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2 fluorine-substituted cyclohexene analogues, thereby identifying 8 and 9 as novel selective hOAT time
3 to obtain a composite material (PF-TMPPCo), thereby achieving a homogeneous catalysis environment in
4 improved aqueous solubility (up to 28-fold), thereby addressing a key shortcoming of this antibiotic.
5 formalisms), and genetic repressor kinetics, thereby allowing a large class of models to be transform
6 regulated the pro-survival PI3K-AKT cascade, thereby changing a balance between cell death and surviv
7 s to supporting inclusivity in cell biology, thereby creating a future where diversity, equity, and i
8 on global network states and state changes, thereby creating a unifying account of local influences
9 ) to detect poorly soluble natural products, thereby defining a form of contact-dependent, aquatic ch
10 on through the EGF receptor/ERK/Fos pathway, thereby demonstrating a potential neuroprotective mechan
11 ccessibility and photoreceptor degeneration, thereby elucidating a potential new therapeutic strategy
13 ) directly enhances Flower channel activity, thereby establishing a positive feedback loop for PI(4,5
14 HD1 loss results in chromatin dysregulation, thereby establishing a state of transcriptional plastici
15 ed 6 trillion liters of oil from the ground, thereby giving a striking illustration of the impact of
16 biont strain, then embryos develop properly, thereby imparting a relative fitness benefit to symbiont
17 and 3.2 Ga and soon afterwards disappeared, thereby indicating a complex ancient Martian hydrosphere
18 homeostatic reduction in ribosomal subunits, thereby offering a mechanism for the suppression results
20 age in decision processing on single trials, thereby providing a detailed picture of the network dyna
21 prey bacterium, which leads to its killing, thereby providing a growth advantage for P. aeruginosa i
22 found to affect the local glycan processing, thereby providing a molecular basis of the site-specific
23 ergent functionality of the heterostructure, thereby providing a new approach to designing oxide hete
24 gether to form intralamellar water channels, thereby providing a pathway for the permeation of hydrop
25 parasite's digestive vacuole to the cytosol, thereby providing a source of amino acids for parasite m
26 der of magnitude below the background value, thereby realizing a long-lived sample of polar molecules
27 ell analyses offer individual consideration, thereby revealing a broad spectrum of diversity as well
28 tive memory deficits in specific cell types, thereby revealing a mechanism by which IEDs disrupt medi
29 ed depend on the type of gene and/or stress, thereby suggesting a 'personalized', rather than general
31 classic miR-146a targets (IRAK1 and TRAF6), thereby blocking activation of NF-kappaB in target cells
32 it tumor progression by stabilizing LATS and thereby promoting activity of the Hippo tumor suppressor
33 t (HFD)-induced adipose tissue inflammation, thereby improving adipose tissue and hepatic insulin sen
34 s a phenotypic trait beyond a tipping point, thereby resulting (after a substantial delay) in a selec
35 escent cells and diminish cf-mt-DNA release, thereby dampening age-specific immune responses and prol
37 sional (2D) (15)N-(1)H NMR correlations, and thereby combining an enhanced spectral resolution with s
39 distinct gene sets at each transition point, thereby providing an accurate transcriptional timeline f
40 d inverting such trial-to-trial differences, thereby revealing an a priori hidden, precise temporal s
41 he feedback to down-regulate Spo11 activity, thereby revealing an additional function for the SC.
42 erentiation of immature Schwann cells (SCs), thereby forming and maintaining the myelin sheath around
43 nsion of the 5'Hoxd second expression phase, thereby establishing anterior-posterior asymmetry in the
45 e same partners, MtTT8 and MtWD40-1, as RH1, thereby acting as a competitor in the regulatory complex
46 ved at -1.2 V wherein Fc(+) is reduced to Fc thereby facilitating As desorption from the electrode su
47 ood cell counts (neutrophils and monocytes), thereby increasing atherosclerosis severity, even when o
49 e (MAO) metabolizes cytosolic dopamine (DA), thereby limiting auto-oxidation, but is also thought to
50 9orf72-HRE impairs Mitf/TFEB nuclear import, thereby disrupting autophagy and exacerbating proteostas
52 ria secrete and sense a diffusible molecule, thereby enabling bacterial groups to coordinate their be
53 and phosphorylates Beclin 1 at Ser90/Ser93, thereby impairing Beclin 1-Bcl-2 autophagy-regulatory co
55 wanella oneidensis MR-1 to a gold electrode, thereby increasing biocurrent ~150-fold over control bio
56 mal tubule, these agents promote glycosuria, thereby reducing blood glucose concentrations and often
58 inciple within real-life cultural processes, thereby enriching both sociocultural theories and Bayesi
60 sample collected from a single cultivation, thereby reducing by a factor of 2 both the number of cul
61 NMDP induces PDE3A-SLFN12 complex formation, thereby killing cancer cells with high levels of PDE3A a
62 low resistance of all brain vessel segments, thereby controlling capillary flow while protecting the
63 broadly attenuate sympathetic dysregulation, thereby improving cardiovascular regulation and immunity
65 o RUX, this apoptotic potential is restored, thereby sensitizing CD8 T cells to DEX-induced apoptosis
66 1)-DNA complexes trapped by PARP inhibitors, thereby promoting cell survival after drug treatment.
67 om the extracellular matrix to tendon cells, thereby triggering cell signaling pathways which lead to
68 K and PI3K-Akt signaling pathway activation, thereby regulating cementoblast function and affecting I
69 els of RNAs comprising multiple RNA classes, thereby regulating chromatin structure, gene expression
70 nd to directly regulate BRCA1 transcription, thereby increasing cisplatin sensitivity and serving as
71 without a significant loss in data quality, thereby supporting clinical translation of said non-cont
73 ring ESC differentiation de-represses Dot1l, thereby allowing coordinated expression of differentiati
74 inflammation and thrombotic microangiopathy, thereby increasing coronavirus 2019 (COVID-19) mortality
76 hotel" to simultaneously image up to 4 mice, thereby reducing costs and maximizing the efficiency of
77 s associated with the stepwise condensation, thereby providing critical information for a variety of
78 eads the absorbed energy over many crystals, thereby reducing damage, has rendered room temperature (
79 ndent of methyltransferase activity or PRC2, thereby facilitating DDB2 localization to cyclobutane py
80 ng during imaging with high-speed detectors, thereby lessening demands on cryostage precision and sta
81 iptional regulation, and RNA processing, and thereby mediating developmental and metabolic processes
82 se in the absence of structural abnormality, thereby enhancing diagnostic sensitivity, but its simult
83 ange rates between the amides and the water, thereby yielding diagnostic information about solvent ac
84 leads to the selective reaction of graphene, thereby completing direct laser writing on graphene towa
85 dy can be used to trap GFP in the cell body, thereby enabling direct visualization of previously unde
86 ystems by releasing drug at a constant rate, thereby maintaining drug concentrations within the thera
88 and functional trait profiles and diversity, thereby affecting ecosystem processes of the whole tundr
93 lls and migrate along the midgut epithelium, thereby conveying endosymbionts to midgut sites where fu
94 properly suspended when they are not needed, thereby conserving energy for growth and development.
95 ing of reef geography and its human impacts, thereby guiding environmental management for reef resili
97 ith fast kinetics and exquisite selectivity, thereby enabling facile modification of NCys-bearing pro
98 f the reaction with the organozinc reagents, thereby allowing for the synthesis of cyclic and acyclic
100 gitudinal data from a real glaucoma patient (thereby controlling for other variables, such as age and
101 by-area fixed effects in all specifications, thereby controlling for overall trends in antidepressant
102 nd macrophages carry out hematoma clearance, thereby facilitating functional recovery after ICH.
105 deprivation, Gcn2 phosphorylates eIF2alpha, thereby repressing general translation while enhancing t
106 risk into medically actionable information, thereby improving genetic diagnosis and identifying nove
107 ese projects in other low-resource settings, thereby bringing genomic medicine in these countries clo
108 f inducing a profound cell state transition, thereby linking genomic plasticity, phenotypic plasticit
109 assaying the fitness of millions of mutants, thereby relating genotype to phenotype and contributing
111 roxymethylation of genes important for GSCs, thereby increasing GSC tumorigenicity and resistance to
112 cluding appropriate rehabilitative services, thereby maintaining health, productivity, and quality of
114 ecognition of HERVs in myeloid malignancies, thereby implicating HERVs as potential targets for immun
118 r latent HIV reactivation in CNS reservoirs, thereby reducing HIV-associated neuroinflammation.IMPORT
119 factor(s) from attenuated transgenic arrays, thereby preventing HLB formation and gene expression on
122 HSP27 phosphorylation and depolymerization, thereby blocking HSP27-regulated survival signaling and
123 r down, altering viscoelastic properties and thereby driving immiscibility between different condensa
124 tion can be excessive and/or become chronic, thereby resulting in considerable tissue damage and path
125 mitochondria in Angpt2-silenced tumor cells, thereby resulting in enhanced reactive oxygen species (R
127 ing transcription of inflammation inhibitors thereby enabling inflammatory macrophage activation.
129 me a major agricultural pest in these areas, thereby prompting intense research activities to better
130 upt methionine metabolism in CD8(+) T cells, thereby lowering intracellular levels of methionine and
131 jugating enzyme UBE2N by transglutamination, thereby abolishing its function in the synthesis of K(63
132 nhance expression of flagellin by Salmonella thereby amplifying its ability to elicit cell death.
133 excellent yields and with high selectivity, thereby demonstrating its broad utility and functional g
134 une surveillance by neighboring macrophages, thereby exacerbating its relative survival advantage.
137 umor volumes, angiogenesis, and oxygenation, thereby reflecting its effectiveness for extending progr
138 ce the evolution of oxygenic photosynthesis, thereby exerting key influence on Earth's climate and th
140 can benefit from any available sensory cue, thereby permitting learning under different natural cond
142 the conversion of l-tyrosine to dopaquinone, thereby initiating melanin synthesis, i.e., melanogenesi
143 ithin interphase bridges and then shattered, thereby producing micronuclei whose encapsulated ecDNAs
145 pplied to interpretation of literature data, thereby providing more rigorous insights into previous o
148 ates PTEN by dephosphorylating PTEN at Y336, thereby augmenting NEDD4-mediated PTEN ubiquitination an
151 elevating intracellular aKG concentrations, thereby sequestering nitrogen from aspartate through glu
152 mesenchymal-myeloid unit of the distal lung, thereby opening numerous new avenues to study lung devel
153 aling distinct phenotypes upon perturbation, thereby informing on the function and mechanism of actio
154 s were subjected to accurate quantification, thereby defining operative ranges to accept/reject incom
156 ast two mechanisms: by complexing Fe(2+) and thereby raising pe, and by making hematite more negative
158 t the bifurcation anatomy and plaque burden, thereby enabling planning, education, and decision makin
160 ion of costimulatory ligands CD70 and OX40L, thereby inducing potent cytotoxic CD4(+) and CD8(+) T ce
161 tin expression on erythroid precursor cells, thereby lowering potentially toxic-free intracellular ir
162 he nascent A-tail from uridylation and decay thereby protecting pre-mRNA upon KPAF3 displacement by e
163 diffusion rate of molecules and organelles, thereby affecting processes such as metabolism and signa
164 lant responses to eCO(2) under P limitation, thereby improving projections of future global change im
165 r adequate expression of maternal behaviour, thereby ensuring proper development of the offspring.
166 site-specific phosphorylation of protamine, thereby triggering protamine-to-histone exchange in the
167 ed with cytosolic pool of D and L-glutamate, thereby coupling protein and cell envelope synthesis wit
168 enerates modifications to the RNA sequences, thereby increasing protein diversity and shaping various
171 novel therapeutic strategy to restore PTEN, thereby obliterating PTEN deficiency-induced malignancie
172 r reductively monofunctionalized byproducts, thereby offering rapid access to these privileged scaffo
174 nd promotes PMN apoptosis and efferocytosis, thereby facilitating resolution of E. coli-evoked lung i
176 ints on the backbone to the gold electrodes, thereby giving rise to multiple conductance pathways.
178 tery cell as a resonator in a tuned circuit, thereby allowing signals to be excited inside the cell,
179 er, and plant uptake of nutrients and water, thereby accelerating SOC turnover through both stabiliza
183 rmula: see text] compounds may now be drawn, thereby providing suggestions for additional experiments
184 for degradation products of sulfur mustard, thereby indicating suitability of the SMS-PID unit for f
185 Fe site has a suitable coordination number, thereby providing support for the intermediacy of organo
186 cing APT in the presence of 2-fluoroadenine, thereby establishing survival itself as a reporter of RN
187 ulation to exchange cell surface components, thereby increasing survival during mammalian infection.
189 nd CD38 inhibition improved NAD homeostasis, thereby alleviating telomere damage, defective mitochond
190 regulated in Phase II than it is in Phase I, thereby indicating that the Phase II is more mature.
191 HIV-1 replication in primary CD4(+) T cells, thereby suggesting that Tim-3 expression might represent
192 e best synthesizability and phase stability, thereby achieving the highest conductivity of 2.3 x 10(-
193 P degraded p3 through the autophagy pathway, thereby affecting the silencing suppression activity of
194 potentially elucidate mechanisms of injury, thereby aiding the medical diagnosis and decision-making
195 cenario associated with CcMADS19 repression, thereby allowing the activation of CiFT2 the following c
196 regulating chromatin accessibility changes, thereby allowing the activation of gene expression progr
198 the ability of flies to sense seasonal cues, thereby altering the extent of female reproductive dorma
200 orods and the stability of their assemblies, thereby assisting the design of ordered, anisotropic nan
201 ors from triggering nitric oxide production, thereby attenuating the flow increase evoked by neural a
202 ral modulations on face scanning strategies, thereby challenging the notion of universality in face p
203 ssociation of individual replisome subunits, thereby challenging the notion that lagging-strand DNA p
204 nfidence judgments varied across conditions, thereby changing the amount of action information (e.g.,
205 tuned through the addition of a surfactant, thereby controlling the surface energies, which then lea
206 ion-specific neuronal differentiation genes, thereby controlling the timing of neuronal maturation.
207 ost, diamondback moth (Plutella xylostella), thereby countering the virulence effect of Bacillus thur
208 d/or infiltration of microglia to the region thereby curtailing the deleterious consequences of neuro
209 ptional upregulation and expression of KCC2, thereby delaying the GABA switch in pups of both sexes.
210 tufts while sparing healthy retinal vessels, thereby demonstrating the therapeutic potential of this
212 the selective regulation of AXL by p85beta, thereby disrupting the autophagic degradation of the AXL
214 ing to substantially reduce measurement time thereby enabling the acquisition of reasonably large tra
215 llow expanding current screening capacities, thereby enabling the expansion of detection in the commu
216 Beclin-1 from LRPPRC-mediated sequestration, thereby enabling the initialization of downstream autoph
217 tor, carboxy-S-adenosyl-l-ethionine (cxSAE), thereby enabling the stereoselective transfer of a chira
218 ane velocity at frequencies above the shift, thereby enabling the transfer of electrical to mechanica
219 ass by oxidatively cleaving polysaccharides, thereby enhancing the efficiency of glycoside hydrolases
220 ably maintains methylation over generations, thereby establishing the robustness of the epigenetic co
221 nt organic and metal cation functionalities, thereby expanding the key physicochemical properties tha
222 nding of miRNA-AGO complexes to target RNAs, thereby explaining the basis of cooperative action.
223 te to such a teaching signal for plasticity, thereby facilitating the formation of fear memories.
224 gens spread and the impact of interventions, thereby facilitating the safe reopening of schools.
225 osomes with the non-canonical histone H2A.Z, thereby focusing the pathway on select sites such as tra
226 etection of certain GPL classes over others, thereby hampering the analysis of suppressed species and
227 o the field of far-IR spectroscopy is given, thereby highlighting the opportunities that are provided
228 angstrom cryo-EM structure of human DEC-205, thereby illuminating the structure of the mannose recept
229 ees -view increases small-bowel CE accuracy, thereby improving the clinical management of CD patients
232 n the electrolyte surrounding the electrode, thereby increasing the sensitivity of the SWV-based dete
233 of the channel in the top virus-PEDOT layer, thereby increasing the sensitivity of the VBR and enabli
234 istribution of tumor cells within an animal, thereby influencing the global pattern of metastasis in
235 , and histone modifiers to engage chromatin, thereby initiating the formation of an activating or rep
236 phosphine reduction of azide trigger groups, thereby liberating the individual RNA components for fur
237 ligand-binding modes of FPR2 remain elusive, thereby limiting the development of potential drugs.
239 the inositol trisphosphate receptor (IP3R), thereby linking the endo-/sarcoplasmic reticulum to the
241 s with lifetimes as long as 61 microseconds, thereby mimicking the functions of the natural systems.
243 edd8 conjugated VHL is unable to bind to p53 thereby preventing the induction of antiangiogenic facto
244 only recognizes cultures as 'type material', thereby preventing the naming of uncultivated organisms.
245 termediate acceptors of cellular-derived UC, thereby preventing the saturation of HDL particles and f
246 stabilization of the domain-domain interface-thereby promoting the allosteric transition that trigger
247 ines or [B(2)C(4)H(4)](2-) diboratabenzenes, thereby proving the higher persistence of the aromaticit
248 e depth of synthesized vector DNA libraries, thereby raising the discovery cost of novel vectors.
249 o regulate its interaction kinetics with SR, thereby reducing the nonspecific targeting of signalless
250 itude current and desensitize the receptors, thereby reducing the peak amplitude of subsequent synapt
251 of Uqcrb, and with the 5'UTR of Ndufb6 mRNA, thereby regulating the splicing of Apob mRNA and the tra
252 ABA(A)R accumulation at inhibitory synapses, thereby regulating the strength of synaptic inhibition.
253 ciency governs monogenic TCRbeta expression, thereby restraining the expression of multiple AgRs on a
254 l protein encoded on the same messenger RNA, thereby revealing the use of functional bicistronic oper
255 extends to both size and spatial topologies, thereby rivaling the synaptic specificity of chemical sy
256 light reflex and circadian photoentrainment, thereby shifting the dynamic range of these behaviors to
258 zation and YAP-dependent expression of CDX2, thereby specifying the first trophectoderm cells of the
259 s in cells of mammals, flies, and nematodes, thereby specifying the half-lives of most short-lived mi
260 nd modification of a nearby cysteine (C665), thereby stabilizing the loop in an activating configurat
261 ctivate chemoreflex and suppress baroreflex, thereby stimulating the sympathetic nervous system and c
262 a(i)) that decreases the depolarizing I(NCX) thereby suppressing the action potential plateau and del
263 maller than those found in related hydrides, thereby violating the so-called Switendick criterion.
264 rogram toward ferroptosis in cardiomyocytes, thereby worsening the progression of diabetic cardiomyop
265 rm arrest on high endothelium venules (HEV), thereby attributing their inefficient trafficking to alt
266 ors continuously logging absorbance spectra, thereby challenging their applicability for monitoring.
267 m conventional diagnostics and therapeutics, thereby facilitating their clinical applications in a ra
268 inity to PS externalized by apoptotic cells, thereby hindering their interaction with immune cells.
272 urfs downslope along an elevational gradient thereby introducing them to warmer climates and novel pl
273 laborious procedures, or bulky instruments, thereby decentralizing this important test for combating
278 the monocyte chemoattractants CCL2 and CCL7, thereby contributing to the replenishment of the RPM net
279 ration, proliferation and immune reactivity, thereby contributing to tumour immune evasion and promot
280 educed lipopolysaccharides content in blood, thereby helping to reduce systemic inflammation and reve
281 ccessibility of hnRNP K for host transcripts thereby leading to a program of host splicing changes th
283 l local reproduction and local interactions, thereby leading to interacting individuals being genetic
285 formation that can bind specific DNA motifs, thereby serving to either activate or repress transcript
286 -cysteine depleted both NADPH and GSH pools, thereby allowing toxic accumulation of reactive oxygen s
288 change factor eIF2B to block eIF2 recycling, thereby halting translation initiation and reducing glob
290 ates non-degradative ubiquitination of TSC1, thereby promoting TSC1-TSC2 dimerization and TSC2 stabil
293 variance and covariance in risk for disease, thereby identifying underlying biological processes and
294 ramework derived from an energy perspective, thereby allowing us to study effects of thrombus microst
295 dramatic reductions in acquisition times and thereby enabling us to probe fast interaction kinetics s
296 cally inhibits USP8 deubiquitination of FZD, thereby governing USP8 substrate specificity and promoti
297 ons alter mitochondrial dynamics in neurons, thereby facilitating viral replication and pathogenesis.
298 ke volume, cardiac output and O(2) delivery, thereby impairing VO2 peak and thus exercise capacity.
299 ion of chitin from shrimp shell waste (SSW), thereby offering water-soluble chitin hydrolysates for t
300 rotation of fluorine atoms in anionic sites, thereby enabling ZU-61 to effectively differentiate xyle