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1 erence, their activity in DNA binding is not thermolabile.
2 early intracellular folding intermediate is thermolabile.
3 ster protecting groups that additionally are thermolabile.
4 can be eaten raw, while indole compounds are thermolabile.
5 s the wild type enzyme, whereas GK(K414E) is thermolabile.
6 rminal ATPase domain nucleotide depleted and thermolabile.
7 olase activity in vitro, but were profoundly thermolabile.
8 ombinant wild-type enzyme, which is somewhat thermolabile.
9 tions of DnaC reveals that their activity is thermolabile.
10 tide has been functionalized with either the thermolabile 4-hydroxy-1-butyl or the 4-phosphato-/thiop
12 gated the utility of primers with one or two thermolabile 4-oxo-1-pentyl phosphotriester modification
13 oach in PCR where primers contain one or two thermolabile, 4-oxo-1-pentyl (OXP) phosphotriester (PTE)
14 is synthetic phenotype is due to a naturally thermolabile activity that confers a telomere-specific d
16 (1p36.3), and two common alleles, the C677T (thermolabile) allele and the A1298C allele, have been de
18 has revealed a strong bias against specific thermolabile amino-acid residues (i.e. N and Q) in hyper
19 da albicans guanylyltransferase Cgt1 is also thermolabile and is stabilized by binding to Cet1(232-26
20 tion, has been reported to render the enzyme thermolabile and less active and has been associated wit
21 e-to-valine substitution, renders the enzyme thermolabile and may cause elevated plasma levels of the
23 changes p.(Gly63Ser) and p.(Arg608Cys) were thermolabile and showed a decrease in Vmax and increase
24 in the absence of Ca(2+), the P8 subunit is thermolabile and unstable, manifested by a slow alpha-he
25 n alpha-helix (approximately 40%), is highly thermolabile, and is characterized by noncooperative unf
26 uctase activity of this mutant was extremely thermolabile, and the rate of fatty acid synthesis measu
27 l mutations, which render the mature protein thermolabile, and tsf (temperature sensitive folding) mu
29 at both Gsalpha R258W and Gsalpha R258A were thermolabile at higher temperatures and that denaturatio
32 ecreased ATP concentration exacerbates their thermolabile behavior, we suggest that the F231S and W23
33 ecules showed that excessive accumulation of thermolabile collagen II was associated with the activat
35 two major components, one corresponding to a thermolabile complex with transition temperature, T(m(la
38 strate that polymers can be first doped with thermolabile cross-linkers before low-temperature carbon
39 o both of the alleles is responsible for the thermolabile defect and lag in DNA synthesis of these mu
43 sense mutation within this domain results in thermolabile DNA binding and conditional lethality in ye
44 37 degrees C during amplification using the thermolabile DNA polymerases Sequenase 1.0, Sequenase 2.
45 in contrast to the thermostable domains, the thermolabile domains are able to accommodate amino acid
47 o previously identified independently folded thermolabile domains, one in each half of the module, th
52 homozygous state for the 677C-->T (so-called thermolabile) enzyme variant (TT genotype), is associate
53 wild-type (WT) coat protein by protecting a thermolabile folding intermediate from aggregation, ther
54 egation pathway, sequential multimers of the thermolabile folding intermediates, have been directly i
57 ons are identical to those of a gene for the thermolabile form of PST in humans, STM; a rat PST gene;
58 ntrifugal separation of the thermostable and thermolabile fractions revealed that almost all the tran
59 h in air), but the purified enzyme was more thermolabile (half-lives at 90 degrees C of 1 and 25 h,
61 nactivation method (except for subjects with thermolabile hexosaminidase B) and may be helpful in gen
62 Tay-Sachs disease, including a patient with thermolabile hexosaminidase B, had less than 2% of nonca
63 However, tHcy was significantly higher in thermolabile homozygotes than in nonthermolabile homozyg
64 trength between 0.2 and 0.5kV/cm, AAO became thermolabile (i.e. increase in inactivation rate (k valu
65 t that the F231S and W233L substitutions are thermolabile in ATP binding, which correlates with defec
66 no change in cofactor affinity but was more thermolabile in the absence of NADPH as judged by CD spe
67 anylyltransferase activity of Ceg1 is highly thermolabile in vitro (98% loss of activity after treatm
70 of the GroE chaperonin, indicating that the thermolabile intermediate is a physiological substrate f
71 uggest that many proteins are likely to have thermolabile intermediates in their intracellular foldin
73 of Streptococcus mutans NG8 which produces a thermolabile L-(+)-lactate dehydrogenase (LDH) activity.
74 s between the thermostable TS09-C strain and thermolabile LaSota strain using reverse genetics techno
75 soform differed from wild-type COMT by being thermolabile, leading to 2-3-fold lower levels of produc
77 ents of cleaved RNA are all held together by thermolabile linkages, indicating the presence of tether
78 ture-sensitive mutant was shown to produce a thermolabile lipoyltransferase and a tagged version of t
79 al terms as a need to reduce the build-up of thermolabile metabolic intermediates that would be susce
83 gnificant difference in plasma tHcy level or thermolabile MTHFR allele frequency between subjects and
84 lates in RBCs only from individuals with the thermolabile MTHFR is consistent with the hypothesis tha
85 studies suggest that the reduced activity of thermolabile MTHFR is due to the inappropriate loss of i
89 o maintain the complex integrity of the more thermolabile mTORC2 during isoelectric focusing and dete
90 owth arrest in a cell line which expresses a thermolabile mutant of p53 and extended the in vitro lif
91 mortalized by retroviral transduction with a thermolabile mutant Simian virus 40 (SV40) large T antig
92 us capable of transferring a gene encoding a thermolabile mutant simian virus 40 T antigen (SV40ts).
94 or V Leiden, hemoglobin C, hemoglobin S, the thermolabile mutation of methylenetetrahydrofolate reduc
95 mostability along the collagen molecule with thermolabile N-terminal domains and thermostable C-termi
97 thermostable NDV could be engineered into a thermolabile NDV vaccine strain for developing novel the
99 forms two domains, a thermostable one and a thermolabile one, leaving the rest of the module to be r
101 BP3 was found to be due to the presence of a thermolabile PBP3 in the strain used in that study.
103 oplasts indicated that (a) this Hsp protects thermolabile photosystem II and, consequently, whole-cha
104 esented, and methods to avoid loss of highly thermolabile plant ribosomal RNA species are discussed.
105 catalytic core of RSV IN exhibited the same thermolabile properties for 3' OH processing and strand
107 for modulating the stability of 2-Pyridinyl Thermolabile Protecting Groups (2-Py TPGs) in the "chemi
108 nucleophilicity and stability of 2-Pyridinyl Thermolabile Protecting Groups in thermal deprotection.
111 dative protein unfolding in vitro and target thermolabile proteins for irreversible aggregation in vi
113 A mutation at the dimer-dimer interface in a thermolabile psychrophilic homologue of ht-ADH, ps-A25Y,
114 emonstrated that chondrocytes expressing the thermolabile R992C mutant collagen II molecules endured
115 ng base pairs G1-G9* and G4*-G1, is the most thermolabile region of the DNA quadruplex in all three c
116 ollectively, our results show that EftM is a thermolabile, SAM-dependent methyltransferase that direc
117 different infectivity loss: RML was the most thermolabile strain (6 to 7 log10 infectivity loss), fol
118 sociation of the small peptide with PCNA was thermolabile, suggesting that portions of p21 adjoining
120 n other P22 structural proteins and from the thermolabile temperature-sensitive mutants described for
121 2 and Dpo3 are much less functional and more thermolabile than Dpo1 and Dpo4 in vitro but have bypass
122 ther characteristic superantigenic toxins or thermolabile toxins believed to be staphylococcal alpha-
123 ts20 is a mutant cell line that contains a thermolabile ubiquitin-activating enzyme (E1) that is in
125 tor MG132, analysis in CHO-ts20 cells with a thermolabile ubiquitin-activating enzyme, and direct det
127 ensitive mutant cell line, which expresses a thermolabile ubiquitin-activating enzyme, we observed a
129 is in vivo impairment in the activity of the thermolabile variant of MTHFR and that this impairment r
130 nzyme in one-carbon metabolism, results in a thermolabile variant of the MTHFR enzyme with reduced ac
131 ranes, exposing isolated SR membranes to the thermolabile water soluble free radical initiator, 2,2'-
132 itive mutants were also found to be markedly thermolabile when grown at the permissive temperature, s