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1 we were unable to demonstrate any beneficial therapeutic effect.
2 prevent mTOR inhibitors from achieving a net therapeutic effect.
3 uch inhibition is sufficient for achieving a therapeutic effect.
4 ox enzymes that ostensibly contribute to the therapeutic effect.
5 euthyroidism may help to achieve an ultimate therapeutic effect.
6 "solid stress," leading to better anticancer therapeutic effect.
7 ticancer treatment potentiates the prolonged therapeutic effect.
8 inically favourable by achieving a prolonged therapeutic effect.
9 for activating FcgammaRs led to an enhanced therapeutic effect.
10 PD-1 antibody alone failed to elicit obvious therapeutic effect.
11 ther such inhibition would have a beneficial therapeutic effect.
12 -soluble contrast) influences this potential therapeutic effect.
13 es, the nanovaccine demonstrates substantial therapeutic effect.
14 ch as the price tag, can strongly affect its therapeutic effect.
15 ulate when, where, and how a drug exerts its therapeutic effect.
16 relate of disease severity, progression, and therapeutic effect.
17 ung with sufficient efficacy for a sustained therapeutic effect.
18 fficacious, tumor-specific, and long-lasting therapeutic effect.
19 longer half-life and significantly improved therapeutic effect.
20 er than cross-correction, contributes to the therapeutic effect.
21 nhance the cell-killing effect and boost the therapeutic effect.
22 the initial testosterone surge and delay in therapeutic effect.
23 necessary degree of weight loss required for therapeutic effect.
24 so raise questions as to how FR achieves its therapeutic effect.
25 P) facilitates local exposure to enhance its therapeutic effect.
26 1) plays a significant role in mediating its therapeutic effects.
27 o modulate NPY/AgRP neurons, and blunted its therapeutic effects.
28 ibitor, with radiation generates synergistic therapeutic effects.
29 n activity, which may underlie its potential therapeutic effects.
30 in which US can provide both protective and therapeutic effects.
31 ing cytokine signals can have deleterious or therapeutic effects.
32 e mucin disulfide bonds with little, if any, therapeutic effects.
33 ity, aiming to evaluate safety and potential therapeutic effects.
34 rant nucleic acid sensing can mediate robust therapeutic effects.
35 sgRNA, and BDDF8 donor, we observe the same therapeutic effects.
36 oral bioavailability and significant in vivo therapeutic effects.
37 ides a novel approach to achieving prolonged therapeutic effects.
38 f some RTK inhibitors to produce the desired therapeutic effects.
39 hanisms through which NAcc volume exerts its therapeutic effects.
40 of action potentially responsible for their therapeutic effects.
41 tion and better understand their cooperative therapeutic effects.
42 nous and endogenous cannabinoids exert their therapeutic effects.
43 a potential novel mechanism contributing to therapeutic effects.
44 hese exosomes is largely responsible for the therapeutic effects.
45 o ketamine or as possible transducers of its therapeutic effects.
46 a potential novel mechanism contributing to therapeutic effects.
47 e biomarkers for target engagement and early therapeutic effects.
48 diseases where GSK-3beta inhibition exhibits therapeutic effects.
49 e to ketamine or have a role in its possible therapeutic effects.
50 ent co-regulators to produce tissue-specific therapeutic effects.
51 ng how anti-CTLA4 immunotherapy mediates its therapeutic effects.
52 microneedles (MHMs) while maintaining the MH therapeutic effects.
53 ions are still restricted due to the limited therapeutic effects.
54 nostimulatory molecules into tumors can have therapeutic effects.
55 ing B cell pathogenesis that are provided by therapeutic effects.
56 ained possible mechanisms of actions and the therapeutic effects.
57 ligand hydrogen bond drives these remarkable therapeutic effects.
58 ration and concentration in order to achieve therapeutic effects.
59 tests on rat survival demonstrate excellent therapeutic effect (72% survival compared to 0% of the c
61 enchymal stem cell (MSC) studies assume that therapeutic effects accrue from local myocardial effects
62 he literature on gold salt pharmacokinetics, therapeutic effects, adverse reactions, and the present
64 embered ring (11-cis-6mr)-retinal, which has therapeutic effects against certain degenerative retinal
66 dose 17-AAG liposomes demonstrated a limited therapeutic effect alone on 4T1 tumor, promising efficac
67 effects of opioids that underlie both their therapeutic effects (analgesia) and their adverse effect
68 ion therapy has long been applied to enhance therapeutic effect and deal with the occurrence of multi
69 BCM-PTX injection further improved the tumor therapeutic effect and elongated the survival time of th
70 nalog of NSC-370284, exhibited a more potent therapeutic effect and prolonged the median survival of
71 systemic inflammation condition, we compared therapeutic effect and protein cargo of exosomes isolate
73 cal HIFU system revealed correlation between therapeutic effect and thermal parameters, which was abs
74 Theranostics, systems that have combined therapeutic effects and diagnostic capabilities, have ga
76 the survival rate of grafted cells, but the therapeutic effects and mechanisms mediating encapsulati
77 hese results suggest a theory to explain the therapeutic effects and support the use of PBM for amino
78 the underlying mechanisms surrounding THC's therapeutic effects and the role of gut metabolite profi
79 gaining more and more attention due to their therapeutic effects and their potential technological ap
80 (reg) cells as the central arbiters of these therapeutic effects and thereby delineate a pharmacologi
81 rowing interest in better characterizing the therapeutic effects and toxicities of antibiotics in mam
82 Whether RB pathway reactivation will have therapeutic effects and whether targeting CDK4 and CDK6
83 t with diabetes mellitus from a mechanistic, therapeutic effect, and clinical management perspective
84 effectors that maximize the longevity of the therapeutic effect, and we discuss limitations of the pl
85 xhibits enhanced stability, more significant therapeutic effects, and a more than 10-fold improvement
86 e precise mechanisms mediating its long-term therapeutic effects are not fully resolved, they likely
87 is unaltered by antipsychotic treatment, and therapeutic effects are not mediated by changes in this
91 y may also provide a neurochemical basis for therapeutic effects as witnessed in ongoing clinical tri
92 the salt, which enables one to maximize the therapeutic effect, as well as exhibit a complete time-d
93 tivity than either drug alone and exhibits a therapeutic effect at a physiologically reasonable conce
95 naling can be an important mediator of these therapeutic effects at the sites of acute or persistent
96 xt, particularly regarding achieving desired therapeutic effects based on an individual's drug regime
97 ibution could be balanced to achieve maximum therapeutic effect by exquisite control of the molecular
99 140K) system that allowed for increasing the therapeutic effect by short-term treatment with low-dose
101 is still unknown, SSRIs are thought to exert therapeutic effects by elevating extracellular serotonin
103 so to deliver within the cells new drug-free therapeutic effects by using pure physical modes of acti
104 o-sized polymeric vector induces a favorable therapeutic effect, especially when in combination with
105 rug-protein interactions contribute to their therapeutic effect (even when DNA is the dominant target
106 and demonstrated a targeted immunomodulation therapeutic effect ex vivo and in vivo, in the DSS colit
108 consistent with the idea that its potential therapeutic effects for treating posttraumatic stress di
109 al to increase the clinical relevance of MSC therapeutic effects from small model systems (such as ra
110 s and spinal muscular atrophy, and long-term therapeutic effects have been achieved for other rare di
111 preclinical studies of lung injury, but its therapeutic effects have never been investigated in acut
112 Stimulation in each DBS target had similar therapeutic effects, however, antidromic activation of M
113 only one of the six classes correlates with therapeutic effects: if the targets of the drugs both hi
114 reactive oxygen species (ROS) diminishes the therapeutic effect in a hypoxic environment, such as sol
117 h as gemcitabine and irinotecan elicit their therapeutic effect in cancer cells by producing hydrogen
118 a promising approach to achieve a desirable therapeutic effect in complex diseases through the multi
120 y and can deliver adjustable stimulation for therapeutic effect in neurological and psychiatric disor
121 thought to contribute to how ECP exerts its therapeutic effect in patients with chronic graft-versus
122 ia its arterial blood supply, has a superior therapeutic effect in reducing tumor growth compared to
123 prescription drug for Type 2 diabetes, has a therapeutic effect in several mouse models of lupus thro
126 s has been more challenging and only limited therapeutic effects in animal models have been achieved
127 ly, JNK inhibitors exerted potent antifungal therapeutic effects in both mouse and human cells infect
128 enhances cognitive memory processes and has therapeutic effects in brain-injured mice without displa
133 r (HDACi) treatment, potentially linking the therapeutic effects in P23H rhodopsin animals and negati
134 tage of disease resulted in potent sustained therapeutic effects in PD mice for more than a year afte
135 evidence suggests that these agents may have therapeutic effects in specific psychiatric disorders.
136 rapeutic peptides and demonstrated promising therapeutic effects in xenografts harboring EGFR mutatio
137 CR) is defined as an unresponsiveness to the therapeutic effects, including the antiinflammatory ones
138 of the immune response contributes to their therapeutic effects independently of BRCA1/2 mutations.
139 ion of modulation of drug target activity to therapeutic effect is a critical aspect for all drug dis
140 iral or bacterial control, this advantageous therapeutic effect is associated with a significantly at
144 In order to obtain better targeting and therapeutic effects, it is necessary to understand the p
145 ves as a stable drug carrier, but also has a therapeutic effect itself through SR-B1-mediated intrace
147 s important in drug development, because the therapeutic effect may arise from only one signalling ca
150 n in nonhematopoietic tissues, the potential therapeutic effect of allogeneic hematopoietic stem cell
160 spontaneous pain recovery and abolished the therapeutic effect of EHD2-sc-mTNF(R2) This study theref
161 rate the dual-targeted delivery and enhanced therapeutic effect of eHNP-A1-CD15-LDE225 via scavenger
162 , we elucidate the mechanisms underlying the therapeutic effect of EPIT, by characterizing the kineti
164 cular endothelial growth factor enhances the therapeutic effect of human amniotic fluid stem cells in
169 g agent (111)In-3BP-227, we investigated the therapeutic effect of its (177)Lu-labeled analog on the
176 urther investigated the relation between the therapeutic effect of pHIFU and thermal parameters in bu
177 , a key upstream factor of PI3K/AKT, and the therapeutic effect of PIP5Kalpha inhibitor on subtypes o
184 study was to investigate the protective and therapeutic effect of Syphacia obvelata in the treatment
188 e role of TLRs in different diseases and the therapeutic effect of their natural and synthetic modula
189 bear mechanistic relevance for the putative therapeutic effect of these class of compounds in brain
191 he downstream events mediating the potential therapeutic effect of Wnt proteins are not fully underst
194 ontrolled hemorrhage was used to compare the therapeutic effects of 8.7 x 10(8) fresh platelets (FPLT
197 ogical tools for investigating the potential therapeutic effects of AC inhibition in relevant sphingo
198 posed in this study could be responsible for therapeutic effects of adenosine and other analogues of
202 ith alcoholic hepatitis, we investigated the therapeutic effects of bacteriophages that target cytoly
203 overexpressing exogenous DUX4 confirmed the therapeutic effects of berberine in downregulating DUX4
205 ed efficacy.Humans are less sensitive to the therapeutic effects of botulinum neurotoxin B (BoNT/B) t
207 d by an antagonist of GPR55, suggesting that therapeutic effects of CBD are mediated through this lip
208 his finding leads us to hypothesize that the therapeutic effects of CoQ10, frequently administered to
209 f this study is to investigate the potential therapeutic effects of cortistatin in two well-establish
214 e level of M1 are an important factor in the therapeutic effects of DBS.SIGNIFICANCE STATEMENT Recent
217 y aimed to elucidate the role of IL-8 in the therapeutic effects of hUCBCs in a mouse model of hypoxi
218 IONALE: Paracrine secretions seem to mediate therapeutic effects of human CD34(+) stem cells locally
221 ketamine metabolite, reproduces some of the therapeutic effects of ketamine and appears to lack abus
223 reduced mortality, probably by extending the therapeutic effects of lung protective ventilation.
226 bitin as a potential target in mediating the therapeutic effects of PDD005 for the treatment of cogni
229 tion in patients with PAH, and the potential therapeutic effects of pyridostigmine (PYR), an oral dru
231 of kidney function and limit engraftment and therapeutic effects of renal epithelial progenitors.
236 rents by ~3-fold and further potentiated the therapeutic effects of small-molecule correctors (e.g.,
238 NT Whether STN local cells contribute to the therapeutic effects of subthalamic nucleus (STN) deep br
241 ological activity, the structural basis, and therapeutic effects of the family of multitargeted compo
245 The different phenotypes, functions and therapeutic effects of these phagocytes have, however, b
246 , to determine the extent to which the cross-therapeutic effects of these treatments help to elucidat
250 ate the role of the 5-HT(1B) receptor in the therapeutic effects of vortioxetine and as a potential t
251 ing antibiotic linezolid has an advantageous therapeutic effect on alpha-toxin-induced lung damage, a
252 growth factor receptor 2 yielded an additive therapeutic effect on both area and number of spontaneou
253 el data provide evidence that SC-Exos have a therapeutic effect on DPN in mice and suggest that SC-Ex
254 odulation (PBM) has been suggested to have a therapeutic effect on irreversible hearing loss induced
255 rs EPC-derived exosome function, content and therapeutic effect on myocardial repair by upregulating
258 IRADS classifications) but also evaluate the therapeutic effects on cancer tumors after chemotherapy/
259 alpha-specific inhibitor, had preventive and therapeutic effects on metabolic disorders that were dep
260 ype 2 diabetes, Roux-en-Y gastric bypass has therapeutic effects on metabolic function that are indep
261 wer intraocular pressure (IOP); however, its therapeutic effects on outflow physiology are location-
262 herapy/radiotherapy treatment to enhance the therapeutic effects on p53-deficient neuroblastoma.
267 novel mechanism by which ketamine exerts its therapeutic effects on stress-induced cognitive dysfunct
268 of small diameter afferent nerve fibres and therapeutic effects on the associated visceral organs, w
269 t (5 weeks) only produced very limited or no therapeutic effects on the autistic and cognitive phenot
270 nducible deletion of IL-4Ralpha demonstrated therapeutic effects, on established allergic airway dise
273 f continuous treatment is required to elicit therapeutic effects, prolonging the period of depression
276 Moreover, transplantation does not exert therapeutic effects solely by restoring wild-type circui
277 ent of inflammatory diseases would produce a therapeutic effect superior to global inhibition of pros
278 In addition to potentially achieving greater therapeutic effects than the respective monotherapies, t
279 preparations show antidepressant activity, a therapeutic effect that has been linked to hippocampal n
280 ne-regulating compound acivicin, with potent therapeutic effects that decrease oxidative stress and a
282 warrant further investigation to examine the therapeutic effects that STN HFS may have on relapse in
283 ty of HU may significantly contribute to its therapeutic effects, the underlying mechanisms remain po
284 ion maxima in NIR region, and showed similar therapeutic effect to gemcitabine but at one-third the m
285 monstrate that VEGFCc156s had a multifaceted therapeutic effect to prevent angiotensin II-induced car
286 DNA replication, and mitosis display similar therapeutic effects to ionizing radiation on cancer cell
289 t of depressive disorders, which may exert a therapeutic effect via functional changes within the bra
290 ental periodontitis was induced in vivo, and therapeutic effect was evaluated with microcomputed tomo
291 n-small cell lung cancer (N = 14), where the therapeutic effect was measured by pathologic assessment
292 r the Fc domain of HJ8.5 is required for the therapeutic effect, we engineered single-chain variable
297 ight dose (50 J/cm(2)) produced an excellent therapeutic effect with profound tumor regression and lo
298 arget enables the possibility of an enhanced therapeutic effect with reduced off-target toxic side ef
299 enuated eGFR decline between 4 and 48 weeks (therapeutic effect) with higher doses of selonsertib.
300 r the development of biopharmaceuticals with therapeutic effects within the central nervous system.