% theophylline, and 16.0% oral corticosteroids.

91 hat a group of xanthines including caffeine, theophylline, and dyphylline can dramatically decrease A

92 trosodimethylamine, acetominophen, caffeine, theophylline, and methoxyflurane into the model CYP2E1 e

93 N-Acetylcysteine, theophylline, and other agents have shown inconsistent r

94 single demethylated analogues: theobromine, theophylline, and paraxanthine, highlighting the effect

95 Here, we develop RNA linkers to combine theophylline- and 3-methylxanthine (3MX)-binding aptamer

96 aptamer reporters, using both the synthetic theophylline- and naturally occurring thiamine pyrophosp

97 se, activation of HDAC2 expression by use of theophylline, antioxidants, or phosphoinositide-3-kinase

98 fore, no compound has been shown to bind the theophylline aptamer with greater affinity than theophyl

99 anthine complex than what is observed in the theophylline aptamer-theophylline complex.

100 s leukotriene blockers and slow-release oral theophylline are added, with oral corticosteroids and an

101 ilators-beta agonists, anticholinergics, and theophylline-are available and can be used individually

102 Eleven (50%) participants in the theophylline arm and 6 (26%) in the placebo arm had a ch

103 d of treatment, 13 (59%) participants in the theophylline arm reported at least slight improvement in

104 olecular markers, caffeine, theobromine, and theophylline, associated with the use of cacao.

105 fter intravenous administration of 1.2 mg of theophylline at 0.6 mg/kg per hour (serum level, 5.6 mic

106 d A7H+-C27 base pair forms in the absence of theophylline at low pH, which explains the unusual pH de

107 ion for the ligands caffeine, aminophylline, theophylline, ATP, and ryanodine but not for Ca(2+) or 4

108 compounds featuring imidazole (AuNHC-1) and theophylline (AuTMX(2)) scaffolds were successfully radi

109 f alpha-aminonitriles with benzimidazole and theophylline backbones has been developed.

110 A new series of theophylline-based analogs as potent ALDH1A1 inhibitors

111 ence spectroscopy to probe the mechanism for theophylline binding in this RNA aptamer.

112 which explains the unusual pH dependence of theophylline binding of the C27 RNA aptamer.

113 The picosecond data show that theophylline binding shifts the equilibrium for conforma

114 to the bronchodilator theophylline, but the theophylline binding site is not stably formed in the ab

115 The kinetics for theophylline binding were measured here by stopped-flow

116 ns in the free state of the RNA that inhibit theophylline binding.

117 of residue 27 is not directly involved with theophylline binding.

118 atform structural motif and therefore blocks theophylline binding.

119 By using the dopamine-, serotonin-, and theophylline-binding aptamers as testbeds, we found that

120 Simultaneously, the local structure of the theophylline-binding core of the molecule was refined un

121 The theophylline-binding RNA aptamer contains a 15 nucleotid

122 The theophylline-binding RNA aptamer forms a very stable str

123 een measured for the bases and sugars in the theophylline-binding RNA aptamer, dissolved in filamento

124 sed here to probe picosecond dynamics of the theophylline-binding RNA aptamer.

125 e of conformations in the free state of this theophylline-binding RNA are discussed and compared with

126 e receptors with 50 microM 8-(p-sulfophenyl) theophylline but was unaffected by addition of 20 nM N6-

127 ate or P1-receptor antagonist sulfonylphenyl theophylline, but not the P2-receptor antagonist suramin

128 e structure when bound to the bronchodilator theophylline, but the theophylline binding site is not s

129 chloroethyl), which enhanced the affinity of theophylline by 6.5-fold to 800 nM.

130 inactive state, whereas neutral antagonists (theophylline, caffeine, and istradefylline) demonstrated

131 ivation was systematically investigated with theophylline, caffeine, and theobromine.

132 Quantified substances were theobromine, theophylline, caffeine, catechin, epicatechin, procyanid

133 substances, namely sparfloxacin, piroxicam, theophylline, caffeine, ibuprofen, acetaminophen (parace

134 ecretory changes caused by prostaglandin E2, theophylline, calcium-ionophore A23187, 8-bromoadenosine

135 with AAH and to address the extent to which theophylline can improve this response.

136 cigarette smokers, and low concentrations of theophylline can increase HDAC activity.

137 eutic concentrations used for asthma relief, theophylline causes lung COX inhibition and decreases ce

138 ion and drug release profiles in a system of Theophylline/cellulose (K15M) demonstrate that API-water

139 nergic receptor blocker 7-(beta-chloroethyl) theophylline (CET; given at 5 x 10-6 M and 10-4 M) had n

140 and is implicated in drug interactions with theophylline, clozapine, and others.

141 olled rate, and the high affinity of the RNA-theophylline complex arises primarily from a slow dissoc

142 not from unfavorable interactions in the RNA-theophylline complex but instead from stable interaction

143 r the structure refinement of an RNA aptamer/theophylline complex for which extensive NOE and residua

144 tic studies showed that formation of the RNA-theophylline complex is over 1000 times slower than a di

145 The RNA-theophylline complex requires divalent metal ions, such

146 the free RNA to mostly unstacked in the RNA-theophylline complex, as observed in the previous NMR st

147 ther refine the overall structure of the RNA-theophylline complex, whose long-range order was poorly

148 what is observed in the theophylline aptamer-theophylline complex.

149 ly dynamic in the otherwise well-ordered RNA-theophylline complex.

150 e days of treatment, the mean (+/-SD) plasma theophylline concentration was 11 +/- 2 microgram per mi

151 tion of the theophylline-RNA complex at high theophylline concentration, indicating that a conformati

152 itors; decreased bioavailability of digoxin, theophylline, cyclosporin, and phenprocoumon when these

153 ession of distinct pathways for caffeine and theophylline degradation in bacteria.

154 This riboswitch allowed reversible, theophylline-dependent down-regulation of the GFP report

155 t operate in concert as an obligate FMN- and theophylline-dependent molecular switch.

156 an effect similar to ATP and 8-sulphophenyl-theophylline did not block them.

157 which the main components were respectively theophylline, digoxin, 17beta-estradiol, and aldrin.

158 Theophylline (dimethylxanthine) has been used to treat a

159 Similar results were obtained with theophylline-doped PLA films.

160 etramethyl uric acid or TMU, 552 M(-1)), and theophylline ethylenediamine (aminophylline, 596 M(-1)).

161 ine receptor antagonist, aminophylline (AMO; theophylline ethylenediamine) and, for the first time to

162 during normal maturation and in response to theophylline, even though the latter effectively inhibit

163 els during the recovery period, while in the theophylline experiments cerebral blood flow fell below

164 During theophylline experiments, however, there was no signific

165 ing site for FMN is rendered inactive unless theophylline first binds to its corresponding site and r

166 he lungs of four sheep aged 4-13 days, while theophylline given after sotalol had no effect.

167 had no effect on LL absorption rate, whereas theophylline given after sotalol increased LL absorption

168 as observed in the CPA, propentofylline, and theophylline groups.

169 also detected in the crude cell extracts of theophylline-grown CBB5.

170 mine" to the native double helical DNA, and "theophylline>/=theobromine>caffeine to the denatured for

171 the order of binding affinity as "caffeine>/=theophylline>theobromine" to the native double helical D

172 Lungs stored in STH containing rolipram or theophylline had improved function on reperfusion.

173 The administration of theophylline had no significant effect on cerebral blood

174 s (CPA, propentofylline) nor the antagonist (theophylline) had any effect on extracellular glutamate

175 Theophylline has antiinflammatory effects in asthma, and

176 These results suggest that theophylline has antiinflammatory properties that may be

177 Theophylline has been shown to ameliorate impaired stero

178 and reversible, noncompetitive inhibition by theophylline has been studied.

179 Theophylline has been used in the treatment of asthma an

180 Theophylline has been used to treat central apnea associ

181 w ribozyme-based RNA devices that respond to theophylline, hypoxanthine, cyclic-di-GMP, and folinic a

182 the use of the adenosine receptor antagonist theophylline, implicating both the nucleoside and its re

183 olamide, riboflavin, sodium fluorescein, and theophylline in 2-hydroxyethyl methacrylate/methacrylic

184 we demonstrated the antitussive activity of theophylline in a cigarette smoke exposure model that ex

185 Because the PDE target for theophylline in CLL remains unknown, we examined the abi

186 cognition regions specific for ATP, FMN, and theophylline in combinations with malachite green bindin

187 ipratropium, long-acting beta-agonists, and theophylline in the 6 months preceding death.

188 nformational selection mechanism for binding theophylline in the absence of Mg(2+).

189 er than 10000-fold reduction in affinity for theophylline in the absence of Mg2+.

190 uppressed by administration of isosorbide or theophylline in the drinking water.

191 A theophylline-independent rate was observed for formation

192 a positive short circuit current response to theophylline indicating intact ion transfer.

193 methylxanthines (caffeine, theobromine, and theophylline) indicative of stimulant drinks, probably c

194 Theophylline induced a sixfold increase in HDAC activity

195 , 5.0, or 10.0 g/L GA to the ORS neutralized theophylline-induced abolition of net sodium and potassi

196 ious demonstration that acutely administered theophylline induces respiratory-related recovery in an

197 The theophylline infusion was begun 30 min prior to and ende

198 trast, the cAMP phosphodiesterase inhibitor, theophylline, inhibited mTOR activity not only when adde

199 Theophylline inhibits capsaicin-induced cough under both

200 Determining how theophylline inhibits cough might lead to the developmen

201 Theophylline is given systemically (orally as slow-relea

202 Theophylline is now usually used as an add-on therapy in

203 ophylline aptamer with greater affinity than theophylline itself.

204 ve compression forces; they were composed of theophylline, lactose, and microcrystalline cellulose (P

205 rrences were associated with decreased serum theophylline levels, possibly caused by enzyme induction

206 ventilation, arterial blood gases, and serum theophylline levels.

207 This may be achieved by theophylline-like drugs, more effective antioxidants and

208 e protein levels, blood neutrophil count and theophylline maintenance use.

209 Theophylline may also reduce risk for contrast-induced n

210 Theophylline may be a rapid and effective therapy for li

211 In the future, low-dose theophylline may be useful in reversing corticosteroid r

212 Rather, we suggest that theophylline may exert its inhibitory effects on maturat

213 tically significant renoprotective effect of theophylline may result from insufficient data or study

214 mal delivery of small hydrophilic compounds (theophylline, methylene blue, and fluorescein sodium) ac

215 Therefore, theophylline might restore steroid responsiveness in COP

216 terenol effect, whereas forskolin, cAMP, and theophylline mimic it.

217 systems allowing detecting the adenosine and theophylline molecules.

218 3)), well below the sensitivity required for theophylline monitoring where the target range is 10-20

219 o our knowledge, this is the first report of theophylline N demethylation and coexpression of distinc

220 We conclude that theophylline not only induces, but also maintains recove

221 mixing droplets of caffeine with droplets of theophylline on an open DMF device and comparing the pea

222 We measured the effect of theophylline on HDAC activity and inflammatory gene expr

223 of techniques, we investigated the effect of theophylline on human and guinea pig vagal sensory nerve

224 y, the influence of chronically administered theophylline on maintaining recovery was assessed.

225 ht to investigate the inhibitory activity of theophylline on vagal sensory nerve activity and the cou

226 the methylxanthines antagonists caffeine and theophylline, on CBF responses to hypercapnia can potent

227 y to alcohol withdrawal, and in those due to theophylline or isoniazid toxicity.

228 tion were coexpressed when CBB5 was grown on theophylline or on caffeine or its metabolites.

229 blind crossover study, the patients received theophylline or placebo orally twice daily for five days

230 Combination therapy with theophylline or salmeterol may allow clinicians to minim

231 denosine receptor antagonist 8-p-sulfophenyl theophylline or the specific protein kinase C inhibitor

232 denosine receptor antagonist 8-p-sulfophenyl theophylline or with the selective A1-receptor antagonis

233 eine metabolism, and 3 of these metabolites, theophylline (OR for 90th compared with 10th percentiles

234 4 weeks gestation, is treated with caffeine, theophylline, or aminophylline.

235 BA], leukotriene receptor antagonist [LTRA], theophylline, or long-acting muscarinic antagonist [LAMA

236 ia, hypothermia, cyclopentyladenosine (CPA), theophylline, or propentofylline).

237 s with or without long-acting beta agonists, theophyllines, or leukotriene-receptor antagonists, adju

238 s of the parent molecular ion for each drug (theophylline, paracetamol, prednisolone) showed their di

239 mD catalyzed N(1)-demethylation of caffeine, theophylline, paraxanthine, and 1-methylxanthine to theo

240 fraction during the base-line, placebo, and theophylline phases of the study.

241 ty-five patients with COPD were treated with theophylline (plasma level of 9-11 mg/L) for 4 weeks in

242 , parenteral aminophylline, and slow-release theophylline preparations in response to this trend.

243 four sheep aged 6-12 weeks, confirming that theophylline produced its effect of increasing LL absorp

244 However, the nonselective agent, theophylline, provided the best protection of function a

245 transcriptional activation in RA, cAMP, and theophylline (RACT)-treated F9 Rex1(-/-) cells (approxim

246 recipients did not have a greater risk than theophylline recipients of severe nonfatal asthma.

247 800-1600-fold in the presence of 1 mM ATP or theophylline, respectively.

248 d P(BAD) to versions that have an additional theophylline-responsive riboswitch (P(tac)-riboswitch an

249 Here, we characterize the properties of a theophylline-responsive synthetic aptazyme for control o

250 ponse of the rationally designed, artificial theophylline riboswitch RS3.

251 neered phage T7, enabling the evolution of a theophylline riboswitch.

252 ational approach for the design of synthetic theophylline riboswitches based on secondary structure p

253 Tandem fusions of these riboswitches with theophylline riboswitches represent logic gates respondi

254 ndent rate was observed for formation of the theophylline-RNA complex at high theophylline concentrat

255 We uncovered that Theophylline's metabolism and elimination could be retar

256 A regimen of terbutaline and theophylline seems to be effective prophylaxis against t

257 nt adenosine A3 receptors are not blocked by theophylline, selective A1, A2A, and A2B receptor antago

258 After infusion of 2.4 mg of theophylline (serum level, 11.6 microg/mL), Cheyne-Stoke

259 Neutrophils from subjects treated with theophylline showed reduced chemotaxis to N-formyl-met-l

260 reated with 100 micromol/L 8-(p-sulfophenyl) theophylline (SPT), an adenosine receptor antagonist; pr

261 polar A2 antagonist 8-SPT (8-(p-sulfophenyl)theophylline) suggesting that the effects of DMPX on LTP

262 explain a very unusual property of this RNA-theophylline system: slow exchange on the NMR chemical s

263 ent RNA aptamers to sense diverse chemicals (theophylline, tetramethylrosamine, fluoride, dopamine, t

264 aneous analysis of MX i.e. Theobromine (TB), Theophylline (TH) and Caffeine (C), with application in

265 are anything more than expensive "designer" theophylline, the archetypal non-selective phosphodieste

266 were also eliminated, as was the response to theophylline, the methylxanthine in tea.

267 The FTIR analysis divulged that theophylline, theobromine and caffeine interact with all

268 naturally occurring methylxanthines such as theophylline, theobromine and caffeine with DNA, using U

269 udy (GWAS) of plasma caffeine, paraxanthine, theophylline, theobromine and paraxanthine/caffeine rati

270 ding profiles of three caffeine metabolites, theophylline, theobromine, and paraxanthine, were also i

271 e structures of caffeine and its metabolites-theophylline, theobromine, paraxanthine, 1-methylxanthin

272 We studied the effect of short-term oral theophylline therapy on periodic breathing associated wi

273 In patients with stable heart failure, oral theophylline therapy reduced the number of episodes of a

274 Theophylline therapy resulted in significant decreases i

275 the platelet inhibitors prostaglandin E1 and theophylline, these inhibitors had no effect on platelet

276 thines such as caffeine, pentoxifylline, and theophylline, they do not deregulate the G2 checkpoint.

277 NAD(P)H-dependent conversion of theophylline to 1- and 3-methylxanthines was also detect

278 exhibits an effector specificity change from theophylline to 3-methylxanthine.

279 theobromine, 3-methylxanthine, caffeine, and theophylline to 7-methylxanthine, xanthine, paraxanthine

280 y diarrhea or luminally exposed to 10 mmol/L theophylline to induce jejunal secretion.

281 ent on and off rate constants for binding of theophylline to its RNA aptamer in the absence of Mg(2+)

282 e mice was 50% of controls, but injection of theophylline, together with glucagon, resulted in a norm

283 In theophylline-treated animals, NMDA responses were comple

284 of photovoltaic device was demonstrated with theophylline treatment.

285 %) to induced sputum samples obtained during theophylline treatment.

286 umin) and agents that prevent NAD depletion (theophylline) upregulate SIRT1 and reduce proinflammator

287 confirmed that CBB5 initially N demethylated theophylline via a hitherto unreported pathway to 1- and

288 rding olfactory improvement using intranasal theophylline warrant confirmation in a randomized contro

289 Theophylline was antitussive in a guinea pig model, inhi

290 de-out experiments showed that the effect of theophylline was due to an increase in the open probabil

291 5 cells did not metabolize caffeine, whereas theophylline was metabolized at much reduced levels to o

292 Then, benzimidazole/theophylline was reacted with the latter to generate the

293 Theophylline was then injected i.p. for 3-30 consecutive

294 Theophylline was well tolerated.

295 kg CPA, 5 mg/kg propentofylline, or 20 mg/kg theophylline were administered intravenously.

296 Aptamers that bound adenosine and theophylline were appended to the core structure, and th

297 by methylxanthine drugs such as caffeine and theophylline, which are contraindicated in ADPKD patient

298 signaling pathways for both Amphetamine and Theophylline with data mining of available literature.

299 gly, the U27 and G27 RNAs were found to bind theophylline with low affinity (Kd values > 4 microM).

300 ease in CBFV was significantly attenuated by theophylline, with no significant differences between su