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1 lcalase 2.4 L FG, Alcalase(R)PURE 2.4 L, and Thermolysin).
2 entration of proteolytic enzymes (trypsin or thermolysin).
3 on binding Tva, as assayed by sensitivity to thermolysin.
4 tion identical to that of the zinc peptidase thermolysin.
5 r structures from different X-ray studies of thermolysin.
6 is of fragments produced on proteolysis with thermolysin.
7 at of an insect metalloprotease inhibitor in thermolysin.
8  C1 and C2 collagenases and ChNP in place of thermolysin.
9 th the active-site region related to that of thermolysin.
10 rial zinc metalloendopeptidases, typified by thermolysin.
11 e, human serum albumin, gamma-globulins, and thermolysin.
12 similar to those of metalloproteases such as thermolysin.
13 f the general zinc-dependent metalloprotease thermolysin.
14 ), an inhibitor bound to human rhinovirus 14 thermolysin.
15 eptidase pepsin, and with the zinc peptidase thermolysin.
16 metalloamidases, like carboxypeptidase A and thermolysin.
17 rocrystals of Geobacillus stearothermophilus thermolysin (2.2-A structure), Thermosynechococcus elong
18 e enzyme, with a Ki of 3 x 10(-9) M, whereas thermolysin and a metalloproteinase from A. flavus were
19 th different peptidases (pepsine, chymosine, thermolysin and a non-specific peptidase from Aspergillu
20                                    Proteases Thermolysin and Alcalase were evaluated to release pepti
21 ates of archetypical zinc hydrolases such as thermolysin and carboxypeptidase A.
22 nd chemoselective: various proteases such as thermolysin and chymotrypsin catalyze amine acyl exchang
23 d statistically better results (P < 0.01 for thermolysin and P < 0.05 for GP datasets) than the CoMFA
24 e hydrodabcyl-Ser-Phe-EDANS by the proteases thermolysin and papain.
25               Its structural comparison with thermolysin and the available pool of LC structures reve
26 l results, within this series, of binding to thermolysin and to a lesser extent to NEP was observed.
27 step enzymatic modification method involving thermolysin and transglutaminase.
28 approaches use the X-ray structures of ZFpLA-thermolysin and ZGpLL-thermolysin structures.
29 equally susceptible to digestion by trypsin, thermolysin, and proteinase K.
30 man leukocyte elastase, pancreatic elastase, thermolysin, and Pseudomonas elastase.
31             For example, carboxypeptidase A, thermolysin, and sonic hedgehog possess the same ligand
32 143 catalytic base in B. thermoproteolyticus thermolysin, and the E181A VanX mutant has no detectable
33 rotein are readily hydrolyzed by trypsin and thermolysin, around residues 127-128, indicating that th
34                                Inhibition of thermolysin by the silanediol (K(i) = 41 nM) was compara
35         We show that the thermophilic enzyme thermolysin can be remotely activated in 17.76 MHz radio
36 s released during digestion of repolymerized thermolysin-casein hydrolysates had no immuno-reactivity
37                                In kinesin, a thermolysin cleavage at L154 in L8 is protected in AMPPN
38  conformational changes, it can increase the thermolysin cleavage resistance up to 50-fold depending
39                                 We show that thermolysin-cleaved MccJ25 and MccJ25 lacking amino acid
40 ometry and N-terminal sequencing showed that thermolysin cleaves the peptide bond between Thr92 and A
41      To address this question, we utilized a thermolysin-derived product of the alpha1alpha2alpha1 ne
42 r data and structural analysis of intact and thermolysin-digested MccJ25 suggest that distinct region
43 mutations in the first epitope identified by thermolysin digestion (Ssa2128-132A3) significantly redu
44                                              Thermolysin digestion and immunoprecipitation experiment
45 astellin binds to (III)11, where it enhances thermolysin digestion of (III)11.
46 ovel molecular strain typing assay that used thermolysin digestion of caudal medulla samples to produ
47 ronger than actin-binding domain produced by thermolysin digestion of native alpha-actinin (residues
48                                              Thermolysin digestion of the isolated omeprazole-labeled
49                     Proteomic analysis using thermolysin digestion of three predominant non-native mo
50 f the Rieske iron-sulfur protein, removed by thermolysin digestion, into PL vesicles together with mi
51     Maltose binding protein, a survivor from thermolysin digestion, was characterized by in vitro bio
52 reased the sensitivity of the polypeptide to thermolysin digestion.
53  of Delta G(proteolysis), we determined that thermolysin digests this protein through a local fluctua
54     Protealysin-like proteases (PLPs) of the thermolysin family are natural targets of emfourin-like
55 mbinant leptospiral metalloprotease from the thermolysin family cleaved C3 in serum and could be one
56 f such a mechanism for protein inhibitors of thermolysin family metalloproteases, which puts forward
57 metric similarity to the active sites of the thermolysin family.
58 family and a 42-kDa metalloproteinase of the thermolysin family.
59  some non-specific enzymes such as pepsin or thermolysin for proteolysis in proteomic study, in that
60                               We have mapped thermolysin, for which experimental mapping results are
61 ive binding mode for ordinary substrates and thermolysin, forces reinterpretation of previous mechani
62 l coordination identical to that observed in thermolysin from Bacillus thermoproteolyticus.
63 ease (pepsin at pH>2) and metalloproteinase (thermolysin) have strong prospects for use in simultaneo
64 lthough both A2ML1s conjugated and inhibited thermolysin, His-1084 was required for the conjugation a
65        Ile39Glu and Ile39Lys were cleaved by thermolysin in both the absence and presence of Tva.
66                              A tight-binding thermolysin inhibitor, Cbz-Phe-psi[PO2NH]-Leu-Ala (ZFpLA
67 dentified by comparing this structure with a thermolysin-inhibitor complex structure.
68    A previously studied congeneric series of thermolysin inhibitors addressing the solvent-accessible
69 investigate the thermodynamic fingerprint of thermolysin inhibitors featuring terminal charged ammoni
70 ifference between conformationally different thermolysin inhibitors ZFpLA and ZGpLL is estimated usin
71 /or inhibitors of hen egg-white lysozyme and thermolysin interact with the same side chains identifie
72 een applied to hen egg-white lysozyme and to thermolysin, interacting with eight and four different l
73 rates, which indicates that their binding to thermolysin is largely productive, unlike normal peptide
74 temperatures using the thermophilic protease thermolysin led to selective removal of the zeins, where
75 rity with MPs of the gluzincin tribe such as thermolysin, leukotriene A4 hydrolase relatives, and cow
76 Bacillus anthracis lethal toxin contains the thermolysin-like active-site and zinc-binding consensus
77 ight chain structures, including a conserved thermolysin-like core inserted between structurally dist
78           The first (designated Npr599) is a thermolysin-like enzyme highly homologous to bacillolysi
79  di-chain protein composed of an N-terminal, thermolysin-like metalloprotease light chain domain (LC/
80 rotease (Mpl) of Listeria monocytogenes is a thermolysin-like protease that mediates the maturation o
81  predicted preproenzyme structure typical of thermolysin-like proteases and is distantly related to B
82 boxypeptidase A makes only Ndelta1 contacts, thermolysin makes only Nepsilon2 contacts, and sonic hed
83         Collagenase I, II, Liberase MTF C/T, thermolysin/neutral protease share similar cleavage site
84  the novel peptide substrate is collagenase, thermolysin/neutral protease specific and can be applied
85 , II, Liberase MTF C/T, collagenase NB1, and thermolysin/neutral protease, which was significantly en
86 ent with five different proteases: Alcalase, Thermolysin, Neutrase, Flavourzyme and PTN.
87                                  Cleavage by thermolysin of N-(4-methoxyphenylazoformyl)-L-leucyl-L-l
88 NP) from Bacillus thermoproteolyticus rokko (thermolysin) or Ch (ChNP).
89                   In this work, we show that thermolysin, or an endogenous activity present in R. cap
90 t by clostripain, trypsin, neutral protease, thermolysin, or elastase.
91 es, including trypsin, chymotrypsin, pepsin, thermolysin, papain, and calpain.
92 te calcium, or magnesium or zinc ions [e.g., thermolysin (PDB code: 3tln), mannose-binding protein (2
93                      Data presented for four thermolysin phosphonamidate inhibitors demonstrate that
94 teolysis of purified S. aureus DNA ligase by thermolysin produced products with apparent molecular ma
95 alysis of isolated chloroplasts treated with thermolysin protease.
96 aspartic (HIV protease) and metallo (ACE and thermolysin) proteases.
97 ormation of the correct membrane-associated, thermolysin-protected assembly is strictly dependent of
98 5 between residues Gln197-Arg198 and, unlike thermolysin, recognizes an extended region of SNAP25 for
99  within a standard triple helix, trypsin and thermolysin resistance indicated a tightly packed struct
100    The combined analyses of C2 fragments and thermolysin-resistant PrP species within caudal medulla,
101                                              Thermolysin-responsive peptide-based polymeric amphiphil
102 y, pea and wheat, with both chymotrypsin and thermolysin, resulted in hydrolysates, which are efficie
103 ligase from Bacillus stearothermophilus with thermolysin results in two fragments which were resistan
104 ly hydrolyzed with chymotrypsin, trypsin, or thermolysin retained about 80%, 30%, and 20% of the orig
105       Temperature-dependent proteolysis with thermolysin revealed a stable core region within the N-
106 ntial role of apo(a) O-glycans in protecting thermolysin-sensitive regions of the polypeptide.
107 change in that domain that exposed a cryptic thermolysin-sensitive site.
108 we identified an ester bond formed between a thermolysin serine residue and the A2ML1 thiol ester.
109      Soybean protein hydrolysate digested by thermolysin showed an IC50 value of 53.6 mug/mL, decreas
110 orimetry together with the susceptibility to thermolysin showed that the deamidation process reinforc
111 sive activity, the hydrolysate obtained with Thermolysin showed the most significant values.
112 ay structures of ZFpLA-thermolysin and ZGpLL-thermolysin structures.
113 placing the presumed tetrahedral carbon of a thermolysin substrate with a silanediol group, resulting
114 oth of these strategies to produce imprinted thermolysin, subtilisin, and lipase TL possessing up to
115 le to digestion by the thermostable protease thermolysin, suggesting that it is more rigid than the P
116 cking studies were carried out in a model of thermolysin (TLN) using the MACROMODEL and QXP modeling
117                                              Thermolysin treatment also dissociates F185 from the det
118 HA2 (residues 24-185), which is analogous to thermolysin treatment of HA in the low-pH-induced confor
119                                              Thermolysin treatment of the aggregated protein removed
120 titions, sensitivity to pre- and post-import thermolysin treatment, photochemical cross-linking and o
121 es: (k(cat)/K(m))(SSP) > (k(cat)/K(m))(THP) (thermolysin, trypsin, and MMP-13) or (k(cat)/K(m))(THP)
122                            However, a 140-kD thermolysin TSP fragment, containing the carboxy-termina
123 o acid sequences revealed the HEXXH motif of thermolysin-type metalloproteases and an HHH polyhistidi
124 ase 1), MMP-13 (collagenase 3), trypsin, and thermolysin using triple-helical peptide (THP) and singl
125 f the silanediol bound to the active site of thermolysin was found to have a conformation very simila
126          Proteolytic digestion of MutY using thermolysin was found to produce two relatively stable f
127           Also, one type of HEXXH-containing thermolysin was inactive in the C. albicans assay, where
128            Potent inhibition of both NEP and thermolysin was obtained.
129  silanediol inhibitor of the metalloprotease thermolysin was prepared for comparison to a known phosp
130 idate inhibitors (1-3) to the zinc peptidase thermolysin was probed by varying the solvent compositio
131                                              Thermolysin was the enzyme which yielded the hydrolysate
132 s released during digestion of repolymerized thermolysin-whey protein hydrolysate had less than 5% im
133 the conjugation and inhibition of acetylated thermolysin, which lacks primary amines.
134  proteases (e.g., trypsin, proteinase K, and thermolysin) while obeying Michaelis-Menten kinetics.
135 1' specificity pocket of the metalloprotease thermolysin with purposefully designed ligands using hig
136 oMFA with the use of ILP on the well-studied thermolysin zinc protease inhibitor dataset and a glycog
137  with other zinc metalloproteases, including thermolysin, ZMPSTE24 preferred hydrophobic residues at

 
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