ライフサイエンスコーパス: thermosensitive

1 heat-shock response in vivo, rendering cells thermosensitive.

2 y the addition of Casamino Acids, and it was thermosensitive.

3 yeast cell growth, but sec28 Delta cells are thermosensitive.

4 odel osmoreceptors, recently described to be thermosensitive.

5 in a temperature range at which TRPM8 is not thermosensitive.

6 nded to these chemesthetic stimuli were also thermosensitive.

7 inducible, and mutants deficient in TPS5 are thermosensitive.

8 The prevalence of thermosensitive Adelta-fibers was too low to permit comp

9 o preferentially enhance the regeneration of thermosensitive afferents, suggesting that it may play a

10 tify powerful genetic interactions between a thermosensitive allele (sec14-1(ts)) of the structural g

11 Yeast containing a thermosensitive allele in the gene encoding Hsp90 also e

12 Schizosaccharomyces pombe strain carrying a thermosensitive allele of DNA polymerase delta (pol delt

13 PSI regulates the thermosensitive alternative splicing of timeless (tim),

14 In this work, thermosensitive, amine-reactive and amine-functionalized

15 mutants lacking portions of this region are thermosensitive and arrest with highly elongated buds an

16 the mitochondrial respiratory complexes were thermosensitive and function inefficiently.

17 llowed characterisation of mechanosensitive, thermosensitive and gustatory afferents.

18 d relevance of the nucleocapsid, we analyzed thermosensitive and inducible mutants in the L4R gene.

19 Here, we show that TREK-1 and TRAAK, the thermosensitive and mechanosensitive two-pore-domain pot

20 D sensory neurons, which are extraordinarily thermosensitive and respond to thermal fluctuations at t

21 e release system was based on an injectable, thermosensitive, and fast gelation hydrogel and bFGF.

22 soil microbiome, inducing the replacement of thermosensitive bacterial species with more thermotolera

23 We identify the rice THERMOSENSITIVE BARREN PANICLE (TAP) gene, which encodes

24 ts cultivation temperature (Tc) and exhibits thermosensitive behaviors at temperatures relative to Tc

25 Here we report the synthesis of a thermosensitive, biodegradable hydrogel consisting of bl

26 from the protein macroinitiators resulted in thermosensitive BSA-polyNIPAAm and lysozyme-polyNIPAAm i

27 ent of airway sensory nerves, presumably the thermosensitive C-fiber afferents.

28 receptor potential vanilloid 3 (TRPV3) is a thermosensitive Ca(2+)-permeable ion channel that plays

29 SpySwitch is also thermosensitive, capturing at 4 degrees C and releasing

30 ion of c-di-GMP signaling networks, and that thermosensitive catalysis of a second messenger constitu

31 t activation of Kenyon cells by expressing a thermosensitive cation channel (dTrpA1) leads to a decre

32 in a heterologous cellular context using the thermosensitive CCT-mutant CHO-MT58 cell line.

33 Membranes are highly thermosensitive cell components, and the ability to modu

34 deltorphin-II exerts its action directly on thermosensitive cells of the preoptic anterior hypothala

35 t and TrkA receptor tyrosine kinases and the thermosensitive channel TRPV1.

36 conserved molecular thermosensors, including thermosensitive channels and receptors, act as the initi

37 onserved molecular logic for gating of these thermosensitive channels by chemical agonists.

38 We demonstrate that thermosensitive channels TRPV1 and TRPM4 mediate heat-in

39 This system exploits the thermosensitive characteristic of N-isopropyl acrylamide

40 Furthermore, its thermosensitive characteristics enhance the adherence of

41 was able to distinguish thermotolerant from thermosensitive Cladocopium goreaui ecotypes; epigenetic

42 hock proteins (sHsps) prevent aggregation of thermosensitive client proteins in a first line of defen

43 We describe herein a thermosensitive co-polymer hydrogel system formed from b

44 Thermosensitive composite hydrogels that consist of a po

45 uch as formate, acetate, and lactate and the thermosensitive compound epigallocatechin gallate were r

46 der alternative to sonication that preserves thermosensitive compounds.

47 Using a thermosensitive conjugative system, we provide evidence

48 To determine the thermosensitive contribution of persistent, TTX-sensitiv

49 t biomass and seed set more significantly in thermosensitive cultivars than in thermotolerant cultiva

50 sslinked pNIPAm cores via diffusion produced thermosensitive, degradable nanoparticles with low densi

51 nd exacerbated the mutation rate only in the thermosensitive deletion replication mutators but had no

52 on of deletion mutations specifically in the thermosensitive deletion replication mutators.

53 We investigated a miniaturized thermosensitive detection system (CalorQuanti) and integ

54 bacteria order Gallionellales also displayed thermosensitive diguanylate cyclase activity.

55 Furthermore, the thermosensitive DnaB allele prevents UV-induced DNA degr

56 eplication forks following inactivation of a thermosensitive DnaB helicase and found that they are di

57 d the use of a tumor-penetrating peptide and thermosensitive doxorubicin (DOX)-loaded nanoparticles i

58 of seven ventral HDB neurons (14%) remained thermosensitive during SB.

59 in iDEP devices experimentally employing the thermosensitive dye Rhodamin B (RhB) and compare the mea

60 With this thermosensitive dye, we imaged intracellular heat waves

61 We identified spontaneous suppressors of the thermosensitive eco1-1 allele in budding yeast.

62 However, in cells containing a thermosensitive eIF4E allele, their inability to grow at

63 e inserted into a conditionally replicating, thermosensitive, Escherichia coli-mycobacterial shuttle

64 een proposed to involve direct activation of thermosensitive excitatory transient receptor potential

65 The thermosensitive F127-g-Gelatin hydrogel that was evaluat

66 Thermosensitive F127-g-Gelatin hydrogels thus improve up

67 e the contribution of peripheral and central thermosensitive factors in the control of human circulat

68 e first application of a small molecule-type thermosensitive fluorescent dye, ERthermAC, to monitor t

69 The application of thermosensitive fluorescent dyes in oligonucleotide labe

70 The generation of unique thermosensitive fluorescent dyes via heteroaromatic Heck

71 id-infrared photothermal microscopy in which thermosensitive fluorescent probes are harnessed to sens

72 e was analyzed molecularly in mutant strains thermosensitive for essential replication factors.

73 induction, showing that (i) Int is partially thermosensitive for excision at 42 degrees C and (ii) in

74 fusing it to FtsZ could partially suppress a thermosensitive ftsA mutation.

75 ing channel gating is a major determinant of thermosensitive gating.

76 lactic-co-glycolic acid) (PLGA-b-PEG-b-PLGA) thermosensitive gel (g-E).

77 um contact time with respect to conventional thermosensitive gelling formulations and commercial eye

78 discussed for the development of implantable thermosensitive gels for the controlled release of drugs

79 his work provides programmable and versatile thermosensitive genetic toolkits for dynamic regulation

80 a long-standing mystery; in particular, the thermosensitive genetic triggers for gonadal sex differe

81 named accordingly: the idnK gene, encoding a thermosensitive gluconate kinase, is monocistronic and t

82 oth human and Drosophila MMS19 cDNAs correct thermosensitive growth and sensitivity to killing by UV

83 The first class causes thermosensitive growth due to single amino acid substitu

84 -activated protein kinase and can rescue the thermosensitive growth of slt2 null mutants.

85 ll-length CpMMS19 was able to complement the thermosensitive growth of the yeast mms19 deletion mutan

86 resulted in partial catalytic defects and a thermosensitive growth phenotype.

87 e first 75 amino acids (pta1-Delta75) causes thermosensitive growth, while the deletion of an additio

88 Petite cells were thermosensitive, had increased nuclear mutation frequenc

89 This thermosensitive hollow nanoparticle system provides an e

90 In detail, an injectable and thermosensitive hydrogel based on poly(ethylene oxide) (

91 ntenna arrays (BNAs) with a submicron-thick, thermosensitive hydrogel coating.

92 chemoimmunotherapy delivery system, a novel thermosensitive hydrogel comprised of gelatin and Pluron

93 s (MPs) and embedded them in a biodegradable thermosensitive hydrogel designed to gel rapidly and rel

94 r lymphatic uptake, this rationally designed thermosensitive hydrogel facilitates modulation of two o

95 We established a composite micellar thermosensitive hydrogel made of clinically approved met

96 judiciously designed MXene nanomonomer with thermosensitive hydrogel network.

97 shapes and sizes, and assessed the effect of thermosensitive hydrogels (poly(lactic-co-glycolic acid)

98 Injectable in situ thermosensitive hydrogels have potential applications in

99 All seven strains were thermosensitive in the E. faecalis host FA2-2; colony mo

100 these properties, we propose that hTRPV3 is thermosensitive in the physiological range of temperatur

101 Thermosensitive injectable hydrogels have been used for

102 e have highlighted the typical PCL-PEG-based thermosensitive injectable hydrogels progress in the las

103 report the development of a novel, flowable, thermosensitive, injectable drug delivery system compris

104 es this cold-dependent exon skipping via its thermosensitive interaction with a G-rich motif within t

105 Hence, not only is VRL3 a thermosensitive ion channel but it may represent an addi

106 TRPV3 is a thermosensitive ion channel primarily expressed in epith

107 loid 3 (TRPV3) channel is a Ca(2+)-permeable thermosensitive ion channel widely expressed in keratino

108 nnae contain infrared-activated neurons with thermosensitive ion channels that are structurally tuned

109 Since this new liposome is thermosensitive, it can be used for ultrasound-mediated

110 o proprioceptive, and six principal types of thermosensitive, itch sensitive, type C low-threshold me

111 This natural variation is absent from the thermosensitive kiwifruit species.

112 to INH and a related drug, ethionamide; (ii) thermosensitive lethality; and (iii) auxotrophy.

113 Thermosensitive liposomal doxorubicin was administered s

114 thermosensitive liposome (NTSL), traditional thermosensitive liposome (TTSL), and low temperature sen

115 cal temperature range, TTSL is a traditional thermosensitive liposome that triggers in the range of a

116 received a 30-min infusion of DOX containing thermosensitive liposomes (50 mg DOX/m(2)).

117 Thermosensitive liposomes (LipoTherm) were prepared with

118 Bs) can improve tumor drug delivery from non-thermosensitive liposomes (NTSLs) and low temperature se

119 These polymer-modified thermosensitive liposomes (PTSL) demonstrated sensitivit

120 ocal drug delivery of Doxorubicin (Dox) with thermosensitive liposomes (TSL) and hyperthermia (HT) ha

121 ously-injectable formulation with R848 using thermosensitive liposomes (TSLs) as a delivery vehicle.

122 s show that combining mild hyperthermia with thermosensitive liposomes (TSLs) significantly increases

123 Traditional thermosensitive liposomes are composed of lipids that un

124 a controlled manner, and when combined with thermosensitive liposomes can potentially reduce tumor b

125 Thermosensitive liposomes composed of DPPC:DSPC:DSPE-PEG

126 Thermosensitive liposomes have emerged as a viable strat

127 ocal drug release of DOX using DPPG(2) based thermosensitive liposomes in stationary targets.

128 from phosphatidyldiglycerol (DPPG(2)) based thermosensitive liposomes using MR-HIFU mediated hyperth

129 hesis has been used to design drug-releasing thermosensitive liposomes, the effect has yet to be quan

130 ound system to release doxorubicin from lyso-thermosensitive liposomes.

131 vated levels of Mtg2p partially suppress the thermosensitive loss of mitochondrial DNA in a 21S rRNA

132 A thermosensitive magnetic-molecularly-imprinted polymer (

133 f an Escherichia coli fabD mutant encoding a thermosensitive malonyl coenzyme A-acyl carrier protein

134 The findings indicate that local thermosensitive mechanisms modulate regional blood veloc

135 We especially highlight advances in the thermosensitive mechanisms underpinning SA-mediated immu

136 itis elegans, this process is regulated by a thermosensitive membrane TRP channel and the DAF-16/FOXO

137 Surprisingly, a substantial number of thermosensitive mitral cells were also chemosensitive.

138 material properties are incorporated in this thermosensitive model.

139 retinal is substituted in spermatozoa with a thermosensitive molecule.

140 netic support, N-isopropyl acrylamide as the thermosensitive monomer, ethion as the template, and met

141 Strains carrying the thermosensitive mrsC505 allele stopped growing soon afte

142 ion) at the nonpermissive temperature in the thermosensitive mutant cell line tsBN2 caused nuclear ac

143 he four novel mutants, rad4-c17(TopBP1) is a thermosensitive mutant.

144 We have identified thermosensitive mutants of five Schizosaccharomyces pomb

145 FtsA*, FtsZL169R also can partially suppress thermosensitive mutants of ftsQ or ftsK, which encode ad

146 Spp1 is essential for cell viability, and thermosensitive mutants of spp1(+) exhibit an allele-spe

147 We generated a panel of fission yeast thermosensitive mutants of the B-subunit (termed Spb70)

148 Here, we use thermosensitive mutants to show that the replisome's pol

149 amined the effects of combining a well-known thermosensitive mutation of ftsZ, ftsZ84, with DeltaminC

150 Thermosensitive mutations in ftsA, such as ftsA27, map i

151 SNARE proteins on the vesicle docking step, thermosensitive mutations in Sed5p, Bet1p, Bos1p and Sly

152 Thermosensitive mutations of spp2(+) destabilize the Pol

153 Thermosensitive mutations were created in the mycobacter

154 In conclusion, thermosensitive myogenic tone is a fundamental homeostat

155 ectrophysiological recordings, we identified thermosensitive neurons and examined their physiologic r

156 hat GABAA receptor induced inhibition of HDB thermosensitive neurons can modulate both thermoregulati

157 Drosophila larva are a set of exceptionally thermosensitive neurons critical for larval cool avoidan

158 Thermosensitive neurons of the preoptic/anterior hypotha

159 ition, a distinct anatomical distribution of thermosensitive neurons was found in the HDB.

160 demonstrate that the HDB contains inherently thermosensitive neurons, and that a difference in therma

161 efined a transcriptional network controlling thermosensitive NHP biosynthesis via the master transcri

162 d receptor-1 (VR1, also known as TRPV1) is a thermosensitive, nonselective cation channel that is exp

163 s C, isolates could be grouped into either a thermosensitive or thermostable fraction for both egg- a

164 scover a module comprising two linked genes, THERMOSENSITIVE PARTHENOCARPY 4a (TSP4a) and TSP4b, whic

165 AINTEGUMENTA (ANT), respectively, to control thermosensitive parthenocarpy.

166 tion delayed virus maturation and produced a thermosensitive particle.

167 The QD-containing thermosensitive particles were assembled with protein mo

168 The thermosensitive pathway requires cGMP-gated channels in

169 combination of distinct mechanosensitive and thermosensitive pathways.

170 onA (ts) strain, which lacks PBP1b and has a thermosensitive PBP1a, at nonpermissive temperature and

171 nt studies on the biomedical applications of thermosensitive PEG/PCL hydrogels have also been discuss

172 indicate that heat-sensing is mediated by a thermosensitive Per-Arnt-SIM (PAS) domain.

173 , high-temperature treatment during critical thermosensitive periods can induce XX females into XXm p

174 lity of the coiled coils and showed that the thermosensitive phase behavior of the RLPs was preserved

175 ral wild-type backgrounds conferred a strong thermosensitive phenotype but partially rescued ydj1-151

176 ess Gre mutants are unable to complement the thermosensitive phenotype of GreA(-):GreB(-) E. coli str

177 isruption of CNGCb or CNGC2 produced a hyper-thermosensitive phenotype, giving rise to an HSR and acq

178 Consistent with its thermosensitive phenotype, TAP expression is induced by

179 Dysfunction of SLG1 results in plants with thermosensitive phenotype, while overexpression of SLG1

180 unctional copy of the pgsA gene carried on a thermosensitive plasmid.

181 lic acid) (PLGA) nanoparticles embedded in a thermosensitive Pluronic F127 hydrogel (1,25 NP) could a

182 A thermosensitive poloxamer-based gel for drug delivery wa

183 tion rate of rad2Delta was also reduced in a thermosensitive polymerase background, but not in a liga

184 Thermosensitive polymeric delivery system (PLA-PEG-PLA)

185 san-zinc-insulin complex incorporated in the thermosensitive polymeric delivery system can be used as

186 he combination of RNA nanoparticles with the thermosensitive polymers increased the retention of the

187 known as poloxamers) are typical examples of thermosensitive polymers, but their use in drug delivery

188 Gametogenesis is a thermosensitive process in numerous metazoans, ranging f

189 maintain mammalian spermatogenesis, a highly thermosensitive process that must be preserved throughou

190 Of particular interest, CLKs exhibit unique thermosensitive properties characterized by increased ac

191 cules in such a way that they retained their thermosensitive properties, including the completely rev

192 To demonstrate thermosensitive properties, the precursor was converted

193 imed at rescuing the defects of a yeast Rpt6 thermosensitive proteasome mutant, we identified a prote

194 e lower critical solution temperature of the thermosensitive PVCL polymer.

195 in sensory neurons--suggest the existence of thermosensitive receptors distinct from VR1.

196 dynamic stability and dynamics that suggests thermosensitive regions in the fold that could initiate

197 The deletion mutation rates of all the thermosensitive replication mutators decreased in a rad2

198 Both UV-induced DNA damage and thermosensitive replication proteins have been used in m

199 truncated from both ends was cloned into the thermosensitive replicon pVE6007 and used to inactivate

200 When expressed in the thermosensitive S. cerevisiae ero1-1 strain, both eroA a

201 Injectable in situ thermosensitive scaffolds are therefore a less invasive

202 Thermosensitive sec12 and sec16 mutations caused a colla

203 Incubation of cells with thermosensitive Sec17-1p at nonpermissive temperature ca

204 ess lacZ (beta-galactosidase gene), into the thermosensitive shuttle replicon pG+host4 and assayed fo

205 yethylene glycol (PEG) to obtain amphiphilic thermosensitive "smart" copolymers (PCL-PEG), to form ra

206 le poly(organophosphazenes), a hydrogel with thermosensitive sol-gel transition behavior, almost comp

207 y(organophosphazenes) (I-5), a hydrogel with thermosensitive sol-gel transition behavior, almost comp

208 We show that a thermosensitive splicing event in the 3' untranslated re

209 s only from a transgene that cannot form the thermosensitive splicing isoforms.

210 conserved catalytic residues are viable but thermosensitive, suggesting that SAPHIRE has both an imp

211 ogen bonding is utilized to yield the highly thermosensitive supramolecular polymeric materials.

212 he adenovirus DNA polymerase or the use of a thermosensitive TESSA mutant decreased adenovirus genome

213 ns, the double mutant was significantly more thermosensitive than the ftsZ84 single mutant.

214 Both mutant proteins were more thermosensitive than the wild-type protein, but AdhE(A26

215 wth by comparing a set of thermotolerant and thermosensitive tomato cultivars.

216 therefore vascular conductance; remarkably, thermosensitive tone counterbalances this effect, thus p

217 h enables robust activation of neurons using thermosensitive transient receptor potential (TRP) catio

218 isms are a large family of proteins known as thermosensitive transient receptor potential (TRP) ion c

219 Several thermosensitive transient receptor potential channels (t

220 The homotetrameric thermosensitive transient receptor potential vanilloid 1

221 solution containing a low concentration of a thermosensitive triblock copolymer for extended ocular d

222 Many of these thermosensitive trigeminal orosensory afferent neurons a

223 the cloning and characterization of a novel thermosensitive TRP channel.

224 nsic temperature sensitivity common to other thermosensitive TRP channels.

225 tial molecular framework for deciphering how thermosensitive TRPM channels perceive temperature chang

226 root ganglia (DRG) neurons that also express thermosensitive TRPM3 channels.

227 We were unable to confirm the presence of thermosensitive TRPV1 and TRPM8 that has previously been

228 ole for the TRPV6-ARD than in the paralogous thermosensitive TRPV1 channel.

229 vanilloid (TRPV) channels, which include the thermosensitive TRPV1-V4, have large cytoplasmic regions

230 ther to define the primary thermal sensor of thermosensitive TRPV4 or TRPV2 once the same heat capaci

231 f the mutations (R321A and D425A) elicited a thermosensitive (ts) yeast growth phenotype.

232 The thermosensitive vector pTV1-OK harboring Tn917 was used

233 lum (ER) of living cells, we made use of the thermosensitive vesicular stomatitis virus tsO45 glycopr

234 The attachment of the thermosensitive VSVGtsO45 lumenal domain to proteins pro

235 ing a mixture of depletants, one of which is thermosensitive, we induce solid-to-solid phase transiti

236 Previous studies of thermosensitive yeast COPI mutants yielded the surprisin

237 74W-A as a novel multicopy suppressor of the thermosensitive yip1-4 strain.