ライフサイエンスコーパス: thermosensory

1 These studies imply that thermosensory activity coupled to serotonergic signaling

2 he core thermotaxis circuit comprised of AFD thermosensory and AIY interneurons.

3 tified a new class of neurons that integrate thermosensory and behavioral information that eluded us

4 atory cells are driven by a genetic class of thermosensory and nociceptive fiber.

5 Disruption of thermosensory and pain integration may account for the c

6 demonstrate that an individual DAG-dependent thermosensory behavior of an organism is effected specif

7 functions in a neural network that regulates thermosensory behavior.

8 mutants exhibit altered AFD-ending shape and thermosensory behavior.

9 nderlying experience-dependent plasticity in thermosensory behavior.

10 he downstream effector for DAG regulation of thermosensory behavior.

11 f tax-6 and that it acts in the formation of thermosensory behavioral memory in C. elegans.

12 TRP) family of cation channels contribute to thermosensory behaviors in animals from flies to humans.

13 The AFD sensory neurons are essential for thermosensory behaviors, but the molecular mechanisms by

14 t cell autonomously to regulate AFD-mediated thermosensory behaviors.

15 migration in vitro and in wound healing and thermosensory behaviours in vivo.

16 nstrate that keratinocytes can indeed act as thermosensory cells and that they do so via at least two

17 . sensory innervation and trafficking of the thermosensory channel TRPV1 and the mechanosensory chann

18 tion of developmental mechanisms between the thermosensory circuit in C. elegans and the vertebrate p

19 urons are newly identified components of the thermosensory circuit, and that different combinations o

20 l HSR regulation is independent of canonical thermosensory circuitry and known neurotransmitters but

21 can identify much of the previously reported thermosensory circuitry as well as identify several unre

22 he finger cell neurons (AFD) are the primary thermosensory class in H. contortus.

23 itize TRPV1-expressing afferents revealed no thermosensory consequences of TRPV2 absence.

24 Here, we identify a thermosensory diguanylate cyclase (TdcA) that modulates

25 vanilloid 1 (TRPV1)-lineage nociceptive and thermosensory fibers are primary neurons that drive trig

26 OCHROME INTERACTING FACTOR 4 (PIF4)-mediated thermosensory growth and architecture adaptations are di

27 ificance, the molecular mechanisms that link thermosensory growth and defense responses are not known

28 This study reveals a molecular link between thermosensory growth and immunity in plants.

29 blue-light receptor CRYPTOCHROME2 (CRY2) in thermosensory growth responses.

30 omplete populations of neurons in olfactory, thermosensory, hygrosensory, and memory systems in the f

31 al circuit in the rat POA that processes the thermosensory information and outputs thermoregulatory e

32 gh protein dilution to provide the long-term thermosensory information for VIN3 upregulation.

33 However, less is known how thermosensory information is integrated to gate thermore

34 ng pathway, showing that ttx-3 specifies AIY thermosensory information processing of both motor and a

35 ow that H2A.Z-containing nucleosomes provide thermosensory information that is used to coordinate the

36 trace the connections that relay peripheral thermosensory information to higher brain centres, and s

37 We hypothesized that coupling thermosensory information with motor output enhances the

38 l accuracy, the GC still encodes significant thermosensory information.

39 the GC still encodes a substantial amount of thermosensory information.

40 shroom body-intrinsic neurons solely receive thermosensory input from the lACA, while most receive ad

41 erm plasticity, and the ability to transform thermosensory input into different patterns of motor out

42 traction correlates with specific changes in thermosensory input to the lateral horn, the main target

43 sions on the basis of temporal variations in thermosensory input, thereby augmenting the likelihood o

44 hermotactic behavior and exhibit deregulated thermosensory inputs into a neuroendocrine signaling pat

45 ensitivity and dynamics of the conversion of thermosensory inputs into motor responses.

46 e-lock their calcium dynamics to oscillatory thermosensory inputs.

47 at reveals the central inhibition of pain by thermosensory integration.

48 r potential vanilloid subtype I (TRPV1) is a thermosensory ion channel that is also gated by chemical

49 tion of TRPA1 activity is critical: when the thermosensory isoform is expressed in chemosensors, flie

50 Here, we investigate how thermosensory learning shapes our subjective experience

51 e transition represents a previously unknown thermosensory mechanism.

52 ics of FLC transcriptional shutdown, but the thermosensory mechanisms are still unresolved.

53 MP-gated channels that are part of canonical thermosensory mechanisms in worms and can be prevented i

54 These data reveal a new type of thermosensory molecule and uncover a functional distinct

55 The short life span of thermosensory mutants at warm temperature is completely

56 Thermosensory mutations shorten life span by decreasing

57 innocuous cold transducer in nociceptive and thermosensory nerve endings.

58 ecular mechanism for physiological tuning of thermosensory nerve fibres.

59 e parabrachial nucleus (PBN) as nodes in the thermosensory neural circuitry and indicate that the opi

60 eathes the NREs of 12 neurons, including the thermosensory neuron AFD.

61 AMsh glia engulf sensory endings of the AFD thermosensory neuron by repurposing components of the co

62 sses, the gustatory neuron class ASE and the thermosensory neuron class AFD, from the nematode Caenor

63 protein, to quantify the activity of the AFD thermosensory neuron of individual worms freely navigati

64 Here, we describe the molecular profile of a thermosensory neuron pair in C. elegans experiencing dif

65 hold of responsiveness (T *(AFD)) of the AFD thermosensory neuron pair to temperature stimuli.

66 ot cell-autonomous but rather depends on the thermosensory neuron, AFD, which senses ambient temperat

67 a principal postsynaptic partner of the AFD thermosensory neuron, the AIY interneuron, encodes both

68 ts by monitoring the activity of this single thermosensory neuron.

69 cytoprotective response is regulated by the thermosensory neuronal circuitry of C. elegans.

70 d for temperature-evoked activity in the AFD thermosensory neurons (T*(AFD)) in C. elegans is set by

71 n be generated via different combinations of thermosensory neurons acting degenerately, and emphasize

72 By recording from the C. elegans thermosensory neurons AFD in vivo, we found that cooling

73 Our data suggest that thermosensory neurons affect life span at warm temperatu

74 omous control of chaperone expression by the thermosensory neurons allows C. elegans to respond diffe

75 ll stimuli reliably activate both peripheral thermosensory neurons and central circuits.

76 Additionally, thermosensory neurons and circuits in different species

77 ted as thermosensory neurons, but additional thermosensory neurons are also predicted to play a role

78 SI and the previously identified AFD and AWC thermosensory neurons are necessary and sufficient under

79 s underlying the development and function of thermosensory neurons are poorly understood.

80 Surprisingly, inhibiting the function of thermosensory neurons by mutation or laser ablation caus

81 , we study the physiological role of the AFD thermosensory neurons by quantifying intracellular calci

82 P (transient receptor potential) channels in thermosensory neurons detect a variable range of tempera

83 emperature variations carried out by the DOG thermosensory neurons emerges in distinct motor response

84 Thermosensory neurons enable the nematode to remember it

85 Excitation of the AFD thermosensory neurons enhances serotonin release.

86 Random optogenetic stimulation of the DOG thermosensory neurons evokes behavioral patterns that mi

87 ium and voltage imaging reveals that the DOG thermosensory neurons exhibit activity patterns with sen

88 The single pair of AFD thermosensory neurons in Caenorhabditis elegans exhibits

89 We discover three thermosensory neurons in each dorsal organ ganglion (DOG

90 s elegans ortholog of mammalian CaMKI/IV, in thermosensory neurons in vivo.

91 ent begins with the activation of peripheral thermosensory neurons innervating the body surface.

92 r (HSF1), we show that excitation of the AFD thermosensory neurons is sufficient to activate HSF1 in

93 se in Caenorhabditis elegans is regulated by thermosensory neurons led us to consider whether neurona

94 lamp electrophysiology to show that internal thermosensory neurons located within the fly head capsul

95 range, suggesting that neuromodulation among thermosensory neurons maintains coherence of behavioral

96 ponses, uncover unique functional classes of thermosensory neurons mediating heat and cold sensing, a

97 , the expression of IR93a and IR25a includes thermosensory neurons of the arista.

98 Instead, LPNs receive independent drive from thermosensory neurons of the fly antenna via a new class

99 Here, we identify the thermosensory neurons of the human threadworm Strongyloi

100 We show that thermosensory neurons play a regulatory role in the temp

101 utamine expansion-expressing animals with WT thermosensory neurons readily express protein aggregates

102 specific roles of these channels in central thermosensory neurons remain unclear.

103 ed immunity through ADF chemosensory and AFD thermosensory neurons that regulate longevity.

104 ated at the organismal level by a network of thermosensory neurons that senses elevated temperatures

105 ame PLC that leads to activation of TRPA1 in thermosensory neurons was also required in the TRPA1-exp

106 ilateral AFD neurons have been implicated as thermosensory neurons, but additional thermosensory neur

107 either pan-neuronally or specifically in AFD thermosensory neurons, converted wild-type worms to a pk

108 at is expressed in olfactory, gustatory, and thermosensory neurons, implicating this channel in multi

109 a key role in the control of immunity by AFD thermosensory neurons, it did not control longevity thro

110 s are post-synaptic to most chemosensory and thermosensory neurons, it is probable that these activit

111 However, when the putative thermosensory neurons, the finger cell neurons (AFD), we

112 The internal AC (anterior cell) thermosensory neurons, which express TRPA1, detect warm

113 ession, morphology, and functions of the AFD thermosensory neurons.

114 using RNA from sorted AWB olfactory and AFD thermosensory neurons.

115 og ttx-1 specifies the identities of the AFD thermosensory neurons.

116 C. elegans senses temperature using the AFD thermosensory neurons.

117 dult AIY interneuron pair, which connects to thermosensory neurons.

118 uitry as well as identify several unreported thermosensory neurons.

119 avior is mediated by rapid adaptation of the thermosensory neurons.

120 ctivating temperature-sensitive receptors in thermosensory neurons.

121 but not temperature sensitivity, of the AFD thermosensory neurons.

122 The ttx-3-dependent thermosensory pathway also couples to the temperature-mo

123 Here, we report a thermosensory pathway that triggers physiological heat-d

124 the lateral horn, the main target of central thermosensory pathways and a region of the fly brain imp

125 thermomorphogenesis requires two additional thermosensory pathways.

126 e integration of parallel mechanosensory and thermosensory pathways.

127 ring and nonshivering thermogenesis, whereas thermosensory perception and heat conservation were norm

128 nucleosomes performs a central role in plant thermosensory perception.

129 The thermosensory phenotype is recapitulated in Caenorhabdit

130 For example, DN1a neurons link thermosensory PNs in the lACA to the circadian clock via

131 role of sensorimotor integration in refining thermosensory processing, revealing critical neural mech

132 First, we show that second-order thermosensory projection neurons (TPN-IIIs) and their La

133 We identify second-order thermosensory projection neurons (TPN-IIs) exhibiting su

134 ing in vivo calcium imaging, we describe the thermosensory projection neurons selectively activated b

135 nd that multiple domains contribute to their thermosensory properties.

136 ts in the activation threshold of peripheral thermosensory receptor proteins to a substantial change

137 rly understood that involves mobilization of thermosensory receptors to the neuronal surface.

138 Our results reveal a novel thermosensory reflex circuit within the mammalian CNS th

139 m, a region we now define as a major site of thermosensory representation.

140 ates the motor representation in AIY, allows thermosensory representations to reach downstream premot

141 We show that a bidirectional thermosensory response (increasing temperature raises an

142 Here, we show that rapid thermosensory response adaptation in AFD is mediated via

143 By analyzing the thermosensory response of AFD dendrites severed from the

144 However, because AFD thermosensory responses appear to be similar at all exam

145 gans, because BBS mutants manifest deficient thermosensory responses at both physiological and nocice

146 cultivation temperature (T(c)) modulates the thermosensory responses exhibited by C. elegans on therm

147 that promote axonal regeneration and improve thermosensory responses in a mouse nerve injury model.

148 Nicotinamide also potently modulates thermosensory responses in L3s, suggesting a polymodal s

149 e independent tuning of an animal's distinct thermosensory responses.

150 Identification of thermosensory rGCs in C. elegans provides insight into m

151 We describe a major thermosensory role for the phytochromes (red light recep

152 members of the TRPA subfamily have distinct thermosensory roles in Drosophila, and mammalian TRPA1 i

153 In contrast, thermosensory signal transduction, which also requires t

154 Caenorhabditis elegans and in particular for thermosensory signaling and behavior.

155 erved GPCRs that are required for initiating thermosensory signaling cascades.

156 change, being exploited by nature to create thermosensory signaling networks.

157 es (19 degrees to 24 degrees C) depends on a thermosensory signaling pathway that includes a heterotr

158 irect comparison of the decoding accuracy of thermosensory signals between the two cortices reveals t

159 as also started to uncover the role of these thermosensory signals in cognition.

160 Thermosensory signals may contribute to the sense of bod

161 by glutamatergically transmitting cutaneous thermosensory signals received from spinal somatosensory

162 This review examines how thermosensory signals travel from the skin to the brain

163 to effectively encode both chemosensory and thermosensory signals.

164 proteins in the acquisition of mechano- and thermosensory stimuli and highlight potentially clinical

165 h important implications for the etiology of thermosensory symptoms under chronic pain conditions.

166 We propose that this thermosensory system allows C. elegans to reduce the eff

167 of Caenorhabditis elegans indicate that its thermosensory system exhibits exquisite temperature sens

168 we show that ON responses in the Drosophila thermosensory system extrapolate the trajectory of tempe