ライフサイエンスコーパス: therapeutic activity

1 was selected as an endpoint associated with therapeutic activity.

2 er the drug's pharmacokinetics to enable its therapeutic activity.

3 re a time-dependent "cold chain" to maximize therapeutic activity.

4 op more potent agents that exhibit increased therapeutic activity.

5 trials, and the most recent iterations show therapeutic activity.

6 malaria and shows potent in vivo blood-stage therapeutic activity.

7 he compound, indicating tumor cell-selective therapeutic activity.

8 ral fusion, and shows promising postexposure therapeutic activity.

9 cal role for iTreg IL-10 production in their therapeutic activity.

10 esting that the L2 polypeptide vaccines lack therapeutic activity.

11 both the IgV and stalk domains of TIM-1 have therapeutic activity.

12 ing additional SERT substrates for potential therapeutic activity.

13 ication via NF-kappaB, may have considerable therapeutic activity.

14 viral therapy that may confound estimates of therapeutic activity.

15 n of Ab did not make optimal use of the Ab's therapeutic activity.

16 nd selectivity of their DNA interactions for therapeutic activity.

17 ed vaccination resulted in T cells with less therapeutic activity.

18 the patient's weight, determines the desired therapeutic activity.

19 h low gastrointestinal toxicity and restored therapeutic activity.

20 local drug concentration and to prolong the therapeutic activity.

21 n and dosimetry before the administration of therapeutic activity.

22 of fatty acid and a substantial loss in the therapeutic activity.

23 o circumvent such obstacles towards superior therapeutic activity.

24 , which is critical for immune functions and therapeutic activity.

25 HER2, and tumor senescence with significant therapeutic activity.

26 opsychiatric diseases, with a rapid onset of therapeutic activity.

27 PK in cases where plasma PK does not reflect therapeutic activity.

28 g these potential reactions without altering therapeutic activity.

29 constitute an important component of ACE2-Fc therapeutic activity.

30 defined stereocenter does not play a role in therapeutic activity.

31 olic fitness and significant potentiation of therapeutic activity.

32 the same target elicits different levels of therapeutic activity.

33 ing in tumor cells that contributes to their therapeutic activity.

34 s that affect stem cells and thus have novel therapeutic activity.

35 ccine-induced cytotoxic T-cell responses and therapeutic activity.

36 gher than the pM concentrations required for therapeutic activity.

37 ck viral entry, suppress viremia, and confer therapeutic activity.

38 s a critical structural feature that governs therapeutic activity.

39 better understand both adverse and favorable therapeutic activities.

40 unknown how CLR01 exerts these two distinct therapeutic activities.

41 s and contributes to its pharmacological and therapeutic activities.

42 elop screens for NR modulators with specific therapeutic activities.

43 t of a wide variety of natural products with therapeutic activities.

44 alomicin analogues with potentially improved therapeutic activities.

45 ceptor lifetime and influences breast cancer therapeutic activities.

46 le photosensitiser with promising anticancer therapeutic activities.

47 target FKBP65 and LH2 may have complementary therapeutic activities.

48 correlations, with special emphasis on their therapeutic activities.

49 tural units responsible for their pronounced therapeutic activities.

50 he HSA binding capacity without compromising therapeutic activities.

51 dation through switching between imaging and therapeutic activities.

52 has been shown to have cancer-preventive and therapeutic activities.

53 rafts (PDX) in mice could efficiently define therapeutic activity across heterogeneous tumors.

54 croorganisms with potential prophylactic and therapeutic activities against gut infections.

55 nge model of mice, only three MAbs exhibited therapeutic activity against a homologous strain when ad

56 Tryptanthrins have potential therapeutic activity against a wide variety of pathogeni

57 rating their broad-spectrum prophylactic and therapeutic activity against currently circulating influ

58 tigen receptors (CARs) have shown remarkable therapeutic activity against different types of cancer.

59 resulted in T cells that possessed enhanced therapeutic activity against established pulmonary metas

60 vo, the LF-Zn-NPs displayed a protective and therapeutic activity against induced pulmonary fibrosis

61 selective lymphotoxic properties and potent therapeutic activity against lupus-like disease in autoi

62 red probiotic shows in vivo prophylactic and therapeutic activity against P. aeruginosa during gut in

63 creening, indicative of drugs with potential therapeutic activity against this virus.

64 These modified CAR-T cells show enhanced therapeutic activity against xenografted lymphomas.

65 cross resistance with existing tuberculosis therapeutics, activity against multidrug-resistant (MDR)

66 because the novel IgA antibody demonstrated therapeutic activity also in non-FcalphaRI transgenic mi

67 derstanding why antibodies display different therapeutic activities and for the development of more e

68 eveloping the approach to improve CAR T-cell therapeutic activity and also to broaden the range of tu

69 ing antibody nivolumab has shown substantial therapeutic activity and an acceptable safety profile in

70 Nivolumab had substantial therapeutic activity and an acceptable safety profile in

71 Furthermore, this allopeptide has strong therapeutic activity and highlights the importance of TC

72 erimental T cell-induced colitis, GMaMs show therapeutic activity and protect mice from colitis.

73 ystem pathologies and possessing accentuated therapeutic activity and reduced side effects.

74 ght to obtain preliminary information on the therapeutic activity and safety of imetelstat in patient

75 r cells is an attractive approach to achieve therapeutic activity and selectivity.

76 ciently to the target cells to promote their therapeutic activity and several delivery technologies h

77 s, associated with a moderate improvement in therapeutic activity and survival.

78 We investigated the therapeutic activity and underlying mechanisms of adenov

79 will be inaccurate for time points at which therapeutic activities are high.

80 Therefore, novel PRRT regimens with improved therapeutic activity are needed.

81 owever, the specific mechanisms underpinning therapeutic activity are unclear and require further res

82 Id, despite targeting irradiation and having therapeutic activity as an unconjugated antibody, protec

83 f alpha2delta ligands may help explain their therapeutic activity as supplemental therapy for major d

84 el strategy for the reconstitution of potent therapeutic activity at the site of disease, sparing hea

85 NBI-6024) was further characterized for its therapeutic activity because it consistently induced T-c

86 avasate out of blood vessels is critical for therapeutic activity, because molecular targets for most

87 availability, physicochemical properties and therapeutic activity can be dramatically altered by meta

88 However, the high therapeutic activity can interfere with the PET camera p

89 resulted in a homogeneous ADC with increased therapeutic activity compared to the clinically approved

90 or (TCR) targeting MSLN (TCR(MSLN)) mediated therapeutic activity, delaying tumor growth and prolongi

91 , anti-FcgammaRIIB mAbs demonstrated limited therapeutic activity despite optimized treatment regimen

92 in will expand the utilities of albumin as a therapeutic activity extender to proteins with a complex

93 to increase tumor drug exposure and improve therapeutic activity following intratumoral drug adminis

94 polypeptide (GIP), a protein with potential therapeutic activity for diabetes.

95 combination of peptide amount and pertaining therapeutic activity for each patient.

96 rmacologically has not achieved the expected therapeutic activity for the treatment of autoimmune dis

97 JAK-2-inhibitory activities may broaden the therapeutic activity (i.e. anemia improvement), as has b

98 encephalomyelitis and show that, for optimum therapeutic activity, IL-10 must either access the CNS f

99 Resveratrol has demonstrated preventive and therapeutic activities in a variety of tumors.

100 ble potency that have shown prophylactic and therapeutic activities in animal models.

101 sts and antagonists, which display promising therapeutic activities in cancer and autoimmunity, respe

102 has been extensively studied for its various therapeutic activities in cell cultures and animal model

103 diaquine showed substantial prophylactic and therapeutic activities in hamsters challenged with nativ

104 to also possess anti-inflammatory and other therapeutic activities in mammalian cells.

105 inal domain inhibitors (BETi) have exhibited therapeutic activities in many cancers.

106 d prolonged in vivo persistence and superior therapeutic activities in models of lymphoma and neurobl

107 tially provide a very beneficial spectrum of therapeutic activities in multiple disease states.

108 ptor coregulatory molecule GITR exert potent therapeutic activities in preclinical tumor models.

109 ntrol the localization, timing and dosage of therapeutic activities in response to specific disease b

110 and provided experimental evidence for their therapeutic activities in vitro and in vivo using precli

111 FGF-20, having demonstrated therapeutic activity in 2 experimental models of intesti

112 (ETP-ALL), with both agents contributing to therapeutic activity in a dose-dependent manner.

113 nds alter T cell function, we assessed their therapeutic activity in a mouse model of T cell-mediated

114 mbination with blinatumomab, had significant therapeutic activity in a systemic human diffuse large B

115 macological inhibition of BET proteins shows therapeutic activity in a variety of different pathologi

116 the immune checkpoint receptor PD1 produces therapeutic activity in a variety of solid tumors, but m

117 vo, CD5xDR-CR3 was shown to have significant therapeutic activity in a xenograft model of human leuke

118 nalidomide is an immunomodulatory agent with therapeutic activity in chronic lymphocytic leukemia (CL

119 ted drug delivery showed potent and specific therapeutic activity in CLL, thus providing proof of con

120 indings imply that CHK2 inhibitors may exert therapeutic activity in combination with PARP inhibitors

121 ne expression changes, may contribute to its therapeutic activity in COPD.

122 bstrates for the enzyme and showed excellent therapeutic activity in CPG2-expressing MDA MB 361 xenog

123 in EL4 tumors, as well as excellent in vivo therapeutic activity in EL4 lymphoma and moderate effica

124 now been shown to display equally impressive therapeutic activity in eosinophilia-associated chronic

125 Lometrexol had limited therapeutic activity in folate-deficient mice bearing th

126 demonstrated a manageable safety profile and therapeutic activity in heavily pretreated patients with

127 liminary clinical data demonstrate promising therapeutic activity in heavily pretreated populations a

128 zation potency in vitro and enhanced in vivo therapeutic activity in HIV-1-infected humanized mice.

129 protein (CRP) is an acute-phase protein with therapeutic activity in mouse models of systemic lupus e

130 tion of STING agonists results in remarkable therapeutic activity in mouse models, and STING agonists

131 ates at doses equivalent to those displaying therapeutic activity in murine cancer models.

132 an erythrocyte-specific Ab with anti-D-like therapeutic activity in murine ITP, while also exhibitin

133 ge with a wide variety of pathogens, and has therapeutic activity in murine models of cancer and alle

134 all-molecule Usp9x/Usp24 inhibitors may have therapeutic activity in myeloma.

135 homas and autoimmune diseases, demonstrating therapeutic activity in non-Hodgkin lymphoma (NHL) and s

136 , BW1843U89, and Thymitaq, have demonstrated therapeutic activity in patients with advanced cancer.

137 eptors (CARs) have proven - and impressive - therapeutic activity in patients with certain subtypes o

138 imately 0.1% of serum levels associated with therapeutic activity in patients with systemic non-Hodgk

139 ate and its active metabolite, nitrite, have therapeutic activity in preclinical models of pulmonary

140 ases, or PI3K itself, might have significant therapeutic activity in PTEN-null cancers.

141 which suggests that exogenous IL-11 may have therapeutic activity in RA.

142 However, the mechanisms of therapeutic activity in responding versus nonresponding

143 used to treat breast cancer, but it also has therapeutic activity in several other types of cancer.

144 If rhIL-1ra treatment has any therapeutic activity in severe sepsis, the incremental b

145 ecognising tumour antigens could improve its therapeutic activity in specific indications, like in th

146 criptomics have not been used to probe their therapeutic activity in the heart.

147 ies suggest that melarsoprol shows promising therapeutic activity in these diseases, and a study to e

148 of inducible nitric oxide synthase may have therapeutic activity in these tumors.

149 cribed immunoregulatory cytokine with potent therapeutic activity in various preclinical models of in

150 ral control over T cell-mediated anti-tumour therapeutic activity in vivo with greatly mitigated side

151 tumor cell killing and substantially enhance therapeutic activity in vivo.

152 experiments to determine whether Bz-423 had therapeutic activity in vivo.

153 n cancer cells in vitro, and elicited strong therapeutic activity in vivo.

154 -2843 and vincristine significantly impacted therapeutic activity in vivo.

155 hemoselective albumin conjugation to prolong therapeutic activity in vivo.

156 wer doses or less intensive schedules retain therapeutic activity include reduced toxicity and large

157 shown to have a number of pharmacologic and therapeutic activities including antioxidant, anti-micro

158 molecular carrier to deliver molecules with therapeutic activity into ER(+) cells for diagnostic pur

159 e and anti-P-glycoprotein siRNA, synergistic therapeutic activity is achieved in multidrug resistant

160 Although the biochemical basis for their therapeutic activity is not known, these macrolactones e

161 b that also exhibits antiepileptic and other therapeutic activities, is a highly potent KCNQ channel

162 organs of interest to establish appropriate therapeutic activity levels.

163 as a monotherapy demonstrates marked in vivo therapeutic activity, meriting consideration for clinica

164 These results suggested that this therapeutic activity might involve mechanisms in additio

165 ytes or muscle cells may explain some of the therapeutic activities of 4-AP as a neurotransmission en

166 A-induced hepatitis, and alterations in the therapeutic activities of alpha-GalCer.

167 In this regard, the therapeutic activities of cationic dyes, such as rhodami

168 toxicity to mammalian cells but retains the therapeutic activities of PMB.

169 target fishing and network analysis revealed therapeutic activities of the phytochemicals, demonstrat

170 ent review comprehensively elaborates on the therapeutic activities of their bioactive compounds, the

171 also useful for calculating the administered therapeutic activity of (131)I to treat hyperthyroidism

172 In this study, we investigated the potential therapeutic activity of a formulation of pIC with polyet

173 The potential therapeutic activity of a human monoclonal antibody to t

174 Blood, Yang et al have demonstrated that the therapeutic activity of a targeted therapy, the tyrosine

175 ancing their survival and also the antitumor therapeutic activity of a tumor-specific peptide vaccine

176 omoting the TD Ab response, by improving the therapeutic activity of Ab-mediated effector mechanisms.

177 ibutes to the transcriptional inhibition and therapeutic activity of abemaciclib.

178 As a result, NGR-TNF enhanced the therapeutic activity of adoptive and active immunotherap

179 To determine whether the therapeutic activity of alphaB crystallin, small heat sh

180 h the capacity to carry siRNA to enhance the therapeutic activity of an anticancer gene therapy.

181 This study is the first to report therapeutic activity of an APL derived from an islet bet

182 ce requires both activities, we measured the therapeutic activity of an HA-specific MAb (VN and YR) a

183 We therefore evaluated the safety and therapeutic activity of another immunomodulatory drug, p

184 The therapeutic activity of anti-CD73 monoclonal antibody ag

185 t Fc domain interactions are critical to the therapeutic activity of anti-DR5 antibodies and, togethe

186 e immune cells play an important role in the therapeutic activity of anti-ErbB2 mAbs, such as trastuz

187 The trans-disease therapeutic activity of anti-IL-1 strategies argues for

188 kedly reduced CNV severity and abolished the therapeutic activity of anti-Scg3 hFab, but not afliberc

189 The therapeutic activity of anti-TIM3 was abrogated in mice

190 ide a plausible mechanism for the documented therapeutic activity of anti-TNF-alpha and antiviral che

191 ation of M. tuberculosis and demonstrate the therapeutic activity of antiviral treatment (efavirenz)

192 Accordingly, the therapeutic activity of ATROSAB is mediated by shifting

193 lement depletion had no effect on the potent therapeutic activity of B1, a mAb that does not redistri

194 To date, although the therapeutic activity of both direct and indirect inhibit

195 ogenous IL-15 pathway in contributing to the therapeutic activity of CD40 agonism in orthotopic bladd

196 tors and provided mechanistic explanation of therapeutic activity of cholinomimetics in PV patients.

197 rmore, in vivo CISC engagement increased the therapeutic activity of CISC EngTreg.

198 Significant in vivo therapeutic activity of combination rituximab and milatu

199 Significant in vivo therapeutic activity of combination treatment was also d

200 flammation in RA and a target to amplify the therapeutic activity of CS.

201 r competition for glucose may facilitate the therapeutic activity of CTLA-4 blockade, thus supporting

202 Our study provides novel insights on the therapeutic activity of DAC in the backdrop of the newly

203 novel role of CXCL10 in the immunologic and therapeutic activity of DC-based cancer vaccines.

204 one metastasis and, as such, may enhance the therapeutic activity of docetaxel (Taxotere), the most c

205 The novel therapeutic activity of fenofibrate in this mouse model

206 therapy on the gastrointestinal toxicity and therapeutic activity of free and phospholipid-associated

207 These results demonstrate the therapeutic activity of GBS polysaccharide conjugate vac

208 We evaluated the therapeutic activity of human monoclonal antibodies to D

209 To evaluate the safety and potential therapeutic activity of humanized anti-IL-2 receptor mAb

210 y engineering efforts aimed at enhancing the therapeutic activity of immunomodulatory antibodies.

211 The therapeutic activity of lithium required functional IFN-

212 ive to human folate intake, the toxicity and therapeutic activity of lometrexol was studied in mice u

213 s on cardiac left ventricular tissue and the therapeutic activity of melatonin on these effects.

214 on with the control group (P >0.05); and the therapeutic activity of melatonin was limited (P >0.05).

215 so hypothesized that estrogen influences the therapeutic activity of MPA because it promotes cervical

216 we performed a systematic evaluation of the therapeutic activity of over 5,000 pairs of FDA-approved

217 ENT1 deficiency notably potentiated the therapeutic activity of PD-1 blockade.

218 The enhanced therapeutic activity of PD-L1 blockade by ibrutinib was

219 The therapeutic activity of perhexiline was further demonstr

220 compounds that are often associated with the therapeutic activity of plant extracts used in tradition

221 ammation, when LL37 levels are elevated, the therapeutic activity of poly(I:C) will be compromised.

222 This study indicates the therapeutic activity of radiolabeled oligonucleotides th

223 sity in the dorsal raphe (DR) attenuates the therapeutic activity of selective serotonin-reuptake inh

224 m of action in vivo is not always known, the therapeutic activity of several approved mAbs depends on

225 in the IFN-I receptor (IFNAR) abolished the therapeutic activity of SFV-IL12, as did a specific anti

226 Heparin also increased the therapeutic activity of SLPI against antigen-induced air

227 beta is likely a key mechanism mediating the therapeutic activity of Tanshinone IIA, because sodium n

228 Here, we investigated whether enhanced therapeutic activity of temperature sensitive liposomes

229 mouse mammary tumor model, the stability and therapeutic activity of the antibody conjugate were affe

230 d, Haroche and colleagues report significant therapeutic activity of the BRAF inhibitor, vemurafenib,

231 While the therapeutic activity of the deoxycytidine analogue decit

232 implications for the carcinogenicity and/or therapeutic activity of the drug.

233 el model system demonstrates that the potent therapeutic activity of the IL-12/pulse IL-2 combination

234 his study, we investigated the targeting and therapeutic activity of the immunocytokine F8-IL4 in the

235 Despite the transformative therapeutic activity of the multiple iterations of EGFR

236 We tested the possible therapeutic activity of the peroxisome proliferator-acti

237 viation of autoreactive T cells, but not the therapeutic activity of the RMTC.

238 The therapeutic activity of these antitumor agents can be co

239 concert with FcgammaR3 by CS counteracts the therapeutic activity of these drugs.

240 therefore provide a rational to explore the therapeutic activity of these promising agents in CLL.

241 n, and this may be exploited to increase the therapeutic activity of Topo II drugs.

242 he linker-drug and antibody engineering, the therapeutic activity of trastuzumab maytansinoid ADCs ca

243 The therapeutic activity of tumor vaccines is limited by the

244 Hypoxia also is well known to attenuate the therapeutic activity of various therapies in cancer mana

245 stems could thus coincide with the long-term therapeutic activity of vmPFC DBS.

246 We assessed the therapeutic activity of zanamivir in adults with acute i

247 y component of parasitic hookworms for their therapeutic activity on experimental colitis.

248 CD4(+) T-cell activities had no significant therapeutic activity on their own; in fact, they were ha

249 oforms, which might contribute to unexpected therapeutic activity or adverse side effects.

250 lective for KRAS(G12V) and exhibits improved therapeutic activity over pan-KRAS targeting, including

251 se studies indicate that this mAb might have therapeutic activity, particularly in patients with CLL

252 The sCR2-targeting vehicle contributes to therapeutic activity, possibly via modulation of autoimm

253 ortunity for both direct and immune-mediated therapeutic activity provided by inhibition of a single

254 levels of the activators cover the expected therapeutic activity ranges found in the plasma of patie

255 y to engineer clinical reagents with defined therapeutic activity regardless of FcgammaR expression l

256 Therapeutic activity required tumor antigen specificity

257 nes, may provide improved immunogenicity and therapeutic activity simultaneously.

258 However, to achieve the desired therapeutic activity, siRNA requires a suitable delivery

259 Each compound's potential for preventive and therapeutic activity stems from the compound's potential

260 ed ablation of HMBG1 is sufficient to elicit therapeutic activity, suggesting a novel therapeutic app

261 environment could cooperate to exert maximal therapeutic activity, suggesting a promising clinical st

262 We review the mechanisms of tRNA therapeutic activity, the nature of the therapeutic wind

263 aR interactions are required to achieve full therapeutic activity through clearance of IgG-opsonized

264 Recognition of the role of the Fc domain in therapeutic activities, through the depletion of immunos

265 racteristics were combined to guide a single therapeutic activity to achieve a high tumor dose withou

266 lated concepts for determining the amount of therapeutic activity to be administered.

267 that PDE4 inhibition alone is sufficient for therapeutic activity to be realized.

268 d was then used to determine the appropriate therapeutic activity to deliver a specific total-body ra

269 Neo-2/15 has superior therapeutic activity to IL-2 in mouse models of melanoma

270 cell activity allows continual modulation of therapeutic activity to improve the safety profile of CA

271 MiD) thalidomide was discovered to exert its therapeutic activity via a novel and unexpected mechanis

272 Results: The average therapeutic activity was 14 GBq.

273 This therapeutic activity was correlated with inhibition of o

274 The therapeutic activity was crucially performed by CD8 T ce

275 d heterologous strains, and prophylactic and therapeutic activity was evaluated with two mouse models

276 cell STING is epigenetically silenced, 8803 therapeutic activity was maintained, further attesting t

277 This pH-dependent block in therapeutic activity was overcome if the NSAID was preas

278 Their therapeutic activity was validated in the passive transf

279 To understand their therapeutic activity, we determined cryo-EM structures o

280 tify the cell fraction in BMCE with the most therapeutic activity, we sorted human bone marrow into 3

281 As a result anti-inflammatory and therapeutic activities were revealed.

282 Tissue distribution and in vivo therapeutic activity were studied using different heatin

283 -type restricted protection, and no reported therapeutic activity, which might be addressed with the

284 load and produced the expected reduction in therapeutic activity with the anti-MHCII, but surprising

285 luding very deep B-cell depletion and unique therapeutic activity within inflamed tissues and associa

286 these patients might benefit from increased therapeutic activity without exceeding the radiation dos