ライフサイエンスコーパス: therapeutic modality

1 e safety, efficacy and applicability of this therapeutic modality.

2 ncer, and radiation reactions may limit this therapeutic modality.

3 sing chemotherapy, as a potential definitive therapeutic modality.

4 fic down-regulation can serve as an improved therapeutic modality.

5 tention over the past few decades as a novel therapeutic modality.

6 % confidence interval, 0.29-0.48; P<0.00001) therapeutic modality.

7 mization and broader application of this new therapeutic modality.

8 sses established the broad potential of this therapeutic modality.

9 ration of (90)Y microspheres is an effective therapeutic modality.

10 cts of the tumor microenvironment limit this therapeutic modality.

11 oon prove to be an important and widely used therapeutic modality.

12 and cardiovascular disease, and a potential therapeutic modality.

13 tion of development of these structures as a therapeutic modality.

14 fficacy and safety in using acupuncture as a therapeutic modality.

15 ed a large amount of interest as a potential therapeutic modality.

16 olutions for overcoming challenges with this therapeutic modality.

17 reduce the risk of escape mutations to this therapeutic modality.

18 dly growing class and have become a dominant therapeutic modality.

19 so have implications for the use of MIH as a therapeutic modality.

20 nsfer has long been a compelling yet elusive therapeutic modality.

21 lities observed in patients and suggests new therapeutic modalities.

22 nt of improved diagnostic, prophylactic, and therapeutic modalities.

23 agnostic and prognostic strategies and novel therapeutic modalities.

24 e and chimeric antigen receptor (CAR) T cell therapeutic modalities.

25 and highly resistant to currently available therapeutic modalities.

26 FN signals will help in designing additional therapeutic modalities.

27 for assessing the clinical potential of some therapeutic modalities.

28 s of antibody fragments with applications as therapeutic modalities.

29 is incurable, highlighting the need for new therapeutic modalities.

30 il organ recovery and as a bridge to further therapeutic modalities.

31 ergy between checkpoint modulation and other therapeutic modalities.

32 otential benefits and limitations of various therapeutic modalities.

33 potency and/or efficacy of prophylactic and therapeutic modalities.

34 unknown and could pave the way toward novel therapeutic modalities.

35 point to targets in the development of novel therapeutic modalities.

36 ng approach towards the development of novel therapeutic modalities.

37 pressing need to develop novel antimicrobial therapeutic modalities.

38 tors of Taspase1 as a new candidate class of therapeutic modalities.

39 both of which must be addressed by effective therapeutic modalities.

40 ave been described to enhance the effects of therapeutic modalities.

41 stic nanoparticles, combining diagnostic and therapeutic modalities.

42 sis should suggest strategies for developing therapeutic modalities.

43 may have implications in the development of therapeutic modalities.

44 vance opportunities to safely pursue them as therapeutic modalities.

45 fluence the acceptance of minimally invasive therapeutic modalities.

46 ural course seems to be ideal for evaluating therapeutic modalities.

47 h adaptations may enhance development of new therapeutic modalities.

48 most common allergens and discusses various therapeutic modalities.

49 rgeted NPs as highly selective and effective therapeutic modalities.

50 e significant effect on the response to such therapeutic modalities.

51 hogenesis, and responses to new and evolving therapeutic modalities.

52 sease and thereby to rational application of therapeutic modalities.

53 rgets for the development of antiproteinuric therapeutic modalities.

54 to its intrinsic and acquired resistance to therapeutic modalities.

55 or as adjunctive therapy combined with other therapeutic modalities.

56 esponse to immune-dependent and conventional therapeutic modalities.

57 o provide potential targets to develop novel therapeutic modalities.

58 nities to develop disease biomarkers and new therapeutic modalities.

59 enetic principles, pathogenic mechanisms and therapeutic modalities.

60 al of developing innovative disease-specific therapeutic modalities.

61 , it is critical to find new target-specific therapeutic modalities.

62 study human disease biology and provide lead therapeutic modalities.

63 lar, have been tested in both preventive and therapeutic modalities.

64 lymphoma and melanoma status and associated therapeutic modalities.

65 nts of allergenicity, and ways of developing therapeutic modalities against newly identified targets.

66 data support the use of sorafenib as a novel therapeutic modality against human multiple myeloma, and

67 orting the candidacy of probiotics as such a therapeutic modality against obesity and diabetes.

68 on of miR-383 expression may be an effective therapeutic modality against PCa.

69 her development of antisense technology as a therapeutic modality against tuberculosis.

70 cell activation and the increasing number of therapeutic modalities aimed at manipulating the CD28/CT

71 mia biology and for the development of novel therapeutic modalities aimed at modifying the hematopoie

72 isms of aging and aid in the design of novel therapeutic modalities aimed at prevention and regressio

73 ch must be overcome to enable their use as a therapeutic modality, among which efficient and selectiv

74 ocol results in significant empirical use of therapeutic modalities and a moderately effective treatm

75 es to selective chemical inhibitors, both as therapeutic modalities and as powerful research tools.

76 ummarize relevant information on the various therapeutic modalities and controversies involved in the

77 nform the development of safe HPbetaCD-based therapeutic modalities and may enable engineering HPbeta

78 l transplantation recipients with a focus on therapeutic modalities and outcomes.

79 often associated with resistance to standard therapeutic modalities and poor survival.

80 patient tumors by prognosis and response to therapeutic modalities and to identify the drivers of tu

81 al studies have demonstrated efficacy across therapeutic modalities and tumour types.

82 ubiquitin-proteasome system represent a new therapeutic modality and are the focus of great interest

83 d endpoints in trials should incorporate the therapeutic modality and cancer type because these facto

84 Ionizing radiation is a common therapeutic modality and following irradiation dermal ch

85 the expanding spectrum of cross-linking as a therapeutic modality and its complications.

86 internalization of receptors can be a useful therapeutic modality and the article by Wu et al. illust

87 l practice to treat such tumor masses, these therapeutic modalities are always associated with substa

88 Several therapeutic modalities are currently in clinical trials

89 ecule therapeutic engagement, and additional therapeutic modalities are needed to overcome this defic

90 At such an advanced stage, therapeutic modalities are often inadequate.

91 Accurate early diagnosis and new therapeutic modalities are therefore urgently needed.

92 odies are regarded as the next generation of therapeutic modalities as they can simultaneously bind m

93 cyclic peptides are increasingly attractive therapeutic modalities as they often have improved affin

94 has yet to provide a cure, and there are few therapeutic modalities available for patients with advan

95 appraisal of the underlying pathogenesis and therapeutic modalities available for PV.

96 However, there are few therapeutic modalities available for SD-associated itch

97 per gastrointestinal bleeding and understand therapeutic modalities available in achieving hemostasis

98 Most therapeutic modalities available or under development ta

99 treating metastatic malignant melanoma with therapeutic modalities based on gene expression profilin

100 ts, immunotherapy is emerging as a plausible therapeutic modality because of the recent advances in o

101 Heparin provides a potential therapeutic modality, because it not only prevents exten

102 ontribution in optimizing the prognostic and therapeutic modalities, biological interaction of nanoma

103 In addition, new therapeutic modalities, both recombinant and plasma deri

104 ll, predatory bacteria may have utility as a therapeutic modality but further work is required to und

105 However, the value assigned to a therapeutic modality by the oncology community at large

106 With such a wide variety of therapeutic modalities, clinicians are faced with the ta

107 Three distinct therapeutic modalities (combination therapies, ex-vivo g

108 In ideal scenarios, the drug or therapeutic modality combinations have different mechani

109 Therapeutic modalities consist of identification/withdra

110 LL) are not curative, and the search for new therapeutic modalities continues.

111 However, the currently available therapeutic modalities do not allow for targeted interve

112 uring pregnancy, and a discussion of various therapeutic modalities during pregnancy and lactation.

113 are many new interesting, potentially useful therapeutic modalities emerging in pediatric dermatology

114 therapy, and surgical intervention if other therapeutic modalities fail to prevent progression.

115 terventional strategies showed that existing therapeutic modalities for asthma, such as inhaled corti

116 e tumor cells, provide previously unexplored therapeutic modalities for cancer treatment.

117 the development and improvement of anti-Wnt therapeutic modalities for cancer.

118 ygenase-2 risks, and the potential for novel therapeutic modalities for cardiovascular disease focuse

119 metabolism and may provide the basis for new therapeutic modalities for cardiovascular disease.

120 y of beta-cell function and for enabling new therapeutic modalities for diabetes.

121 These results may help in therapeutic modalities for early treatment of HCV genoty

122 eviously discarded or currently unconsidered therapeutic modalities for genomically stratified melano

123 on of CXCL10 could aid in the development of therapeutic modalities for HAD.

124 synapses could aid in the development of new therapeutic modalities for immunological, neurological,

125 red to combine a wide variety of imaging and therapeutic modalities for improved and personalized can

126 y developed to combine NIR-II PTT with other therapeutic modalities for improved efficacies in treati

127 in resistance and suggest new diagnostic and therapeutic modalities for managing the disease.

128 urotoxicity is crucial to the development of therapeutic modalities for Meth abusing HAD patients.

129 extensively studied in an effort to develop therapeutic modalities for multiple sclerosis and, indee

130 seases to develop guidance on diagnostic and therapeutic modalities for NASH.

131 d to identification of new, context-specific therapeutic modalities for precision medicine.

132 ritional adjuncts that are emerging as novel therapeutic modalities for preventing surgical infection

133 the anesthesiologist with current and rising therapeutic modalities for pulmonary disease.

134 These data suggest new therapeutic modalities for resistant hypertension based

135 -theta and indicate V3-based 'decoys' may be therapeutic modalities for T cell-mediated inflammatory

136 is essential for development of efficacious therapeutic modalities for the disease.

137 e potential to be used in the development of therapeutic modalities for the possible treatment, cure

138 These findings suggest a number of therapeutic modalities for the treatment and detection o

139 the development of effective dual-targeting therapeutic modalities for the treatment of cancer are t

140 There have been many new developments in therapeutic modalities for the treatment of pediatric de

141 the longer term, generate new diagnostic and therapeutic modalities for treating high-grade malignanc

142 rize current state-of-the-art diagnostic and therapeutic modalities for treatment of AF.

143 n and deep brain stimulation have emerged as therapeutic modalities for treatment refractory depressi

144 EG 10, merits further testing as a potential therapeutic modality for a variety of clinically importa

145 ntation (allo-HCT) is a potentially curative therapeutic modality for ALL, and this review describes

146 assess safety and efficacy of this potential therapeutic modality for application in diabetes treatme

147 pe II receptor (TbetaRII), as an alternative therapeutic modality for blocking TGF-beta signaling in

148 c event, suggesting a previously undescribed therapeutic modality for cerebral ischemia/hypoxia and i

149 ther, ormeloxifene represents an alternative therapeutic modality for cervical cancer which may have

150 ta suggest that Nano-CUR may be an effective therapeutic modality for cervical cancer.

151 ill not enough evidence to support tDCS as a therapeutic modality for depression.

152 uggest that TSC may be a safe and beneficial therapeutic modality for early stroke intervention, irre

153 ficacy and safety of gene-modified HSCs as a therapeutic modality for engineered cancer immunotherapy

154 Hb sequestration by Hp might therefore be a therapeutic modality for enhancing transfusion safety in

155 ting TAM fatty acid oxidation as a potential therapeutic modality for human cancers.

156 cyst(e)inase represents a safe and effective therapeutic modality for inactivating antioxidant cellul

157 ter who had undergone surgery as their first therapeutic modality for invasive breast cancer from Sep

158 evels of MDMX and may offer a more effective therapeutic modality for MDMX-overexpressing cancers.

159 argeting PAR-1 could potentially be a useful therapeutic modality for melanoma patients.

160 Here, we review the development of RNAi as a therapeutic modality for neurodegenerative diseases affe

161 sidered as an alternative minimally invasive therapeutic modality for patients who are not candidates

162 otential use of antioxidants as a supportive therapeutic modality for patients with RD.

163 formed to evaluate the effectiveness of this therapeutic modality for patients with sclerotic chronic

164 The blockage of H4R could be a new therapeutic modality for prevention of bone destruction

165 at PIM1 inhibition might offer an attractive therapeutic modality for prostate cancer, particularly f

166 ed, double-blind multinational trial of this therapeutic modality for ragweed allergy.

167 e adjacent photoreceptors is a promising new therapeutic modality for RPE-related retinal diseases.

168 Thus, PPCA is a therapeutic modality for selective, antigen-specific imm

169 rhBMP-2 represents a potential therapeutic modality for severe peri-implant hard tissue

170 rationale to target the OX40L-OX40 axis as a therapeutic modality for SLE.

171 been employed during the past 30 years as a therapeutic modality for spinal cord injury (SCI) in ani

172 t omega-3 PUFAs could potentially serve as a therapeutic modality for T1D.

173 conjugates (ADCs), an increasingly important therapeutic modality for targeted cancer treatment, have

174 t a novel, broadly applicable, and versatile therapeutic modality for targeted cell depletion.

175 ease provide a path for using electrons as a therapeutic modality for targeting molecular mechanisms

176 tive ST266 is a potential novel, noninvasive therapeutic modality for the eyes, optic nerves and brai

177 DALK is an effective therapeutic modality for the management of advanced kera

178 deep brain stimulation (DBS) is a promising therapeutic modality for the treatment of addiction.

179 brain stimulation (DBS), a well established therapeutic modality for the treatment of movement disor

180 ngly, inhibition of Nox4 may provide a novel therapeutic modality for the treatment of neuropathic pa

181 tation (FMT) has been shown to be a superior therapeutic modality for the treatment of recurrent Clos

182 pon TCR signaling may represent an effective therapeutic modality for this class of lethal human canc

183 targeting upregulated Wnt signaling as a new therapeutic modality for this disease.

184 re modulate anti-tumor immune responses as a therapeutic modality for this untreatable disease.

185 a key aspect is the selection of the optimal therapeutic modality for translating advances in rare di

186 n of the alternative pathway may represent a therapeutic modality for treating acute phases of inflam

187 Tyrosine kinase inhibition is one tractable therapeutic modality for treating human malignancy.

188 r approaches is potentially an effective new therapeutic modality for treating the activated B cell-l

189 ade of PDK1/PI3K signaling might offer a new therapeutic modality for wild-type PTEN tumors.

190 eby validating this model to test innovative therapeutics modalities for this disease.

191 Lung transplantation is a therapeutic modality frequently used in end-stage lung d

192 that treatment with vismodegib adds a novel therapeutic modality from which patients with advanced b

193 Preclinical development of new therapeutic modalities has been hindered by models with

194 Aside from early surgical resection, no therapeutic modality has been found to afford a high lik

195 However, the application of this therapeutic modality has been impeded by a number of con

196 Minimally invasive therapeutic modalities have become the standard treatmen

197 Common adverse effects of this therapeutic modality have been previously documented.

198 lity in more clinically-relevant imaging and therapeutic modalities, here we have explored the use of

199 s of antigen-smIg interactions may represent therapeutic modalities in CLL.

200 argeting long noncoding RNAs and circRNAs as therapeutic modalities in humans are specifically discus

201 he advent of a new generation of much-needed therapeutic modalities in leukemia and other cancers.

202 ly diagnosis, and application of appropriate therapeutic modalities in sepsis-induced AKI include lim

203 e neoplasia type 1, and the precise order of therapeutic modalities in the treatment of patients with

204 ing of EPCR may lead to development of novel therapeutic modalities in treating hemophilia, inflammat

205 ough modulation of PPARgamma signaling, as a therapeutic modality in a large proportion of AML patien

206 trategies to mobilize the immune system as a therapeutic modality in cancer necessitates a better und

207 l cellular protein levels and promises a new therapeutic modality in drug discovery.

208 we re-examine passive antibody transfer as a therapeutic modality in HIV-1-infected humanized mice.

209 manized mice, and should be re-examined as a therapeutic modality in HIV-1-infected individuals.

210 targeting selective autophagy as an emerging therapeutic modality in NDDs.

211 poE in the central nervous system might be a therapeutic modality in neurodegenerative disorders.

212 e the importance of alpha particles as a new therapeutic modality in patients with bone metastatic ca

213 zation has shown to be an effective and safe therapeutic modality in patients with lower gastrointest

214 Administration of CO may have potential as a therapeutic modality in patients with ruptured cerebral

215 septic animals and appears to be a promising therapeutic modality in sepsis.

216 Wnt5a as a potential target for an efficient therapeutic modality in severe human diseases as diverse

217 and suggest cytokine blockade as a potential therapeutic modality in severe infection.

218 ntial translational utility of DC.Tbets as a therapeutic modality in the cancer setting.

219 g the transformation of RNAi into a powerful therapeutic modality in the clinic.

220 erventions are becoming a safe and effective therapeutic modality in the management of various valvul

221 roteasome inhibition has been validated as a therapeutic modality in the treatment of multiple myelom

222 and aim to enable studies of cancer, and new therapeutic modalities, in a physiologically-relevant ma

223 apy, as well as explores novel and effective therapeutic modalities including antiviral therapy with

224 clinical trial data with currently available therapeutic modalities, including DES and drug-coated ba

225 al evidence for potential new diagnostic and therapeutic modalities, including imaging, biomarkers, p

226 s and rare disease applicability of the main therapeutic modalities, including small molecules, monoc

227 ordant means of achieving resistance to this therapeutic modality, including tyrosine kinases, RAF, R

228 the implementation of simple preventive and therapeutic modalities, infant mortality has almost been

229 or to introduce a broad range of imaging or therapeutic modalities into a single conduct.

230 following chemotherapy, and developing such therapeutic modalities is a key priority.

231 rs and acquired or innate resistance to this therapeutic modality is a major clinical problem.

232 Messenger RNA as a therapeutic modality is becoming increasingly popular in

233 metastatic melanoma, but resistance to these therapeutic modalities limits the percentage of patients

234 sponses represents a possible small-molecule therapeutic modality (microbiome-biosynthetic gene thera

235 sary for surgeons and their patients and new therapeutic modalities must continue to be explored.

236 Our results set the stage for an emerging therapeutic modality of "conformational disruptors" to i

237 Radiotherapy, a therapeutic modality of cancer treatment, nonselectively

238 le for using Aurora kinase A inhibition as a therapeutic modality of CTCL.

239 /or NADPH oxidase inhibition may represent a therapeutic modality of diabetic kidney disease.

240 Its dismal prognosis stems from inefficient therapeutic modalities owing to the lack of understandin

241 nsion, renalase replacement is an attractive therapeutic modality owing to its role in catecholamine

242 the genetic engineering of T cells is now a therapeutic modality pursued at an increasing number of

243 ffer significant advantages over using these therapeutic modalities separately, it remains largely un

244 Combining ALK inhibition with other novel therapeutic modalities should prove even more effective.

245 LT may hold promise for a broadly applicable therapeutic modality specific to mesenchymal lineage tum

246 particularly in combination with established therapeutic modalities such as radiation.

247 uction arises from the fact that traditional therapeutic modalities, such as autologous bone grafting

248 different types of immunotherapies and other therapeutic modalities, such as drugs against specific s

249 Despite the reported therapeutic modalities, such as topical and systemic cor

250 lymphatics in CNS disorders and develop new therapeutic modalities targeting these systems.

251 elivered using BPM31510 provide an effective therapeutic modality targeting cancer-specific modulatio

252 oals and endpoints of management, and latest therapeutic modalities that includes the harnessing of i

253 ution of vasculopathy in SCD and may suggest therapeutic modalities that interrupt heme-mediated infl

254 regulation of iron in cancer cells, and new therapeutic modalities that leverage the iron dependence

255 cranial focused ultrasound is a non-invasive therapeutic modality that can be used to treat essential

256 tion of a natural product, WDB002, reveals a therapeutic modality that dramatically expands the curre

257 py (PDT) is an important clinically relevant therapeutic modality that has proven to compensate for t

258 ively ablate senescent cells from tissues, a therapeutic modality that holds potential for treating m

259 geneic stem cell transplantation is the only therapeutic modality that provides a cure for myelofibro

260 rsistent despite exhaustion of all available therapeutic modalities, then an argument can be made tha

261 based use of anticoagulation, and adjunctive therapeutic modalities (thrombolysis, vena cava interrup

262 dysfunction) that must be overcome by these therapeutic modalities to achieve cancer clearance.

263 Our results identify RNF5 as a target for therapeutic modalities to antagonize mutant CFTR protein

264 ansduction may eventually lead to innovative therapeutic modalities to improve the clinical response

265 Present therapeutic modalities to limit the adverse consequences

266 prove useful in evaluating antivirals and/or therapeutic modalities to prevent or inhibit demyelinati

267 At present, therapeutic modalities to prevent or treat AKI are extre

268 vide evidence for TCR-like mAbs as potential therapeutic modalities to target EBV-associated diseases

269 use of FAAH inhibitors may constitute novel therapeutic modalities to treat immune-mediated liver in

270 ancer, thus opening up the potential for new therapeutic modalities to treat these diverse diseases.

271 replacement might be a potentially promising therapeutic modality to attenuate or block negative neur

272 rovides biochemical evidence for a potential therapeutic modality to correct beta-oxidation deficienc

273 a novel strategy that may be promising as a therapeutic modality to eliminate the C481S-mutant BTK c

274 nanoparticles, this repressor can serve as a therapeutic modality to influence the course of septicae

275 ivo inhibition of NFAT may represent a novel therapeutic modality to preserve endothelial function in

276 ation and vascular remodeling is a promising therapeutic modality to preserve tissues subject to isch

277 e GRK2-mediated signaling can be a potential therapeutic modality to prevent or treat beta(2) AR dese

278 Cs) was firstly attempted for CLI as a novel therapeutic modality to provide superior angiogenic pote

279 e only identified ligand for CXCR4, as a new therapeutic modality to recruit stem cells to individual

280 restoring mTOR signaling may be an effective therapeutic modality to reduce neuronal cell death in di

281 otherapy has emerged as a potential adjuvant therapeutic modality to reduce the incidence and mortali

282 ing factors to the pre-mRNA, are a promising therapeutic modality to treat a range of genetic disease

283 suggest that elafin could be engineered as a therapeutic modality to treat breast cancer without toxi

284 py is being increasingly recognized as a key therapeutic modality to treat cancer and represents one

285 namic therapy (PDT) is a clinically approved therapeutic modality to treat certain types of cancers.

286 effects and so may be most appropriate as a therapeutic modality to treat GVHD.

287 and/or enhance innate immune responses as a therapeutic modality to treat respiratory infections.

288 implications, and, finally, drugs and other therapeutic modalities used in HF treatment that target

289 ed health-care workers who have expertise in therapeutic modalities used in the treatment of patients

290 al complement complex, and its blockade as a therapeutic modality, was investigated in a mouse model

291 to the poor response of GBM patients to any therapeutic modalities, which include ionizing radiation

292 nd the modulation of microglia activity as a therapeutic modality will be discussed.

293 regulatory levels, suggesting that no single therapeutic modality will be universally effective again

294 in using miRNAs as circulating biomarkers or therapeutic modalities, will hopefully be able to provid

295 siRNAs are a new class of therapeutic modalities with promising clinical efficacy

296 ionized the life sciences and introduced new therapeutic modalities with the potential to treat a wid

297 ng of the human ribosome is an unprecedented therapeutic modality with a genome-wide selectivity chal

298 n in endothelial cells may represent a novel therapeutic modality with the potential to inhibit infla

299 address the complexities to make such novel therapeutic modalities work in the clinic.

300 uggests that preclinical efficacy testing of therapeutic modalities would be most informative when th