ライフサイエンスコーパス: threonyl

1 5)L-Lys-D-Ala-Gly4] linked to its C-terminal threonyl.

2 rate 4-fold higher than that for the cognate threonyl adenylate (Thr-AMP) while releasing 20% of Ser-

3 al tRNA2(Thr) and non-hydrolyzable analog of threonyl adenylate.

4 ld faster by the ThrRS catalytic domain than threonyl-adenylate.

5 or editing found in bacterial and eukaryotic threonyl- and all alanyl-tRNA synthetases is missing fro

6 required for a universal tRNA modification, threonyl carbamoyl adenosine (t6A), found in all tRNAs t

7 N(6)-threonyl-carbamoylation of adenosine 37 of ANN-type tRNA

8 The difluoromethyl-allo-threonyl hydroxamate-based compound LPC-058 is a potent

9 potent LpxC inhibitors contain an essential threonyl-hydroxamate headgroup for high-affinity interac

10 s containing an additional aryl group in the threonyl-hydroxamate moiety, which expands the inhibitor

11 reover, we show that the enzyme will convert threonyl peptides to the corresponding ketone product, a

12 corresponding ketone product, and also allo-threonyl peptides, but with a significantly reduced effi

13 Protein seryl/threonyl phosphatase inhibitors such as calyculin A bloc

14 ovalent flavoproteins confirmed the designed threonyl-phosphate linkage.

15 er RNA synthetases, such as histidyl (Jo-1), threonyl (PL-7), alanyl (PL-12), glycyl (EJ), and isoleu

16 of phospho-tyrosyl (pTyr) and phospho-seryl/threonyl (pSer/pThr) residues in specific proteins.

17 domain showed that the identified seryl and threonyl residues are necessary for the Rlm1 transcripti

18 and a long region that is rich in seryl and threonyl residues.

19 threonyl-tRNA 670-fold more efficiently than threonyl-RNA, and assign a role to FthC in fluorothreoni

20 When L-threonyl-S-pantetheine or L-threonyl-S-(N-acetyl)cysteamine was used as a small-mole

21 When L-threonyl-S-pantetheine or L-threonyl-S-(N-acetyl)cysteam

22 ored by providing CyCyA with the substrate L-threonyl-S-peptidyl carrier protein (PCP)-C2, suggesting

23 s a small-molecule thioester analogue of the threonyl-S-VibF acyl enzyme intermediate, the Cy domain(

24 lization validates a two-stage mechanism for threonyl, seryl, and cysteinyl heterocyclization domains

25 ms2t6A containing tRNA ASL indicate that the threonyl side chain adopts a conformation similar to tha

26 oninol and the adenylate analogue 5'-O-[N-(L-threonyl)sulfamoyl]adenosine (Thr-AMS), exhibited linear

27 ococcus aureus by sortase A, which links the threonyl (T) of its C-terminal LPXTG motif to peptidogly

28 odeling reveal similarity between MRP-L5 and threonyl-t-RNA synthetases, and a likely RNA binding sit

29 s) of a CyCyA fragment of VibF generated DHB-threonyl-thioester products of the condensation step but

30 e Rosetta was used to design a pocket within threonyl-transfer RNA synthetase from the thermophile Py

31 allotype was protective in adults with anti-threonyl-transfer RNA synthetase or anti-U RNP autoantib

32 er of C to U edited tRNAs to include all the threonyl tRNA isoacceptors.

33 TARS2 encodes human mitochondrial threonyl tRNA-synthetase that is responsible for generat

34 that Saccharomyces cerevisiae mitochondrial threonyl-tRNA synthetase (MST1) could attach threonine t

35 Here, we show that yeast mitochondrial threonyl-tRNA synthetase (MST1), which lacks an editing

36 Threonyl-tRNA synthetase (TARS) is an autoantigen in the

37 These include angiogenesis, and human threonyl-tRNA synthetase (TARS) represents a potent pro-

38 dentification of an NPS-TTD-associated gene, threonyl-tRNA synthetase (TARS), found by next-generatio

39 Here we show that in addition to ATD, threonyl-tRNA synthetase (ThrRS) can clear the error in

40 ification of a non-translational function of threonyl-tRNA synthetase (ThrRS) in myogenic differentia

41 A series of potent and bacteria-selective threonyl-tRNA synthetase (ThrRS) inhibitors have been id

42 Threonyl-tRNA synthetase (ThrRS) misactivates serine and

43 Threonyl-tRNA synthetase (ThrRS) must discriminate among

44 Threonyl-tRNA synthetase (ThrRS) participates in protein

45 pathways to the fidelity of Escherichia coli threonyl-tRNA synthetase (ThrRS) were investigated by ra

46 ears weakly related to an appended domain of threonyl-tRNA synthetase (ThrRS), but is unrelated to th

47 Borrelidin, a natural inhibitor of threonyl-tRNA synthetase (ThrRS), stands out for its pot

48 tivities through the selective inhibition of threonyl-tRNA synthetase (ThrRS).

49 , the enzyme closely resembles the bacterial threonyl-tRNA synthetase (ThrRS).

50 e investigated the class II Escherichia coli threonyl-tRNA synthetase (ThrRS).

51 a known inhibitor of bacterial and eukaryal threonyl-tRNA synthetase (ThrRS).

52 Here, we identify threonyl-tRNA synthetase 1 (TARS1) as an activator of ST

53 tase editing mechanism is also applicable to threonyl-tRNA synthetase and provides a paradigm for syn

54 anyl-, asparaginyl-, glycyl-, isoleucyl-, or threonyl-tRNA synthetase occur in approximately 25% of p

55 he requirement of TARS2, but not cytoplasmic threonyl-tRNA synthetase TARS, for this effect demonstra

56 in threonine (Thr) levels via mitochondrial threonyl-tRNA synthetase TARS2.

57 00 contains a mutation in THS1 (encoding the threonyl-tRNA synthetase).

58 A-binding proteins, ribosomal protein S4 and threonyl-tRNA synthetase, reveals a novel RNA-binding mo

59 nserved residue betaHis-265, as proposed for threonyl-tRNA synthetase, was excluded because replaceme

60 specificity of some synthetic inhibitors of threonyl-tRNA synthetase.

61 idelity by impairing the editing activity of threonyl-tRNA synthetase.

62 e similarity to the N-terminal end of the Ec threonyl-tRNA synthetase.

63 ryotic organism that expresses two different threonyl-tRNA synthetases, responsible for Thr-tRNA(Thr)

64 e unusual allosteric inhibitors of bacterial threonyl-tRNA synthetases.

65 d P2-OLD causes cell death by degrading host threonyl-tRNA with the UGU anticodon (tRNAThrU).

66 Phage threonyl-tRNAs resist P2-OLD cleavage due to CNG motif a

67 Phage-encoded threonyl-tRNAs with the same anticodon rescued P2-OLD-in