ライフサイエンスコーパス: therapeutic index

1 e targets, which potentially compromises its therapeutic index.

2 drug biocompatibility, and improves the drug therapeutic index.

3 e insulin-sensitizing efficacy with improved therapeutic index.

4 A) before being abandoned because of its low therapeutic index.

5 uded in combination chemotherapy to increase therapeutic index.

6 g/kg or higher), providing a relatively high therapeutic index.

7 iding a remarkable improvement in the drug's therapeutic index.

8 ent and selective siRNA carriers with a wide therapeutic index.

9 fic distribution, systemic toxicity, and low therapeutic index.

10 specific targeting are needed to enhance its therapeutic index.

11 towards developing compounds with a maximal therapeutic index.

12 st the same cells, thereby displaying a high therapeutic index.

13 ccentuated antitumor efficacy along with the therapeutic index.

14 a targeted strategy likely to have a useful therapeutic index.

15 as a potential solution for improving their therapeutic index.

16 their GVHD activity, leading to an improved therapeutic index.

17 of drug delivery systems to achieve a better therapeutic index.

18 and low cytotoxicity, giving a markedly high therapeutic index.

19 onoclonal antibody (mAb) therapy with a safe therapeutic index.

20 rotection of patients and the improvement of therapeutic index.

21 rovides a remarkable improvement in the drug therapeutic index.

22 esulted in a conjugate (25) with an improved therapeutic index.

23 olerated similarly, thus showing an improved therapeutic index.

24 ss than two, which accords with its clinical therapeutic index.

25 arkers predictive of benefit may enhance its therapeutic index.

26 DNA gap resulted in dramatic improvements in therapeutic index.

27 MM cell lines tested, suggesting a favorable therapeutic index.

28 ively high cytotoxicity, resulting in narrow therapeutic index.

29 rahepatic tissues and thereby to improve the therapeutic index.

30 tability and aqueous solubility and a larger therapeutic index.

31 resistance genes and increase the antibiotic therapeutic index.

32 oduct in the hopes of optimizing potency and therapeutic index.

33 for the activated form could provide a high therapeutic index.

34 tive to extrahepatic tissues and an improved therapeutic index.

35 a drug class associated with an unacceptable therapeutic index.

36 with improved properties, including a higher therapeutic index.

37 unities exist for further enhancement of the therapeutic index.

38 ibit in each cancer to maximize efficacy and therapeutic index.

39 roach to lung cancer growth with a favorable therapeutic index.

40 acid 4 had the best profile with respect to therapeutic index.

41 n of this compound to rationally improve its therapeutic index.

42 efficacy and have the potential for improved therapeutic index.

43 permit therapeutic targeting with favorable therapeutic index.

44 f the TRAIL receptor may provide an enhanced therapeutic index.

45 controlled as well, in order to maximize the therapeutic index.

46 is a promising anticancer target with a high therapeutic index.

47 e dual EGFr/erbB2 inhibitors in efficacy and therapeutic index.

48 dulation of irinotecan by Cs may improve its therapeutic index.

49 nerabilities of tumor cells while maximizing therapeutic index.

50 ormal-tissue ratios that predict an improved therapeutic index.

51 However, 361 demonstrated a narrow therapeutic index.

52 as selective GR modulators with an improved therapeutic index.

53 c effects will help design GCs with a better therapeutic index.

54 present a general strategy to increase their therapeutic index.

55 somal selectivity, predictive of an enhanced therapeutic index.

56 ng to reduced systemic toxicity and improved therapeutic index.

57 eatment of invasive brain tumors due to poor therapeutic index.

58 ents, but its utility is limited by a narrow therapeutic index.

59 chemical modifications dramatically improves therapeutic index.

60 quired drug resistance with a more favorable therapeutic index.

61 bitor, BI6727, suggesting a potentially good therapeutic index.

62 owever, its utility is limited by its narrow therapeutic index.

63 al bone marrow cells, suggesting a favorable therapeutic index.

64 milar to full mGlu5 NAMs, but with a broader therapeutic index.

65 elivery can improve pharmacokinetics and the therapeutic index.

66 corticosteroids) have a relatively favorable therapeutic index.

67 ecent years and the current drugs have a low therapeutic index.

68 entification of LXR modulators with improved therapeutic indexes.

69 ar M. tuberculosis MIC values and acceptable therapeutic indexes.

70 ith both target inhibition bias and improved therapeutic indexes.

71 isplatin chemotherapy regimens with improved therapeutic indexes.

72 ng glioma lines and xenografts with improved therapeutic index, a finding with potential translationa

73 We used the IMS Health National Disease and Therapeutic Index, a nationally representative audit of

74 Also, substantial advances in therapeutic index achieved with modern targeted radionuc

75 xidized forms of a sulfur atom, display high therapeutic indexes against several reference Hp strains

76 inical characterization suggests an adequate therapeutic index, aided by low projected human oral pha

77 dermatologists from the National Disease and Therapeutic Index (an IMS Health Incorporated database)

78 This novel molecule demonstrated an improved therapeutic index (analgesia vs adverse effects) in rode

79 monly prescribed anticoagulant with a narrow therapeutic index and a large variation in individual do

80 Warfarin is a drug with a narrow therapeutic index and a wide interindividual variability

81 serum albumin (HSA) may demonstrate a higher therapeutic index and be suitable for treatment of PCa b

82 a tailored approach would maximize both the therapeutic index and cost-effectiveness of treatments.

83 ck liposomal delivery systems to improve the therapeutic index and decrease systemic toxicity.

84 l adrenal hyperplasia (CAH) but has a narrow therapeutic index and dose optimisation is challenging.

85 The improved therapeutic index and elimination of corticosteroid prem

86 n, and pravastatin showed the most favorable therapeutic index and enhanced the antitubercular activi

87 ers has the potential to improve further the therapeutic index and extend the spectrum of clinical PD

88 model predicts that they would have a higher therapeutic index and greater antitumour activity than m

89 This selectivity may lead to a broader therapeutic index and help explain the greater antitumor

90 We propose that ormeloxifene has high therapeutic index and in a combination therapy with gemc

91 ndence, leading to a narrowing of the drug's therapeutic index and increased side effects.

92 However, concerns associated with its narrow therapeutic index and its concentration-dependent mechan

93 is a widely used anticoagulant with a narrow therapeutic index and large interpatient variability in

94 hort path length, potentially increasing the therapeutic index and making them an attractive alternat

95 inhibition of NF-kappaB may have a superior therapeutic index and may constitute a viable therapeuti

96 h MCL1 antagonists in melanoma could improve therapeutic index and patient outcomes.

97 The available ICSs vary in their therapeutic index and potency.

98 ibition of ERK signalling results in a broad therapeutic index and RAF inhibitors have remarkable cli

99 ic agents is an important way to improve the therapeutic index and reduce side effects.

100 These factors contribute to a beneficial therapeutic index and support continued clinical develop

101 mib nanoparticles that demonstrates improved therapeutic index and the potential to improve patient o

102 Warfarin has a narrow therapeutic index and there is wide interindividual vari

103 prepare material to determine their relative therapeutic index and to gain an oversight as to their p

104 ivity profile that may result in an improved therapeutic index and, consequently, better clinical eff

105 t that deferred renal dose reduction of wide therapeutic index antibiotics could improve outcomes in

106 le in human plasma for more than 24 h with a therapeutic index approaching 30000.

107 o group of patients for whom agents of lower therapeutic index are appropriate first-choice antiemeti

108 novel inhibitors of autophagy with a better therapeutic index are needed.

109 th remarkably low cell-toxicity and improved therapeutic indexes as shown by the LC(50) to IC(50) rat

110 nsfer vectors may allow improvement of their therapeutic index, as lower doses can be administered to

111 ly improved potency, working toward a higher therapeutic index at the earliest stages of drug develop

112 and sold as racemates can exhibit a limited therapeutic index because of side effects resulting from

113 approaches that could maximally exploit the therapeutic index between tumor cells and normal tissues

114 n vivo conversion of CPT-11 and increase the therapeutic index, bifunctional derivatives of SN-38 wer

115 Illudins have a low therapeutic index, but acylfulvene derivatives display p

116 nt of patients with cancer could improve the therapeutic index by allowing better individualisation o

117 ounds to particular cell subsets can enhance therapeutic index by concentrating their action on the c

118 ing tumors that have lost RB1, and expanding therapeutic index by mitigating therapy-associated adver

119 at it may be possible to achieve an improved therapeutic index by selectively targeting subsets of th

120 s over oral therapies in terms of increasing therapeutic index, by maximizing drug delivery to cartil

121 hibitor of HCV (EC50 = 4.6 nM), with greater therapeutic index (CC50/EC50 > 10000).

122 compound 9 was >100 muM, corresponding to a therapeutic index (CC50/EC50) of approximately 100.

123 the GEMCAP combination does not improve the therapeutic index compared to GEM alone.

124 ide range of cancer cells, with a favourable therapeutic index compared to non-transformed cells.

125 Thus, this compound has a much wider therapeutic index compared with that of the existing ant

126 the ID regimen has a significantly improved therapeutic index compared with the CD regimen.

127 gh variability in drug response and a narrow therapeutic index complicate warfarin therapy initiation

128 ts level of myelotoxicity indicates that the therapeutic index could be altered by changing the metho

129 to that of wild-type Ad5, thus enhancing the therapeutic index (cytotoxicity in tumor cells versus th

130 tail pharmacies and the National Disease and Therapeutic Index database provided data on patient visi

131 y effectiveness and rational improvements in therapeutic index depend on understanding the mechanism.

132 position that bioequivalence for the narrow therapeutic index drug tacrolimus translates from health

133 that the criteria for registration of narrow therapeutic index drugs are going to change, and bioequi

134 ting that during meropenem treatment, narrow therapeutic index drugs metabolized by these CYPs requir

135 Agency (EMA) acceptance criteria for narrow therapeutic index drugs were also met, with the only exc

136 Among narrow therapeutic index drugs, clinical equivalence was report

137 and for selecting dosing regimens for narrow-therapeutic-index drugs.

138 The enhanced therapeutic index due to folate conjugation was also evi

139 These drugs have a poor therapeutic index due to toxicity caused by additional e

140 Cardiovascular drugs with narrow therapeutic indexes (e.g., antiarrhythmic agents, antico

141 ned the first anti-CXCR4 ADC with favourable therapeutic index, effective in xenografts of haematopoi

142 olite, exhibiting reduced toxicity, improved therapeutic index, enhanced pharmacodynamic effect, and

143 orted the long duration of action and a wide therapeutic index following administration to the lung,

144 icient breast cancers and shows a favourable therapeutic index for a novel targeted treatment strateg

145 fferentiated neurons, suggesting a potential therapeutic index for anticancer therapy.

146 rovides a remarkable improvement in the drug therapeutic index for cancer, Alzheimer's disease, and o

147 cells supports a mitochondrial basis to the therapeutic index for chemotherapy.

148 boronic ester bond formation to enhance the therapeutic index for improved patient outcome.

149 tions studies in diabetic minipigs, a higher therapeutic index for MK-2640 (threefold) was observed v

150 phase clinical trials have demonstrated good therapeutic index for oncolytic adenoviruses in patients

151 delivery (CED) of liposomes may improve the therapeutic index for targeting brain tumors, we conduct

152 n cell line revealed an encouraging in vitro therapeutic index for the most active compounds.

153 e a more straightforward path to an improved therapeutic index for this clinically vital but also hig

154 encies, suggesting the possibility of a wide therapeutic index for use of Taspase1 inhibitors in canc

155 cord, concerns remain for approval of narrow therapeutic index generic immunosuppressants, such as ta

156 omolar anti-HIV potencies, with advantageous therapeutic indexes going close to those of the clinical

157 established BCL xenografts leading to cures (therapeutic index > 10).

158 iviral activity against HIV-1 and HBV with a therapeutic index >100000 for our most potent conjugate.

159 ivo to produce agents with a relatively wide therapeutic index (>500) in rodents.

160 otent antibacterial agent with low toxicity (Therapeutic Index>200).

161 among individuals and for the existence of a therapeutic index has remained obscure.

162 Improvements in the therapeutic index have been based mainly on physical imp

163 r validating new anticancer drugs, assessing therapeutic index, identifying surrogate markers of tumo

164 y bioequivalence testing approach for narrow therapeutic index immunosuppressants in transplant recip

165 , and all SSTR2-expressing organs; thus, the therapeutic index improved considerably.

166 response to CIRT, i.e., CIRT may show a high therapeutic index in EGFR mutation-negative NSCLC.

167 log of ABT-737, navitoclax, has shown a high therapeutic index in lymphoid malignancies; developing a

168 ed on day 1, demonstrates the most favorable therapeutic index in patients with advanced NSCLC.

169 This intervention serves to enhance the therapeutic index in relapsed/refractory patients and pr

170 ns may provide the biochemical basis for the therapeutic index in response to flavopiridol.

171 o PMB in vivo, suggesting a lack of improved therapeutic index in spite of apparent in vitro advantag

172 with certain HDAC inhibitors may elevate the therapeutic index in the treatment of hematologic malign

173 emcitabine and PLD seem to have a comparable therapeutic index in this population of Pt-R taxane-pret

174 vitro toxicity assay, and showed an improved therapeutic index, in comparison to the parent drug, MTM

175 identification of targeted agents with high therapeutic index is a major challenge for cancer drug d

176 tion of specific neural circuits to optimize therapeutic index is an unrealized goal in neurology and

177 The challenge of achieving an optimal therapeutic index is especially augmented in the elderly

178 d receptor (GR) modulators with an increased therapeutic index is impelling.

179 The enzymatic therapeutic index is only 42 in favoring inhibition of t

180 toxicity suggests that an improvement in the therapeutic index is required.

181 One approach to improving IFN-alpha's therapeutic index is to increase its half-life and tumor

182 terogenous conjugates with relatively narrow therapeutic index (maximum tolerated dose/curative dose)

183 These results suggest that a positive therapeutic index may be generated for other drug combin

184 n replication was approximately 5 nM, with a therapeutic index of >10,000.

185 subcutaneous metrazol (scMET) models with a therapeutic index of 10 for MES activity.

186 ld have significant utility in expanding the therapeutic index of a range of clinical and preclinical

187 may be an effective strategy to enhance the therapeutic index of abdominal radiotherapy, with potent

188 eavable linkers are unlikely to increase the therapeutic index of ADCs and that resistance based on l

189 In an effort to improve the therapeutic index of adefovir, 1-aryl-1,3-propanyl prodr

190 These findings imply that the therapeutic index of anthracycline cancer chemotherapeut

191 These findings indicate that the therapeutic index of anti-cancer drugs can be altered by

192 herapies, the data strongly imply a superior therapeutic index of anti-FcmuR CAR T cells for the trea

193 Multistep targeting can improve the therapeutic index of antibody-based targeting, particula

194 l (IP) administration can be used to improve therapeutic index of anticancer drugs used for PC treatm

195 uld potentially be exploited to increase the therapeutic index of anticancer treatments and thereby i

196 ivation of Wnt/STOP signaling to improve the therapeutic index of asparaginase.

197 The dramatically improved therapeutic index of bispecific antibody pretargeting ap

198 TLR5 agonists could potentially improve the therapeutic index of cancer radiotherapy and serve as bi

199 gies used to improve the bioavailability and therapeutic index of capsaicin are discussed in detail.

200 lectively to tumor cells, thus improving the therapeutic index of chemotherapeutic agents.

201 This increased delivery increases the therapeutic index of cisplatin and reduces side effects

202 ar permeability in the tumor to increase the therapeutic index of co-administered drugs.

203 nsport properties of albumin yet improve the therapeutic index of current in situ albumin-binding pro

204 lationship, leading to improvements upon the therapeutic index of current standard-of-care chemothera

205 t and selective agents should improve on the therapeutic index of currently used drugs.

206 nvironment have been explored to improve the therapeutic index of cytotoxic drugs.

207 The therapeutic index of DDCs was 2-3-fold higher than uncon

208 sed as a potential prodrug for improving the therapeutic index of Dox and potentially many other cyto

209 However, the therapeutic index of doxorubicin is undermined by dose-d

210 tic and colorectal cancer cells improved the therapeutic index of doxorubicin with C646 cotreatment.

211 IONS: This review provides evidence that the therapeutic index of drugs is narrowed during hypothermi

212 Systemic injection with iRGD improved the therapeutic index of drugs of various compositions, incl

213 t of novel anti-cancer agents and the narrow therapeutic index of existing drugs.

214 aintenance of tmTNF activity may improve the therapeutic index of future anti-inflammatory agents.

215 (ERBB2) signaling translated to an improved therapeutic index of hSGZ treatment.

216 To improve the therapeutic index of IFO, we have designed preactivated

217 nalysis is needed in order to understand the therapeutic index of imatinib in SSc.

218 o facilitate tumor detection and improve the therapeutic index of IPC for peritoneal carcinomatosis.

219 the addition of Apo2L/TRAIL can improve the therapeutic index of irinotecan against both p53-profici

220 The therapeutic index of L-alanosine can be increased by the

221 action and hold great promise to improve the therapeutic index of many drugs.

222 The therapeutic index of many medications, especially in chi

223 pies, both as a monotherapy and to widen the therapeutic index of MEK inhibitors.

224 selective replication levels to improve the therapeutic index of MV and other viruses in ongoing cli

225 Fever may therefore augment the therapeutic index of oncolytic viruses by inhibiting rep

226 0 could be a future target for improving the therapeutic index of opioid drugs.

227 alysis justify prospective evaluation of the therapeutic index of PCB regimen in elderly patients.

228 have the clinical potential to increase the therapeutic index of proton therapy.

229 c antigen targeting is likely to enhance the therapeutic index of rNDV owing to tumor-restricted repl

230 Summarizing, the therapeutic index of SERMs might be improved by this bif

231 SN-38 in plasma, which suggests an improved therapeutic index of SG.

232 as a drug delivery vehicle for improving the therapeutic index of SN-38, the active metabolite of iri

233 This approach may increase the therapeutic index of T cells engineered to express power

234 PNA enhances the therapeutic index of TEMPOL, and the recycling antioxida

235 e cells to circumvent MDR and to enhance the therapeutic index of the chemotherapy.

236 articular interest, as they may increase the therapeutic index of the cytokine payload.

237 ine to cobalamin is expected to increase the therapeutic index of the drug by limiting the side effec

238 To determine the factors governing the therapeutic index of the labeled MAb, as well as the fac

239 pha-therapy, it is necessary to increase the therapeutic index of the targeted radioligands.

240 test barrier to such treatment is the narrow therapeutic index of the vitamin K antagonists ([VKAs]:

241 cent advances hold promise for improving the therapeutic index of these anti-cancer drugs.

242 of CAR T cells can potentially increase the therapeutic index of these cells in solid tumors.

243 This resulted in a narrow therapeutic index of these drugs, limiting ability to do

244 rmediate as a means of addressing the narrow therapeutic index of these molecules.

245 The therapeutic index of this emerging modality is attenuate

246 The therapeutic index of V681 was improved 90- and 23-fold a

247 deleterious side effects, and increasing the therapeutic index of virotherapeutic agents.

248 Therapeutic indexes of 50-500 suggest significant cellul

249 anomolar and low micromolar lethal doses and therapeutic indexes of 500 and 75, respectively.

250 Some are novel bactericidal inhibitors with therapeutic indexes of 9, 38 and 12, significantly highe

251 er efficacy, decreased toxicity and improved therapeutic index over conventional anticancer therapies

252 abine followed by gefitinib may increase the therapeutic index over gemcitabine alone and, combined w

253 ts such as temozolomide, providing a natural therapeutic index over normal tissue.

254 108491 exhibited more than 270-fold improved therapeutic index over the naturally occurring VDR ligan

255 acy while providing a significantly improved therapeutic index over vasodilation (flushing) with resp

256 f next-generation inhibitors to optimise the therapeutic index, overcome drug resistance, and establi

257 agnosed glioblastoma (GBM) by increasing the therapeutic index, overcoming common mechanisms of temoz

258 ors and organs would be helpful in assessing therapeutic index, personalizing individual dose, and po

259 The enhanced therapeutic index provided by the addition of IFN-beta t

260 irst time, with the assay range matching the therapeutic index range.

261 ns in humans offers the potential to improve therapeutic index, reduce cost of therapy and support a

262 Insulin has a narrow therapeutic index, reflected in a small margin between a

263 Compound 2g displayed a good therapeutic index regarding free fatty acids (FFA) reduc

264 ic brain regions to potentially increase the therapeutic index relative to known non-TARP-dependent A

265 n inhibitors with improved HMGR affinity and therapeutic index relative to statin-induced myalgia.

266 ay improved potency over MOE and an improved therapeutic index relative to that of LNA antisense olig

267 ly to the site of action and may improve the therapeutic index required to overcome side effects.

268 odies after their infusion can enhance their therapeutic index, resulting in improved therapeutic and

269 RPS-072 therefore exhibits an increased therapeutic index, shows the potential to increase the d

270 yc4PG-14 and Tyc4PG-15, have a 6-fold better therapeutic index than the natural tyrocidine.

271 gical complications, RBC transfusion holds a therapeutic index that exceeds that of many common medic

272 While efficacy may be hampered by a narrow therapeutic index, the contribution of biologic heteroge

273 On the basis of their activity and favorable therapeutic indexes, these compounds were identified as

274 cell were also measured in order to assess a therapeutic index (TI) of selectivity.

275 Thus, the therapeutic index (TI) was >/= 10 for both compounds.

276 d classified as "pass" if a suitable in vivo therapeutic index (TI) was achieved for advancement into

277 (KB) cell line to enable an estimate of the therapeutic index (TI).

278 ivity with little or no motor impairment and therapeutic indexes (TI) of 2.8-44 (mice, ip) were obser

279 from 0.00032 to 0.0057 microM and remarkable therapeutic indexes (TI) ranging from 5.6 x 10(3) to 1.1

280 rticularly in children, achieving an optimal therapeutic index to avoid damage to normal tissue is ex

281 e ratios are noted, allowing for an improved therapeutic index to leptomeningeal disease and reduced

282 The 'translational therapeutic index' (TTI) is a drug's ratio of nonclinica

283 been approved on the basis of efficacy, the therapeutic index varies substantially in different sett

284 which demonstrated a significantly enhanced therapeutic index versus ciprofloxacin for the treatment

285 ne marrow) absorbed dose ratio, that is, the therapeutic index, was higher in the THW-aided than rhTS

286 at contribute to its anticancer activity and therapeutic index, we used lung cancer cell lines that a

287 To enhance DON's therapeutic index, we utilized a prodrug strategy to inc

288 dentification of GR ligands with an improved therapeutic index, we wished to discover selective nonst

289 To improve their therapeutic indexes, we have now identified and tested 1

290 , of which tumor accumulation, efficacy, and therapeutic index were enhanced 2, 7, and 10-fold, respe

291 APT-6K had a favorable therapeutic index when tested on eukaryotic cells (TI: >

292 y to normal cells should also provide a high therapeutic index when used in gene therapy protocols fo

293 exhibits characteristics predicting a higher therapeutic index with a greater potential to reach maxi

294 pplications such as imaging, determining the therapeutic index with antibody drug conjugates, and dos

295 Although Hsp90 inhibitors have a high therapeutic index with limited effects on normal cells,

296 decreasing hepatotoxicity and improving the therapeutic index with minimal impairment of antisense a

297 These results indicate an improved therapeutic index with pretargeted radioimmunotherapy (R

298 release within a tumour results in improved therapeutic index with reduced toxicity.

299 duce apoptosis of CLL cells with a favorable therapeutic index, with enhanced killing of genomically

300 trials to determine whether improvements in therapeutic index within KRAS versus BRAF preclinical mo