ライフサイエンスコーパス: therapeutic use

1 uman proteins would greatly facilitate their therapeutic use.

2 new agents targeting PSMA for diagnostic and therapeutic use.

3 of polymyxin B could further discourage its therapeutic use.

4 diagnostic, investigative, and, ultimately, therapeutic use.

5 gical functions and have great potential for therapeutic use.

6 dies have failed to harness this finding for therapeutic use.

7 w opportunities for genetic manipulation and therapeutic use.

8 nus face, of RA signaling that may guide its therapeutic use.

9 ifferent cell types can also be produced for therapeutic use.

10 oviral particles have broad applications for therapeutic use.

11 engineering of pathway activating agents for therapeutic use.

12 omers to optimize DNA binding properties for therapeutic use.

13 pment of new classes of hGGT1 inhibitors for therapeutic use.

14 ombocytopenia thereby limiting its potential therapeutic use.

15 xic effects and developing safer vectors for therapeutic use.

16 r identity over time could be unsuitable for therapeutic use.

17 ivo, but their anticoagulant activity limits therapeutic use.

18 injury, alternative compounds are needed for therapeutic use.

19 toxic in vivo, which makes it unsuitable for therapeutic use.

20 generation vaccines and for prophylactic and therapeutic use.

21 osition of the tablets and on their possible therapeutic use.

22 f adult HSCs and early progenitors for human therapeutic use.

23 ed with severe side effects that limit their therapeutic use.

24 etabolism, generating increasing interest in therapeutic use.

25 operties make them attractive candidates for therapeutic use.

26 used frequently as functional medicines for therapeutic use.

27 fy potential H(2)S donors and inhibitors for therapeutic use.

28 inflammatory cytokines hampers its potential therapeutic use.

29 n emphasis on translational implications for therapeutic use.

30 robes and, in the longer term, for potential therapeutic use.

31 p these new anti-influenza agents for better therapeutic use.

32 in vitro and in vivo expansion of Tregs for therapeutic use.

33 blishing a safe, clinical grade of cells for therapeutic use.

34 ein and peptide sequences for diagnostic and therapeutic use.

35 develop functional alloreactive NK cells for therapeutic use.

36 and cardiovascular side effects limit their therapeutic use.

37 logues with improved properties for possible therapeutic use.

38 rent classes of p53 activators for potential therapeutic use.

39 esign chemically modified siRNA destined for therapeutic use.

40 the cells derived from iPSCs for any future therapeutic use.

41 ture, for the design of partial agonists for therapeutic use.

42 hting discoveries of genetic engineering and therapeutic use.

43 in bone quality with disease, aging and with therapeutic use.

44 se injection (510 mg iron in 17 seconds) for therapeutic use.

45 nisms that limit the true potential of their therapeutic use.

46 ancer that has potential to be exploited for therapeutic use.

47 and readily available type of stem cells for therapeutic use.

48 A-dependent cellular processes for potential therapeutic use.

49 all molecules and biologics that could be of therapeutic use.

50 geting nucleic acid sensors are approved for therapeutic use.

51 es are under development for prophylactic or therapeutic use.

52 vere side-effects, limiting their widespread therapeutic use.

53 crucial step in developing safer vectors for therapeutic use.

54 ctions for harnessing adult neurogenesis for therapeutic use.

55 and drugs that target NRs are in widespread therapeutic use.

56 of selective PAR2 antagonists for a range of therapeutic uses.

57 probabilistic associations between drugs and therapeutic uses.

58 lecule inflammation suppressant for possible therapeutic uses.

59 r protein to tumor cells, PTEN-Long may have therapeutic uses.

60 interest for food preservation and possible therapeutic uses.

61 progenitor populations for both research and therapeutic uses.

62 itate the optimization of ADCs for a host of therapeutic uses.

63 other small molecules has numerous potential therapeutic uses.

64 hologically active sites and their potential therapeutic uses.

65 ndent functions of EBI3 could compromise its therapeutic uses.

66 om biomaterials development to peptides with therapeutic uses.

67 upport development of a CMV-specific CAR for therapeutic use against CMV and potentially other applic

68 ggest new candidate targets for clinical and therapeutic use against oncocytic tumors.

69 nd support the translation of 25(OH)D in the therapeutic use against these chemical agents.

70 nflammatory inhibitor could potentially have therapeutic uses against fungal infections that have an

71 ents a summary of protein-PEG conjugates for therapeutic use and alternative technologies in various

72 alyzed a human cell line being developed for therapeutic use and found it to be PMCA-negative for vCJ

73 gs, with over 50 such molecules approved for therapeutic use and hundreds more currently in clinical

74 is of protein/peptide-polymer conjugates for therapeutic use and other applications.

75 for ADHD, but the association between their therapeutic use and suicide is unclear.

76 iction; these properties limit its long-term therapeutic use and this has led to a quest for therapeu

77 the present study, we explored the potential therapeutic uses and mechanisms of action of eritoran in

78 Consequently, methods to expand Tregs for therapeutic use are of great interest.

79 that inhibition of these proteins could have therapeutic use as a diuretic strategy.

80 esults suggest that AC inhibitors might find therapeutic use as adjuvant therapy for advanced melanom

81 ells indicating its potential application in therapeutic use as an anti-fibrotic agent.

82 compounds with high added value due to their therapeutic use as drugs and their remarkable biological

83 To be of therapeutic use, autologous stem cells derived from pati

84 These compounds may also be of therapeutic use because they have distinct functional an

85 tal toxicities associated with ICIs as their therapeutic use becomes widespread with a myriad of appr

86 esearch requires pre-clinical testing of new therapeutics using both in-vitro and in-vivo models.

87 immune response, which is crucial for their therapeutic use, demonstrated that constitutive expressi

88 New, simpler therapeutics using direct-acting antivirals that target

89 Here, we review all the therapeutics used during MP in different organ systems (

90 re II score at admission, and procedures and therapeutics used during the first 48 hours before the r

91 Of most promise for therapeutic use, even 1-18 alone fully suppressed viremi

92 Therapeutic Use Exemptions containing objective evidence

93 interfere with this interaction could be of therapeutic use for Alzheimer disease.

94 l post-irradiation, and point to a potential therapeutic use for anti-miR-34 as a radiosensitizing ag

95 by fungal allergens and suggests a possible therapeutic use for cholesterol lowering compounds in re

96 by autoantibodies and highlight a potential therapeutic use for clinically licensed antagonists, suc

97 and in pathology, as well as their potential therapeutic use for lymphatic regeneration.

98 opment of specific cell-cycle inhibitors for therapeutic use for pediatric cancer.

99 ay have the potential to be developed into a therapeutic use for the treatment of mTORC1-driven tumor

100 ntific and medical interest in its potential therapeutic use for the treatment of psychopathologies a

101 enia and effects of ketamine relevant to its therapeutic use for treating major depression.

102 These studies suggest numerous therapeutic uses for ferrostatins, and that lipid peroxi

103 n be exploited to investigate nontraditional therapeutic uses for H1 and H2 biased agonists in malign

104 We also describe how therapeutics used for psychiatric disorders act on the p

105 Proteins are important biologic therapeutics used for the treatment of various diseases.

106 CIN through the BMI1-AURKA axis and suggest therapeutic use from inhibiting Aurora A in head and nec

107 sm, but development of NMDAR antagonists for therapeutic use has been a challenge, in part due to sev

108 s, but progress in developing inhibitors for therapeutic use has been limited largely due to challeng

109 RNAi silencing of specific genes, but their therapeutic use has faced numerous challenges involving

110 er, a more ambitious goal is to develop cell therapeutics using hPSCs to generate and replace somatic

111 Cs) as a source of embryonic-derived AMs for therapeutic use in acute and chronic airway diseases has

112 y, with a focus on their roles and potential therapeutic use in autoimmunity and cancer.

113 cal role of RSA as well as its any potential therapeutic use in cardiac disease.

114 ore efficacious compounds to be explored for therapeutic use in CF.

115 farnesoid X receptor (FXR) and its potential therapeutic use in cholestatic liver diseases.

116 on of TGF-beta1, suggesting that it may have therapeutic use in CKD treatment.

117 upport the application of allogeneic EVs for therapeutic use in clinical studies in which an adaptive

118 prescribed drug for humans, may find further therapeutic use in demyelinating diseases.

119 est that miR-661 be further investigated for therapeutic use in down-regulating the expression of MTA

120 viral monoclonal antibody (mAb) approved for therapeutic use in humans, and remains a prophylactic tr

121 e immune responses to evaluate its potential therapeutic use in mucosal inflammation.

122 th types of compounds hold great promise for therapeutic use in multiple hormonal disorders involving

123 his suggests that calcitonin has a potential therapeutic use in nephrogenic diabetes insipidus.

124 These factors may have therapeutic use in osteoclastogenic removal of mineral d

125 le that an apelin receptor agonist may be of therapeutic use in PAH in humans.

126 monoamine levels and could potentially be of therapeutic use in psychiatric conditions such as depres

127 l target for the development of ligands with therapeutic use in several pathophysiological states.

128 AP2 inhibitors are clearly not optimized for therapeutic use in the clinic.

129 observation of furoxan activity of potential therapeutic use in the CNS warrants further studies.

130 rtant homeostatic process with potential for therapeutic use in the future.

131 coagulation raises the possibility of their therapeutic use in treating thrombotic disorders associa

132 , in combination with Le(b) glycoconjugates, therapeutic use in treatment of drug-resistant H. pylori

133 , survival, and tolerability, supporting its therapeutic use in untreated metastatic urothelial cance

134 , survival, and tolerability, supporting its therapeutic use in untreated metastatic urothelial cance

135 mental mechanisms of action and differential therapeutic uses in cardiovascular diseases.

136 ecular targets) have been proposed for novel therapeutic uses in neuroprotection, cognitive impairmen

137 s as an ECM scaffold at MTJs, with potential therapeutic uses in tendon strengthening and repair.

138 odeficiency virus (HIV) entry, CCR5-targeted therapeutics used in HIV, [small molecules (maraviroc an

139 is a new lead for the development of better therapeutics used in treating wounds of diabetics.

140 Therapeutic use includes visualization of the coronary v

141 O) is promising for neuroprotection, but its therapeutic use is limited because it causes a systemic

142 Its therapeutic use is limited by hypercalcaemic toxicity.

143 However, its therapeutic use is limited by nephrotoxicity, in part me

144 peptides are promising drug leads, but their therapeutic use is often limited by stability and bioava

145 Our aim was to develop unique CXCR4-targeted therapeutics using lipopeptide GPCR modulators called pe

146 eveloping TWEAK- or Fn14-targeted agents for therapeutic use, much more basic science research is req

147 proliferation, may place restrictions on the therapeutic use of a Cdk1 inhibitors.

148 However, the actual therapeutic use of a CocH in cocaine addiction treatment

149 An emerging concept of bacteriotherapy, the therapeutic use of a defined mixture of harmless, health

150 The authors investigated the therapeutic use of a novel recombinant form of fH, CR2-f

151 Thus, we propose the therapeutic use of Abs for the treatment of intracellula

152 The therapeutic use of Abs in cancer, autoimmunity, transpla

153 ffects induced by tumor-MDSC and support the therapeutic use of AMPK inhibitors to overcome MDSC-indu

154 une thrombocytopenia (ITP) has justified the therapeutic use of anti-CD20 antibodies such as rituxima

155 mune liver disease and emphasize caution for therapeutic use of anti-IL-6R antibody.

156 Our findings have implications for the therapeutic use of antibodies and suggest that high leve

157 ith HNFS angiosarcoma had received off-label therapeutic use of antibody to the programmed death-1 pr

158 forward, this review discusses the potential therapeutic use of antigen-specific tolerance strategies

159 In contrast, the proposal for therapeutic use of antihypoxic oxygenation described her

160 crobiology, Liu et al. (2016) show that even therapeutic use of antimicrobials in dairy calves has an

161 The therapeutic use of antisense and siRNA oligonucleotides

162 re, this work provides new insights into the therapeutic use of ATP-competitive RAF inhibitors.

163 cy and also provide a proof of principle for therapeutic use of autophagy enhancers.

164 However, the effective therapeutic use of autophagy induction requires detailed

165 These data provide the rationale for therapeutic use of avelumab in metastatic urothelial car

166 Therapeutic use of blocking antibodies to PD-L1 or its r

167 In the capacity of therapeutic use of BMSCs other than structural repair an

168 This finding raised the possibility of therapeutic use of Bmx tyrosine kinase inhibitors, which

169 infected macaques would be important for the therapeutic use of bnAbs and eventually towards the func

170 and may have important implications for the therapeutic use of bnAbs to treat acute HIV infections.I

171 ABSTRACT: Therapeutic use of c-kit(+) cardiac progenitor cells (CP

172 y shifts in the legality of recreational and therapeutic use of cannabis in the United States, as wel

173 The therapeutic use of cardiac glycosides (CGs), agents comm

174 ntial implications for our understanding and therapeutic use of CD8(+) T cells, as well as mechanisms

175 gs have implications for the development and therapeutic use of cells that are reprogrammed by any me

176 the appearance of resistance and support the therapeutic use of combined cell-cycle inhibitors with B

177 However, the practical therapeutic use of CRISPR/Cas9 is still questionable due

178 drug, and the results support the potential therapeutic use of CRLX522 as a new anticancer agent.

179 at facilitate physical isolation, study, and therapeutic use of culture-expanded, stromal cell subpop

180 ting on autophagy, providing a rationale for therapeutic use of DBS and synaptic stimulation in tauop

181 These results support future therapeutic use of decorin as a next-generation protein

182 -dependent fashion, supporting the potential therapeutic use of DOR agonists in pain management under

183 The discovery, development, and therapeutic use of drugs that inhibit MAO-B are major ch

184 Future therapeutic use of engineered site-directed nucleases, l

185 However, therapeutic use of estrogens in this and other regards r

186 Therapeutic use of FDA-approved perampanel treatment mig

187 We summarize the latest information on therapeutic use of fecal microbial transplantation and p

188 ave important implications for the potential therapeutic use of FLT3 inhibitors in that patients with

189 Despite the broad-spectrum therapeutic use of GC, the biochemical rationale for loc

190 s study provides an improved approach to the therapeutic use of GHRH agonists in the treatment of dia

191 These results support the therapeutic use of GHRH-R agonists for stimulating endog

192 The therapeutic use of guanidine is limited, however, becaus

193 on and may also provide implications for the therapeutic use of HDAC inhibitors.

194 ant implications for mechanism of action and therapeutic use of HDAC inhibitors.

195 Two major hurdles for therapeutic use of Hsp90 inhibitors are systemic toxicit

196 her study of the genomic consequences of the therapeutic use of hydroxyurea.

197 r exercise tolerance provide a rationale for therapeutic use of IL-37 in the treatment of inflammatio

198 tiating and regulating immune responses, the therapeutic use of individual cytokines as anticancer im

199 nd important to define, given the widespread therapeutic use of inhaled GCs.

200 In addition, the therapeutic use of iPSCs relies on the development of ef

201 iTreg differentiation and may facilitate the therapeutic use of iTregs in immune disorders.

202 ve important implications with regard to the therapeutic use of l-arginine and the methylarginine-NOS

203 due to its impaired brain delivery prevents therapeutic use of leptin in overweight and moderately o

204 less well-known clinical application is the therapeutic use of low-dose biophotonics termed photobio

205 Resistance has compromised the therapeutic use of many antimalarial drugs, including ch

206 A major challenge for the therapeutic use of many peptides and proteins is their s

207 Our findings suggest the potential therapeutic use of MAP4343 for the treatment of DDs, bas

208 search is needed in all areas related to the therapeutic use of marijuana in oncology.

209 d create the basis for future studies on the therapeutic use of melatonin in retinal degeneration.

210 Also, we consider the potential therapeutic use of memory T cell inflation as a vaccine

211 Cmec element, some 14 years before the first therapeutic use of methicillin.

212 Here the authors demonstrate the in-vivo therapeutic use of micromotors to treat H. pylori infect

213 rovide a cogent foundation for the potential therapeutic use of miRNA-facilitated gene delivery strat

214 We describe here an approach for the therapeutic use of monoclonal antibodies based on contex

215 ent of more-specific receptor modulators for therapeutic use of MS.

216 les control MSC responses and may impact the therapeutic use of MSCs.

217 equent adverse condition associated with the therapeutic use of mTOR inhibitors.

218 The therapeutic use of muscle stem cells for improving muscl

219 vide a conceptual framework for the combined therapeutic use of neurotrophic factors in degenerative

220 signaling in AML and elucidate the potential therapeutic use of Notch receptor agonists in the treatm

221 ion of p75(NTR) and open new avenues for the therapeutic use of p75(NTR) inhibition to combat diabete

222 ion predicts HR deficiency and the potential therapeutic use of PARP inhibitors in DLBCL and T-ALL.

223 effects and, thus, do not limit a potential therapeutic use of PDGF-CC inhibition in renal fibrosis.

224 vestigation into the clinical prognostic and therapeutic use of PDGFB-to-PDGFRbeta signaling in women

225 many would make terrific drugs; however, the therapeutic use of peptides is limited by poor metabolis

226 ide a preclinical rationale for the possible therapeutic use of PF-956980 in conjunction with convent

227 ector designs, targeted gene delivery or the therapeutic use of pluripotent stem cells, herald the ad

228 suggest that increased amylin levels or the therapeutic use of pramlintide could increase the risk o

229 ition, this study provides rationale for the therapeutic use of prolyl hydroxylase inhibitors in the

230 lation and progression of the diagnostic and therapeutic use of radiology was slow and affected by pe

231 These results suggest the potential therapeutic use of ranolazine and GS-967 and call for fu

232 Despite advances in the therapeutic use of recombinant granulocyte colony-stimul

233 ough purely chemical means, which would make therapeutic use of reprogrammed cells safer and more pra

234 Resistance to therapeutic use of retinoids in glioma has been observed

235 These data also suggest a potential for therapeutic use of ribavirin for human EBOV infections.

236 Therapeutic use of SDF-1 in hindlimb ischemia may be cha

237 g brain plasticity and support the potential therapeutic use of selective GABA(A) alpha5 NAMs to trea

238 heir experiences; 2) Facilitating growth; 3) Therapeutic use of self; 4) Choosing the right approach

239 hese findings also have implications for the therapeutic use of sex hormones and sex hormone modulato

240 ur strategy for therapeutic applications.The therapeutic use of single-chain antibodies (VHHs) is lim

241 nistic studies to explore the diagnostic and therapeutic use of smoking-related microRNAs.

242 es may limit the prognostic, diagnostic, and therapeutic use of SNP markers such as those in MAMDC1.

243 Although this raises safety issues for therapeutic use of such cells, the frequent observation

244 e myeloid leukemia and suggest a potentially therapeutic use of synthetic miR-29b oligonucleotides as

245 of cardiac pathology in KD and the relative therapeutic use of targeting these cytokines.

246 Our results strongly suggest an important therapeutic use of test compounds, especially TQ, in the

247 del applies physiological movement, emulates therapeutic use of the electrodes, and enables advanced

248 nmet medical need, and our results suggest a therapeutic use of the pertinent antagonists in clinical

249 ests that clinicians can make diagnostic and therapeutic use of their responses to patients.

250 However, the therapeutic use of these agents is associated with serio

251 The possible therapeutic use of these GSLs has been studied in many w

252 The potential therapeutic use of these peptides, however, is limited b

253 considered for appropriate experimental and therapeutic use of these reagents.

254 hese findings strongly support the potential therapeutic use of this antibody in the treatment of sys

255 antitumor immunity, supporting the potential therapeutic use of this novel immunomodulator in the tre

256 ole in the complications associated with the therapeutic use of tPA in stroke is not yet available.

257 Interest in the therapeutic use of turmeric and the relative ease of iso

258 Furthermore, therapeutic use of type I IFN is associated with PAH.

259 (Therapeutic Use of Ultrasound in Acute Coronary Artery D

260 This supports therapeutic use of vitamin B3 in glaucoma and potentiall

261 de a mechanistic rationale for exploring the therapeutic use of vitamin C for CRCs with KRAS or BRAF

262 which impacts Th2 responses and supports the therapeutic use of vitamin D in diseases regulated by OX

263 vation may be important when considering the therapeutic use of VLPs.

264 ly, we provide an outlook on possible future therapeutic uses of BAT in the treatment of obesity and

265 butes to human AD neuropathology and suggest therapeutic uses of blocking LilrB2 function.

266 cent in vivo studies demonstrating potential therapeutic uses of catalytic nanomaterials.

267 While many early therapeutic uses of electricity did not produce effectiv

268 PR35 signaling and for identifying potential therapeutic uses of GPR35.

269 pact of IFN-I signaling, discuss the current therapeutic uses of IFN-I, and explore the strategy of b

270 chemical constituents of kenaf and roselle, therapeutic uses of kenaf and roselle.

271 Therapeutic uses of mesenchymal stromal cells (MSCs) hav

272 We discuss the main therapeutic uses of polymeric drugs as sequestrants, ant

273 asis, with a specific focus on the roles and therapeutic uses of protein chaperones.

274 , which should be considered when developing therapeutic uses of stem cells.

275 h as functional analysis of the pathways and therapeutic uses of the drugs.

276 basis for the different binding, action, and therapeutic uses of these drugs remains unknown.

277 e use of altered alpha-1-antitrypsin propose therapeutic uses of these serpins for the management of

278 repositioning histaminergic ligands for new therapeutic uses, or even including agonists of the hist

279 For therapeutic uses, our predictions significantly overlapp

280 gies included have shown varying promise for therapeutic use, specifically having been used to delive

281 We have developed an antivascular tumor therapeutic using the F3 peptide to target cisplatin-loa

282 With regard to therapeutic use, the compound exhibited a rapid clearanc

283 read beyond the laboratory to diagnostic and therapeutic use, the demands of gRNA synthesis have incr

284 advances that have been made in HIV research/therapeutics using these models.

285 nical development of RNA interference (RNAi) therapeutics using these small RNAs.

286 of selective targeting of specific GEFs for therapeutic use, this notion is largely unexplored for S

287 e mammalian host with implications for their therapeutic use to precisely modulate the microbiome.

288 on of the viral life cycle and has potential therapeutic use to reduce virus production with low asso

289 id regulating brain development as well as a therapeutic used to relieve the negative components of p

290 Rifampicin (Rif) is a first-line therapeutic used to treat the infectious disease tubercu

291 Erythropoietin (EPO) is one of the main therapeutics used to treat anemic patients, greatly impr

292 There is an opportunity to repurpose therapeutics used to treat other diseases to treat type

293 sed as a tool for the further development of therapeutics used to treat RVFV infection.

294 f chronic lymphocytic leukemia (CLL) and the therapeutics used to treat this disease.

295 e development of human variants suitable for therapeutic use, we determined the structure of human l-

296 d clinical stages, including 48 approved for therapeutic use, were collected and used to construct is

297 cells (iPSCs) are attractive candidates for therapeutic use, with the potential to replace deficient

298 pathogen that has been widely developed for therapeutic uses, with only limited success to date.

299 nds, many in clinical trials or approved for therapeutic use, yielded >200 hits.

300 sessing potential efficacy and toxicities of therapeutics use young mice.