ライフサイエンスコーパス: therapeutic efficacy

1 e balance between absence of BM toxicity and therapeutic efficacy.

2 rotein-drug conjugates plays a major role in therapeutic efficacy.

3 ]hu11B6-IgG(1) but offered no improvement of therapeutic efficacy.

4 ework that imaging is a robust surrogate for therapeutic efficacy.

5 in order to monitor disease progression and therapeutic efficacy.

6 umors is recognized as a limiting factor for therapeutic efficacy.

7 profound impact on their immunogenicity and therapeutic efficacy.

8 the heterogeneity of RBC health and improve therapeutic efficacy.

9 ular devices, improving their diagnostic and therapeutic efficacy.

10 umulation in the targeted site, and enhanced therapeutic efficacy.

11 to improve 5FU-nanocarrier compatibility and therapeutic efficacy.

12 oxic effects of chemotherapy while enhancing therapeutic efficacy.

13 clinical studies are required to demonstrate therapeutic efficacy.

14 dies for functional studies and for improved therapeutic efficacy.

15 minimizing nephrotoxicity while maintaining therapeutic efficacy.

16 vivo exposure and tolerability while driving therapeutic efficacy.

17 monitoring disease progression or evaluating therapeutic efficacy.

18 an propagate antitumoral immunity to augment therapeutic efficacy.

19 xaliplatin after long-term use, limiting its therapeutic efficacy.

20 tural history of orthotopic colon cancer and therapeutic efficacy.

21 nt antibodies, and can be used for improving therapeutic efficacy.

22 quires T cell migration from lymph nodes for therapeutic efficacy.

23 reatment goal and to long-term monitoring of therapeutic efficacy.

24 d can lead to self-quenching and sub-optimal therapeutic efficacy.

25 findings serve as noninvasive indicators of therapeutic efficacy.

26 ventricular tissues exhibit widely scattered therapeutic efficacy.

27 ior readouts of drug mechanism of action and therapeutic efficacy.

28 overy of new druggable targets with improved therapeutic efficacy.

29 line levels, whereas LC lesions suppress VNS therapeutic efficacy.

30 h other targeted immunotherapies to increase therapeutic efficacy.

31 t there is a paucity of data identifying its therapeutic efficacy.

32 affinity to human receptors and enhance its therapeutic efficacy.

33 er siRNAs in vivo, and none has demonstrated therapeutic efficacy.

34 ted at these autoimmune processes could have therapeutic efficacy.

35 the AAV capsid protein can, however, affect therapeutic efficacy.

36 ic molecules can improve bioavailability and therapeutic efficacy.

37 alteration is often insufficient to predict therapeutic efficacy.

38 py will likely be required to impart durable therapeutic efficacy.

39 ultiple copies of disease-associated RNA and therapeutic efficacy.

40 eve high local drug concentrations with good therapeutic efficacy.

41 osomes, which can significantly impair their therapeutic efficacy.

42 therapy in HCC, and if so, if it impacts the therapeutic efficacy.

43 er quantitative muscle ultrasound can detect therapeutic efficacy.

44 es display sufficient targeted receptors for therapeutic efficacy.

45 s and create a modified BoNT/B with improved therapeutic efficacy.

46 stability (short half-life) has hindered its therapeutic efficacy.

47 superior gene editing approaches to improve therapeutic efficacy.

48 onals that exploit FcRn functions to enhance therapeutic efficacy.

49 eptide from plasma degradation and improving therapeutic efficacy.

50 onitoring disease progression and evaluating therapeutic efficacy.

51 and GR inhibitors could provide synergistic therapeutic efficacy.

52 e United States due to its broad spectrum of therapeutic efficacy.

53 ct since these variables can markedly affect therapeutic efficacy.

54 l combination therapies that may enhance its therapeutic efficacy.

55 ion for clinical prognosis and monitoring of therapeutic efficacy.

56 ines delivery should be conquered for strong therapeutic efficacy.

57 ction severity and reduces immune modulating therapeutic efficacy.

58 ich personalized interventions have enhanced therapeutic efficacy.

59 ved hematological values without sacrificing therapeutic efficacy.

60 therapeutics can significantly influence the therapeutic efficacy.

61 eritoneally alongside ampicillin to test its therapeutic efficacy.

62 o or more pharmacological systems to enhance therapeutic efficacy.

63 ophenotypes with somatic alterations impacts therapeutic efficacy.

64 s that (at least in some settings) influence therapeutic efficacy.

65 d toxicities, and thereby enhancing a drug's therapeutic efficacy.

66 reagents enhances immune response alongside therapeutic efficacy.

67 To evaluate therapeutic efficacy, 2 groups of mice received the radi

68 cal use of Lipiodol as imaging biomarker for therapeutic efficacy after cTACE.

69 ARP inhibitors (PARPi) have shown remarkable therapeutic efficacy against BRCA1/2-mutant cancers thro

70 ve immune responses with both preventive and therapeutic efficacy against cancer.

71 but the impact of intestinal transporters on therapeutic efficacy against enteric diseases has not be

72 exacerbating replication stress and enhances therapeutic efficacy against homologous recombination (H

73 CRISPR-Cas9/gRNA exhibits therapeutic efficacy against latent human immunodeficien

74 icient CD8(+) T cells show markedly improved therapeutic efficacy against mouse models of melanoma an

75 g nanoparticles (uPtDs NPs) and tested their therapeutic efficacy against TNBC metastasis.

76 inhibition and dexamethasone treatment share therapeutic efficacies and establishes interleukin-1 sig

77 As a result, they can improve therapeutic efficacies and reduce side effects of antica

78 These PTX/MTAs show excellent therapeutic efficacy and biosafety in 4 T1 xenograft mou

79 ssion and severe toxicity still hinder their therapeutic efficacy and broad applicability.

80 s in which genetic engineering could enhance therapeutic efficacy and install novel cellular function

81 xorubicin-loaded (D)CDX-RBCNPs have superior therapeutic efficacy and markedly reduced toxicity as co

82 of these prodrugs may further improve their therapeutic efficacy and minimize the off-target adverse

83 ered through topical instillation limits its therapeutic efficacy and poses a challenge for potential

84 We aimed to determine the therapeutic efficacy and potential mechanism of action o

85 Their therapeutic efficacy and preliminary toxicology profiles

86 -Syt II may improve botulinum neurotoxin B's therapeutic efficacy and reduce adverse effects.

87 f chemotherapy at the tumor site can improve therapeutic efficacy and reduce systemic toxicity.

88 ns and T cells in NSCLC is needed to improve therapeutic efficacy and reduce toxicity with immunother

89 To achieve a sustained therapeutic efficacy and reduced toxicities, macromolecu

90 Drug combinations, offering increased therapeutic efficacy and reduced toxicity, play an impor

91 red therapeutic agents to MM cells improving therapeutic efficacy and reducing side effects in vivo.

92 macromolecular prodrugs with the most potent therapeutic efficacy and safety for the management of in

93 sonalized treatment strategies that maximize therapeutic efficacy and safety.

94 avir and lamivudine demonstrated noninferior therapeutic efficacy and similar tolerability compared t

95 (TME), and profoundly affect drug delivery, therapeutic efficacy and the emergence of drug and radio

96 translate into interventions for prevention, therapeutic efficacy and toxic effects to enhance health

97 e highlight clinical trials that demonstrate therapeutic efficacy and toxicities associated with each

98 Therapeutic efficacy and tumor necrosis area were compar

99 als, with efficient transport, low cost, and therapeutic efficacy, and they can act as antibiotic pot

100 with foam was quantified as an indicator of therapeutic efficacy, and was correlated with foam physi

101 Here, we discuss how drug delivery and therapeutic efficacy are greatly hindered by barriers pr

102 eutic mAbs that require FcgammaR binding for therapeutic efficacy are now frontline treatments for mu

103 Hence, strategies targeting an increased therapeutic efficacy are urgently needed.

104 ddition, HS showed a significantly prolonged therapeutic efficacy as compared to N-acetylcysteine.

105 ith a more advanced disease revealed reduced therapeutic efficacy, as compared to younger males.

106 itative PET or MRI metrics in the context of therapeutic efficacy assessments with integrated PET/MRI

107 Obtaining therapeutic efficacy at a low cell dose in the microgel

108 vides localized delivery in order to enhance therapeutic efficacy at the site of action.

109 isomers might contribute differently to the therapeutic efficacy because of the variation in conjuga

110 se width, amplitude, and frequency predicted therapeutic efficacy better than frequency alone.

111 We sought to enhance drug delivery and therapeutic efficacy by remodeling the dense extracellul

112 umor proliferation, can efficiently maximize therapeutic efficacy, decrease drug dosage, and reduce d

113 That is, females exhibit superior therapeutic efficacy, defined as extended periods of abs

114 icles for liver-targeted gene transfer, with therapeutic efficacy demonstrated in preclinical models

115 er the noncovalent wild-type PD-1, attaining therapeutic efficacy equivalent or superior to anti-PD-L

116 we observed normal protrusion formation and therapeutic efficacy following disruption of anti-inflam

117 These results provide in vivo evidence of therapeutic efficacy for a selective pharmacological TRP

118 Therapeutic efficacy for advanced or metastatic melanoma

119 -PD-L1 immune checkpoint blockade to enhance therapeutic efficacy for human cancers.

120 IL-2 has been shown to have therapeutic efficacy for immune diseases by preferential

121 ase responsible for this cap-snatching shows therapeutic efficacy for the treatment of influenza.

122 These results demonstrate clinical therapeutic efficacy from gene therapy for ADA-deficient

123 clinical trial endpoint metrics to determine therapeutic efficacy have not been identified.

124 logical checkpoints, to achieve major cancer therapeutic efficacy, IL-15 will be used in combination

125 gG1 ab1 also exhibited high prophylactic and therapeutic efficacy in a hamster model of SARS-CoV-2 in

126 2 mg/kg and exhibited high prophylactic and therapeutic efficacy in a hamster model of SARS-CoV-2 in

127 nsights to generate an EcN strain that shows therapeutic efficacy in a mouse model of phenylketonuria

128 anti-PD1/PD-L1 have demonstrated significant therapeutic efficacy in a subset of patients partly thro

129 biosynthesis, together with AKT, could have therapeutic efficacy in a subset of T-ALL patients.

130 The emulsion polyplexes showed promising therapeutic efficacy in ALI and in early fibrinogenic st

131 ties of these important cells and test their therapeutic efficacy in animal models of neurological di

132 n to boost anti-tumor immunity(4), exhibited therapeutic efficacy in APOE4 mice but not in APOE2 mice

133 he immune compartment to sustain and improve therapeutic efficacy in cancer.

134 gent that shows selective HK2 inhibition and therapeutic efficacy in cell culture and in animal model

135 trials and that this agent shows promise of therapeutic efficacy in children with Proteus syndrome.

136 cological inhibition has been shown to exert therapeutic efficacy in chronic obstructive pulmonary di

137 ker classification and for the evaluation of therapeutic efficacy in clinical trials.

138 SH encapsulation significantly enhanced its therapeutic efficacy in controlling mouse melanoma (8-fo

139 y similar "molecular phenotypes" may improve therapeutic efficacy in COPD.

140 a (ERalpha) leading to enhanced anti-hormone therapeutic efficacy in ERalpha-negative breast cancer.

141 As conventional models fail to predict therapeutic efficacy in GBM, in vitro 3D models of GBM a

142 etics, and drug delivery, while also showing therapeutic efficacy in GIST-bearing xenograft mice foll

143 terruption (ATI) have been used to determine therapeutic efficacy in HIV cure trials; however, such d

144 diagnostic tests and the lack of evidence of therapeutic efficacy in intervening in patients with asy

145 the metallo-complex Cu(II)(atsm) tested for therapeutic efficacy in mice expressing SOD1(G93A) on a

146 d in vitro, characterized, and evaluated for therapeutic efficacy in mice subjected to MI.

147 llular levels, and PAD inhibitors have shown therapeutic efficacy in mouse models of inflammatory art

148 ts, as well as agonists of FGFR3, have shown therapeutic efficacy in mouse models of spontaneous and

149 ibition provides an opportunity for improved therapeutic efficacy in MPNs and in other malignancies d

150 hibits castration-resistant PCa and exhibits therapeutic efficacy in pre-established tumors.

151 cted T lymphocytes (CAR T cells) show modest therapeutic efficacy in solid tumors.

152 g as a potentially valuable tool for gauging therapeutic efficacy in the disorder.SIGNIFICANCE STATEM

153 and the MAP kinase pathway provided enhanced therapeutic efficacy in the in vivo models of MPN.

154 a(7) antibody administration did not provide therapeutic efficacy in the model of pathogenic SIVmac25

155 Here, we evaluated T(reg) engraftment and therapeutic efficacy in the nonobese diabetic (NOD) mous

156 will form the basis of future assessments of therapeutic efficacy in this large animal disease model.

157 The small molecule remdesivir showed therapeutic efficacy in this Marburg virus disease model

158 To achieve robust therapeutic efficacy in this multifactorial pathology, c

159 manipulating the immune response to enhance therapeutic efficacy in TNBC.

160 We show that ENb-TRAIL has therapeutic efficacy in tumor cells from different cance

161 for further investigation of pitavastatin's therapeutic efficacy in tumor-induced bone loss, as well

162 of GCN2 phenocopies eIF2B5 depletion and has therapeutic efficacy in tumour organoids, which demonstr

163 We reveal the compound's therapeutic efficacy in various models, including a clin

164 on the thermosensitivity of LTSLs and their therapeutic efficacy in vitro and in vivo.

165 ment were favorable for both cell types, the therapeutic efficacy in vivo was remarkably different.

166 in a broad spectrum of cancer types and has therapeutic efficacy in vivo.

167 inical study, we investigated the protective therapeutic efficacy, in the guinea pig model of recurre

168 dely used chemotherapeutic drug, but limited therapeutic efficacy is achieved due to chemoresistance.

169 Therapeutic efficacy is associated with increases in the

170 However, their therapeutic efficacy is presumably decreased by their en

171 ministered before hearing onset, after which therapeutic efficacy is significantly diminished or lost

172 arly detection of relapse and for monitoring therapeutic efficacy may have a huge impact on risk stra

173 gonist immunotherapies resulting in superior therapeutic efficacy.MEK inhibition in breast cancer is

174 The therapeutic efficacy might be further increased by pepti

175 hnologies are ineffective at maintaining the therapeutic efficacies of drugs in space.

176 o assess the biodistribution, dosimetry, and therapeutic efficacy of (19)F/(177)Lu-rhPSMA-7.3 in comp

177 d compare the tumor-targeting properties and therapeutic efficacy of (213)Bi and (177)Lu for PRIT of

178 This 6-week trial demonstrated therapeutic efficacy of 40 mg/day F17464 in improving sy

179 Here we report the comparative study of the therapeutic efficacy of a bnAb in acutely and chronicall

180 H constitutes a framework for predicting the therapeutic efficacy of a GRI candidate from its user-sp

181 This study sought to determine the therapeutic efficacy of a re-engineered adenoassociated

182 The therapeutic efficacy of a single 30-MBq dose of (19)F/(1

183 Second, we compared the therapeutic efficacy of a single high activity vs. fract

184 In this study we have explored the therapeutic efficacy of adeno-associated viral vector-me

185 patibility complex mismatch, we compared the therapeutic efficacy of adoptively transfer Treg with or

186 found impact on the biological functions and therapeutic efficacy of antibodies.

187 diseases to study autophagy and evaluate the therapeutic efficacy of autophagy inducers in neuronal c

188 Methods: We have compared the potential therapeutic efficacy of beta- versus alpha-emitter radio

189 large cohort of pSS patients and tested the therapeutic efficacy of BMP signaling inhibitors in two

190 ration and regeneration and to establish the therapeutic efficacy of candidate neuroregenerative trea

191 implicated in BAD, and support the potential therapeutic efficacy of CFTR inhibition in bile acid-ass

192 nally, inducible IDH2 knockdown enhanced the therapeutic efficacy of CFZ in a subcutaneous xenograft

193 This leads to enhanced therapeutic efficacy of cGAMP, inhibition of tumour grow

194 self-tolerance is necessary to increase the therapeutic efficacy of checkpoint immunotherapy.

195 nificantly improve the tumor penetration and therapeutic efficacy of chemotherapeutics.

196 on of these vesicles could contribute to the therapeutic efficacy of CIMVs.

197 hat has proven to compensate for the reduced therapeutic efficacy of conventional chemotherapy.

198 The therapeutic efficacy of conventional transdermal drug de

199 Development of biomarkers assessing the therapeutic efficacy of corticosteroids is important.

200 However, the therapeutic efficacy of current JAK2 inhibitors is limit

201 ts for CTD mice, to longitudinally study the therapeutic efficacy of cyclocreatine (cCr) at the precl

202 In this study, the therapeutic efficacy of dinaciclib was assessed using pa

203 ss of thalidomide analogues demonstrates the therapeutic efficacy of drug-induced degradation of tran

204 noninvasive biomarker for assessments of the therapeutic efficacy of drugs targeting CFTR and provide

205 To test the therapeutic efficacy of echinomycin, we established a xe

206 sulted in stabilization of CIC and increased therapeutic efficacy of ERK inhibition in GBM models.

207 Following these experiments, the therapeutic efficacy of gas embolization was investigate

208 , this study is the first to demonstrate the therapeutic efficacy of gas embolotherapy in a tumor mod

209 However, the therapeutic efficacy of glycolysis inhibitors is limited

210 tant clinical parameters that may affect the therapeutic efficacy of HDAC inhibitors.

211 ent of novel antiviral agents to improve the therapeutic efficacy of IFN-alpha.

212 ffector T lymphocyte trafficking and improve therapeutic efficacy of immune checkpoint blockade in br

213 Pi as immunomodulatory agents to harness the therapeutic efficacy of immune checkpoint blockade.

214 masome by targeting TMEM176B may enhance the therapeutic efficacy of immune checkpoint blockers.

215 nst Listeria monocytogenes infection and the therapeutic efficacy of immune checkpoint inhibitors in

216 gated the immunogenicity, allergenicity, and therapeutic efficacy of laminarin-ovalbumin neoglycoconj

217 his study were to test the applicability and therapeutic efficacy of local, catheter-based delivery o

218 Inconsistent therapeutic efficacy of mesenchymal stem cells (MSCs) in

219 s the first evidence for the feasibility and therapeutic efficacy of miR-21 inhibition in a large ani

220 Finally, the superior therapeutic efficacy of MNDEBs was evaluated using an at

221 Inactivation of opioid receptors limits the therapeutic efficacy of morphine-like analgesics and med

222 herapy or combination therapy to improve the therapeutic efficacy of MPS IVA enzyme replacement thera

223 trasound parameters is needed to improve the therapeutic efficacy of MRgFUS and 5-ALA.

224 The therapeutic efficacy of MSCs has never been reported in

225 ays the groundwork for investigations on the therapeutic efficacy of MTP18 expression suppression dur

226 he diffusion, intratumoral distribution, and therapeutic efficacy of nanocarriers.

227 ts, provides a tool to accurately assess the therapeutic efficacy of new promising therapeutic interv

228 ing OT under opioid antagonism may boost the therapeutic efficacy of OT for enhancing social cognitio

229 erefore, we evaluated the immunogenicity and therapeutic efficacy of our MultiTEP platform-based vacc

230 blocking antibody significantly improved the therapeutic efficacy of paclitaxel by reducing tumor bur

231 erse chemoresistance and further enhance the therapeutic efficacy of paclitaxel in paclitaxel-resista

232 Furthermore, the therapeutic efficacy of PD-L1 checkpoint blockade is enh

233 The therapeutic efficacy of PEG-[SN22](4) to CPT-11 was comp

234 T/SIRT3/IDH2 pathway inhibition enhances the therapeutic efficacy of PI, thus providing compelling ev

235 inhibition, and a mechanistic basis for the therapeutic efficacy of PRMT inhibition in cancer.

236 ty, and effects on renal function as well as therapeutic efficacy of prostate-specific membrane antig

237 may be a beneficial approach to enhance the therapeutic efficacy of proteasome inhibitors.

238 Methods: Therapeutic efficacy of PSMA RLT was assessed by tumor v

239 dings offer candidate markers to monitor the therapeutic efficacy of psychostimulants or to predict t

240 y-induced upregulation of PD-L1 and augments therapeutic efficacy of radiation in vivo.

241 s of radiation response that may improve the therapeutic efficacy of radiation.

242 ctors-including PTPN2 and SOCS1-improves the therapeutic efficacy of REGNASE-1-deficient CD8(+) T cel

243 Here, we evaluated the therapeutic efficacy of remdesivir (GS-5734) in nonhuman

244 Further studies to test the therapeutic efficacy of ruxolitinib in CLL are warranted

245 his is the first study that demonstrates the therapeutic efficacy of simultaneously upregulating miR-

246 The aim of this study was to evaluate the therapeutic efficacy of site-specifically conjugated duo

247 s a potential adjunctive approach to improve therapeutic efficacy of SSRI antidepressants.

248 ce and electrophysiologic studies and on the therapeutic efficacy of targeted catheter ablation and m

249 Here we demonstrate therapeutic efficacy of targeting FAO in clinical prosta

250 Finally, our results highlight the potential therapeutic efficacy of targeting the alpha4-alpha5 dime

251 ong mechanistic rationale to investigate the therapeutic efficacy of targeting the MALT1-MYC axis in

252 xperiments demonstrated the prophylactic and therapeutic efficacy of the AAV-IFN-alpha or AAV-IFN-alp

253 We also demonstrate that the therapeutic efficacy of the anti-OPG antibody approach i

254 arepvec on cytotoxic T cell infiltration and therapeutic efficacy of the anti-PD-1 antibody pembroliz

255 Extinction of residual HR might improve the therapeutic efficacy of the emerging inhibitors of DNA d

256 ombination strategies to further enhance the therapeutic efficacy of the PORCN inhibitor ETC-159.

257 antitumoral immune effects could enhance the therapeutic efficacy of the proposed combination therapy

258 can improve the tissue penetration and thus therapeutic efficacy of these biologics.

259 ovided scientific evidence for the potential therapeutic efficacy of these medicinal plants in the Gr

260 ch as transcranial magnetic stimulation, the therapeutic efficacy of these technologies remains subop

261 Here, we compared the therapeutic efficacy of these two modification chemistri

262 initiation of clinical trials to assess the therapeutic efficacy of this oligomer for those patients

263 20FMDV2 as a targeting moiety for L-ALD, the therapeutic efficacy of this therapy can be increased in

264 The onset of therapeutic efficacy of traditional antidepressants is d

265 With the final aim of testing the therapeutic efficacy of UCB in MPS-I mice transplanted a

266 Main aim of this trial was to assess if the therapeutic efficacy of UDCA manufactured by the univers

267 SARS-CoV-2, in light of emerging data on the therapeutic efficacy of various repurposed antimicrobial

268 sed neurofeedback protocol and evaluated its therapeutic efficacy on nicotine addiction.

269 to determine whether opioid antagonists have therapeutic efficacy on positive, negative, total, or ge

270 their effects post-radiation could increase therapeutic efficacy. Our integrated analysis provides a

271 ocking by anti-PD1 antibodies, and increased therapeutic efficacy over anti-PD1 in mouse tumour model

272 rm, local wound healing agents with superior therapeutic efficacy over wildtype hMSCs in the diabetic

273 To improve therapeutic efficacy, polymer drug conjugates carrying s

274 (+) cells in vivo abrogated the retention of therapeutic efficacy postdiscontinuation of treatment, i

275 boptimal photothermal conversion and limited therapeutic efficacy remain the major challenges for NIR

276 use in the clinic to assess tumor status and therapeutic efficacy.See related article by Ron et al.,

277 ites of interest, it is possible to increase therapeutic efficacy significantly while simultaneously

278 expression levels, and to confer exceptional therapeutic efficacy suggests that CD40 is a central dis

279 ibution to infected organs and in a superior therapeutic efficacy than the free drug.

280 mor models in mice, the variants show higher therapeutic efficacy than the parent ADC and a clinicall

281 been suggested as a more pertinent metric of therapeutic efficacy than the traditionally used affinit

282 ogical late sodium current may provide added therapeutic efficacy to beta-blocker therapy.

283 o identify signaling pathways underlying CB2 therapeutic efficacy to identify appropriate indications

284 ting levels that correlated with significant therapeutic efficacies, using either the mouse peritonit

285 s of cellular interaction, proliferation and therapeutic efficacy via spatiotemporal monitoring and s

286 Therapeutic efficacy was assessed by tumor volume measur

287 Drug therapeutic efficacy was evaluated in vitro by monitorin

288 Therapeutic efficacy was monitored by tumor volume measu

289 Immunogenicity and therapeutic efficacy were analyzed in BALB/c mice.

290 Its epidermal delivery and therapeutic efficacy were evaluated alongside PNA-specif

291 Clinical safety and therapeutic efficacy were evaluated in a phase II study.

292 Importantly, multiple lines of evidence for therapeutic efficacy were observed including: diminished

293 understanding of the effect of lipidation on therapeutic efficacy, where increased research and devel

294 larities in males and females underlie early therapeutic efficacy, whereas these posttreatment sex di

295 ous or sequential drug treatment has maximal therapeutic efficacy, which is based on a mechanistic ra

296 of H(2) O(2) for enhancing the nanocatalytic-therapeutic efficacy, which successfully achieves a rema

297 for these differences to increase chances of therapeutic efficacy while minimizing risk of adverse ef

298 Combination therapy has shown to improve therapeutic efficacy while reducing side effects.

299 prodrug delivery and activation for enhanced therapeutic efficacy with low side toxicity.

300 and payload combination, to achieve maximal therapeutic efficacy without excessive toxicity, present