ライフサイエンスコーパス: throughput

1 the depth of characterization with speed and throughput.

2 eart development in unprecedented detail and throughput.

3 ms, which tend to have lower accuracy and/or throughput.

4 y reliable prediction method with reasonable throughput.

5 uantitative analysis of chemotaxis, and high throughput.

6 loader automates 3D imaging for high sample-throughput.

7 dramatically increased volumetric and sample throughput.

8 ge data sets of mitochondrial images in high throughput.

9 h less inter-observer variability and faster throughput.

10 needed that are both high fidelity and high throughput.

11 methods with high sensitivity, accuracy and throughput.

12 ectors were critical to increasing scale and throughput.

13 tructural studies with similarly accelerated throughput.

14 llelized across multiple samples to increase throughput.

15 our microfluidic approach greatly increases throughput.

16 epresents a four-fold increase in genotyping throughput.

17 ducts, soft bread had the highest extraction throughput.

18 Here we report the development of a high throughput, all-solution phase, and isothermal detection

19 In summary, the platform affords high-throughput analyses of antibodies, including bispecific

20 For high-throughput analyses of sphingolipids, tandem mass spectr

21 y and velocity compatible with those of high-throughput analyses.

22 e inefficient, and often prevent rapid, high-throughput analyses.

23 High-throughput analysis of 3D cultures enabled by this TTA h

24 ration method was developed, allowing a high-throughput analysis of a significant number of cells.

25 Patterning is combined with high-throughput analysis of grafted-from polymerization kinet

26 Here we describe 'circularization for high-throughput analysis of nuclease genome-wide effects by s

27 in seconds, holding great potential for high-throughput analysis.

28 nt acquisition (DIA) has potential as a high-throughput analytical method due to the reduced time nee

29 Here we describe a high-throughput analytical platform based on denaturing size-

30 st-effective and objective approach for high throughput analytical screening to discard defective coc

31 Here we use high-throughput and DR subdomain-targeted single-cell transcr

32 ee if pooling samples could increase testing throughput and efficiency and facilitate early detection

33 The high-throughput and high reproducibility provided by the arra

34 tic or chemical) rely on time-consuming, low-throughput and inherently variable whole-plant assays.

35 he convolutional neural network allowed high-throughput and large-scale, quantitative and comparative

36 lity with automated measurements to increase throughput and minimize observer biases.

37 and uniformity at less cost, leading to high throughput and practical preclinical in vivo therapeutic

38 To further improve the throughput and sensitivity of the offline approach, we d

39 lized with COVID-19 were analyzed using high-throughput and ultrasensitive proteomic platforms and co

40 emerged enhanced SPR biosensors towards high-throughput and ultrasensitive screening of miRNAs using

41 ng device (ToMMx), which is a portable, high-throughput and user-friendly microfluidic platform.

42 ology to develop multiple all-inclusive high throughputs and customized organ-on-a-chip-like platform

43 SOCM) technique that offers label-free, high-throughput, and large-volume imaging of ex vivo mouse or

44 et the stringent requirements of resolution, throughput, and uniformity of the pattern profile while

45 This high-throughput antibody assay is accurate, requires only 2.5

46 To address this issue, we used a high-throughput approach to profile the alphabeta TCR reperto

47 Using a high-throughput approach, we have directly identified specifi

48 manually intensive, low-sensitivity and low-throughput approach.

49 Whilst high throughput approaches have been used for more than 30 ye

50 lternative splicing, no correspondingly high-throughput assay exists for functionally interrogating i

51 ible to cytidine deaminase, we set up a high-throughput assay for assessing sgRNA-independent off-tar

52 developed a novel co-culture cell-based high throughput assay system to identify compounds that could

53 Hence, with the proliferation of high-throughput assay technology, there is an imminent need t

54 Here, using a high-throughput assay that analyses both V(D)J segment usage

55 Here we use a high-throughput assay that we term SaMBA (saturation mismatch

56 gical properties and the development of high-throughput assays for drug development targeting this ch

57 Over the past 30 years, only a few high-throughput AST methods have been developed and widely im

58 Here we developed simultaneous high-throughput ATAC and RNA expression with sequencing (SHAR

59 d and validated an open-source tool for high-throughput, automated histological analysis of cardiac t

60 h sensitivity, and ability to carry out high-throughput automation analysis (i.e., sensing arrays) ha

61 n from smaller peptide fragments, and a high-throughput bacterial expression and assay platform for r

62 von Neumann bottleneck, which constrains the throughput between the processing unit and the memory.

63 , we successfully demonstrated the ultrahigh-throughput bioanalysis of metformin, a small polar subst

64 earch and the computational analysis of high-throughput biochemical data.

65 terogeneity and wide-ranging quality of high-throughput biological data means that even data with des

66 Herein, we report a high-throughput bottom-up proteomic method enabled by a newly

67 g with biological nanopores is fast and high-throughput but suffers reduced accuracy in homonucleotid

68 Our benchmarked method approach increased throughput by reducing the necessary machine time.

69 ombinations using monotherapy data from high-throughput cancer cell line screens.

70 both academia and industry owing to its high throughput capability, prompt availability, and high spa

71 catalysts, we developed a hierarchical high-throughput catalyst screening (HHTCS) approach based on

72 ering approach enriches the toolbox for high-throughput cell imaging.

73 To this end, a high-throughput, cellular NanoBRET assay was developed target

74 m local pathology laboratories and into high-throughput, centralized (and often for-profit) laborator

75 EA), a computational tool that analyzes high-throughput chromatin accessibility genomic data to ident

76 interactions (81), identified by Hi-C (high-throughput chromatin conformation assay) and HiChIP (hig

77 f these efforts still rely on the use of low-throughput chromatography-based screening methods.

78 mosome), using an optimized single-cell high-throughput chromosome conformation capture (HiC) protoco

79 genetic, high-resolution microscopy and high-throughput co-immunoprecipitation strategies.

80 cedures enable significantly improved sample throughput compared to an established thermal ionization

81 anoid barcoding in situ (TOBis) enables high-throughput comparison of signaling networks between orga

82 erization, first-principles simulation, high throughput computation, machine learning, and artificial

83 Machine learning and high-throughput computational screening have been valuable to

84 various 3D culture applications such as high-throughput/content screening, drug discovery, disease mo

85 ytical platform that enables direct and high-throughput coupling to electrospray ionization mass spec

86 Here, we performed high-throughput CRISPR screening using a ubiquitin regulator-

87 Here, we apply Hi-C, a high-throughput, culture-independent method, to surveil the b

88 mbining metabarcoding analyses with mid/high-throughput culturing approaches.

89 ful tool for unsupervised processing of high-throughput data across a range of single-molecule experi

90 system at high resolution, translating high-throughput data into knowledge of immune mechanisms has

91 Inferring cell-signaling networks from high-throughput data is a challenging problem in systems biol

92 for organisms where these, or similar, high-throughput datasets are available.

93 Combining high-throughput discovery and subsequent structure-function c

94 rbohydrate-degrading systems and in the high-throughput discovery of alpha-l-arabinofuranosidases.

95 est and its modified version based on a high-throughput DNA extraction method (Fast96-qPCR).

96 With the development of the high-throughput DNA sequencing of organisms at the population

97 omatin immunoprecipitation coupled with high-throughput DNA sequencing, with cells grown in the prese

98 mine dehydrogenase biocatalyst via ultrahigh throughput droplet screening.

99 development of improved mixture-based, high-throughput drug discovery techniques.

100 peutic utility of BAs in a platform for high-throughput drug screening (HTS).

101 rt-term transplant platform amenable to high-throughput drug screening studies, yet animals eventuall

102 This method provides high sample throughput due to a rapid response time of less than fiv

103 tandard epifluorescence microscopes for high-throughput efficiency and the new sequencing chemistry r

104 ed signal-to-noise, all without compromising throughput efficiency of imaging large fields of view.

105 tly identical genotype perturbations, 2) low-throughput electrophysiological measurements, and 3) an

106 this work, we report the combination of high-throughput elicitor screening (HiTES) with matrix-assist

107 TP replication machinery, the amplified high-throughput emergence of CDNs is demonstrated.

108 ly adapted into an automated format for high-throughput engineering of small-molecule-binding aptamer

109 Together, our method enables a high-throughput enrichment of glycan, glycosites, and IGPs fr

110 methylated TFBSs derived from in vitro high-throughput EpiSELEX-seq binding assays and in vivo methy

111 obtained from 16 055 datasets using 12 high-throughput experiment methods (e.g. H3K4me1/H3K27ac, DNa

112 velopment are increasingly in demand as high-throughput experimentation protocols in academia and ind

113 cribed herein was enabled in microscale high-throughput experiments to allow for the rapid identifica

114 a crucial step at the design stage for high-throughput experiments.

115 In this study, a high-throughput fluorescence assay method for determination o

116 epatoblast spheroids were reseeded in a high-throughput format and induced to form hepatic organoids;

117 We utilized a high-throughput full-factorial experimental system and the mo

118 We analyzed high throughput gene expression and chromatin accessibility d

119 All high-throughput gene expression datasets of solid organ trans

120 es expression of clock-related genes in high throughput gene expression studies, compared with the pl

121 Recently, using a high-throughput genetic screen of a human interferon-stimulat

122 s shown herein by genotyping assays and high-throughput genome-wide sequencing of DNA translocations,

123 aberrations are routinely determined by high-throughput genomic measurements.

124 unners that pioneered the revolution of high-throughput genomic technologies is the genotyping microa

125 males, intersex or males using either medium-throughput genotyping (31,811 SNPs) or whole-genome sequ

126 Here, high-throughput growth, completed in 12 min, of 6-inch wafer-

127 sensitive (>100-fold improvement), and high-throughput (>96 wells) characterization of bacterial ele

128 Image-based high throughput (HT) screening provides a rich source of info

129 ium Pseudomonas syringae by combining a high-throughput ice nucleation assay with surface-specific su

130 we combined NMR structural biology with high-throughput iCLIP approaches to identify a regulatory mec

131 NA binding domain interaction, enabling high-throughput identification of proteins with high sensitiv

132 -time Peptide Search filtering enabled a ~2x throughput improvement for quantification.

133 d to a minimum while maintaining high sample throughput in a robust manner as all of the advantages o

134 a maximal density of holes, which increases throughput in automated cryo-EM without degrading data q

135 Here, we demonstrate that high-throughput in vitro DNA binding assays coupled with unbi

136 High-throughput in vitro drug assays have been impacted by re

137 multifaceted approach, starting with a high-throughput in vitro primary screen to identify inhibitor

138 his 3D printed device provides a unique high-throughput in vitro system that combines both mechanical

139 small polar substrate commonly used in high-throughput in vitro transporter inhibition assays in the

140 use model of glioblastoma, we develop a high-throughput in vivo screening platform and discover sever

141 or a variety of transformations where higher throughput is needed.

142 -tracking applications, especially when high throughput is required and image artifacts are difficult

143 In a recent high-throughput kinome screen in NF2-null human arachnoidal a

144 promising demonstrations, the lack of a high-throughput label-free method of detecting bacteria in na

145 High- and ultrahigh-throughput label-free sample analysis is required by man

146 t or invasive probes and as a result are low throughput, labor intensive, and limited by probe placem

147 rom <=10 to 74 copies/ml for commercial high-throughput laboratory analyzers (Roche Cobas, Abbott m20

148 The recent development of high throughput magnetic tweezers has enabled the simultaneou

149 resource for S. viridis in a rapid and high throughput manner, and has the potential to be widely ap

150 using a conventional plate reader in a high-throughput manner.

151 cell RNA-sequencing (scRNA-seq) enables high-throughput measurement of RNA expression in single cells

152 New technologies allow high-throughput measurement of the relative fitness of bacter

153 for pollen tetrad analysis that enables high-throughput measurements of crossover frequency and inter

154 We demonstrate an autonomous, high-throughput mechanism for sorting of emulsion droplets wi

155 ased on various clinical phenotypes and high-throughput metabolic profiles in the Angiography and Gen

156 Progress in high-throughput metabolic profiling provides unprecedented op

157 batch correction and quantification for high-throughput metabolomics.

158 We have developed a novel, high-throughput method of quantifying seven terpenes (alpha-p

159 omputational framework that serves as a high throughput method to evaluate risk of genetic mutations

160 High-throughput methods for introducing mutations and charact

161 Several studies used high-throughput methods to identify various RREs in mRNAs tha

162 In this study, we describe a novel high throughput, micro-macro approach for the identification

163 Here, we present a high-throughput microfluidic platform that enables the quanti

164 Here, we developed a high-throughput microscopy-based retrotransposition assay tha

165 tion mass spectrometry have enabled the high-throughput, multiplexed chemical analysis of single cell

166 We analyze high-throughput mutagenesis data obtained for an alternativel

167 try (MALDI-MS) is an important tool for high-throughput N-glycan profiling and, upon use of tandem MS

168 Here we present a high-throughput nanoluciferase severe respiratory syndrome co

169 g the precision of digital PCR with the high-throughput nature of 16S rRNA gene amplicon sequencing.

170 upstream sample preparation steps, limit the throughput of high-volume workflows, and prevent the har

171 in cryoEM images reduces the confidence and throughput of structure determination during several ste

172 c drawbacks in specificity, sensitivity, and throughput of traditional ligand-binding assay (LBA) and

173 ed several decades before the advent of high-throughput omic techniques, and it is unclear whether th

174 While high-throughput omics approaches have been increasingly utili

175 The advent of high-throughput (omics) technologies gives opportunities to p

176 nstrates LAMIMS as a broadly applicable high-throughput operando screening method for heterogeneous c

177 generation affords precise, low volume, high throughput opportunities for molecular diagnostics.

178 in mammalian systems has been limited to low-throughput or computational methods.

179 of the current methodologies suffer from low throughput or rely on antibody recognition, increasing t

180 tion of smaller stations, operating at lower throughput per station, than the data used to develop th

181 ce between OPI and ESI electrode for optimum throughput performance and broadens the scope of applica

182 d hardware and method setup resulted in high-throughput performance and enables further implementatio

183 rehensive serological profiling using a high-throughput phage immunoprecipitation sequencing assay co

184 High-throughput phenotyping (HTP) technologies can produce da

185 High-throughput phenotyping and data mining can capture dozen

186 and water-limited growth conditions, a high-throughput phenotyping facility was used to measure WUE(

187 An automated high-throughput platform can screen for molecules that change

188 A high-throughput platform would greatly facilitate coronavirus

189 to future integration into multiplexed high-throughput platforms for screening of molecules that mod

190 technique for the precisely controlled high-throughput preparation of well-defined interfaces contai

191 pplications are examined, spanning from high-throughput, printing-technology-compatible synthesis of

192 nadequate at present and does not allow high-throughput processing.

193 and sequencing (PETRI-seq)-a low-cost, high-throughput prokaryotic scRNA-seq pipeline that overcomes

194 In this study, we describe an optimized high-throughput proof-of-principle method for the expanded ge

195 romatin conformation assay) and HiChIP (high-throughput protein centric chromatin) performed on a sub

196 y-to-manipulate system that enables the high-throughput protein characterization in insect cells by t

197 Metabolomics was performed using a high-throughput proton nuclear magnetic resonance metabolomic

198 g device that holds great potential for high-throughput quantitative omics analysis of ultralow-volum

199 ents Black 31 and 32 is demonstrated, with a throughput rate of about 1500 g day(-1) , corresponding

200 et microfluidic platform, which enables high-throughput reaction discovery in flow to generate pharma

201 Another advantage was the enhanced throughput, requiring 1.2 min of analysis per analyte.

202 ne learning (ML) is uniquely suited for high-throughput research.

203 and assessed their specificities using high-throughput RNA-SELEX (HTR-SELEX).

204 c tissues or cells, process and analyze high-throughput RNA-sequencing data, and define sets of genes

205 pled with targeted gene knockouts and a high-throughput RNAi assay enabled the first characterisation

206 ange nuclear morphology, we conducted a high-throughput RNAi screen to identify epigenetic regulators

207 mance, in particular the performance of high-throughput SARS-CoV-2 RT-PCR systems.

208 We employed a high-throughput scheduled multiple-reaction monitoring (MRM)-

209 In a high-throughput screen for inhibitors of HPIV3 (a major cause

210 dazoles previously identified through a high-throughput screen of human kinase inhibitors, and the su

211 he identification of CVM-05-002 using a high-throughput screen of PI5P4Kalpha against our in-house ki

212 We developed a high-throughput screen to identify compounds approved by the

213 ce factors needed to cause pneumonia, a high-throughput screen was performed with an arrayed library

214 Using a high-throughput screen, we identified decitabine as a potent

215 This need is being addressed using high-throughput screening (HTS) in vitro approaches and compu

216 We performed high-throughput screening (HTS) of a chemical library to iden

217 High-throughput screening (HTS) research programs for drug de

218 High-throughput screening and fragment-screening campaigns pu

219 High-throughput screening and gene signature analyses frequen

220 mized CBS workflow allows for rapid and high-throughput screening and quantitation of 105 veterinary

221 ange, paving the way toward T-dependent high-throughput screening applications by HDX-MS.

222 seconds, opening up the possibility of high-throughput screening applications of relevance to the bi

223 sive drug discovery techniques allowing high-throughput screening are now required to develop effecti

224 Using a FRET-based high-throughput screening assay that we previously reported,

225 With the increase in high-throughput screening data, scaffold graphs have proven u

226 s, targeted biochemical assays enabling high-throughput screening have become increasingly interestin

227 port the multifactorial optimization of high-throughput screening hit 8 to a potent, metabolically st

228 tanoyl)phenyl]acetate (TMPA), and three high-throughput screening hit derivatives.

229 High-throughput screening identified doxorubicin (DXR) as an

230 We use high throughput screening of large libraries of materials wit

231 We searched for new agents by high-throughput screening of selected targeted compounds and

232 of the functional analysis step enables high-throughput screening of shRNA or CRISPR-Cas9 constructs

233 propose a reliable and convenient ultrahigh-throughput screening platform based on flow cytometric d

234 e observations prompted us to develop a high-throughput screening platform of cancer drugs in a quest

235 acchaomyces cerevisiae, which allow for high-throughput screening to patient-derived cell-lines that

236 ivo, and generating new developments in high-throughput screening used to identify functional lncRNAs

237 Label-free high-throughput screening using mass spectrometry has the pot

238 lly automated platform for ESI-MS-based high-throughput screening.

239 f 4096 possible combinations using ultrahigh-throughput screenings combining coupled transcription/tr

240 ration of more physiologically relevant high-throughput screens (HTS).

241 split-pool ligation transcriptomics), a high-throughput scRNA-seq method for Gram-negative and Gram-p

242 e development and characterization of a high throughput sensing device for single liposome detection.

243 quantitate cGAMP with an assay that is high-throughput, sensitive, and precise.

244 limited by the fundamental trade-off between throughput, sensitivity, and spatial resolution.

245 High-throughput sequencing (HTS) provides opportunities for i

246 High-throughput sequencing and the availability of large onli

247 entire mtDNA genome enrichment prior to high-throughput sequencing are not readily available.

248 DNA as a clinically relevant target and high-throughput sequencing as an analytical tool, we investig

249 High-throughput sequencing can establish the functional capac

250 ducing pseudouridylation of the miRNAs, high-throughput sequencing crosslinking immunoprecipitation (

251 uickly, accurately and reliably process high-throughput sequencing data.

252 ment is a popular method for annotating high-throughput sequencing data.

253 High-throughput sequencing experiments followed by differenti

254 ded viral barcoding in combination with high-throughput sequencing is a powerful technology with whic

255 e-Map techniques, we built and analyzed high-throughput sequencing libraries of rNMPs derived from mi

256 High-throughput sequencing of RNA (RNA-seq) has expedited the

257 reptomyces diversity was examined using high-throughput sequencing of rpoB amplicons generated with a

258 However, even with standard high-throughput sequencing techniques, complex rearrangements

259 erformed a compound screen coupled with high throughput sequencing to assess key transcriptional chan

260 skeletal banding patterns, and utilise high-throughput sequencing to comprehensively characterise th

261 High-throughput sequencing was used to characterize the molec

262 High-throughput sequencing, liposomal nanoallergen display, b

263 family can routinely be identified via high-throughput sequencing, we believe our strategy offers a

264 ons, Argonaute-immunoprecipitations and high-throughput sequencing, we provide experimental evidence

265 nes chromatin conformation capture with high-throughput sequencing.

266 osome affinity purification followed by high-throughput sequencing.

267 din beads before library production and high-throughput sequencing.

268 DNA copy number that can be measured by high-throughput sequencing.

269 quantified after liver repopulation via high-throughput sequencing.

270 ratory with access to FACS, robotic and high-throughput-sequencing facilities.

271 Ortho anti-SARS-CoV-2 total Ig and IgG high-throughput serological assays (HTSAs) and the Abbott SAR

272 es can be implemented in many different high-throughput settings to ultimately improve power.

273 High-throughput short-read and long-read sequencing of VLP DN

274 Ahigh-throughput shRNA library screen in IRF8 expression-restr

275 ions with exceptionally high water flux (and throughput), single-pass water recovery and heat utiliza

276 idate RAN translation inhibitors from a high-throughput small-molecule screen for fragile X tremor at

277 Here, we develop a facile, general, and high throughput solvent-free self-assembly strategy to synthe

278 We describe a microfluidic system for high-throughput sorting of nanoliter droplets based on direct

279 urface click chemistry in bacteria with high-throughput sorting, we developed a method to quantitativ

280 The recent work by Mann et al. used high-throughput synthesis and screening of polyacrylamide-bas

281 is the first step in making EBSD into a high-throughput technique.

282 ntation will be hampered by the lack of high-throughput techniques for exfoliating single-crystal mon

283 verse drug discovery' programs that use high-throughput techniques to isolate effective compounds bas

284 High-throughput technologies for genomics, transcriptomics, p

285 The widespread adoption of high throughput technologies has democratized data generation

286 mics, facilitated by recent advances in high-throughput technologies, have given us unprecedented ins

287 as only recently, through the advent of high-throughput technologies, that scientists gained the abil

288 Using a high-throughput technology to interrogate most single transme

289 tremendous potential for scaling up curation throughput, thus enabling EHR-powered early disease diag

290 In a previous high-throughput time-resolved FRET (TR-FRET) screen, we ident

291 ex can actively and dynamically gate sensory throughput to higher brain centers.

292 e complex sample analysis necessary for high-throughput top-down proteomics.

293 Leveraging high-throughput transcriptomics we identify NMD targets trans

294 We propose a new high-throughput ultrafast method for large-scale proteomics a

295 ehavior with PsychoGenics' SmartCube, a high-throughput unbiased automated phenotyping platform that

296 a fast (less than 1 min per sample) and high-throughput (up to 384 samples per run) way.

297 barrier for labs who are interested in high-throughput variant calling applications on a large scale

298 We performed a high-throughput whole-genome RNAi screen to identify novel in

299 learning to create a quantitative and higher throughput workflow for producing palynological identifi

300 demonstrations of the utility of IMS in high-throughput workflows such as liquid chromatography-fluor

301 uate sperm at the microscopic level, at high-throughput, would be useful for assisted reproductive te