ライフサイエンスコーパス: threonine phosphorylation

1 tein interactions are governed by serine and threonine phosphorylation.

2 n MAPK activity and a 4-fold increase in CAD threonine phosphorylation.

3 f cellular activities as effectors of serine/threonine phosphorylation.

4 ipper motif and a target sequence for serine/threonine phosphorylation.

5 and demonstrated increased levels of serine/threonine phosphorylation.

6 tory factors, as well as tyrosine and serine/threonine phosphorylation.

7 ng events in B cells, focusing on serine and threonine phosphorylation.

8 ntly activated by TNF-alpha through tyrosine/threonine phosphorylation.

9 a suggest that phytochromes signal by serine-threonine phosphorylation.

10 is accompanied by an increase in serine and threonine phosphorylation.

11 oprotein, and cAMP inhibited both serine and threonine phosphorylation.

12 profiles, perhaps transduced through serine-threonine phosphorylation.

13 that this effect may be regulated by serine/threonine phosphorylation.

14 tor of kinase activity and global serine and threonine phosphorylation.

15 phospholipid metabolism, and protein serine/threonine phosphorylation.

16 e pH, binds ATP noncovalently, and undergoes threonine phosphorylation.

17 PKCalpha-dependent ZO-1 and myosin 1C serine/threonine phosphorylation.

18 incident with PKCalpha-dependent ZO-1 serine/threonine phosphorylation.

19 ion, and ERK1, JNK, and p38, which catalyzed threonine phosphorylation.

20 which can regulate ADAM17 activity by serine/threonine phosphorylation.

21 regions (IDRs) that undergo multisite Serine/Threonine phosphorylation.

22 which itself is robustly activated by serine/threonine phosphorylations.

23 phosphorylated on its RTPPKSP motif and that threonine phosphorylation abolished the MAP-2c/Fyn bindi

24 initiates insulin signaling, whereas serine/threonine phosphorylation alters the ability of IRS-1 to

25 in binding interfaces by tyrosine and serine/threonine phosphorylation and acetylation that may under

26 cell surface receptors via dual tyrosine and threonine phosphorylation and are thought to be involved

27 NOO(-) activates AMPK, resulting in enhanced threonine phosphorylation and consequent inhibition of F

28 volved inhibition of beta(1) integrin serine/threonine phosphorylation and decreased phosphorylation

29 rthermore, this same mutant showed increased threonine phosphorylation and decreased serine phosphory

30 antagonizes EGF signaling by increasing EGFR threonine phosphorylation and decreasing EGF-induced EGF

31 ity is regulated by a balance between serine/threonine phosphorylation and dephosphorylation.

32 c-fos whose function is modulated by serine/threonine phosphorylation and fig is a predicted PP2C ph

33 This leads to the serine/threonine phosphorylation and redistribution of actin an

34 duced by mutations that prevented its serine-threonine phosphorylation and restored by phosphomimetic

35 equential signaling mediated by tyrosine and threonine phosphorylation and ubiquitination.

36 UX4 toxicity could be counteracted by serine/threonine phosphorylation and/or inhibition of arginine

37 ck on EGFR signaling and trafficking by EGFR threonine phosphorylation, and Akt has a pivotal role in

38 a B alpha in vivo, induces multisite (serine/threonine) phosphorylation, and is required for the basa

39 nt Spc110p (Nuf1p) undergoes specific serine/threonine phosphorylation as the mitotic spindle apparat

40 ected by PTP101, an antibody that recognizes threonine phosphorylation at consensus motifs for ERK-in

41 ositol-4,5-bisphosphate (PIP2) binding and a threonine phosphorylation at position 567.

42 or p190RhoGAP is decreased due to its serine/threonine phosphorylation at this time.

43 ing; this interaction is dependent on serine/threonine phosphorylation but independent of tyrosine ph

44 Activation of BVR involved increased serine/threonine phosphorylation but not its protein or transcr

45 nthase (eNOS) is regulated in part by serine/threonine phosphorylation, but eNOS tyrosine phosphoryla

46 ed as the kinase responsible for the mitotic threonine phosphorylation by (1) immunodepletion of the

47 chondrial localization of PLS3 but abolished threonine phosphorylation by PKC-delta in vitro and AD19

48 the insulin receptor may be caused by serine/threonine phosphorylation by PKC.

49 s the capping enzymes and is a substrate for threonine phosphorylation by the Cdk9 kinase.

50 the plasma membrane through their serine and threonine phosphorylation by the phosphoinositide-depend

51 tner-switching mechanism in which serine and threonine phosphorylation controls protein interactions

52 Hyperphosphorylation (due to serine and/or threonine phosphorylation) correlates with the unrespons

53 Wild-type, but not a threonine phosphorylation-defective endoglin mutant bloc

54 The 14-3-3 family of serine-threonine phosphorylation-dependent adapter proteins are

55 r import of myopodin are regulated by serine/threonine phosphorylation-dependent binding of myopodin

56 port of myopodin are regulated by the serine/threonine phosphorylation-dependent binding of myopodin

57 impairs insulin-induced Akt-mediated serine/threonine phosphorylation despite a decrease in the prot

58 d pharmacological manipulation of serine and threonine phosphorylation did not alter cGMP-dependent r

59 a argue that PKG mediates a conserved serine/threonine phosphorylation event specifically for flavivi

60 g paradigm in which the half-lives of serine/threonine phosphorylation events can be influenced by ac

61 ivity often occurring in proximity to serine/threonine phosphorylation events points to the broad imp

62 osine kinase activation to downstream serine/threonine phosphorylation events regulating proliferatio

63 oach failed to detect significant changes in threonine phosphorylation following deoxygenation.

64 ger than 70 000 kilodaltons, and that serine/threonine phosphorylation follows tyrosine phosphorylati

65 ish tyrosine phosphorylation from serine and threonine phosphorylation for peptides containing a sing

66 hosphoproteomics, 90,000 sites of serine and threonine phosphorylation have so far been identified, a

67 cesses in eukaryotic cells, and thousands of threonine phosphorylations have been identified.

68 aqueous humor sCD44 was positive for serine-threonine phosphorylation; however, POAG sCD44 was hypop

69 ovR in vitro, these data suggest that serine/threonine phosphorylation impacts CovR-mediated regulati

70 been extensively studied, the role of serine/threonine phosphorylation in controlling these effectors

71 sent study we sought to identify the site of threonine phosphorylation in FcepsilonRIgamma and invest

72 t report of the functional outcome of serine/threonine phosphorylation in gelsolin regulation and pro

73 insulin has profound effects on IRS-1 serine/threonine phosphorylation in healthy humans.

74 eferred TGFbeta receptor kinase for endoglin threonine phosphorylation in HUVECs and indicate a role

75 To investigate the regulation of serine/threonine phosphorylation in IL-2 signaling, the roles o

76 (MS)-based analysis of HNF-4alpha serine and threonine phosphorylation in response to cytokine stimul

77 findings also suggest novel roles for serine/threonine phosphorylation in the assembly of protein-pro

78 BB3 as a result of the loss of an inhibitory threonine phosphorylation in the conserved juxtamembrane

79 duced a complex response including decreased threonine phosphorylation in the ERK1 and ERK2 activatio

80 Here, we tested the role of serine/threonine phosphorylation in the Mtb response to altered

81 although this is the first example of serine/threonine phosphorylation in the subfamily of CD33-like

82 cking all known sites of tyrosine and serine/threonine phosphorylation in their carboxyl-terminal tai

83 The late-specific threonine phosphorylation in this domain is essential fo

84 electrophoretic mobility retarded by serine/threonine phosphorylation) in M phase and the escape of

85 e-specific substitution mutations that block threonine phosphorylation increased ATF4 stability and a

86 Furthermore, serine and threonine phosphorylation increased the interaction of L

87 u hyperphosphorylation, inhibition of serine/threonine phosphorylation induced upregulation of cdk5 l

88 ified PECAM-1; 3) PKC-derived PECAM-1 serine/threonine phosphorylation inversely correlates with gamm

89 ne residue His197 and the presence of serine/threonine phosphorylation is an experimental artifact du

90 Our results provide evidence that serine/threonine phosphorylation is an important regulatory mec

91 Furthermore, TNF-alpha-induced Raf-1 threonine phosphorylation, kinase activity toward MEK1,

92 tion prevents apoptosis by increasing serine/threonine phosphorylation leading to either inactivation

93 GPCRs), upon agonist binding, undergo serine-threonine phosphorylation, leading to either receptor re

94 This reduced threonine phosphorylation led to increased FGF-induced t

95 er, TGF-beta did not affect either serine or threonine phosphorylation levels of Ets1.

96 Threonine phosphorylation mapped to a single residue, th

97 or JNK3 alpha 1 activation and that a single threonine phosphorylation may be all that is needed for

98 We also provide evidence that Dab1 serine/threonine phosphorylation may be important for Dab1 tyro

99 of murine erythroleukemia cells, and serine/threonine phosphorylation may be involved in this proces

100 nd to proteins harboring specific serine and threonine phosphorylation motifs, 14-3-3 proteins can in

101 nthetic SSAP mRNAs encoding either serine or threonine phosphorylation mutants results in the failure

102 en together, these data indicate that serine/threonine phosphorylation negatively regulates IL-2 sign

103 The serine/threonine phosphorylation occurred subsequent to tyrosin

104 ogether, these data indicate that the serine/threonine phosphorylation of 66-kDa Shc impairs its abil

105 ovel mode of STAT activation, whereby serine-threonine phosphorylation of a cognate protein tyrosine

106 nsulin receptor substrate and Cbl, or serine/threonine phosphorylation of Akt.

107 Although serine and threonine phosphorylation of AMPA receptors has been wel

108 eral cross-linking of CD98 or ICAM-1 induces threonine phosphorylation of an approximately 160-kDa su

109 fication and functional characterization for threonine phosphorylation of an interleukin receptor.

110 man EGF receptor also resulted in the serine/threonine phosphorylation of approximately 50% of the 66

111 ng that both membrane association and serine/threonine phosphorylation of AQP5 are required for prope

112 ased by IL-1beta due to JNK-regulated serine/threonine phosphorylation of ASBT protein at both Ser-33

113 5-HT stimulated an increase in serine/threonine phosphorylation of BMPR1A, supporting the acti

114 Serine/threonine phosphorylation of Cas has previously been sho

115 acid, a PP2A inhibitor, augments the serine/threonine phosphorylation of Cas that occurs at mitosis.

116 TGFbeta treatment also caused threonine phosphorylation of Cdc2 in the TGFbeta RII-cyc

117 ion of Cdc25 appears to depend on the serine/threonine phosphorylation of Cdc25 and the presence of R

118 The functional consequence of threonine phosphorylation of CovR in GBS was evaluated u

119 ion of FeS protein in complex III, increased threonine phosphorylation of COX IV (cytochrome oxidase

120 We found DAG accumulation, increased threonine phosphorylation of EGFR, enhanced phosphorylat

121 dings negatively correlate with ERK-mediated threonine phosphorylation of EGFR, implicating it as a p

122 effect requires PRL-induced ERK activity and threonine phosphorylation of EGFR.

123 hatase 2A, suggesting that GH induced serine/threonine phosphorylation of ErbB-2.

124 ts demonstrated significantly greater serine/threonine phosphorylation of extracellular signal-regula

125 irectly correlates with increased C-terminal threonine phosphorylation of ezrin/moesin/radixin (ERM)

126 Notably, AMPK activation increased threonine phosphorylation of FAS, and this effect was bl

127 ng prevented ERK1/2 membrane recruitment and threonine phosphorylation of fibroblast receptor substra

128 embrane, thereby inhibiting ERK1/2-dependent threonine phosphorylation of FRS2alpha to promote activa

129 phorylation site and for the first time show threonine phosphorylation of human p53.

130 Serine/threonine phosphorylation of IL-2Rbeta by a staurosporin

131 IL-2 stimulation also induced serine/threonine phosphorylation of IL-2Rbeta, but not IL-2Rgam

132 hosphorylation of JAK3 and STAT5, and serine/threonine phosphorylation of IL-2Rbeta.

133 tion of IRS-1 from IM is dependent on serine/threonine phosphorylation of IM.

134 In addition, however, serine/threonine phosphorylation of important effector molecule

135 Serine/threonine phosphorylation of insulin receptor substrate

136 We found that PDGF causes serine/threonine phosphorylation of insulin receptor substrate

137 t and stress-sensing kinases leads to serine/threonine phosphorylation of insulin receptor substrate

138 ation with okadaic acid increased the serine/threonine phosphorylation of IRS-1 and its degradation,

139 Serine/threonine phosphorylation of IRS-1 is affected by many f

140 Serine/threonine phosphorylation of IRS-1 might inhibit insulin

141 In conclusion, 1) PDGF causes serine/threonine phosphorylation of IRS-1, and PI3K, or a kinas

142 tyrosine phosphorylation followed by serine/threonine phosphorylation of multiple cytoplasmic STAT t

143 atal dopamine depletion increases the serine/threonine phosphorylation of multiple striatal proteins

144 eonine 574 to alanine dramatically decreases threonine phosphorylation of MyoGEF in transfected HeLa

145 The level of serine/threonine phosphorylation of Na(v) 1.6 and In Na(v)1.8 i

146 To resolve the controversy of whether serine/threonine phosphorylation of NDPK occurs as has been sug

147 ole for CaM kinase stimulation and resultant threonine phosphorylation of NMHC-IIA in RBL-2H3 m1 cell

148 cated that the p115HEF1 resulted from serine/threonine phosphorylation of p105HEF1.

149 t anti-HER2 antibody significantly decreases threonine phosphorylation of p27Kip1 protein at position

150 n that activation of p96h2bk requires serine/threonine phosphorylation of p96h2bk.

151 nd End3p may be regulated by Prk1p-dependent threonine phosphorylation of Pan1p within the consensus

152 hese data suggest that HGF can induce serine/threonine phosphorylation of paxillin most probably medi

153 ase kinase 3beta, as well as contributing to threonine phosphorylation of PKB.

154 tive PKC-delta, and AD198 treatment enhanced threonine phosphorylation of PLS3.

155 Threonine phosphorylation of pp31 by the virus-specific

156 g at 10 min, as well as increased serine and threonine phosphorylation of PP4.

157 activity and both agents also induce serine-threonine phosphorylation of PTP3.

158 inase (ERK) kinase/ERK signaling cassette by threonine phosphorylation of Raf-1, regulating prolifera

159 Collectively, our findings show that serine/threonine phosphorylation of RUNX1 promotes Mk fate spec

160 Similarly, S1P-elicited threonine phosphorylation of S1P1 Rs was suppressed by a

161 However, NGF still stimulates serine/threonine phosphorylation of SH2-Bbeta(S96A).

162 ealed that high glucose or PMA led to serine/threonine phosphorylation of similar peptides.

163 mulated feedback pathway in which the serine/threonine phosphorylation of SOS results in disassociati

164 PMA induced serine/threonine phosphorylation of Src, which was blocked by b

165 cer element, suggesting that both serine and threonine phosphorylation of SSAP are required for the a

166 at1alpha or Stat3; 3) marked serine, but not threonine phosphorylation of Stat5a and Stat5b; and 4) t

167 This results in serine/threonine phosphorylation of such important regulatory m

168 ther analyses demonstrated that tyrosine and threonine phosphorylation of the A17 membrane component

169 and threonine phosphoproteome, and increased threonine phosphorylation of the activation loop of the

170 ) activity, which, in turn, increases serine/threonine phosphorylation of the adaptor protein, Gab-1

171 NaC regulation involving an ERK1/2-catalyzed threonine phosphorylation of the channel gamma subunit:

172 pounds that cause a 2- to 3-fold increase in threonine phosphorylation of the cotransporter which can

173 rt, we delineate a potential role for serine/threonine phosphorylation of the cytoplasmic tail of the

174 e EET effects were associated with increased threonine phosphorylation of the ENaC beta and gamma sub

175 to stimulate calcium mobilization and serine/threonine phosphorylation of the Erk1/2 mitogen-activate

176 lvement of protein kinase C (PKC) and serine/threonine phosphorylation of the insulin receptor in ins

177 canonical form of signaling involving serine/threonine phosphorylation of the linker connecting its k

178 Threonine phosphorylation of the MMAC1/ PTEN-PDZBD pepti

179 Serine/threonine phosphorylation of the nonstructural protein 5

180 revious data suggest that IR-mediated serine/threonine phosphorylation of the Ras guanine nucleotide

181 endent reporter gene, suggesting that serine/threonine phosphorylation of the transactivation domain

182 Here, we have studied the role of serine/threonine phosphorylation of TJ proteins in 15(S)-HETE-i

183 ine phosphorylation of ZO-2, also stimulates threonine phosphorylation of ZO-1 in the mediation of en

184 lly regulated SSAP activation is promoted by threonine phosphorylation on its transactivation domain,

185 ells identified multiple sites of serine and threonine phosphorylation on the protein, correlating wi

186 r stimulated through a previously identified threonine phosphorylation pathway (TPP) share the proper

187 o B-cell-receptor signaling, critical serine/threonine phosphorylation pathways and apoptosis.

188 ed Cdc42 with SPRK alters the in vivo serine/threonine phosphorylation pattern of SPRK suggesting tha

189 significantly modified both the serine- and threonine-phosphorylation profile of proteasomes; multip

190 An understanding of how threonine phosphorylation regulates biological function

191 caALK1-mediated threonine phosphorylation required prior serine phosphor

192 Prevention of FRS2alpha threonine phosphorylation results in constitutive tyrosi

193 minus, an Akt substrate sequence employing a threonine phosphorylation site for Akt, followed by a tr

194 Finally, overexpression of the C-terminal threonine phosphorylation site mutant of ezrin has a dom

195 SP repeat domain (residues 502-823); and one threonine phosphorylation site observed in a KVPTPEK mot

196 idue, acts as a major determinant for serine-threonine phosphorylation site specificity.

197 The minor threonine phosphorylation site was demonstrated by two-d

198 tand how PRMT5 is regulated, we identified a threonine phosphorylation site within a C-terminal tail

199 P-CIP1 contains multiple consensus serine/threonine phosphorylation sites and a region predicted t

200 domain followed by multiple potential serine/threonine phosphorylation sites and a serine-rich C term

201 ting in identification of 101 tyrosine and 3 threonine phosphorylation sites and quantification of 87

202 Loss of serine or threonine phosphorylation sites from exon 3 of beta-cate

203 and putative regulatory roles for serine and threonine phosphorylation sites have yet to be fully cha

204 study in CHINA: Point mutations of serine or threonine phosphorylation sites in exon 3 of beta-cateni

205 be blocked by mutating three putative serine/threonine phosphorylation sites in hbeta4 (Thr-11/Ser-17

206 ion and relative quantification of 12 serine/threonine phosphorylation sites in HNF-4alpha.

207 Replacement of five serine or threonine phosphorylation sites in ORF63 with alanines r

208 ethod for the characterization of serine and threonine phosphorylation sites in proteins has been dev

209 , site-directed mutagenesis of the consensus threonine phosphorylation sites in the C-terminal domain

210 The serine/threonine phosphorylation sites in the linker region are

211 Twenty-two serine/threonine phosphorylation sites were identified; 15 were

212 nses from rhodopsin lacking native serine or threonine phosphorylation sites.

213 n actin binding protein with multiple serine/threonine phosphorylation sites.

214 invasive cancer, involved loss of serine or threonine phosphorylation sites.

215 -terminal tail containing clusters of serine/threonine phosphorylation sites.

216 C-terminal domain of pp31 failed to prevent threonine phosphorylation, suggesting that the virus-spe

217 On the contrary, we identified that threonine phosphorylation (T669) in the latch domain neg

218 potentially greater structural importance of threonine phosphorylation than serine phosphorylation du

219 first time IL13 induce Stat6 serine but not threonine phosphorylation that closely paralleled early

220 For ErbB-2, GH induces serine/threonine phosphorylation that dampens basal and EGF-ind

221 wild-type population, the additional serine/threonine phosphorylation that gives rise to the 120-kD

222 proteomics, we identified targets of serine-threonine phosphorylation that may regulate bacterial gr

223 thus identified intrinsic pathways of serine-threonine phosphorylation that target chromatin regulato

224 ranslational modifications, including serine/threonine phosphorylation, that differ at various stages

225 e drugs is to activate, by a double tyrosine/threonine phosphorylation, the extracellular signal-regu

226 eomic method to quantitatively relate serine/threonine phosphorylation to changes in the reactivity o

227 to the activation pathway mediated by serine/threonine phosphorylation, tyrosine phosphorylation of I

228 the case of p27, correspond to tyrosine and threonine phosphorylation, ubiquitination, and, ultimate

229 We found that EGF induces ERM c-terminal threonine phosphorylation via activation of the SK/S1P p

230 No serine/threonine phosphorylation was identified in NDPK2 or imp

231 In contrast, serine and threonine phosphorylation was necessary for the interact

232 The Ras-dependent increase in threonine phosphorylation was not observed in Ets2 prote

233 Heterogeneity in serine and threonine phosphorylation was observed at three sites or

234 ytes (CasL), and Chat-H-mediated CasL serine-threonine phosphorylation were required for T cell migra

235 n blocked OxPAPC-mediated S1P(1) activation (threonine phosphorylation), whereas silencing S1P(1) rec

236 hese CCCs are oppositely regulated by serine-threonine phosphorylation, which activates NKCC1 but inh

237 requires PKC-alpha translocation and serine/threonine phosphorylation, which eventually triggers EGF

238 nonalcoholic steatosis VDAC exhibits reduced threonine phosphorylation, which increases the influx of

239 tion is initiated upon amino-terminal serine/threonine phosphorylation, which is believed to be perfo

240 ve regulator of IRS-1, increasing its serine/threonine phosphorylation, which triggers degradation.

241 osphorylation of threonine, and 4) increased threonine phosphorylation with an increase in activation

242 reduces the p38 MAPK-related inhibitory KSRP threonine phosphorylation, without blocking p38 MAPK act