ライフサイエンスコーパス: therapeutic target

1 maintain the bulk tumor and represent a key therapeutic target.

2 tial framework for exploring GLS2 as a novel therapeutic target.

3 nfection of host macrophages and a potential therapeutic target.

4 ralog, SMARCA2, making SMARCA2 an attractive therapeutic target.

5 on of the Hippo pathway as a novel potential therapeutic target.

6 ng trials seeking a measurable response to a therapeutic target.

7 in the complex pathology of TSC and reveal a therapeutic target.

8 tic gene expression and has emerged as a key therapeutic target.

9 n interaction and identify it as a potential therapeutic target.

10 the ubiquitin pathway an important emerging therapeutic target.

11 this reason, it can be considered a possible therapeutic target.

12 We identify NM2C as a specific therapeutic target.

13 al utility as a disease course biomarker and therapeutic target.

14 tic evidence to support COASY as a potential therapeutic target.

15 dults and have identified msi as a potential therapeutic target.

16 ctional in HF and AF, and its potential as a therapeutic target.

17 s of colorectal cancer and a novel potential therapeutic target.

18 imer's disease (AD), making nSMase2 a viable therapeutic target.

19 and has long been recognized as a potential therapeutic target.

20 eases and, therefore, represents a potential therapeutic target.

21 f CatD as novel tools for regulation of this therapeutic target.

22 dynamics, which is increasingly considered a therapeutic target.

23 forms of cancer, and represents an emerging therapeutic target.

24 ysiology with the potential to unravel novel therapeutic targets.

25 receptor kinases (TRKs) are promising cancer therapeutic targets.

26 g to the realization that they are promising therapeutic targets.

27 larity is detrimental to efforts to identify therapeutic targets.

28 ight on the pathogenesis of Spn and identify therapeutic targets.

29 thoretroviruses such as HIV-1 and are proven therapeutic targets.

30 membrane and may reveal novel diagnostic and therapeutic targets.

31 type-selective vulnerability and to identify therapeutic targets.

32 es in the heart and avail the search for new therapeutic targets.

33 n cancer, as well as effective and selective therapeutic targets.

34 ing the potential value of these proteins as therapeutic targets.

35 these proteins are protumorigenic and better therapeutic targets.

36 DRB1, which might help to identify potential therapeutic targets.

37 revised with identification of new potential therapeutic targets.

38 and trophic signaling, are thought be viable therapeutic targets.

39 atients, highlighting a need for alternative therapeutic targets.

40 ma tumorigenesis and representing attractive therapeutic targets.

41 del systems can be leveraged to identify new therapeutic targets.

42 o resilience may identify novel pathways for therapeutic targets.

43 ng both previously known and other potential therapeutic targets.

44 ses have been attractive and major antiviral therapeutic targets.

45 ation may be implicated, providing potential therapeutic targets.

46 in which to study pathogenic mechanisms and therapeutic targets.

47 Sigma-1 and sigma-2 receptors are emerging therapeutic targets.

48 elevant model system may help identify novel therapeutic targets.

49 Thus, they also represent good potential therapeutic targets.

50 se areas with an emphasis on identifying new therapeutic targets.

51 ced neurotoxicity, which may represent novel therapeutic targets.

52 c tone, and may suggest novel biomarkers and therapeutic targets.

53 inflammation and identify several potential therapeutic targets.

54 d identify many potential surface-accessible therapeutic targets.

55 te genes and the results highlight potential therapeutic targets.

56 ring caloric restriction may yield promising therapeutic targets.

57 nfectious diseases-and identifying potential therapeutic targets.

58 ontrolling glioma growth, relevant to future therapeutic targeting.

59 ting the opportunity for enhanced control of therapeutic targeting.

60 and identify potential mechanisms for future therapeutic targeting.

61 hypertension and discuss their potential for therapeutic targeting.

62 rophy, information that is essential for its therapeutic targeting.

63 mor metastasis is crucial for diagnostic and therapeutic targeting.

64 ection, offering opportunities for potential therapeutic targeting.

65 Haptoglobin and the Hb clearance pathway are therapeutic targets after aSAH.

66 TPCs might represent a novel therapeutic target against HIV-1 infection and HIV-assoc

67 risk factors and suggest Rap1 as a promising therapeutic target against the development of atheroscle

68 ion and clearance and to screen and evaluate therapeutics targeting alpha-syn aggregation and LB form

69 predict future CVD events, and are possible therapeutic targets among PLHIV, are warranted.

70 udies identify lncGRS-1 as a glioma-specific therapeutic target and establish a generalizable approac

71 ppressor and highlights RGS12 as a potential therapeutic target and prognostic biomarker of OSCC.

72 this has resulted in the pursuit of a novel therapeutic target and resultant clinical trial.

73 e potential ACE2 and SARS-CoV-2 residues for therapeutic targeting and identification of animal speci

74 ne germline or somatic aberration, 71.4% had therapeutic targets and 5.2% had a change in diagnosis.

75 the GAN DIO-NASH mouse model for identifying therapeutic targets and characterizing novel drug therap

76 Hence, we identify new therapeutic targets and putative therapeutic approaches

77 eterminant of neuropathic pain and potential therapeutic target, and provide insights into its signal

78 volved in virulence, TCS are potential novel therapeutic targets, and elucidating their function is c

79 These SEs have been identified as promising therapeutic targets, and have given rise to a new class

80 eimer disease) and SARM1 may make worthwhile therapeutic targets because they did not have geneticall

81 hus to further validate sChoK as a potential therapeutic target by discovering more powerful sChoK in

82 surveys are often used to identify potential therapeutic targets by finding associations between micr

83 in leukemic sub-clones, causing dichotomy in therapeutic target choices.

84 the IUPHAR/BPS Guide to Pharmacology and the Therapeutic Target Database.

85 H-induced antihyperalgesia and suggest novel therapeutic targets, downstream of CD44, for the treatme

86 Thus, we report a novel therapeutic target expressed on a range of immune cells

87 nd organismal homeostasis, and an attractive therapeutic target for a broad variety of disease condit

88 this reason should be considered as a novel therapeutic target for AD.

89 gression, suggesting that MMA is a promising therapeutic target for advanced carcinomas.

90 dy points to CeA(GA) as a potential powerful therapeutic target for alleviating chronic pain.

91 y phasic NACs dopamine release as a possible therapeutic target for alleviating the excessive risk-ta

92 JNK2 modulation may be a novel therapeutic target for atrial fibrillation prevention an

93 2-PKCalpha signaling axis may be a potential therapeutic target for attenuating chemoresistance signa

94 jury and may therefore represent a promising therapeutic target for attenuating cognitive impairment

95 bviously reduced the enthusiasm for Myc as a therapeutic target for beta-cell regeneration.

96 aM dependent regulation of RyR2 an important therapeutic target for cardiac alternans.

97 This enzyme has also emerged as a therapeutic target for cardiovascular disease due to its

98 torsinA-LINC complex nexus might comprise a therapeutic target for certain laminopathies by preventi

99 bed opioids, DOPr is a promising alternative therapeutic target for chronic pain management.

100 he inhibition of NETs represents a potential therapeutic target for COVID-19.

101 rting further pursuit of detyrosination as a therapeutic target for diastolic dysfunction.

102 s uncover a druggable pathway as a potential therapeutic target for disorders with reduced SHANK3 dos

103 the system could represent a novel potential therapeutic target for DS.

104 ceptor system has been identified as a novel therapeutic target for headache disorders and migraine.

105 poptosis, and that AIF may represent a novel therapeutic target for HPV-induced cervical cancer.

106 s signalling pathway provides an interesting therapeutic target for human sensory nerve regeneration.

107 enin may serve as a new preventive agent and therapeutic target for IBD.

108 findings support mTOR activation as a novel therapeutic target for iMCD, which is being investigated

109 A activity mediated by LC-NE may be a viable therapeutic target for individuals with stress- and trau

110 on and suggest GBP2 may serve as a potential therapeutic target for inhibiting GBM invasion.

111 on and suggest that it may represent a valid therapeutic target for inhibiting metastasis.

112 e 2 (CB2R) represents an interesting and new therapeutic target for its involvement in the first step

113 anism for NRas signaling and may be a viable therapeutic target for its sensitivity to MEKi.

114 fy further investigation into PPARgamma as a therapeutic target for IUGR in pregnancies complicated b

115 er kinase) has been considered an attractive therapeutic target for managing cancer since 2005.

116 in neuronal sensitization and may provide a therapeutic target for many neuroinflammatory pain condi

117 c disease and have thus become an attractive therapeutic target for many types of invasive cancers.

118 rospect of non-rapid eye movement sleep as a therapeutic target for meaningfully reducing anxiety.

119 ive to MEKis, suggesting that PHGDH may be a therapeutic target for melanoma.

120 ivation suggest that this may be a potential therapeutic target for metabolic disease intervention.

121 the importance of peripheral nerves as a new therapeutic target for metabolic disorders.

122 Therefore, it is considered an attractive therapeutic target for modulating tumor metabolism.

123 ecently emerged as a driver of and promising therapeutic target for multiple age-related conditions,

124 ed receptor (GPCR) considered as a promising therapeutic target for neuropsychiatric disorders; its p

125 hmatic Th cells, identifying them as a novel therapeutic target for obesity-related asthma, a disease

126 ream signaling pathways could be a potential therapeutic target for obesity.

127 findings show that furin can be an effective therapeutic target for ovarian cancer prevention or trea

128 mmation and metabolism, representing a novel therapeutic target for patients with obesity.

129 onse in PD and identify Kv1.3 as a potential therapeutic target for PD.

130 ing metaplasia that may serve as a potential therapeutic target for preneoplastic conditions of the G

131 s, cardiac D1R has the potential to become a therapeutic target for preventing heart failure-associat

132 MEGF11 might be a potential therapeutic target for preventing TNBC recurrence.

133 e of oligodendrocytes and offers a potential therapeutic target for prevention of diffuse WMI in prem

134 signaling therefore presents a potential new therapeutic target for promoting SVZ-mediated cellular r

135 vide initial support for CB1R as a potential therapeutic target for relapse prevention.

136 nctional outcomes identify it as a promising therapeutic target for retinal and other neurodegenerati

137 SCs, and indicates that FOXM1 is a potential therapeutic target for selectively eliminating LSCs in M

138 NLRP3-dependent inflammasome is a potential therapeutic target for the cutaneous manifestations of a

139 ing the possibility that VCP may represent a therapeutic target for the treatment of AD.

140 regulator of receptor tyrosine kinases and a therapeutic target for the treatment of diabetes, obesit

141 ssed in the brain and represents a promising therapeutic target for the treatment of Huntington's dis

142 the St3gal2-GT1b-TLR2 axis may offer a novel therapeutic target for the treatment of neuropathic pain

143 identify FTO as a potential HIF-independent therapeutic target for the treatment of VHL-deficient re

144 cle and hepatic function may represent a new therapeutic target for treating disordered energy metabo

145 Thus, FABP5 is potentially a therapeutic target for treating ILC2-mediated allergic l

146 central regulator could serve as a potential therapeutic target for treatment of HCC.

147 ic injury in SIV infection and suggest their therapeutic targeting for promoting neuronal recovery.IM

148 injury or pathology, myeloid cells represent therapeutic targets for a broad range of diseases.

149 ling new diagnostic biomarkers and potential therapeutic targets for age-related human ovarian disord

150 E and beta-amyloid (Abeta) and are potential therapeutic targets for Alzheimer's disease (AD).

151 ivo variant functional assays, and potential therapeutic targets for ASD.

152 ochondrial energetics and redox signaling as therapeutic targets for cardiac aging.

153 n and the potential these mechanisms hold as therapeutic targets for CRPC.

154 tors have demonstrated much promise as novel therapeutic targets for different cancer types.

155 Age-related mechanisms may provide novel therapeutic targets for disability accrual in multiple s

156 s will help in the identification of further therapeutic targets for diseases associated with endothe

157 order of the palm, we sought to identify new therapeutic targets for fibrotic disease.

158 GIN activity while also indicating potential therapeutic targets for GIN-associated disorders, such a

159 this categorization may impact the choice of therapeutic targets for immunotherapy of malignant, infe

160 tein-coupled receptors (GPCRs) are important therapeutic targets for major diseases.

161 plasia, and have been used as biomarkers and therapeutic targets for multiple cancers.

162 ous vascular protective pathways may provide therapeutic targets for neurological disorders.

163 New therapeutic targets for oral squamous cell carcinoma (OS

164 of the anterolateral pathway are attractive therapeutic targets for pain treatment because nocicepti

165 native activation of microglia are potential therapeutic targets for psychiatric disorders induced by

166 in the last decades, making MMPs attractive therapeutic targets for several diseases.

167 identified genes and exosomes are potential therapeutic targets for stopping cancer and attenuating

168 ulatory mechanism in HGP and offer potential therapeutic targets for T2D.

169 role for epsin proteins and may provide new therapeutic targets for the treatment of atherosclerosis

170 This provides potential therapeutic targets for the treatment of EBV-associated

171 ion of GLUT4 trafficking represent potential therapeutic targets for the treatment of insulin resista

172 inflammasome activation and may provide new therapeutic targets for the treatment of NLRP3-associate

173 crotaline-induced PAH to delineate potential therapeutic targets for the treatment of this severe dis

174 epigenomic landscape and identify candidate therapeutic targets for this dismal cancer.

175 X3, thus providing additional possible novel therapeutic targets for tumors having deregulated Wnt/be

176 ne and BP and suggest a novel mechanism, and therapeutic target, for aging-induced essential hyperten

177 In contrast, several therapeutic targets have been identified in CCA, and bio

178 sed in diverse cancers and could be an ideal therapeutic target if not for the fact that the complex

179 tors (CXCL10, CD4, CD3E) and investigational therapeutic targets (IL1A) for COVID-19.

180 New therapeutics targeting immune checkpoint proteins have s

181 suggest the host cell mitochondria may be a therapeutic target.IMPORTANCE Human cytomegalovirus (HCM

182 ariants, demonstrating that AR remains a key therapeutic target in advanced disease.

183 Thus, IKBKE is a therapeutic target in advanced PC suggesting repurposing

184 ivating PFKFB3 and suggest PFKFB3 as a novel therapeutic target in AML.

185 This makes S1R a potential therapeutic target in amyotrophic lateral sclerosis (ALS

186 tream mediator CCAT1, represents a potential therapeutic target in ATC.

187 These findings validate GSTO1 as a therapeutic target in cancer and implicate GSTO1 in the

188 megakaryocytic cell line and is an emerging therapeutic target in cancer, yet its role in immune cel

189 GAPDH in DNA repair and suggest a potential therapeutic target in chemotherapy.

190 Although autophagy is being pursued as a therapeutic target in clinical oncology trials, its effe

191 er stemness networks, marking it a potential therapeutic target in colorectal cancer.

192 thelial glycocalyx HA and its potential as a therapeutic target in diabetic vascular complications.

193 glioma tumorigenesis that may serve as a new therapeutic target in glioblastoma.

194 CSC phenotype, indicating it is a potential therapeutic target in HNSCC.

195 aseline, a predictive marker and presumptive therapeutic target in humans infected with SARS-CoV-2.

196 regulator of pMo development and a potential therapeutic target in inflammatory diseases regulated by

197 fy BET bromodomain inhibition as a potential therapeutic target in LMNA-associated cardiomyopathy, fo

198 Pygo2 represents a potential therapeutic target in metastatic breast cancer, as its h

199 phingolipid metabolism may represent a novel therapeutic target in metastatic melanoma, the most leth

200 l migration and supports FASN as a potential therapeutic target in metastatic prostate cancer.

201 t to examine its function and potential as a therapeutic target in MFS/UPS.

202 These findings provide the basis for a new therapeutic target in MLL-rearranged leukemia and act as

203 licate the MCL/MINCLE pathway as a potential therapeutic target in MS.

204 oll-like receptor 7 (TLR7) is an established therapeutic target in myriad autoimmune disorders, but n

205 Our findings highlight 4E-BP1 as a therapeutic target in neurodegenerative disease and unde

206 date the palmitoylation cycle as a promising therapeutic target in NRAS mutant cancers.

207 sstalk and suggests that UBR5 is a potential therapeutic target in OC treatment for modulating the TM

208 importance of the HIF pathway as a potential therapeutic target in osteolytic disease.

209 A key therapeutic target in PD is alpha-synuclein (alphaS), wh

210 own as CK1alpha or CK1a) as an APA-regulated therapeutic target in PDAC.

211 Thus, Plk1 is a potential therapeutic target in pediatric B-ALL and selective targ

212 ential as a cancer biomarker and as a future therapeutic target in personalized cancer medicine.

213 ate the importance of SMPDL3b as a potential therapeutic target in radiation-induced kidney damage.

214 AML and underscore its value as a potential therapeutic target in this disease.

215 ndent outflow suggests potential for a novel therapeutic target in treating glaucoma.

216 and suggest CYSLTR2 as a promising potential therapeutic target in uveal melanoma.

217 ese findings have important implications for therapeutic targeting in acute lung injury.

218 or of pathological cardiac hypertrophy whose therapeutic targeting in heart disease has been elusive

219 an accompanying metabolic vulnerability for therapeutic targeting in SLC7A11(high) cancers.

220 mising diagnostic, prognostic biomarkers and therapeutic targets in breast cancer.

221 ll-specific transcriptional programs and are therapeutic targets in cancer and inflammation.

222 ication) pinpoint oncogenic driver genes and therapeutic targets in cancer genomes.

223 iate mitosis, directional signaling, and are therapeutic targets in cancer.

224 To identify new therapeutic targets in CIC-DUX4 sarcoma, we performed ch

225 istic and clinical evidence of new promising therapeutic targets in hidradenitis suppurativa (HS).

226 Our results identify candidate therapeutic targets in multiple sclerosis.

227 pproaches can uncover disease mechanisms and therapeutic targets in neurological diseases.

228 logies to identify functional biomarkers and therapeutic targets in rheumatic diseases, but the full

229 Invariant NKT (iNKT) cells are attractive therapeutic targets in sepsis.

230 agnosis of insomnia and provide possible new therapeutic targets in the field of sleep disorders.

231 ralizable approach to rapidly identify novel therapeutic targets in the vast non-coding genome to enh

232 tform for the discovery of much-needed novel therapeutic targets in this chronic disease.

233 ises the knowledge of the life cycle of this therapeutic target, including its biogenesis, traffickin

234 n supporting the mechanistic studies of drug/therapeutic target interactions, but its applications re

235 Often the molecular structure of a therapeutic target is unknown and randomized methods are

236 rts are identifying potential diagnostic and therapeutic targets more rapidly than existing methods c

237 h is identified as a biomarker and potential therapeutic target of AD.

238 ous results showed that HMGA2 is a potential therapeutic target of anticancer and anti-obesity drugs

239 the dopamine D(2) receptor (D(2)R) is a key therapeutic target of antipsychotics for the treatment o

240 Thus, p38beta MAPK is a central mediator and therapeutic target of cancer-induced muscle wasting.

241 toward tumor malignancy and are therefore a therapeutic target of interest.

242 r findings may provide a new perspective for therapeutic targeting of beta-catenin.

243 age-related vascular changes and imply that therapeutic targeting of blood vessels may restore aged

244 Therapeutic targeting of Bruton tyrosine kinase (BTK) ha

245 Therapeutic targeting of epigenetic modulators offers a

246 results provide a mechanistic framework for therapeutic targeting of ligand-dependent Hh signaling i

247 comprehensive but reversible, implying that therapeutic targeting of LM-MDSC could prime the TME in

248 ll fate decisions will ultimately aid in the therapeutic targeting of mTOR in human disease.

249 leukemogenesis, and provide a rationale for therapeutic targeting of oncogenic MYC via AURKB inhibit

250 and NSD3, which could lead to strategies for therapeutic targeting of proteins of the NSD family.

251 ng intra-tumoral heterogeneity and motivates therapeutic targeting of the HPCS.

252 Therefore, identification and therapeutic targeting of the underlying pathways is a us

253 ated BMP9 and BMP10 signalling, facilitating therapeutic targeting of this important pathway.

254 CC regulate melanoma progression, suggesting therapeutic targeting of this signaling axis as a viable

255 identify the molecular mechanisms and novel therapeutic targets of late-onset Alzheimer's Disease (L

256 y actually suffer from a mixed dementia, and therapeutics targeting only Alzheimer's disease-related

257 ible relevance to HD pathology, potential as therapeutic targets, or use as biomarkers of progression

258 ctural feature for targeting a wide range of therapeutic target proteins, including MAO, tyrosine kin

259 s for Rho-family small GTPase inhibitors and therapeutics targeting Ras-driven cancers.

260 nders the oncogenic protein SKP2 a promising therapeutic target.See related article by Li et al., p.

261 to host pathways that may serve as potential therapeutic targets, significant progress has also been

262 N in MM, the associated vulnerabilities, and therapeutic targeting strategies.

263 , we propose that CTGF is a promising cancer therapeutic target that could potentially improve the cl

264 Transcription factors are attractive therapeutic targets that are considered non-druggable be

265 he possibility for novel, microbiome-related therapeutic targets that may effectively alleviate metab

266 ould facilitate the development of antiviral therapeutics targeting the CHIKV attachment step.

267 d DR, there is an urgent need to develop new therapeutics targeting the mitochondria to prevent or re

268 gress to date in the clinical development of therapeutics targeting the Notch, WNT, Hedgehog and Hipp

269 ve previously been identified as a potential therapeutic target, this study for the first time recogn

270 of dopamine neurons, and reveal a potential therapeutic target to attenuate manganese-induced impair

271 In perspective, SOCE may represent a new therapeutic target to counteract Mk proliferation and it

272 he miR-211(-/-) phenotype, pointing to a new therapeutic target to counteract retinal degeneration as

273 notherapy and identify ALKBH5 as a potential therapeutic target to enhance immunotherapy outcome in m

274 Thus, CatC appears as a potential therapeutic target to impair protease-driven tissue degr

275 ing L-AZM as a novel and clinically relevant therapeutic target to improve cardiac recovery and reduc

276 hese findings establish FATP4 as a promising therapeutic target to improve the visual cycle, as well

277 n induced DNA damage repair is an attractive therapeutic target to increase PRRT efficacy and consequ

278 our results suggest that IL-27 represents a therapeutic target to limit susceptibility and improve i

279 Our findings support JUN as a therapeutic target to prevent adhesions.

280 of the microbiome homeostasis as a potential therapeutic target to prevent IAV associated bacterial c

281 immune activation and represents a potential therapeutic target to prevent non-acquired immunodeficie

282 r data suggest that FMNL1 may be a potential therapeutic target to specifically modulate T cell traff

283 nt survival and represents a novel potential therapeutic target to tackle this devastating pathology.

284 ather than autophagy and may provide a novel therapeutic target to treat cardiac proteinopathies.

285 into hippocampal neurogenesis as a potential therapeutic target to treat cognitive deficits associate

286 uch mechanisms may provide a novel source of therapeutic targets to be exploited in the context of be

287 hanisms of metabolic control, and identifies therapeutic targets to correct energy failure.

288 then the rationale to choose CD2 and AMPK as therapeutic targets to enhance CTL activity.

289 CD will facilitate identification of better therapeutic targets to improve nutritional status.

290 ams that may serve as diagnostic markers and therapeutic targets to influence the pathogenesis of LAM

291 al cell migration and may serve as candidate therapeutic targets to manipulate cell motility in disea

292 adenosine- and glutamate-signaling as novel therapeutic targets to treat the NWS.

293 o a variety of human diseases and considered therapeutic targets. To date, systematic and intensive a

294 nesis, and may represent a potentially novel therapeutic target.TRIAL REGISTRATIONClinicalTrials.gov

295 etter understand these variants as potential therapeutic targets, we aimed to characterize their impa

296 7 (H3K27me3) and has emerged as an important therapeutic target with inhibitors targeting its methylt

297 d IGF2, FGFR4, CD200, and CD276 as potential therapeutic targets with clinical relevance for patients

298 f stress, anxiety, and depression, and novel therapeutic targets within serotonin neurons are needed

299 eostasis pathways are discussed and possible therapeutic targets within these pathways indicated.

300 nd are some of the most clinically-effective therapeutic targets, yet low consensus of RNA-Seq fusion