1 rallel disulfide bonds, is characteristic of
theta-defensins.
2 in the structure, stability, and activity of
theta-defensins.
3 y equals or exceeds that of normal alpha- or
theta-defensins.
4 Rhesus
theta-defensin 1 (RTD-1) is a unique tridisulfide, cycli
5 We evaluated the efficacy of rhesus
theta-defensin 1 (RTD-1), a novel cyclic antimicrobial p
6 fensins (hominid retrocyclins 1-3 and rhesus
theta-defensins 1-3) and four human alpha-defensins (hum
7 We tested rhesus
theta-defensins 1-3, retrocyclins 1-3, and several analo
8 The peptide, termed rhesus
theta defensin-
1 (RTD-1), is microbicidal for bacteria a
9 Rhesus theta (
theta) defensin-
1 (RTD-1), a natural macrocyclic antimic
10 Development of modified
theta-defensin analogs provides an approach for creating
11 ta-defensins and illustrate the potential of
theta-defensin analogues as scaffolds for peptide drug d
12 theta-Defensin analogues with different numbers and comb
13 dings also suggest that interactions between
theta-defensins and gp41 may contribute to the ability o
14 n addition, we compared the ability of these
theta-defensins and HNP-1 to protect J53-BL cells (an in
15 ide insights into the mechanism of action of
theta-defensins and illustrate the potential of theta-de
16 Anti-
theta-defensin antibody localized the peptides in circul
17 alpha, beta, and
theta defensins are effectors of the innate immune syste
18 We recently reported that
theta defensins are miniature lectins that bind gp120 of
19 Theta-defensins are circular octadecapeptides that conta
20 Theta-defensins are cyclic octadecapeptides encoded by t
21 theta-Defensins are cyclic octadecapeptides found in non
22 Theta-defensins are lectin-like, cyclic octadecapeptides
23 Theta-defensins are macrocyclic antimicrobial peptides t
24 theta-Defensins are ribosomally synthesized cyclic pepti
25 with lectin-like properties exist in plants,
theta-defensins are the first such molecules to be ident
26 Equal amounts of each
theta-defensin bound to E. coli cells, indicating that t
27 llowing for the prediction of 10 theoretical
theta-defensins (
BTD-1 to BTD-10) produced by binary, he
28 We now report the characterization of baboon
theta-defensins (
BTDs) expressed in bone marrow and peri
29 We previously reported that synthetic
theta-defensins called retrocyclins can neutralize and a
30 Because retrocyclin-1, an ancestral hominid
theta-defensin,
can protect human cells in vitro from in
31 i-disulfide ladder, and arginine residues of
theta-defensins contributed substantially to these prote
32 Theta-defensins (
cyclic octadecapeptides found in nonhum
33 3) whose sequences were inferred from human
theta-defensin (
DEFT) pseudogenes.
34 blotting disclosed the presence of putative
theta-defensins,
distinct from RTD-1, in leukocyte extra
35 ides of many if not all vertebrates, and the
theta-defensins found in certain non-human primates.
36 and RC2, humanized versions of the antiviral
theta-defensins found in the leukocytes of certain nonhu
37 Human
theta-defensin genes contain a premature stop codon that
38 theta-Defensins have multiple arginines and a ladder-lik
39 This study compares the ability of six
theta-defensins (
hominid retrocyclins 1-3 and rhesus the
40 MTD12813 is a
theta-defensin inspired cyclic peptide that is highly ef
41 We found that members of the alpha- and
theta-defensins,
magainins and cathelicidins had substan
42 ure, and multiple host defense activities of
theta-defensins make them intriguing potential therapeut
43 ion of SARS-CoV-2 Spike, and that alpha- and
theta-defensins may be valuable tools in developing SARS
44 cy of a novel macrocyclic peptide, minimized
theta-defensin (
MTD)-12813 in CRE sepsis.
45 Low concentrations of
theta-defensins not only killed vegetative cells of B. a
46 Growing evidence suggests that
theta-defensins offer the best opportunity for therapeut
47 and in vivo led us to examine the effects of
theta-defensins on Bacillus anthracis (Sterne).
48 of broad-spectrum antiviral peptides termed
theta-defensins,
potently inhibits Abeta oligomer and fi
49 Four cDNAs encoding
theta-defensin precursors were characterized, allowing f
50 Overall, these findings suggest that
theta-defensins provide molecular templates that could b
51 a-defensins HNP-1 and HD-5 and the synthetic
theta-defensin RC-101, but not beta-defensins hBD-1 and
52 Results of this study suggest that
theta-defensins represent a new class of host-directed c
53 Here we show that the
theta-defensin retrocyclin 2 (RC2) inhibited influenza v
54 As such, HNP1, as well as a
theta-defensin retrocyclin RC-101, both interfere with S
55 To test the activity of a synthetic
theta-defensin,
retrocyclin (RC)-2, in a murine herpes s
56 The most potent
theta-defensin,
retrocyclin-2, bound with exceptionally
57 theta-Defensin RTD-1 is a noncompetitive inhibitor of an
58 The rhesus
theta-defensin RTD-1 protects mice from an experimental
59 (Crp-4), beta-defensins (HBD-2, HBD-3), and
theta-defensins (
RTD-1, BTD-7), we show how these peptid
60 Two new
theta-defensins,
RTD-2 and RTD-3, were purified by rever
61 The peptides included rhesus
theta defensins (
RTDs) 1 to 3, originally isolated from
62 disulfide bridges of RTD-1, a member of the
theta-defensin subfamily, could be replaced with noncova
63 gh degree of sequence conservation among the
theta-defensins tested.
64 Retrocyclin (RC)-101 is a cationic
theta-defensin that inhibits HIV-1 entry.
65 t progress in our understanding of alpha and
theta-defensins -
the two structural classes composed of
66 g and the antiviral properties of alpha- and
theta-defensins,
the lectin-like behavior of defensins m
67 theta-Defensins,
the only cyclic peptides of animal orig
68 We tested the ability of 20 synthetic
theta defensins to protect cells from infection by type
69 Five of the predicted
theta-defensins were purified from baboon leukocytes, an
70 Thus, baboons express numerous
theta-defensins which appear to differentially contribut
71 ong, widespread downregulation of alpha- and
theta-defensins with anti-HIV activity, which are not ex
72 Synthetic
theta-defensins with sequences that correspond to those