ライフサイエンスコーパス: thoracic aortic aneurysm

1 t insertion for the management of descending thoracic aortic aneurysm.

2 bruary 1996, we operated on 512 patients for thoracic aortic aneurysm.

3 s connective disorder is the risk to develop thoracic aortic aneurysm.

4 rtic disease, and 1 woman (5%) with familial thoracic aortic aneurysm.

5 genetics may be most relevant to predicting thoracic aortic aneurysm.

6 condition, which is commonly associated with thoracic aortic aneurysm.

7 repair for many patients with abdominal and thoracic aortic aneurysms.

8 emodeling and intimal expansion of ascending thoracic aortic aneurysms.

9 om loss of VSMCs occurs in primary ascending thoracic aortic aneurysms.

10 mortality during the resection of ascending thoracic aortic aneurysms.

11 ltaneous detection of both breast cancer and thoracic aortic aneurysms.

12 assess the relationship among COA, BAV, and thoracic aortic aneurysms.

13 at underwent elective surgery for descending thoracic aortic aneurysms.

14 ribute to the development and enlargement of thoracic aortic aneurysms.

15 ase PWS in finite element analysis models of thoracic aortic aneurysms.

16 WS) in finite element analysis of descending thoracic aortic aneurysms.

17 ceptors in AngII-induced atherosclerosis and thoracic aortic aneurysms.

18 repair in the treatment of intact descending thoracic aortic aneurysms.

19 eurysms, but no association was observed for thoracic aortic aneurysm (1.13, 0.88-1.44).

20 bidities for TAAD were hypertension (55.2%), thoracic aortic aneurysms (14.6%), and chronic obstructi

21 e contained 1010 patients: 670 patients with thoracic aortic aneurysm, 195 with chronic type B aortic

22 .2, and 0.4 deaths per 100 patient-years for thoracic aortic aneurysm, acute type B aortic dissection

23 .9, and 3.2 deaths per 100 patient-years for thoracic aortic aneurysm, acute type B aortic dissection

24 smooth muscle isoform of alpha-actin, cause thoracic aortic aneurysms, acute aortic dissections, and

25 Thoracic aortic aneurysm affecting the arch and proximal

26 iscusses published data on genes involved in thoracic aortic aneurysm and attempts to explain diverge

27 The GenTAC (Genetically Triggered Thoracic Aortic Aneurysm and Cardiovascular Conditions)

28 its higher prevalence among men, women with thoracic aortic aneurysm and dissection (TAAD) have lowe

29 Thoracic aortic aneurysm and dissection (TAAD) is an aut

30 ing pathology observed in heritable forms of thoracic aortic aneurysm and dissection (TAAD).

31 Despite a higher prevalence of thoracic aortic aneurysm and dissection among men, women

32 however, excess TGF-beta signaling promotes thoracic aortic aneurysm and dissection in multiple diso

33 enes that confer a highly penetrant risk for thoracic aortic aneurysm and dissection, and a subset of

34 disparities exist between men and women with thoracic aortic aneurysm and dissection.

35 been identified to cause autosomal dominant thoracic aortic aneurysm and dissection.

36 muscle actin, have been identified to cause thoracic aortic aneurysm and dissection.

37 that individual mechanisms may contribute to thoracic aortic aneurysm and dissection.

38 In the case of thoracic aortic aneurysm and dissections (thoracic aorti

39 pression in aortic tissue from patients with thoracic aortic aneurysm and found increased S100A12 exp

40 al controversies and uncertainties regarding thoracic aortic aneurysm and its treatment.

41 y feasible method for treatment of traumatic thoracic aortic aneurysm and may be an effective alterna

42 ochondrial dysfunction in the progression of thoracic aortic aneurysm and mitochondrial boosting stra

43 re significantly predicted prevalent risk of thoracic aortic aneurysm and the need for surgical inter

44 Thoracic aortic aneurysms and acute aortic dissections (

45 ficiency does not affect AngII-induced AAAs, thoracic aortic aneurysms and atherosclerosis.

46 lood Institute GenTAC (Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions)

47 al registry of GenTAC (Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions)

48 l aortic aneurysms are much more common than thoracic aortic aneurysms and combined they account for

49 n of all patients with clinically recognized thoracic aortic aneurysms and constitute the majority of

50 in myosin heavy chain (Myh11) cause familial thoracic aortic aneurysms and dissections (FTAAD).

51 lies identified with dominant inheritance of thoracic aortic aneurysms and dissections (TAA/dissectio

52 most common genetic alterations for familial thoracic aortic aneurysms and dissections (TAAD) are mis

53 otein kinase G1 (PRKG1, p.Arg177Gln) develop thoracic aortic aneurysms and dissections (TAAD) as youn

54 Although thoracic aortic aneurysms and dissections (TAAD) can be

55 Thoracic aortic aneurysms and dissections (TAAD) cause s

56 understanding of the genetic determinants of thoracic aortic aneurysms and dissections (TAAD) has lar

57 Familial thoracic aortic aneurysms and dissections (TAAD) occur a

58 Thoracic aortic aneurysms and dissections (TAAD) represe

59 Heterozygous ACTA2 mutations cause familial thoracic aortic aneurysms and dissections (TAAD), but on

60 Heritable thoracic aortic aneurysms and dissections (TAAD), includ

61 A2, are the most prevalent cause of familial thoracic aortic aneurysms and dissections (TAAD).

62 e responsible for 14% of inherited ascending thoracic aortic aneurysms and dissections (TAAD).

63 Thoracic aortic aneurysms and dissections (TAADs) are de

64 Non-syndromic thoracic aortic aneurysms and dissections (TAADs) are in

65 ic isoform of alpha-actin (alpha-SMA), cause thoracic aortic aneurysms and dissections and occlusive

66 Thoracic aortic aneurysms and dissections are associated

67 es for the medical and surgical treatment of thoracic aortic aneurysms and dissections are becoming i

68 Marfan syndrome, that predispose persons to thoracic aortic aneurysms and dissections are understood

69 genetic contribution to the pathogenesis of thoracic aortic aneurysms and dissections has revealed p

70 hat these variants predispose individuals to thoracic aortic aneurysms and dissections includes the f

71 First, the pathogenesis of thoracic aortic aneurysms and dissections is better unde

72 ominant non-syndromic hearing loss, familial thoracic aortic aneurysms and dissections, and multiple

73 patients with conditions that predispose to thoracic aortic aneurysms and dissections, including MFS

74 P-dependent protein kinase 1 (PKG1) leads to thoracic aortic aneurysms and dissections.

75 domain with an activating mutation linked to Thoracic Aortic Aneurysms and Dissections.

76 SNPs at the FBN1 locus associated with both thoracic aortic aneurysms and dissections.

77 esponsible for 25% of families with familial thoracic aortic aneurysms and dissections.

78 mutation responsible for a large family with thoracic aortic aneurysms and dissections.

79 could lead to new therapeutic strategies for thoracic aortic aneurysms and dissections.

80 This review focuses only on thoracic aortic aneurysms and dissections.

81 ooth-muscle cells (SMCs) can cause inherited thoracic aortic aneurysms and dissections.

82 S100A12 is enriched in human thoracic aortic aneurysms and dissections.

83 the relevance of S100A12 expression to human thoracic aortic aneurysms and type A thoracic aortic ane

84 eases affecting the ascending aorta, such as thoracic aortic aneurysms and type I and II dissections,

85 ity is high in the midterm for patients with thoracic aortic aneurysm, and managing modifiable risk f

86 he variability of penetrance of both BAV and thoracic aortic aneurysm as well as the variability of t

87 line the 'true' natural history of ascending thoracic aortic aneurysm (ATAA) based on a cohort of pat

88 Ascending thoracic aortic aneurysm (ATAA) is caused by the progres

89 c tissue elastic properties of two ascending thoracic aortic aneurysm (ATAA) patients from pre-operat

90 ts contribute to the initiation of ascending thoracic aortic aneurysms (ATAAs) in patients with bicus

91 n syndrome (MFS) is known to cause ascending thoracic aortic aneurysms (ATAAs).

92 Repair of thoracoabdominal and thoracic aortic aneurysm by the traditional clamp-and-go

93 t-to-treat complications in the treatment of thoracic aortic aneurysms by endovascular stent-grafting

94 nd in approximately 25% of clinically stable thoracic aortic aneurysm cases.

95 e is remarkably similar to a subset of human thoracic aortic aneurysms caused by mutations in SMC con

96 ents undergoing elective surgical repair for thoracic aortic aneurysm, despite similar preoperative r

97 0A12 protein expressed in all cases of acute thoracic aortic aneurysm dissection and in approximately

98 o human thoracic aortic aneurysms and type A thoracic aortic aneurysm dissection and to study mechani

99 ts who underwent repair of chronic ascending thoracic aortic aneurysms from 1986 to present.

100 se models and the discovery of several novel thoracic aortic aneurysm genes, the involvement of the t

101 Ascending thoracic aortic aneurysms grew in a very slow manner, an

102 A genetic predisposition to thoracic aortic aneurysm has been established, and gene

103 Overall survival for thoracic aortic aneurysms has improved significantly in

104 Traditionally, thoracic aortic aneurysms have been labeled as a degener

105 rly experiences with endovascular grafts for thoracic aortic aneurysms have met with good to moderate

106 3]); first-degree relatives of patients with thoracic aortic aneurysm (HR, 5.09 [95% CI, 3.80-6.82]);

107 Managing thoracic aortic aneurysms identified incidentally by inc

108 scending aortic diameter was associated with thoracic aortic aneurysm in 385,621 UK Biobank participa

109 patients that underwent TEVAR for descending thoracic aortic aneurysm in the MOTHER database and 231

110 e first line for repair of intact descending thoracic aortic aneurysms in Medicare beneficiaries.

111 ort the hypothesis that FBN1 mutations cause thoracic aortic aneurysms in patients who do not have th

112 trophy is thought to be a cause of ascending thoracic aortic aneurysms in the elderly.

113 Thoracic aortic aneurysm is a potentially life-threateni

114 Although a virulent disease, thoracic aortic aneurysm is an indolent process.

115 The risk of developing thoracic aortic aneurysm is increased more than 17-fold

116 modern understanding of the pathogenesis of thoracic aortic aneurysm is quite limited.

117 odds ratio (OR = 2.29, CI: [0.55,9.61]) for thoracic aortic aneurysms is observed in women with brea

118 Prognosis for thoracic aortic aneurysms is significantly worse for wom

119 including both abdominal aortic aneurysm and thoracic aortic aneurysm, is the cause of death of 1% to

120 ING, AND PARTICIPANTS: The Kaiser Permanente Thoracic Aortic Aneurysm (KP-TAA) cohort study was a ret

121 of the SMC contractile unit, cause familial thoracic aortic aneurysms leading to acute aortic dissec

122 redisposition for progressive enlargement of thoracic aortic aneurysms leading to type A dissection (

123 ellular remodeling of the media in ascending thoracic aortic aneurysms may be an initial adaptive res

124 an unspecified site, which may include some thoracic aortic aneurysms, may have underestimated the t

125 sinotubular junction most strongly predicted thoracic aortic aneurysm (n = 427,016; mean HR: 1.42 per

126 mputed tomographic angiography of descending thoracic aortic aneurysms (n=10 total, 5 fusiform and 5

127 Up to 20% of individuals who have thoracic aortic aneurysms or acute aortic dissections bu

128 had any significant effect on AngII-induced thoracic aortic aneurysms or atherosclerosis.

129 ted the hypothesis that FBN1 mutations cause thoracic aortic aneurysms or dissections in patients who

130 cation of individuals at risk for developing thoracic aortic aneurysms or dissections.

131 identified probands with a diagnosis of BAV, thoracic aortic aneurysm, or thoracic aortic dissection.

132 Ruptured descending thoracic aortic aneurysm (rDTAA) is a life-threatening d

133 ach for the treatment of ruptured descending thoracic aortic aneurysms (rDTAA).

134 For the management of descending thoracic aortic aneurysms, recent evidence has suggested

135 147) and percutaneous endovascular abdominal/thoracic aortic aneurysm repair in 46.3% (68/147) of sub

136 DHCA has been implemented in ascending thoracic aortic aneurysm resection whenever the anatomy

137 ance exercise or competition after ascending thoracic aortic aneurysm resection with bicuspid aortic

138 the risk of first aortic event, specifically thoracic aortic aneurysm surgery or an aortic dissection

139 This study examined trends in mortality from thoracic aortic aneurysm (TAA) and aortic dissection (AD

140 n aortic collagen and elastin content during thoracic aortic aneurysm (TAA) development in a murine m

141 Mutations in fibrillin-1 are associated with thoracic aortic aneurysm (TAA) in Marfan syndrome.

142 Thoracic aortic aneurysm (TAA) is a common progressive d

143 Thoracic aortic aneurysm (TAA) is a life-threatening vas

144 Thoracic aortic aneurysm (TAA) is a potentially fatal di

145 Thoracic aortic aneurysm (TAA) is characterized by dilat

146 tic diameter measurements in patients with a thoracic aortic aneurysm (TAA) show wide variation.

147 n variants in IPO8 cause a syndromic form of thoracic aortic aneurysm (TAA) with clinical overlap wit

148 issection (AoD) is a serious complication of thoracic aortic aneurysm (TAA).

149 Genetic aortopathy (GA) underlies thoracic aortic aneurysms (TAA) in younger adults.

150 N) with 7247 (65%) nonruptured, degenerative thoracic aortic aneurysms (TAA), 2701 (24%) descending a

151 Data on thoracic aortic aneurysms (TAA), type B aortic dissectio

152 ng-term survival of patients with descending thoracic aortic aneurysms (TAAs) after open and endovasc

153 Thoracic aortic aneurysms (TAAs) and valvular insufficie

154 Thoracic aortic aneurysms (TAAs) are common, but experim

155 Thoracic aortic aneurysms (TAAs) develop secondary to ab

156 The cause of thoracic aortic aneurysms (TAAs) is poorly understood.

157 Thoracic aortic aneurysms (TAAs) stem from diverse mecha

158 Marfan syndrome and other forms of inherited thoracic aortic aneurysm taking CCBs display increased r

159 ACTA2, are the most common cause of familial thoracic aortic aneurysms that lead to dissection (TAAD)

160 l model of the initiation and progression of thoracic aortic aneurysms to contrast key predisposing r

161 growth and growth patterns in patients with thoracic aortic aneurysms undergoing CT surveillance.

162 From 1992 to 1996, 85 patients with thoracic aortic aneurysm underwent stent-graft placement

163 amily with autosomal-dominant inheritance of thoracic aortic aneurysms variably associated with the b

164 areas per examination was 1.6 (18 of 11) in thoracic aortic aneurysms versus 0.25 (14 of 57) in abdo

165 medial degeneration is specific for sporadic thoracic aortic aneurysms versus nondilated aortas.

166 genes known to be associated with BAV and/or thoracic aortic aneurysm was performed.

167 l ascending thoracic aortas and 29 ascending thoracic aortic aneurysms was performed by directly meas

168 Thoracic aortic aneurysms were accurately predicted at C

169 which men are affected predominately, 51% of thoracic aortic aneurysms were identified in women who w

170 Thoracic aortic aneurysms were significantly more likely

171 by use of genomic DNA from two patients with thoracic aortic aneurysms who did not have the Marfan sy

172 performed on patients with intact descending thoracic aortic aneurysms who underwent TEVAR or open su