ライフサイエンスコーパス: thermogenic

1 o mitochondrial dynamics are required for BA thermogenic activation and for the control of energy exp

2 nock-out (Lcn2(-/-)) mice have defective BAT thermogenic activation caused by cold stimulation and de

3 Both cold-induced and pharmacological thermogenic activation enhances HDL remodelling, which i

4 cytes and BAF60a-deficient adipose tissue to thermogenic activation in response to ACTH stimulation.

5 ing and leptin but were related to increased thermogenic activation of brown adipose tissue and induc

6 of Ffar4 agonist (GW9508) recapitulated the thermogenic activation of EPA by increasing oxygen consu

7 ochondrial dysfunction, thereby antagonizing thermogenic activation of sWAT.

8 essibility and renders adipocytes poised for thermogenic activation remains elusive.

9 Impairment of thermogenic activation was correlated with diminished ex

10 dissipate chemical energy as heat, and their thermogenic activities can combat obesity and diabetes.

11 ded that the K(+) channel TASK1 controls the thermogenic activity in brown adipocytes through modulat

12 irectly measure BAT temperature and to track thermogenic activity in vivo.

13 RACT: Promoting beige/brite adipogenesis and thermogenic activity is considered as a promising therap

14 cell recruitment into WAT and by supporting thermogenic activity of BAT.

15 expenditure by controlling the oxidative and thermogenic activity of brown adipose tissue (BAT).

16 subpopulation, which could explain the lower thermogenic activity of human compared to mouse adipose

17 offspring BAT had lower Ucp1 expression and thermogenic activity.

18 capular region of recipient mice and exhibit thermogenic activity.

19 geting this pathway could be used to restore thermogenic activity.

20 ks act in concert to regulate key aspects of thermogenic adipocyte biology remains largely unknown.

21 ing visceral white adipocyte precursors to a thermogenic adipocyte fate, and suggest a novel strategy

22 bally profiled lncRNA gene expression during thermogenic adipocyte formation and identified Brown fat

23 selenation, which correlates with impacts on thermogenic adipocyte function and presumably other biol

24 es resembling those of a recruitable form of thermogenic adipocytes (that is, beige adipocytes).

25 However, whether the activation of thermogenic adipocytes affects the metabolism and anti-a

26 -specific mechanism of communication between thermogenic adipocytes and sympathetic neurons.

27 e the notion that high metabolic activity of thermogenic adipocytes confers atheroprotective properti

28 Here we show that thermogenic adipocytes express a previously unknown, mam

29 A small population of thermogenic adipocytes expressing uncoupling protein-1 (

30 adipocyte precursor cell that gives rise to thermogenic adipocytes in subcutaneous adipose tissue.

31 he transcriptomic signature of "brite/beige" thermogenic adipocytes reveals mechanisms for iron accum

32 Thermogenic adipocytes subsets decrease obesity in mice,

33 ortance, how placental mammals license their thermogenic adipocytes to participate in postnatal uncou

34 Two types of thermogenic adipocytes with distinct developmental and a

35 ), results in the accumulation of beige-like thermogenic adipocytes within multiple visceral adipose

36 The 2 types of thermogenic adipocytes, brown and beige, are thought to

37 ance is dependent on the adrenergic state of thermogenic adipocytes, which indirectly regulate tolero

38 tive thermogenesis, a process carried out by thermogenic adipocytes.

39 hat HSF1 is more abundant in differentiated, thermogenic adipocytes.

40 Here we use thermogenic adipose tissue from mice as a model system t

41 However, hurdles exist in activating thermogenic adipose tissue in humans.

42 Thermogenic adipose tissue is a metabolic sink for exces

43 to UCP1, elevated energy expenditure through thermogenic adipose tissue, and protected against obesit

44 The total mass and activity of thermogenic adipose tissues are also tightly linked to s

45 required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat.

46 (rec-Lcn2) resulted in the up-regulation of thermogenic and beige/brown markers (UCP1, PRDM16, ZIC-1

47 We measured formation temperatures of thermogenic and biogenic methane using a "clumped isotop

48 Thermogenic and biogenic sources were compositionally di

49 om the addition of deltaD-CH4 to distinguish thermogenic and biogenic sources.

50 f beige adipocytes ('beige adipogenesis'), a thermogenic and energy-dissipating function mediated by

51 perties of visceral fat, including decreased thermogenic and increased inflammatory gene expression a

52 ilar to the ANKO mice, BANKO mice had normal thermogenic and lipolytic responses.

53 ss to type I IFN in adipose cells to promote thermogenic and mitochondrial function.

54 cumulation of microbial methane mixed with a thermogenic and possibly a minor abiotic gas fraction be

55 brown adipose tissue activates the canonical thermogenic and uncoupling gene expression program.

56 ate brown adipose tissue enhancers to ensure thermogenic aptitude.

57 e mice but these effects do not track with a thermogenic BAT phenotype.

58 acquired high-amplitude circadian rhythms in thermogenic BAT.

59 Activation of thermogenic beige adipocytes has recently emerged as a p

60 types: energy-storing white adipocytes, and thermogenic beige and brown adipocytes.

61 The prevailing dogma is that thermogenic brown adipose tissue (BAT) contributes to im

62 ld exposure on circadian lipid metabolism in thermogenic brown adipose tissue (BAT) has not been stud

63 clearance after insulin challenge, decreased thermogenic brown adipose tissue mass, and exaggerated h

64 y expenditure by increasing energy-utilizing thermogenic brown adipose tissue.

65 Increasing thermogenic brown and beige adipose tissue futile cyclin

66 Thermogenic brown and beige adipose tissues dissipate ch

67 P15 differentially controls the formation of thermogenic brown fat.

68 te the effects of moderate alcohol intake on thermogenic brown/beige adipocyte formation and glucose

69 conclusion, moderate alcohol intake induces thermogenic brown/beige adipocyte formation and promotes

70 Moderate alcohol intake induces thermogenic brown/beige adipocyte formation via elevatin

71 The molecular regulation underlying the thermogenic browning process has not been entirely eluci

72 total of ~24,000 Gt C (including ~12,000 Gt thermogenic C) replicates the proxy data.

73 in species lacking BAT, we investigated the thermogenic capacities of newborn wild boar piglets.

74 ion of Ucp1 and other target genes to reduce thermogenic capacity and energy expenditure, promoting a

75 This is characterised by reduced thermogenic capacity and mitochondrial content, accompan

76 CL316,243, was employed to evaluate whether thermogenic capacity could be impaired by the fall in ox

77 In turn, quantitative analysis of thermogenic capacity determined by estimating the propor

78 This study investigated the regulation of thermogenic capacity in classical brown adipose tissue (

79 ovides an alternative mechanism that reduces thermogenic capacity in core areas and increases it in p

80 in human BAT and potentially to differential thermogenic capacity in human populations.

81 be induced to undergo "browning" and acquire thermogenic capacity in response to physiological stimul

82 Increasing the thermogenic capacity of adipose tissue has been proposed

83 ansition from warm to cold may determine the thermogenic capacity of an individual in a changing temp

84 light in living mice significantly enhanced thermogenic capacity of BAT, and this effect was diminis

85 ranscriptional mechanisms that determine the thermogenic capacity of brown adipose tissue before envi

86 dation revealed that a HF diet increased the thermogenic capacity of the interscapular and aortic bro

87 , the YS mice have more brown adipose tissue thermogenic capacity than their littermate controls.

88 l mice have increased white fat browning and thermogenic capacity, decreased adipose tissue expansion

89 e adipose tissue (WAT) with respect to their thermogenic capacity, we examined two essential characte

90 ration of FGF9 increases UCP1 expression and thermogenic capacity.

91 through acetate-mediated modulation of their thermogenic capacity.

92 These results indicate that thermogenic carbon generated from the contact aureoles a

93 we explore the effects of mantle-derived and thermogenic carbon released from the emplacement of CAMP

94 l plasticity and recruits a distinct form of thermogenic cell that is required for energy homeostasis

95 ding the discovery of beige fat cells, a new thermogenic cell type.

96 Brown adipose tissue (BAT) is composed of thermogenic cells that convert chemical energy into heat

97 ed triglycerides and cholesterol, into these thermogenic cells.

98 mal sample (5% of proximal samples) contains thermogenic CH(4) (2.6 mg/L) from a relatively shallow s

99 Here, we identify the efferent beige fat thermogenic circuit, consisting of eosinophils, type 2 c

100 In particular, with time, thermogenic-competent beige adipocytes progressively gai

101 ly derived from biogenic sources, although a thermogenic contribution could not be excluded.

102 e to cold exposure through activation of the thermogenic coregulator PRDM16.

103 enerated both by biological processes and by thermogenic decomposition of fossil organic material, wh

104 cose uptake and VO(2) measurements confirm a thermogenic defect in NCLX-null mice.

105 hibit signs of metabolic imbalance including thermogenic defects in brown adipose tissue (BAT).

106 ted fat-specific Chrna2 KO mice and observed thermogenic defects in cold and metabolic dysfunction up

107 pecifically in adipose tissue have only mild thermogenic defects, suggesting the presence of addition

108 centrations as economic reserved of biogenic/thermogenic deposits on Earth.

109 tissue, confirming that these cells comprise thermogenic depots in vivo, and explain previous finding

110 k fat and characterized their adipogenic and thermogenic differentiation.

111 rm of triglycerides, brown adipose tissue is thermogenic, dissipating energy as heat via the unique e

112 e-specific deletion of Ip6k1 (AdKO) enhanced thermogenic EE, which protected mice from high-fat diet-

113 Thermogenic emissions did not resume to cause the renewe

114 box-model analysis suggests that diminishing thermogenic emissions, probably from the fossil-fuel ind

115 increases in FGF21 impact metabolic but not thermogenic endpoints.

116 nti-obesity approaches aimed at reactivating thermogenic energy expenditure.

117 PM20D1 is a candidate thermogenic enzyme in mouse fat, with its expression col

118 e cells are a distinct and inducible type of thermogenic fat cell that express the mitochondrial unco

119 tissue (BAT) contains mitochondria-enriched thermogenic fat cells (brown adipocytes) that play a cru

120 Brown and beige adipose tissues contain thermogenic fat cells that can be activated by beta3-adr

121 Thermogenic fat cells that convert chemical energy into

122 eciated that there are two distinct types of thermogenic fat cells, termed brown and beige adipocytes

123 evidence revealing the metabolic impacts of thermogenic fat in humans.

124 is essential in regulating the activation of thermogenic fat, and the past decade has shed significan

125 higher levels of sympathetic innervation of thermogenic fat, compared to white fat, has remained unk

126 Here, we provide evidence that a thermogenic fat-epithelial cell axis regulates intestina

127 storage, and coupled respiration to maintain thermogenic fitness during dormancy.

128 CL6 is specifically required for maintaining thermogenic fitness when mammals acclimate to environmen

129 MFGM-PL+HFD offspring showed promoted thermogenic function in BAT and inguinal WAT through the

130 thermAC as a promising new tool for studying thermogenic function in brown adipocytes of both murine

131 Our data suggest that attenuation of BAT thermogenic function may be a key mechanism linking mate

132 Although neither presence nor thermogenic function of uncoupling protein 1(+) beige ad

133 hite adipose tissue contributes to brown fat thermogenic function or compensates for partial deficien

134 e BAT (18)F-FDG uptake independently of UCP1 thermogenic function.

135 ired for beige adipocyte differentiation and thermogenic function.

136 ramides, which directly compromise beige fat thermogenic function.

137 es not affect adipose tissue maintenance and thermogenic function.

138 Mitochondrial oxidative and thermogenic functions in brown and beige adipose tissues

139 Thermogenic gases yield formation temperatures between 1

140 e the transcription factors and cofactors in thermogenic gene activation and identified zinc finger a

141 indings suggest respiratory capacity governs thermogenic gene expression and BAT function via mitocho

142 as a transcriptional driver of a program of thermogenic gene expression and energy expenditure.

143 e to beta3-adrenergic signaling, to increase thermogenic gene expression and mitochondrial biogenesis

144 cutaneous inguinal white adipose tissue lost thermogenic gene expression and multilocular morphology

145 nRNPU) ribonucleoprotein complex to activate thermogenic gene expression in adipocytes.

146 us white adipose tissue (sWAT) and increased thermogenic gene expression in all fat depots.

147 hese studies demonstrate that TLE3 regulates thermogenic gene expression in beige adipocytes through

148 ne expression in liver and WAT and increased thermogenic gene expression in brown adipose tissue.

149 r 7 days increased SAT adipocyte beiging and thermogenic gene expression in male or female mice.

150 expression of PGC-1alpha are unable to cause thermogenic gene expression in the absence of IRF4.

151 Control of thermogenic gene expression occurs via the induction of

152 of PLA2G2A on the brown adipose tissue (BAT) thermogenic gene expression was explored.

153 line is sufficient to induce cold tolerance, thermogenic gene expression, and allied metabolic benefi

154 ue (inguinal WAT) with upregulated oxidative/thermogenic gene expression, and downregulated lipolysis

155 cytes and is sufficient to promote increased thermogenic gene expression, energy expenditure, and col

156 cytosolic Ca(2+) is sufficient to attenuate thermogenic gene expression, indicating that cytosolic C

157 cant alterations in body temperature and BAT thermogenic gene expression, perhaps contributing to the

158 ilocular brown/beige adipocytes and elevated thermogenic gene expression.

159 epigenetic regulation of adipocyte fate and thermogenic gene expression.

160 d body temperature, UCP1 protein levels, and thermogenic gene expression.

161 obesity-induced inflammation, and control of thermogenic gene expression.

162 beige adipogenesis associated with increased thermogenic gene expressions.

163 Zbtb7b is required for activation of the thermogenic gene program in brown and beige adipocytes.

164 trates that SR1555 induced expression of the thermogenic gene program in fat depots.

165 9 methyltransferase activity is required for thermogenic gene program.

166 h transcription factor EBF2 to stimulate the thermogenic gene program.

167 nt beige-selective epigenetic breaker of the thermogenic gene program.

168 oreover, the suppressive role of TET1 in the thermogenic gene regulation of beige adipocytes is large

169 nduced alternative macrophage activation and thermogenic gene responses.

170 o mediate the epigenetic changes to suppress thermogenic gene transcription.

171 r signatures of brown fat, including the key thermogenic gene Ucp1.

172 tion, fat utilization, and the expression of thermogenic genes (Ucp1 and Ppargc1a) in subcutaneous WA

173 We analyzed the expression of adipogenic and thermogenic genes and proteins in the iWAT from these mi

174 al that IL-10 represses the transcription of thermogenic genes in adipocytes by altering chromatin ac

175 issue browning and ameliorated expression of thermogenic genes in adipose tissue and skeletal muscle

176 ffects of glucagon alone on the induction of thermogenic genes in adipose tissue from C57BL6/J mice w

177 ese mice greatly increased the expression of thermogenic genes in adipose tissue, resulting in simila

178 are cold-tolerant, with higher expression of thermogenic genes in BAT, and are protected from high-fa

179 , harmine potently induced the expression of thermogenic genes in both brown and white adipocytes, wh

180 ucagon treatment increased the expression of thermogenic genes in both iWAT and BAT of C57BL6/J mice.

181 cytosolic Ca(2+) reverses the attenuation of thermogenic genes in brown adipocytes with impaired resp

182 nitrate not only increases the expression of thermogenic genes in brown adipose tissue but also induc

183 y of FGF21 to increase the expression of key thermogenic genes in interscapular and visceral WAT.

184 glucagon is sufficient for the induction of thermogenic genes in iWAT, and the absence of intact glu

185 Tregs enhanced the expression of CL-induced thermogenic genes in SAT from male and female mice.

186 -1 deficiency induced browning and activated thermogenic genes program in WAT but not in BAT by promo

187 cruited by Zc3h10 to the promoter regions of thermogenic genes to function as a coactivator by methyl

188 as heat, in accordance with upregulation of thermogenic genes UCP1 and DIO2.

189 TET1 acts as an autonomous repressor of key thermogenic genes, including Ucp1 and Ppargc1a, in beige

190 tional properties, including upregulation of thermogenic genes, increased mitochondrial content, and

191 ratory capacity, triggers down-regulation of thermogenic genes, promoting a storage phenotype in BAT.

192 d macrophages failed to induce expression of thermogenic genes, such as uncoupling protein 1 (Ucp1),

193 t of PPARgamma to the regulatory elements of thermogenic genes.

194 at PPARgamma and EBF2 binding sites for key thermogenic genes.

195 T through the upregulation of UCP1 and other thermogenic genes.

196 nation occurred, the relative proportions of thermogenic hydrocarbon gas (e.g., CH4, (4)He) were sign

197 e infer that deep-sea sediments experiencing thermogenic hydrocarbon inputs harbor phylogenetically a

198 en species (ROS) signal to support adipocyte thermogenic identity and function.

199 This strongly implicates thermogenic interactions between upwelling fluids and mi

200 s to comprehensively test the premise that a thermogenic-like BAT phenotype is coupled with enhanced

201 Collectively, these findings indicate that a thermogenic-like BAT phenotype is not linked to heighten

202 ostasis, we hypothesized that there might be thermogenic lipokines that activate BAT in response to c

203 p-regulation of the skeletal-muscle adaptive thermogenic marker sarcolipin, with an associated increa

204 In BAT, the induction of thermogenic markers following cold exposure was reduced,

205 ion, improve energy metabolism, and increase thermogenic markers in BAT.

206 Notably, key thermogenic markers in brown and retroperitoneal adipose

207 as an anti-obesity agent by upregulating the thermogenic markers resulting in the browning of WAT.

208 luding increased expression of brown adipose thermogenic markers such as uncoupling protein 1 (UCP1),

209 beige adipocytes, showed elevated levels of thermogenic markers, including UCP1, increased numbers o

210 Here we report a robust UCP1-independent thermogenic mechanism in beige fat that involves enhance

211 the existence of a possible UCP1-independent thermogenic mechanism responsible for this temperature i

212 Our study uncovers a noncanonical thermogenic mechanism through which beige fat controls w

213 y of possible UCP1-independent non-shivering thermogenic mechanisms, whose existence has been shown s

214 likely possess alternative UCP1-independent thermogenic mechanisms.

215 differences in visceral and subcutaneous WAT thermogenic metabolism and demonstrate the distinct meta

216 all, these data provide a timeline of global thermogenic metabolism in adipose depots during acute co

217 ne hydrates, terrigenous organic matter, and thermogenic methane and CO2 from hydrothermal vent compl

218 with reach mass-balance modeling to estimate thermogenic methane concentrations and fluxes in groundw

219 Modeling indicates a groundwater thermogenic methane flux of about 0.5 kg d(-1) dischargi

220 Thermogenic methane was detected in two aquifer wells in

221 molecular features that comprise the adipose thermogenic milieu.

222 se of Ucp1 expression, which encodes the key thermogenic mitochondrial uncoupling protein-1.

223 c thermogenic remodeling of canine tissue by thermogenic murine adipocytes suggests evolutionary cons

224 However, the origin of dry thermogenic natural gas is one of the most controversial

225 utilization needed to ensure that increased thermogenic needs are met.

226 mmunication, which in turn leads to either a thermogenic or storage mode.

227 Brown adipose tissue is a thermogenic organ that dissipates chemical energy as hea

228 s larger than -30 per thousand, typical of a thermogenic origin.

229 that the emitted methane is predominantly of thermogenic origin.

230 on and that loss of heat production from one thermogenic pathway leads to increased recruitment of th

231 al WAT is resistant to adopting a protective thermogenic phenotype characterized by the accumulation

232 utrality, enhanced activation of BAT and its thermogenic phenotype via chronic mild cold stress does

233 regulatory loop to drive adipogenesis toward thermogenic phenotype.

234 signaling in BAT in modulating metabolic and thermogenic physiology.

235 n human preadipocytes that could predict the thermogenic potential of the cells once they were matura

236 ively isolate adipose progenitors with great thermogenic potential using the cell surface marker CD29

237 Enhanced WAT thermogenic potential, brown adipose tissue differentiat

238 own and brite adipocytes, suggesting similar thermogenic potentiality.

239 f locally produced catecholamines during the thermogenic process.

240 where most geologists generally assume that thermogenic processes are the only source of natural gas

241 ing a functional interplay between these two thermogenic processes.

242 ial amino acids can 1) promote the brown fat thermogenic program and fatty acid oxidation, 2) stimula

243 Hence, Dot1l plays a critical role in the thermogenic program and may present as a future target f

244 Kcnk3 is transcriptionally wired into the thermogenic program by PRDM16, a master regulator of the

245 y, Ces3 inhibition attenuated an ISO-induced thermogenic program in adipocytes by downregulating Ucp1

246 ic receptor agonist CL316243 (CL)-stimulated thermogenic program in subcutaneous adipose tissue (SAT)

247 AC1 negatively regulates the brown adipocyte thermogenic program, and inhibiting Hdac1 promotes BAT-s

248 transcriptional suppressor of the adipocyte thermogenic program.

249 of the beige phenotype and activation of its thermogenic program.

250 a negative regulator of the brown adipocyte thermogenic program.

251 with elevated BAT activity and inguinal WAT thermogenic program.

252 yet synergizes with PGC-1alpha to induce the thermogenic program.

253 sympathetic nerve activation and impairs BAT thermogenic programs, leading to reduced core body tempe

254 ecreted protein can alter the physiology and thermogenic properties of adipose tissue to reduce obesi

255 of full-length Angptl4 reveals lipolytic and thermogenic properties with therapeutic relevance to obe

256 ylation reveals that Sirt5 regulates the key thermogenic protein in BAT, UCP1.

257 show that squirrel UCP1 acts as the typical thermogenic protein in vitro.

258 spite substantial decreases in mitochondrial thermogenic proteins in brown fat, mice lacking YY1 in t

259 ed spontaneous locomotor activity and absent thermogenic reaction to the application of the amylin re

260 mitochondrial function in BAT and a blunted thermogenic (rectal temperature, BAT temperature, and wh

261 Thus, unlike other thermogenic regulators, BCL6 is specifically required fo

262 ed disease modeling and unbiased screens for thermogenic regulators.

263 This site-specific thermogenic remodeling of canine tissue by thermogenic m

264 In adipose tissue, creatine controls thermogenic respiration and loss of this metabolite impa

265 We found inefficient thermogenic respiration due to futile proton leak in Fmr

266 an dissipate chemical energy as heat through thermogenic respiration, which requires uncoupling prote

267 signaling, thereby attenuating lipolysis and thermogenic respiration.

268 L(2.1)KOs and D(2.1)KOs both mount a robust thermogenic response and rapidly increase Tc.

269 neous adipocytes with and without engineered thermogenic response in biocompatible microcapsules and

270 e were able to use did not elicit a relevant thermogenic response in humans.

271 ect activation of MnPO neurons induced a BAT thermogenic response in warm rats.

272 n the tail skin vasoconstriction response or thermogenic response to cold.

273 gamma have defects in Ucp1 induction and the thermogenic response to cold.

274 As the thermogenic response to mild cold exposure (COLD) may si

275 SREBP was required in BAT for the thermogenic response to norepinephrine, and depletion of

276 an approach 0 degrees C without triggering a thermogenic response.

277 preoptic area (MnPO) neurons blocked the BAT thermogenic responses during both PGE(2)-induced fever a

278 nergy expenditure and body weight, including thermogenic responses to diet and cold exposure and 'bei

279 and also to integrate systemic metabolic and thermogenic responses.

280 cterial composition of the gut and modulated thermogenic responses.

281 We further establish that thermogenic ROS alter the redox status of cysteine thiol

282 duced by the CO2 reduction pathway, not from thermogenic shale gas.

283 s > -50 per thousand, indicating a potential thermogenic source.

284 Variation within thermogenic sources are detected and tabulated.

285 Large differences between biogenic and thermogenic sources are observed.

286 eta-adrenergic stimulation favors the active thermogenic state, whereas sympathetic denervation or gl

287 Furthermore, thermogenic stimulation promotes HDL-cholesterol clearan

288 key source of IL10 production in response to thermogenic stimuli.

289 ng in horizontal wells, is the main cause of thermogenic stray gas migration in this oil- and gas-pro

290 A total of 42 water wells contained thermogenic stray gas originating from underlying oil an

291 F3 is one of the most highly induced ATFs in thermogenic tissues of mice exposed to cold temperatures

292 ssic stimuli that promote heat generation in thermogenic tissues.

293 sing the expressions of brown adipogenic and thermogenic transcriptional factors via the PI3K/Akt and

294 Thus, HDAC3 uniquely primes Ucp1 and the thermogenic transcriptional program to maintain a critic

295 h EBF2 and blocks its ability to promote the thermogenic transcriptional program.

296 1%, enhanced the expression of sirtuin-1 and thermogenic uncoupling protein 1 (UCP-1) in the iWAT.

297 ty acids and resembles the H(+) leak via the thermogenic uncoupling protein 1 found in brown fat.

298 gy homeostasis by dissipating energy through thermogenic uncoupling.

299 Thermogenic visceral WAT improves cold tolerance and pre

300 ne WAT was increased at sites implanted with thermogenic vs. wild type murine adipocytes.