ライフサイエンスコーパス: thousands of

1 This extensive data was used to define thousands of 5' and 3' untranslated regions, some of whi

2 In this method, the hue (color) value of thousands of 67 nm Au nanoparticles immobilized on a gla

3 d "caged" convulsant that is responsible for thousands of accidental and malicious poisonings.

4 over 100 active leads are representative of thousands of active compounds generated over the past de

5 ecruited the cohesin-loading factor NIPBL to thousands of active enhancers and promoters to dictate w

6 Moreover, by systematically targeting thousands of alternative splicing events, CHyMErA identi

7 f previously uncharacterized transcripts and thousands of alternative transcripts for known genes, re

8 e hope of ending a ground war that threatens thousands of American troops?

9 Opioid use kills tens of thousands of Americans each year, devastates families an

10 ty due to infection, leading to mortality of thousands of amphibian larvae within a pond.

11 yses showed that the combined effect of many thousands of as yet unreported IPF susceptibility varian

12 ich use optical lattices to interrogate many thousands of atoms in parallel(11,12).

13 molecular systems containing hundreds if not thousands of atoms.

14 We observed thousands of AUG-initiated upstream open reading frames

15 t features of bNAb repertoires, encompassing thousands of B cell clones per individual, with correlat

16 Mammalian microbiomes encode thousands of biosynthetic gene clusters (BGCs) and repre

17 d single-cell heteroplasmy and cell state in thousands of blood cells obtained from three unrelated p

18 and visualize splice variants across tens of thousands of bulk and single-cell data sets in the publi

19 e of simulating the mutational landscapes of thousands of cancer genomes at different resolutions wit

20 that enables chemical screens of hundreds to thousands of candidate drugs on freshly isolated tumor c

21 Hundreds of thousands of candidate enhancers have been nominated via

22 nnotate these data and cataloged hundreds of thousands of candidate regulatory elements that exhibit

23 ) can simultaneously measure the function of thousands of candidate regulatory sequences (CRSs) in a

24 s of rod and cone photoreceptors, identified thousands of candidate rod- and cone-specific CREs, and

25 D-19 epidemic in China, averting hundreds of thousands of cases by 19 February (day 50).

26 the developing central nervous system where thousands of cell types are generated.

27 The latest protocols are scalable to thousands of cells and are being used to compile cell at

28 We clonally trace thousands of cells from cancers, linking epigenomic vari

29 lows for doublet annotation of datasets with thousands of cells in a matter of seconds.

30 1,12,18) to barcode transcripts from tens of thousands of cells in a single experiment.

31 rescence and gene expression measurements on thousands of cells in a single experiment.

32 argets across six chromosomes in hundreds to thousands of cells, implying a potential to image thousa

33 ted in 5 d, with a throughput of hundreds to thousands of cells.

34 Of the thousands of chemicals present in the environment, those

35 Projects involving thousands of citizens generate spatially dense data sets

36 Adversity, and GxDisease interactions across thousands of clinical and molecular phenotypes.

37 The opportunity to simultaneously screen thousands of combinations of putative GTs, nucleotide su

38 We carried out an exhaustive study comparing thousands of competing classification algorithms that we

39 e assembly and gene prediction, resulting in thousands of complete genomes for analysis.

40 complexity of SOM, an inseparable mixture of thousands of compounds hinders the determination of stru

41 ey enable identification of hundreds or even thousands of compounds in a single sample.

42 on required to specify atomic structures for thousands of conformations far exceeds that of experimen

43 neously obtain intracellular recordings from thousands of connected mammalian neurons in vitro.

44 ts, global viromics projects have discovered thousands of coronavirus sequences in diverse animals an

45 owever, without simultaneous recordings from thousands of cortical neurons with shared sensory inputs

46 o measure the binding energy between tens of thousands of CRISPR RNA (crRNA) and target DNA sequences

47 TAP-seq permits routine analysis of thousands of CRISPR-mediated perturbations within a sing

48 In humans, thousands of crossover events have been identified by ge

49 into "factories" for generating hundreds of thousands of crRNAs covering 95% of all targetable genom

50 head of time; (2) Use this approach to label thousands of daily large-scale weather patterns over Nor

51 Of thousands of de novo SNPs identified, 2677 were informat

52 ' treatment in intensive care units, causing thousands of deaths and a considerable increase in hospi

53 ransmitted viral disease that causes tens of thousands of deaths each year despite the long-standing

54 dly infectious diseases, causing hundreds of thousands of deaths each year, primarily in young childr

55 Human African trypanosomiasis is causing thousands of deaths every year in the rural areas of Afr

56 e for millions of infections and hundreds of thousands of deaths globally.

57 e coronavirus 2 (SARS-CoV-2) has resulted in thousands of deaths in the world.

58 with millions of infections and hundreds of thousands of deaths to date(1,2).

59 in the United States and caused hundreds of thousands of deaths.

60 hon, with over 600 unique code contributors, thousands of dependent packages, over 100,000 dependent

61 y developing economy is comprised of tens of thousands of different financial assets with an aggregat

62 sequencing of ribosomal DNA (rDNA) suggests thousands of different microbes may be present in a sing

63 nt species, the ubiquitin system consists of thousands of different proteins involved in attaching ub

64 karyotic gene expression regulation involves thousands of distal regulatory elements.

65 Although we experience thousands of distinct events on a daily basis, relativel

66 The human lipidome comprises over tens of thousands of distinct lipid species in addition to total

67 n cells, the spatial compartmentalization of thousands of distinct proteins serves a multitude of div

68 We identified tens of thousands of DNA regions from each sample type with dyna

69 have provided empirical evidence identifying thousands of DNA variants associated with psychiatric di

70 actions have been experimentally assayed for thousands of DNA-binding proteins.

71 we measure gene silencing and activation for thousands of domains.

72 encoded proteins can theoretically regulate thousands of downstream targets in a considerable number

73 lived ocean island volcanoes are crosscut by thousands of dykes, which must be accommodated through a

74 Humans cultivate thousands of economic plants (i.e. plants with economic

75 analysis of RNA editing reveals that tens of thousands of editing sites (>70% of all sites) are edite

76 isolates and metagenomic datasets, revealing thousands of encoded antibiotics.

77 immunoprecipitation of these RBPs identifies thousands of endogenous mRNA targets that respond to cha

78 these contact pools to generate hundreds of thousands of energetically favorable binding sites for a

79 Thousands of epigenomic data sets have been generated in

80 sease appears substantial, with estimates of thousands of episodes of IE among persons with IDU and a

81 ct biological pathways among the hundreds of thousands of eukaryotic species that will become availab

82 Thousands of experiments and studies use the human refer

83 used a sophisticated computational search of thousands of expression datasets to define extended sign

84 ssing, alignment, scaling, and clustering of thousands of features extracted from gas chromatography/

85 Based on the analysis of thousands of floating plastic fragments from a global co

86 ding DNA, greater regulatory complexity, and thousands of fold more protein synthesis per gene.

87 of amyloid fibril formation, beginning with thousands of free monomers and ending with kinetically a

88 Thousands of frozen, archived tissue samples from the hu

89 r study shows that pMEIs are associated with thousands of gene expression and splicing variations, in

90 histone modification ChIP-seq data sets with thousands of gene expression profiles.

91 the clock into a complex network composed of thousands of gene outputs and inputs.

92 sing scale, we show that DropSynth can build thousands of gene-length fragments at >20% fidelity.

93 to monitor the expression levels of tens of thousands of genes and proteins resulting in enormous da

94 rchestrates expression levels of hundreds to thousands of genes in a behavior-related manner.

95 RK is also scalable to datasets with tens of thousands of genes measured on tens of thousands of samp

96 an found in the text of the same papers, and thousands of genes missing from other pathway databases,

97 Differential hydroxymethylation is found in thousands of genes, most significantly in genes related

98 opment require the activation of hundreds to thousands of genes, mostly expressed in symbiotic cells.

99 indirectly the transcriptional regulation of thousands of genes.

100 t life cycle by regulating the expression of thousands of genes.

101 estimates as interaction terms, we identify thousands of genetic associations that are cell-type-ass

102 e test 26 polygenic predictors using tens of thousands of genetic siblings from the UK Biobank (UKB),

103 e association studies (GWAS) have identified thousands of genetic variants associated with a range of

104 that model developing brains, we identified thousands of genetic variants exhibiting allele-specific

105 iplex genetic assays can simultaneously test thousands of genetic variants for a property of interest

106 Whilst thousands of genetic variants have been associated with

107 asure the shifts in transcription induced by thousands of genetic variants.

108 that can reliably construct pangenomes from thousands of genetically diverse bacterial genomes that

109 Although thousands of genetically modified mouse strains have bee

110 The availability of thousands of genome-wide coupling chromatin immunoprecip

111 Here we utilize thousands of genome-wide single-nucleotide polymorphisms

112 acement methods to contextualize hundreds of thousands of genomes must thus be efficiently scalable a

113 equencing technologies allowed sequencing of thousands of genomes.

114 hese techniques typically affect hundreds or thousands of genomic loci.

115 Owing to bursts in the expression of thousands of germline-specific genes, the testis has the

116 By assaying the activity of thousands of guides, we refine on-target design rules an

117 Thousands of health workers have been infected and outbr

118 etitive Parts Calculator to rapidly generate thousands of highly nonrepetitive genetic parts from spe

119 eterogeneity of DNA repair activities across thousands of human lymphocytes, identifying known and no

120 Although thousands of human proteins are known to undergo S-palmi

121 osttranslational modification that occurs on thousands of human proteins, most of which are cytoplasm

122 ide adsorption capacities of several tens of thousands of hypothetical MOFs are evaluated at various

123 Image collections must contain not only thousands of images to provide sufficient example object

124 quantify global transcriptional responses to thousands of independent perturbations at single-cell re

125 o super-resolution, thousands to hundreds of thousands of individual cells can now be analyzed in an

126 echnology for measuring gene expression from thousands of individual cells identified the different c

127 ing technologies enable genome sequencing of thousands of individual cells in parallel, but with extr

128 lipidomics experiment may track hundreds to thousands of individual lipid species.

129 .e. the lethal mutation rate), we manipulate thousands of individual pairs of mother and daughter cel

130 The carboxysome self-assembles from thousands of individual proteins into icosahedral-like p

131 ectly measure the transcriptional outputs of thousands of individual regulatory elements in embryonic

132 neously measuring metabolism and division of thousands of individual Saccharomyces cerevisiae cells u

133 track the developing bower structure and the thousands of individual sand manipulation behaviors perf

134 y of simultaneously analysing the genomes of thousands of individual sperm.

135 As there is no cure, thousands of individuals who are alive at present will s

136 l pleiotropy, and is scalable to hundreds of thousands of individuals.

137 posed method for simulated data with tens of thousands of individuals.

138 multisystem organ failure, are now affecting thousands of infected patients and causing widespread mo

139 rse-grained model that allows us to simulate thousands of interacting multivalent proteins, we invest

140 Tens of thousands of internal mRNA m7G sites have been identifie

141 uptake of bacteria, symbiotic cells carrying thousands of intracellular bacteria without signs of imm

142 animals, O-GlcNAc transferase (OGT) modifies thousands of intracellular proteins, the human pathogen

143 hat eliminates these confounders, and report thousands of intrinsically covarying gene pairs in mouse

144 ghly compressed matter at temperatures up to thousands of kelvins.

145 With the ability to generate reads tens to thousands of kilobases in length with an accuracy approa

146 n-fed discharges in major rivers hundreds to thousands of kilometers downstream.

147 Migratory animals move up to thousands of kilometers every year [1].

148 ring, migratory birds travel tens to tens of thousands of kilometers from their wintering to their br

149 displacements during MHWs vary from tens to thousands of kilometres across the world's oceans and do

150 ement that lasted several months and spanned thousands of kilometres.

151 There are thousands of known cellular phosphorylation sites, but t

152 bles the reference-free alignment of tens to thousands of large vertebrate genomes while maintaining

153 t meta-transcriptomic studies have uncovered thousands of leviviral genomes, but most of these lack a

154 Analysis of tens of thousands of live cells is achieved in minutes without a

155 llions of people and has claimed hundreds of thousands of lives.

156 g of vulnerable populations may save or cost thousands of lives.

157 acent feathers slide apart during extension, thousands of lobate cilia on the underlapping feathers l

158 We map thousands of loci affecting chromatin accessibility and/

159 Studies (GWAS) have successfully identified thousands of loci associated with human diseases.

160 Here, we show that TFL1 is recruited to thousands of loci by the bZIP transcription factor FD.

161 Although thousands of loci have been associated with human phenot

162 e of polygenicity, involving at a minimum of thousands of loci.

163 species tree and individual gene trees using thousands of loci.

164 Of the thousands of long noncoding RNAs (lncRNA) identified in

165 that Neanderthal introgression reintroduced thousands of lost ancestral variants with gene regulator

166 The plant kingdom produces hundreds of thousands of low molecular weight organic compounds.

167 This immunoassay protocol makes thousands of low-abundance proteins accessible to quanti

168 l simulations have shown that samples having thousands of measurements are not large enough for the m

169 ome has been experimentally characterized by thousands of measurements for every basepair in the huma

170 nsory organs (antenniform legs) covered with thousands of mechanosensory, olfactory, and gustatory se

171 s aureus, and Escherichia coli, and identify thousands of MGEs, including candidate insertion sequenc

172 described member of a superfamily comprising thousands of microbial proteins.

173 By training on a dataset composed of thousands of micrographs collected across a wide range o

174 s and species of interest within hundreds or thousands of microorganisms.

175 Additionally, we identified thousands of mobility genes, a subset of which have unkn

176 Time-series analysis revealed thousands of molecular changes and an orchestrated chore

177 ar functioning requires the orchestration of thousands of molecular interactions in time and space.

178 cal hazard assessment are designed to screen thousands of molecules across hundreds of biological tar

179 targeted tandem mass spectrometry can detect thousands of molecules in a biological sample.

180 Among the thousands of molecules that cross the NPC, even very lar

181 observe the electrochemistry of hundreds to thousands of molecules trapped in a femtoliter droplet,

182 s of ancestral proteins but also to identify thousands of mutations in the human exome, some of which

183 Tumors accumulate thousands of mutations, and sequencing them has given ri

184 es of accessibility occurring rapidly across thousands of myeloid enhancers in a monocyte-to-macropha

185 irst it is able to analyze the hue values of thousands of nanoparticles in parallel in less than a mi

186 ess between native and nonnative taxa across thousands of nested locations ranging in size and extent

187 ped a method to record calcium activity from thousands of neurons across a volume of the fly brain du

188 Modern recording methods enable sampling of thousands of neurons during the performance of behaviora

189 Cre-dependent sparse and bright labeling of thousands of neurons, astrocytes, or microglia in each b

190 As sequencing costs have dropped, thousands of new genomes have been sequenced, and scient

191 very of structural variants (SVs), including thousands of new transposon insertions, and of highly po

192 ctivities, and other processes cause tens of thousands of nicks per cell per day.

193 Hundreds to thousands of non-driver genes undergo loss of heterozygo

194 Together these techniques unleash thousands of non-human epigenetic and transcriptional pr

195 Mammalian genomes encode tens of thousands of noncoding RNAs.

196 ome-wide association studies have implicated thousands of noncoding variants across common human phen

197 ncluding reproducible focal demethylation at thousands of normally methylated loci.

198 hloroplast biogenesis requires the import of thousands of nuclear-encoded preproteins by essential im

199 ork of RNA-RNA interactions spanning tens of thousands of nucleotides.

200 ions have revealed that loud speech can emit thousands of oral fluid droplets per second.

201 Until now, thousands of organic hybrid-POMs have been reported; how

202 also used as a knowledge base for generating thousands of organism-specific Pathway/Genome Databases

203 ultivariate feature profiles for hundreds of thousands of organoids to quantitatively describe their

204 Additionally, we generated thousands of other Cas9 variants and screened for varian

205 This finding is then validated over thousands of pairs of data sets obtained by random parti

206 Our comprehensive screen measures thousands of pairwise trait correlations across hundreds

207 sing a 5-y time window and involving tens of thousands of panelists.

208 movement research by orders-of-magnitude to thousands of participants (with explicit consent), enabl

209 the designs considered would require tens of thousands of participants and cost hundreds of millions

210 sectors and regions in Australia, involving thousands of participants, we suggest 18 priority resear

211 ages, which is much smaller than hundreds of thousands of particles required by the existing methods.

212 pathways; however, these searches may return thousands of pathway results.

213 vious pan-Caribbean estimates of hundreds of thousands of people are too large(5,6).

214 has infected millions and killed hundreds of thousands of people worldwide, highlighting an urgent ne

215 strate simplePHENOTYPES' ability to simulate thousands of phenotypes in less than one minute.

216 yping (HTP) technologies can produce data on thousands of phenotypes per unit being monitored.

217 Although tens of thousands of phosphorylation sites have been identified

218 Astronomers have discovered thousands of planets outside the Solar System(1), most o

219 embryonic stem cells, EloA localizes to both thousands of Pol II transcribed genes with preference fo

220 However, the composition and fate of the thousands of pollutants reaching the marine environment

221 handful of biofuel compounds from a list of thousands of potential candidates.

222 cking plastic blocks, allowing for literally thousands of potential geometric configurations, and wit

223 lysis techniques were employed to refine the thousands of potential outputs and elucidate compounds o

224 lear implants (CIs) have enabled hundreds of thousands of profoundly hearing-impaired people to perce

225 d the CCLE through quantitative profiling of thousands of proteins by mass spectrometry across 375 ce

226 In proteomics, the protein turnover of thousands of proteins can be estimated from the gradual

227 lthough computational estimates suggest that thousands of proteins have DFLs, they were annotated exp

228 has facilitated simultaneous measurement of thousands of proteins in large population studies, expos

229 Thousands of proteins localize to the nucleus; however,

230 ine the steady-state subcellular location of thousands of proteins simultaneously within the globally

231 ve approach to map the relative abundance of thousands of proteins, phosphoproteins and phosphorylati

232 emale brains using SEC-cIEF-MS/MS quantified thousands of proteoforms and revealed sex-dependent prot

233 r discovery studies that require analysis of thousands of proteomes.

234 Thousands of published empirical studies and dozens of r

235 Cancer genomics studies have identified thousands of putative cancer driver genes(1).

236 Thousands of putative microRNA (miRNA)-based cancer biom

237 ells and ventricle-like cells and identified thousands of putative REs specific for either human cell

238 We pre-compute smORF annotations for thousands of RefSeq isolate genomes and Human Microbiome

239 ts have already yielded genome sequences for thousands of resistant microbial isolates and require ro

240 random") structure searches over hundreds of thousands of runs.

241 Our results link thousands of RVs to diverse molecular effects and provid

242 e-wide region-based analysis for hundreds of thousands of samples and can account for unbalanced case

243 curated 119 501 variation-ceRNA events from thousands of samples and cell lines, including: (i) more

244 ual cancer metabolic profiles of hundreds to thousands of samples in the Cancer Genome Atlas (TCGA).

245 ncestral alleles of the SNPs are unknown) of thousands of samples produced with genotyping-by-sequenc

246 So far, genomic screenings have profiled thousands of samples providing insights into the transcr

247 egion-based tests cannot analyze hundreds of thousands of samples while accounting for confounders su

248 e massively scalable to hundreds of taxa and thousands of samples, and can be efficiently parallelize

249 ns of thousands of genes measured on tens of thousands of samples.

250 ng individuals is difficult because, despite thousands of sea turtles being satellite tracked across

251 Plants produce several hundreds of thousands of secondary metabolites that are important fo

252 reporter assays (MPRAs) functionally screen thousands of sequences for regulatory activity in parall

253 Thousands of serially linked sarcomeres in muscle make t

254 e association studies (GWAS) have discovered thousands of significant genetic effects on disease phen

255 ation image classifier and was trained using thousands of simulated density maps.

256 Based on thousands of simulations, our research suggests that the

257 line, we examined circadian period length in thousands of single cells and hundreds of clonal cell li

258 iptomes and matching surface phenotypes from thousands of single cells is rapidly changing our unders

259 to measure the gene expression from tens of thousands of single cells simultaneously.

260 es high-confidence mtDNA mutation calling in thousands of single cells with their concomitant high-qu

261 y knockouts to identify memory regulators in thousands of single cells.

262 he analysis of Cas9-introduced gene edits in thousands of single cells.

263 ession of cell-surface markers, from tens of thousands of single immune cells.

264 S), particularly designed with thousands and thousands of single-nucleotide polymorphisms (SNPs) (big

265 patient's genome and agnostically identified thousands of somatic alleles altering the prostate epige

266 on, capitalizing on the cumulative signal of thousands of somatic mutations observed in solid maligna

267 titative precision for detecting hundreds to thousands of species simultaneously.

268 ty (PICS), allowed us to efficiently analyze thousands of sperm cells and identify correlations betwe

269 A second group of recurrent tumors comprises thousands of subclones, has a clonal architecture simila

270 orphisms (SNPs) (big p) genotyped on tens of thousands of subjects (small n), are encountered by a ma

271 the relative risk of an adverse outcome for thousands of subjects in The Cancer Genome Atlas(7-13),

272 intermixing of diverse genotypes, as well as thousands of SVs intersecting genes and cis-regulatory r

273 g technologies have enabled the discovery of thousands of SVs, uncovering information about their ubi

274 ands of cells, implying a potential to image thousands of targets in only five to eight rounds of seq

275 erate diverse hydrocarbon scaffolds found in thousands of terpenoid natural products.

276 tematically examine the relationship between thousands of TF and histone modification ChIP-seq data s

277 Through the collective action of thousands of these biological positive-displacement pump

278 -ray emission from young solar-type stars is thousands of times brighter than that of today's sun.

279 The former is expressed thousands of times in utero and postnatally, whereas the

280 ion to canonical open reading frames (ORFs), thousands of translated small ORFs (containing less than

281 Lightning strikes thousands of tropical trees every day, but is commonly a

282 d to be similar to bulk tests of hundreds of thousands of tumors.

283 ed the analysis of whole genomes, comprising thousands of tumours across populations worldwide, with

284 Thousands of UK doctoral students and early-career resea

285 o neural cell-surface molecules, we identify thousands of unannotated isoforms expressed in retina an

286 Structures with thousands of unique components are routinely assembled i

287 ar genetics tools that can be used to screen thousands of untranscribed or untranslated sequences and

288 ies of neurological diseases have identified thousands of variants associated with disease phenotypes

289 challenge in discerning which among the many thousands of variants identified contribute functionally

290 h that can simultaneously assess function of thousands of variants.

291 Though thousands of various toxin-antitoxins pairs have been pr

292 sing a recent agent-based model, we simulate thousands of wild-type and mutant zebrafish patterns and

293 Opioids have been used for thousands of years to manage pain and cause euphoria, bu

294 ave been insidiously invading human life for thousands of years without obvious signs of their consid

295 iral diseases has been widely recognized for thousands of years, as annual epidemics of the common co

296 living organisms has fascinated mankind for thousands of years.

297 of polities, from multiple continents, over thousands of years.

298 osal, which extend to periods of hundreds of thousands of years.

299 protect carbon stores from decomposition for thousands of years.

300 irwise trait correlations across hundreds of thousands of yeast cells and reveals ample evidence of b