ライフサイエンスコーパス: threonine kinase

1 activating phosphorylation by Mst1, a serine/threonine kinase.

2 epends on the RTKs activating the AKT serine/threonine kinase.

3 segment conformation of tyrosine and serine/threonine kinases.

4 the protein kinase D (PKD) family of serine/threonine kinases.

5 rylation at Ser133 by various protein serine/threonine kinases.

6 phytochromes are autophosphorylating serine/threonine kinases.

7 amino acid sequences of human protein-serine/threonine kinases.

8 clins associate with cyclin-dependent serine/threonine kinase 1 (CDK1) to generate the M phase-promot

9 Microtubule-associated serine/threonine kinase 1 (MAST1) is a central driver of cispla

10 ric inhibitor of receptor-interacting serine/threonine kinase 1 (RIPK-1).

11 uired caspase-8, receptor-interacting serine/threonine kinase 1 (RIPK1), and Fas-associated death dom

12 -activated protein kinase interacting serine/threonine kinase 1 activation significantly suppresses T

13 educed levels of receptor-interacting serine-threonine kinase 1 and CRC cell necroptosis.

14 lower levels of receptor-interacting serine-threonine kinase 1 and shorter survival times of patient

15 ivated protein kinase and phospho-AKT serine/threonine kinase 1 signaling pathways, as well as increa

16 Ripk1 (receptor (TNFRSF)-interacting serine-threonine kinase 1) expression, and miR-155-5p inhibitio

17 in kinase) and MNK1 (MAPK-interacting serine/threonine kinase 1) signaling.

18 TBK1 (TANK-Binding Kinase 1)-AKT (AKT serine/threonine kinase 1)-IRF3 (interferon regulatory factor 3

19 ed levels of the receptor-interacting serine-threonine kinase 1, a mediator of necroptosis, in CRC ce

20 fibroblasts from receptor interacting serine/threonine kinase 1-knockout mice or their WT littermates

21 te-oriented kinase (LOK), also called serine threonine kinase 10 (STK10), is synthesized mainly in ly

22 The tumor suppressor serine/threonine kinase 11 (LKB1/STK11) is one of the most freq

23 The tumor suppressor serine/threonine kinase 11 (STK11 or LKB1) is mutated in 20-30%

24 Liver kinase B1 (LKB1), also known as serine/threonine kinase 11 (STK11) is the major energy sensor f

25 Serine/threonine kinase 11 (STK11, also known as LKB1) function

26 (LKB1) tumor suppressor gene, Stk11 (serine threonine kinase 11), in the fetal Mullerian duct mesenc

27 Liver kinase B1 (LKB1, also known as serine/threonine kinase 11, STK11) is a tumor suppressor mutate

28 containing (Nod)/receptor-interacting serine-threonine kinase 2 (Ripk2) signals in DCs.

29 sregulation of microtubule-associated serine/threonine kinase 2 and protein-o-mannose kinase SGK196 i

30 mediated through receptor-interacting serine/threonine kinase 2, and the transcriptional regulator CC

31 ed in TGF-beta signaling, such as AKT Serine/Threonine Kinase 3 (AKT3) and Sulfatase 1 (SULF1).

32 and in vivo by microtubule-associated serine/threonine kinase 3 (MAST3 kinase), an enzyme of previous

33 cally depends on receptor-interacting serine-threonine kinase 3 (RIPK3) and mixed lineage kinase doma

34 ice deficient in receptor-interacting serine-threonine kinase 3 (RIPK3).

35 -12, and -8 and receptor interacting serine/threonine kinase 3 (RIPK3).

36 We also validated that serine/threonine kinase 35 is a target of miR-377 using a dual

37 lin-1) by RIPK4 (receptor-interacting serine-threonine kinase 4) during epidermal differentiation.

38 We identified GCK-1, a conserved serine/threonine kinase [8], as a putative novel anillin intera

39 KD2) is a member of the PKD family of serine/threonine kinases, a subfamily of the CAMK super-family.

40 ted that IkappaB kinase beta is a key serine/threonine kinase activated by autophagy stimuli and that

41 ng protein kinase (HIPK) 2, a nuclear serine/threonine kinase, activates CREB through Ser271 phosphor

42 cificity kinase and both tyrosine and serine/threonine kinase activities are required for its functio

43 Pak2 serine/threonine kinase activity is required for stromal-derive

44 terms protein kinase activity/protein serine threonine kinase activity, response to heat and reactive

45 The p.E80K mutation abolished serine/threonine kinase activity, resulting in altered ICK subc

46 , including the regulation of protein serine/threonine kinase activity.

47 mice lacking specific isoforms of the serine/threonine kinase AKT and bone marrow chimeras, we found

48 hosphatidylinositol-3-OH kinase), the serine-threonine kinase Akt and the metabolic checkpoint kinase

49 ied a signaling pathway-involving the serine-threonine kinase AKT and the transcription factor XBP1s,

50 Pharmacologic inhibition of the serine/threonine kinase Akt has recently been shown to promote

51 Although the role of the key serine/threonine kinase Akt in promoting CNS myelination has be

52 Here we examined the role of the serine/threonine kinase Akt in the generation of protective imm

53 The serine/threonine kinase AKT is a key mediator of cancer cell su

54 The serine-threonine kinase Akt is a key regulator of cell prolifer

55 In response to growth factors, the serine/threonine kinase AKT phosphorylates Thr(24) and Ser(256)

56 The serine/threonine kinase Akt plays a central role in cell prolif

57 Activation of the serine-threonine kinase Akt promotes the survival and prolifera

58 The serine-threonine kinase AKT regulates proliferation and surviva

59 ckpoint kinase complex mTORC2 and the serine-threonine kinase Akt, and loss of this activity restores

60 depends on the activation of PI3K and serine-threonine kinase Akt, and protein synthesis relies on th

61 The serine/threonine kinase Akt, which regulates HTT function, resc

62 phate (PIP3), and the activity of the serine/threonine kinase AKT.

63 nhibitor of all three isoforms of the serine/threonine kinase AKT.

64 activation-induced phosphorylation of serine-threonine kinases Akt and mechanistic target of rapamyci

65 This results in AKT serine/threonine kinase (Akt) activation, membrane focal adhesi

66 phosphoinositide 3-kinase (PI3K)/Akt serine/threonine kinase (Akt) and mitogen-activated protein kin

67 Akt is a family of three serine-threonine kinases, Akt1, Akt2, and Akt3.

68 has led to the identification of the serine/threonine kinase ALK2 as a potential target for therapeu

69 LKB1 is a serine/threonine kinase and a commonly mutated gene in lung ade

70 se (NLK) is an evolutionary conserved serine/threonine kinase and a negative regulator of the Wnt sig

71 Here we show that SPA1 acts as a serine/threonine kinase and directly phosphorylates PIF1 in vit

72 ion of general control nonrepressed 2 serine/threonine kinase and increased expression of mammalian t

73 ion of general control nonrepressed 2 serine/threonine kinase and mammalian target of rapamycin (both

74 focus on coordination of postsynaptic serine/threonine kinase and phosphatase signaling by scaffold p

75 downstream signaling through the ERK serine/threonine kinase and the Fos transcription factor, there

76 The liver kinase B1 (LKB1) is a serine/threonine kinase and tumor suppressor that couples bioen

77 ATIONALE: LKB1 (liver kinase B1) is a serine/threonine kinase and tumor suppressor, which regulates t

78 The serine/threonine kinases and sole phosphatase of Mtb tune phosp

79 y ataxia telangiectasia mutated (ATM) serine/threonine kinase, and this phosphorylation is required f

80 expression of the oncogenic PIM1/2/3 serine/threonine kinases, and as PIMs modulate transcriptional

81 We show that the apically localized serine/threonine kinase aPKC directly phosphorylates an N-termi

82 ify CDK5, a predominantly cytoplasmic serine/threonine kinase, as an important regulator of DLC1 func

83 ous to penicillin-binding protein and serine/threonine kinase associated (PASTA) domains, and binds f

84 llular penicillin-binding-protein and serine/threonine kinase-associated (PASTA) domains which bind m

85 terial Penicillin-binding-protein And Serine/Threonine kinase-Associated (PASTA) kinases is of partic

86 ent cations and contains a functional serine/threonine kinase at its carboxyl terminus.

87 1 is phosphorylated by the DNA damage serine/threonine kinase ATM, resulting in increased levels of F

88 led to reduced phosphorylation of the serine/threonine kinases ATM and Chk2 and of histone H2AX after

89 rations in FA-complex genes or in ATM serine/threonine kinase (ATM) exhibited significantly longer tr

90 ment of ataxia-telangiectasia mutated serine/threonine kinase (ATM) to the damaged site, where it pla

91 ion of Gene 33 triggers DDR in an ATM serine/threonine kinase (ATM)-dependent fashion and through pat

92 Classically defined as a serine/threonine kinase, BIK1 is shown here to possess tyrosine

93 Mutations in the serine/threonine kinase BRAF are found in more than 60% of mela

94 ement within the RAS/ERK pathway, the serine/threonine kinase BRAF plays a key role in development an

95 The B-Raf proto-oncogene serine/threonine kinase (BRAF) gene is the most frequently muta

96 protein kinase B-Raf proto-oncogene, serine/threonine kinase (BRAF) is an oncogenic driver and thera

97 henotype (CIMP), B-Raf proto-oncogene serine/threonine kinase (BRAF) mutation, and Kirsten rat sarcom

98 ability, and the B-Raf protooncogene, serine/threonine kinase (BRAF), mutation) in the Nurses' Health

99 as PLK1 (Polo-like kinase 1), C-MYC, serine-threonine kinase BUB1B and regulates their expression.

100 nd protein phosphatase-1, as well the serine/threonine kinases CaMKII and PKA.

101 ivity is controlled by the Pkn8/Pkn14 serine/threonine kinase cascade, which phosphorylates MrpC on t

102 Here we report that the conserved serine/threonine kinase, casein kinase II (CK2), promotes miRIS

103 aining both an ion channel pore and a serine/threonine kinase (chanzyme).

104 e 7-amino acid truncation in NUAK2, a serine/threonine kinase, completely abrogated its catalytic act

105 Protein kinase CK2 is a serine/threonine kinase composed of two catalytic subunits (CK2

106 tion of their primary sequences, many serine-threonine kinases display a significant preference for s

107 A key serine/threonine kinase distantly related to the MAPK family is

108 ate 1970s, is composed of at least 10 serine/threonine kinases, divided into three groups based on th

109 apoptotic gene FASTKD2 (fas-activated serine/threonine kinase domains 2; rs7594645-G) with better mem

110 tivated kinases (PAK) are a family of serine/threonine kinases downstream of multiple critical tumori

111 p21-activated kinases (PAKs) are serine/threonine kinase effectors of the small GTPases Rac and

112 nase 1 (DCLK1), a microtubule binding serine threonine kinase, emerged as a promising target due to i

113 show that the kinase activity of the serine/threonine kinase encoded by TAOK2 is required for spine

114 The Escherichia coli eukaryote-like serine/threonine kinase, encoded by yeaG, is expressed in respo

115 , we find that phosphorylation of the serine/threonine kinase ERK (pERK) preferentially occurs in end

116 well appreciated that eukaryotic-like serine/threonine kinases (eSTKs) control essential processes in

117 sactivation of microtubule associated serine/threonine kinase family member 4 (MAST4).

118 cting NEK2, a member of the NIMA-like serine-threonine kinase family, in a patient with congenital he

119 The Fas-activated serine/threonine kinase (FASTK) family of proteins has recently

120 tein kinase C constitutes a family of serine-threonine kinases found in all eukaryotes and implicated

121 arget of rapamycin complex 1 (mTORC1) serine/threonine kinase from the lysosomal membrane.

122 Somatic inactivation of the serine/threonine kinase gene STK11/LKB1/PAR-4 occurs in a varie

123 in vitro functional studies, a novel serine/threonine kinase gene, unc-51-like kinase 4 (ULK4), as a

124 Overexpression of the serine/threonine kinase GLK/MAP4K3 in human lung cancer is asso

125 We previously showed that the serine/threonine kinase, glycogen synthase kinase, GSK-3alpha/b

126 e specificity of the host pleiotropic serine/threonine kinase GSK3.

127 synthase kinase-3 beta (GSK-3beta), a serine/threonine kinase, has been identified as a potential the

128 The serine/threonine kinase HIPK2 functions as a regulator of devel

129 53Ser46(P) by binding and stabilizing serine-threonine kinase HIPK2.

130 The serine/threonine kinase IL-1R-associated kinase (IRAK)4 is a cr

131 ibrain (Mnb; also known as Dyrk1A), a serine/threonine kinase implicated in autism spectrum disorder

132 (GSK-3, isoforms alpha and beta) is a serine-threonine kinase implicated in cellular processes.

133 kinase kinase kinase 4 (MAP4K4) is a serine/threonine kinase implicated in the regulation of many bi

134 Protein kinase C (PKC) is a family of serine/threonine kinases implicated in a variety of physiologic

135 e c-Jun N-terminal kinases (JNKs) are serine/threonine kinases implicated in the pathogenesis of vari

136 PKD) is a family of stress-responsive serine/threonine kinases implicated in the regulation of divers

137 the highly overexpressed genes of the serine/threonine kinase in CTCL.

138 ULK1/Atg1 is the only serine/threonine kinase in the core autophagy pathway and thus

139 ich encodes a type I activin receptor serine/threonine kinase, in 21% of DIPG samples.

140 , we identified PIM1, a non-essential serine-threonine kinase, in a synthetic lethal interaction with

141 a target of casein kinase 2 (CK2), a serine/threonine kinase, in proliferating myoblasts.

142 ycin (TOR), an evolutionary conserved serine/threonine kinase, in the plant defense response.

143 ul stimulus or treatment with the AKT Serine/Threonine kinase inhibitor SH-6 restored splicing factor

144 alciparum exports a family of 18 FIKK serine/threonine kinases into the host cell, suggesting that ph

145 mTOR is a serine/threonine kinase involved in a variety of cellular activ

146 rylation-regulated kinase DYRK1A is a serine/threonine kinase involved in neuronal differentiation an

147 e-3 (GSK3) are ubiquitously expressed serine-threonine kinases involved in a plethora of functions ra

148 an evolutionarily conserved family of serine/threonine kinases involved in mitosis and meiosis.

149 ously determined that a transmembrane serine/threonine kinase (IreK) and its cognate phosphatase (Ire

150 l-originated protein kinase (TOPK), a serine-threonine kinase is activated by SUV irradiation and inv

151 The Aurora family of serine/threonine kinases is essential for mitosis.

152 The specificity of serine/threonine kinases is partly determined by interactions w

153 (CK1alpha), a ubiquitously expressed serine/threonine kinase, is a key negative regulator of oncogen

154 mTOR, a serine/threonine kinase, is a master regulator of cellular meta

155 Liver kinase B1 (LKB1), a serine/threonine kinase, is a tumor suppressor and metabolic re

156 at casein kinase 1 alpha (Csnk1a1), a serine-threonine kinase, is essential for AML cell survival in

157 se (NLK), an evolutionarily conserved serine/threonine kinase, is highly expressed in the brain, but

158 Protein kinase C (PKC) theta, a serine/threonine kinase, is involved in TH2 cell activation and

159 Akt, a serine/threonine kinase, is known to increase cell survival by

160 ber of the polo-like kinase family of serine-threonine kinases, is a master regulator of centriole du

161 the phosphorylation by WNKs of other serine-threonine kinases known as SPAK-OSR1.

162 optosis signal-regulating kinase 1, a serine/threonine kinase, leads to improvement in inflammation a

163 kinase (called microtubule-associated serine/threonine kinase like [Mastl] in mammals) is essential f

164 K2 induced spine loss through the serine and threonine kinase LIMK1.

165 We found that the serine/threonine kinase LKB1 and one of its substrates, AMPK, r

166 We identify the serine/threonine kinase LKB1 as a key driver of synapse layer e

167 The serine/threonine kinase LKB1 has been identified as a potent su

168 We demonstrate that the serine/threonine kinase LKB1 regulates MCU expression, mitochon

169 The serine/threonine kinase mammalian/mechanistic target of rapamyc

170 -activated protein kinase-interacting serine-threonine kinases MAP kinase-interacting kinase 1 (Mnk1/

171 In recent years, the serine/threonine kinase mechanistic target of rapamycin (mTOR)

172 chore attachments is monitored by the serine/threonine kinase monopolar spindle 1 (MPS1).

173 The evolutionarily conserved serine/threonine kinase mTOR (mechanistic target of rapamycin)

174 The serine/threonine kinase mTOR participates in growth factor sign

175 nous PTEN-induced kinase 1 (PINK1), a serine/threonine kinase mutated in a recessive forms of Parkins

176 ntify protein kinase C (PKC) gamma, a serine/threonine kinase mutated in the neurodegenerative diseas

177 In this study, we show that the serine/threonine kinase Ndr2 controls integrin-dependent dendri

178 PRL activates the serine/threonine kinase NEK3, which was reported to enhance bre

179 reen, we identified a mitotic-related serine/threonine kinase, NEK6, as a mediator of androgen-indepe

180 canonical NF-kappaB signaling via the serine/threonine kinase NIK (NF-kappaB-inducing kinase) remains

181 ocated within STK32C, which encodes a serine/threonine kinase, of unknown function.

182 protein kinase (Drak), a cytoplasmic serine/threonine kinase orthologous to the human kinase STK17A,

183 protein kinase (Drak), a cytoplasmic serine/threonine kinase orthologous to the human kinase STK17A.

184 of these binding partners include the serine/threonine kinases, p21-activated kinase 1 (PAK1), apopto

185 determined that d-flow activated the serine/threonine kinase p90RSK, which subsequently phosphorylat

186 Ovaries in flies mutant for the serine/threonine kinase Pak exhibit a novel phenotype, in which

187 Serine/threonine kinase PAK1 is activated by estrogen and plays

188 The p21-activated serine-threonine kinase (PAK1) regulates cell motility and adhe

189 The protein kinase D family of serine/threonine kinases, particularly PKD1, has been implicate

190 The hypoxia-inducible, pro-oncogenic, serine-threonine kinase PIM1 (Proviral Integration site for Mol

191 The serine-threonine kinase PINK1 is responsible for recruiting Par

192 PKD is a family of three serine/threonine kinases (PKD-1, -2, and -3) involved in the re

193 We found that RhoA activated the serine-threonine kinases PKN1 and PKN2 that bind and phosphoryl

194 In eukaryotes, serine/threonine kinases play a central role in antiviral respo

195 Dysregulated oncogenic serine/threonine kinases play a pathological role in diverse fo

196 IRAK4, a serine/threonine kinase, plays a key role in both inflammation

197 The Akt protein, a serine/threonine kinase, plays important roles in cell survival

198 The polo family serine threonine kinase Plk4 has been proposed as a therapeutic

199 We have identified the serine/threonine kinase Polo-like kinase 1 (PLK1) as a host kin

200 In this context, the serine/threonine kinase, polo-like kinase (PLK1) regulates mult

201 terphase of the cell cycle by NEK7, a serine-threonine kinase previously linked to mitosis.

202 coupled receptor kinase 5 (GRK5) is a serine/threonine kinase previously shown to mediate polymicrobi

203 RIPK1 and RIPK3, a pair of homologous serine/threonine kinases previously implicated in the regulatio

204 echanistic target of rapamycin (mTOR) serine/threonine kinase promotes myelination, but factors that

205 dually suppressed RAF1 proto-oncogene serine/threonine kinase (RAF1)/ERK signaling through the intera

206 UHMK1 is a nuclear serine/threonine kinase recently implicated in carcinogenesis.

207 ike kinase 1 (ALK1) is an endothelial serine-threonine kinase receptor for bone morphogenetic protein

208 Here, we have identified the serine threonine kinase receptor-associated protein (STRAP) as

209 Type 1 Serine/Threonine Kinase Receptors (STKR1) transduce a wide spec

210 ng protein kinase (Hipk), a conserved serine-threonine kinase, regulates numerous factors during tiss

211 a B (AURKB) and Aurora C (AURKC), are serine/threonine kinases required for the control of mitosis (A

212 c approach identified PKCtheta as the serine/threonine kinase responsible for alphaPIX serine phospho

213 siRNA-mediated inhibition of various serine/threonine kinases revealed ERK1/2 as a positive regulato

214 RNA virus, triggers activation of the serine-threonine kinases RIP1 and RIP3, which damages mitochond

215 The serine/threonine kinase RIPK1 is recruited to TNFR1 to mediate

216 g cell-death-inducing activity of the serine/threonine kinase RIPK1.

217 Necroptosis is driven by two serine threonine kinases, RIPK1 (Receptor Interacting Protein K

218 , OGT-mediated O-GlcNAcylation of the serine-threonine kinase RIPK3 on threonine 467 (T467) prevented

219 e translocation and activation of the serine/threonine kinase ROCK1, a downstream target of the RhoA

220 ORC1 activation deploys the ribosomal serine/threonine kinase S6K1 and Polycomb proteins at genomic r

221 fibrosis-relevant tyrosine kinase and serine/threonine kinase signaling pathways.

222 n protein folding, protein synthesis, serine/threonine kinase signalling, glycolysis and gluconeogene

223 on-like (drl-1) gene, which encodes a serine/threonine kinase similar to the mammalian MEKK3 kinase.

224 d by mass spectrometry identified the serine-threonine kinase SPEG as the only novel binding partner

225 d by mass spectrometry identified the serine-threonine kinase SPEG as the only novel binding partner

226 horylated at Thr-50 within the LDS by serine/threonine kinase (STK) 3 and STK4.

227 Silencing the serine/threonine kinase STK11 (also known as LKB1) in HT-29 cel

228 identify a previously uncharacterized serine/threonine kinase STK19 as a novel NRAS activator.

229 kers, one (rs10937625) located in the serine/threonine kinase STK32B and one (rs17590046) in the tran

230 YAP1 is under the control of a serine-threonine kinase, STK4.

231 o interferes with the activity of the serine/threonine kinase StkP, the central regulator of pneumoco

232 In plants and algae, the serine/threonine kinase STN7/STT7, orthologous protein kinases

233 Trans-membrane signaling involving a serine/threonine kinase (Stt7 in Chlamydomonas reinhardtii) dir

234 dentifying degrader hits based on the serine/threonine kinase TANK-binding kinase 1 (TBK1) and have g

235 n Lm vacuolar rupture, among them the serine/threonine kinase Taok2.

236 enerated Taok3(-/-) mice, lacking the serine/threonine kinase Taok3, and found cell-intrinsic defects

237 The serine/threonine kinase TBK1 (TANK-binding kinase 1) and its ho

238 vel gene fusion of MAP3K8, encoding a serine-threonine kinase that activates MEK(3,4).

239 mTOR is a serine/threonine kinase that acts in two distinct complexes, mT

240 LKB1 is a multi-functional serine/threonine kinase that associates with actin at the cellu

241 ontaining protein kinase 2 (ROCK2), a serine-threonine kinase that can be therapeutically targeted by

242 istic target of rapamycin (mTOR) is a serine-threonine kinase that coordinates nutrient and growth fa

243 apamycin (MTOR) is a highly conserved serine/threonine kinase that critically regulates cell growth,

244 racting protein kinase 1 (RIPK1) is a serine/threonine kinase that dictates whether cells survive or

245 et of rapamycin (mTOR) is an atypical serine/threonine kinase that exerts its main cellular functions

246 et of rapamycin (mTOR) is a conserved serine/threonine kinase that forms two complexes, mTORC1 and mT

247 protein kinase 2 (HIPK2) is a nuclear serine/threonine kinase that functions in development and tumor

248 Aurora B is a serine/threonine kinase that has been implicated in regulating

249 GSK-3 is a serine/threonine kinase that has numerous substrates.

250 The HipA toxin functions as a serine/threonine kinase that inhibits cell growth, while the Hi

251 e (AMPK) is an evolutionary conserved serine/threonine kinase that integrates cellular energy status

252 eptor-interacting protein (RIP1) is a serine/threonine kinase that integrates inflammatory and necrop

253 AMPK is a serine/threonine kinase that is activated by upstream kinases L

254 led that Polo-like kinase 1 (PLK1), a serine/threonine kinase that is essential for cell cycle progre

255 t cyclin-dependent kinase 5 (Cdk5), a serine-threonine kinase that is highly active in postmitotic ne

256 ublecortin-like kinase 1 (DCLK1) is a serine/threonine kinase that is overexpressed in gastrointestin

257 is PIM2, which encodes a prosurvival serine-threonine kinase that phosphorylates and inhibits the pr

258 Cdc7 is a serine-threonine kinase that phosphorylates components of the p

259 ns was GSG2 (also known as Haspin), a serine/threonine kinase that phosphorylates histone H3 at Thr-3

260 1-like kinase 1 (ULK1) is a conserved serine-threonine kinase that plays a central role in the initia

261 is a highly conserved and pleiotropic serine/threonine kinase that promotes many prosurvival and proi

262 re we identify Stk2, a staphylococcal serine/threonine kinase that provides efficient immunity agains

263 alian target of rapamycin (mTOR) is a serine/threonine kinase that regulates a diverse array of cellu

264 e A (PKA) is a ubiquitously expressed serine/threonine kinase that regulates a variety of cellular fu

265 Tumor progression locus 2 (Tpl2) is a serine-threonine kinase that regulates Th1 differentiation, sec

266 ed kinases (PAKs) are a family of six serine/threonine kinases that act as key effectors of RHO famil

267 OCK1 and ROCK2) are highly homologous serine/threonine kinases that act on substrates associated with

268 Serine-threonine kinases that activate NKCC2 have been identifi

269 are a family of constitutively active serine/threonine kinases that are partially redundant and regul

270 LegK1-4 proteins are eukaryotic-like serine/threonine kinases that are translocated by the Dot/Icm t

271 CK) is a member of a diverse group of serine/threonine kinases that feature cytoskeletal association.

272 NEK family kinases are serine/threonine kinases that have been functionally implicated

273 mologous and functionally overlapping serine/threonine kinases that phosphorylate multiple protein su

274 ceptor-associated kinases (IRAKs) are serine/threonine kinases that play critical roles in initiating

275 y of abundant, ubiquitously expressed serine/threonine kinases that regulate multiple cellular proces

276 ho kinases, or ROCKs, are a family of serine-threonine kinases that serve as key downstream effectors

277 e examine the STE20 family of protein serine-threonine kinases to investigate basic mechanisms of sub

278 gnaling pathway consists of conserved serine/threonine kinases to maintain optimal organ sizes.

279 The translocation of Akt, a serine/threonine kinase, to the plasma membrane is a critical s

280 The serine-threonine kinase TOR, the Target of Rapamycin, is an imp

281 The serine/threonine kinase tumor progression locus 2 (Tpl2, also k

282 through binding and activation of the serine/threonine kinase type II TGF-beta receptor (TbetaRII), w

283 of the essential autophagy initiator serine-threonine kinase ULK1, and increased in the activity upo

284 n of the MTOR complex 1 (RAPTOR), the serine/threonine kinase V-Akt murine thymoma viral oncogene hom

285 Aurora kinases are a family of serine/threonine kinases vital for cell division.

286 pe II (TbetaRII) and type I (TbetaRI) serine/threonine kinases, whereby Smad2 and Smad3 are phosphory

287 kinase 5 (Cdk5) is a proline-directed serine/threonine kinase which is mostly active in the nervous s

288 AKT and mTOR are serine/threonine kinases which play important roles in cell gro

289 interacts with calmodulin-associated serine/threonine kinase, which is implicated in X-linked mental

290 PAK4 is a member of the PAK family of serine/threonine kinases, which act as effectors for several sm

291 AMPK is a conserved serine/threonine kinase whose activity maintains cellular energ

292 se II (CaMKII) is a calcium-regulated serine threonine kinase whose functions include regulation of s

293 ROCK2 is a serine-threonine kinase whose role in lymphomagenesis is unknow

294 protein kinase (AMPK) is a conserved serine/threonine kinase with a critical function in the regulat

295 coupled receptor kinase 2 (GRK2) is a serine/threonine kinase with an important function in the desen

296 racting protein kinase 3 (RIPK3) is a serine/threonine kinase with essential function in necroptosis.

297 Casein kinase 1 alpha (CK1alpha) is a serine/threonine kinase with numerous functions, including regu

298 polo-like kinases (PLK), a family of serine/threonine kinases with well-known roles in cell cycle re

299 Two of these genes encode the serine-threonine kinases WNK1 and WNK4.

300 One such protein, the serine/threonine kinase YopO (YpkA in Yersinia pestis), uses mo