ライフサイエンスコーパス: thwart

1 ed germination and seedling establishment is thwarted.

2 ccumulated in neurons as autophagic flux was thwarted.

3 y acquiring an E3 ligase domain, AvrPtoB has thwarted a highly conserved host resistance mechanism.

4 ut transcriptionally dormant cells currently thwarts a cure for the more than 35 million individuals

5 onmental cues associated with drug use often thwarts abstinence efforts by triggering drug using memo

6 ctor provides the jammer with the ability to thwart active attempts to adapt to their attack.

7 become activated when normal regeneration is thwarted and trigger the appearance of "progenitor" cell

8 the dominant competitor in the hierarchy is thwarted, and the entire community can be sustained.

9 hat combat phage infection and mechanisms to thwart antibiotics, bacteria have also acquired and evol

10 03 coordinates with other cowpox proteins to thwart antigen presentation.

11 ules released within the microenvironment to thwart antitumor immune responses, thereby facilitating

12 that can adapt to changing environments and thwart antiviral therapies.

13 unctional standpoint, interfering with GP130 thwarts APLNR-mediated self-renewal of GSCs ex vivo.

14 stand the diverse mechanisms by which tumors thwart AR-directed therapies, which may inform new thera

15 Innate and adaptive immune responses are thwarted as a consequence of Yop activities.

16 hypothesis that JA-inducible proteins (JIPs) thwart attack by disrupting digestive processes in the i

17 as immediately and consistently effective at thwarting attack and bats regularly performed catching b

18 By adhering, the beetle is able to thwart attacking ants, given that it is able to cling mo

19 Hagfishes thwart attacks by fish predators by producing liters of

20 ed by the NER apparatus and is followed by a thwarted attempt at gap-filling by the replicative Polym

21 on of the remarkably unreactive hemiketal 16 thwarted attempts to elaborate 15 to tedanolide.

22 heterogeneity of Glut4 neurons has thus far thwarted attempts to understand their function.

23 solid-state crystal packing, and this often thwarts attempts to produce isostructural series of crys

24 ow how robust homeostatic control of feeding thwarts attempts to reduce food intake and how this migh

25 We report that the transcription factor MafB thwarts auto-amplification by a metastable switch activi

26 K-4, MyD88, and UNC-93B pathway blockade may thwart autoimmunity in humans.

27 ains largely unknown how anti-B cell therapy thwarts autoimmunity in these pathologies.

28 In pre-BCR(+) ALL, ibrutinib thwarted autonomous and induced pre-BCR signaling, resul

29 ans that developed innate immune pathways to thwart bacterial and viral infections, mitochondrial com

30 ectonics, but palaeomagnetic tests have been thwarted because the planet's oldest extant rocks have b

31 iogenesis does not occur and tumor growth is thwarted beyond 1-2mm in size.

32 xploits the limits of a previous approach to thwart branch migration, but the design of the 12-arm ju

33 ts a liability to melanoma cells, which they thwart by assuming an oncogenic dependency on the E3 lig

34 Reproducibility is typically thwarted by a lack of availability of the original data

35 Unfortunately, achieving our objective was thwarted by a lethal embryonic phenotype.

36 The final step was thwarted by a pinacol-like rearrangement that delivered

37 the analogous 1,3-glucosyl dioxanium ions is thwarted by a prohibitively strong flagpole interaction

38 te 17 containing the silyl ether linkage was thwarted by a slow alkylation and an undesired Peterson-

39 ial to ensure food security, but efforts are thwarted by an apparent trade-off between grain size and

40 f ERCC1 in patients with upper GI tumors was thwarted by an overwhelming predominance of low ERCC1 mR

41 ts interrogation at high resolution has been thwarted by bioinformatic challenges, with most studies

42 espread implementation of cocooning has been thwarted by both individual-level and system-level issue

43 protein functionality has been significantly thwarted by both intrinsic instability and stringent sol

44 eir development for mass production has been thwarted by difficulties in aligning and integrating the

45 based on intraspecific polymorphisms, can be thwarted by difficulties in delineating species' boundar

46 Its study has been thwarted by difficulties in the accurate measurement of

47 ethnic homogeneity in the market and can be thwarted by diversity.

48 ffects of sunlight in human epidermis may be thwarted by either: transient growth arrest and repair o

49 scission by vibrational excitation have been thwarted by energy thermalization.

50 es based on sequencing cancer genomes can be thwarted by genetic heterogeneity within tumors.

51 gas streams using porous materials is often thwarted by humidity.

52 ectroscopy shows that the charge transfer is thwarted by hybridization effects tuned by the rare-eart

53 ents to prevent nutritional rickets has been thwarted by inconsistent case definition, inadequate adj

54 The long-term application of Pt complexes is thwarted by issues, leading scientists to examine other

55 against the enzyme, these efforts have been thwarted by lack of cellular activity.

56 i-obesity hormone, but this role is commonly thwarted by leptin resistance.

57 ted with lymphopenia, such as AIDS, has been thwarted by limited techniques for studying T-lymphocyte

58 Efforts to identify effective treatments are thwarted by limited understanding of IPF pathogenesis an

59 oplet edge, whereas new polymer formation is thwarted by long nucleation times, since the concentrati

60 -term weight loss maintenance (WLM) is often thwarted by metabolic adaptations that suppress energy e

61 the final execution of this death pathway is thwarted by nuclear sequestering of mixed lineage kinase

62 highlight that social change efforts can be thwarted by people's sense of what is possible, but this

63 forts towards an effective vaccine have been thwarted by poor understanding of what constitutes prote

64 nt of HIV-1/AIDS, but their effectiveness is thwarted by rapid emergence of drug resistance.

65 Attempts to resolve these issues have been thwarted by small and noisy datasets, and by lack of com

66 ve centered on neutralizing mAbs, only to be thwarted by strain specificity and rapid viral escape.

67 otentially potent pro-ISIS aggregates can be thwarted by targeting smaller ones.

68 ssively more 'efficient' male-killers can be thwarted by the appearance of host resistance.

69 s, including vancomycin resistance genes, is thwarted by the ATP-dependent endonuclease SauUSI.

70 e, defining the most critical forms has been thwarted by the changeable nature of these aggregates an

71 stereochemistry at the pro-C(11) center were thwarted by the congestion imparted by the presence of t

72 ture of the prothrombinase complex have been thwarted by the dependence of complex formation on phosp

73 uman clinical studies are cumbersome and are thwarted by the extent of investigation that can be perf

74 nt of a vaccine for the common cold has been thwarted by the fact that there are more than 100 seroty

75 Progress toward 29a was thwarted by the failure of the key dithiacyclophane-form

76 These responses may thwarted by the high rate of mutation, which leads to th

77 espread implementation in this role has been thwarted by the lack of a lightweight, safe, on-board hy

78 rease in INS-1 cell IRS-2 protein levels was thwarted by the mammalian target of rapamycin(mTOR) inhi

79 ective control of tuberculosis (TB) has been thwarted by the need for prolonged, complex and potentia

80 Curing HIV infection has been thwarted by the persistent reservoir of latently infecte

81 Remarkably, viral persistence is not thwarted by the presence of apparently vigorous, virus-s

82 gamma-emitting radiosilver isotopes is often thwarted by the presence of concomitant and dominating g

83 ysiological basis of their behavior had been thwarted by the pressurized nature of their internal bod

84 effectiveness of vaccination programs can be thwarted by the public misperceptions of vaccine risk.

85 These studies have been thwarted by the rarity of IgE(+) cells in vivo and the l

86 ternative strategy(4), but progress has been thwarted by the same selectivity issue; HER dominates.

87 ly difficult to diagnose and surveillance is thwarted by the subjectivity of many components of the s

88 bug (Stiretrus anchorago), were shown to be thwarted by the thatch.

89 Progress toward gender equality is thwarted by the underrepresentation of women in politica

90 n of readily available benzils has been long thwarted by their base-sensitivity.

91 h conventional therapeutic modalities, often thwarted by therapy resistance, emphasizes the critical

92 expression in large animal models have been thwarted by transient expression or immune responses to

93 rs, translation of these strategies has been thwarted by two key obstacles: rapid proteolytic degrada

94 everal earlier attempted congresses had been thwarted by World War I and European tensions would also

95 d as an effective and attractive strategy to thwart cancer progression and growth.

96 or vascularity provide a potential avenue to thwart cancer progression.

97 Loss of eIF2alpha phosphorylation thwarts caspase activation and delays apoptosis.

98 st' mitochondria survive quality control and thwart cell death to relay multiple comprehensive 'dange

99 ization of MCP and scaffolding proteins, has thwarted characterization of the earliest steps in shell

100 f Nephromyces, and its unusual habitat, have thwarted characterization of the phylogenetic affinities

101 ixed redox and ligand states in the crystals thwart clear conclusions.

102 ge-derived proteins, anti-CRISPRs (Acrs), to thwart clustered regularly interspaced short palindromic

103 ladder-up in the modal order, concomitantly thwarting coherent field interference, thereby altogethe

104 gy for designing efficient photoreactions by thwarting competitive excited state decay channels.

105 The tumour microenvironment thwarts conventional immunotherapy through multiple immu

106 This review moves beyond the problems thwarting correlational GxE research to propose genetic

107 Policing efforts to thwart crime typically rely on criminal infraction repor

108 ing novel therapies specifically designed to thwart critical pathways responsible for this malignancy

109 ing their own growth and development, whilst thwarting defence responses.

110 oes, the only time a state ever attempted to thwart desegregation by financing a separate Black medic

111 ps in our understanding of pathogenesis that thwart development of optimally effective control progra

112 ction of the receptor-like kinases (RLKs) in thwarting different pathogens remains elusive.

113 are no approved therapeutic agents that can thwart disease progression.

114 icular Vkappa germline genes in promoting or thwarting DNA binding.

115 endoplasmic reticulum stress pathways, while thwarting DNA repair mechanisms.

116 non-genetic cooperation among tumor cells to thwart drug pressure, suggesting that profiling for drug

117 the context of the whole promoter, possibly thwarting drug-discovery efforts.

118 l viruses, reviewing how PTMs facilitate and thwart each step of the replication cycle.

119 S. aureus has the potential to thwart effective neutrophil chemotaxis, and phagocytosis

120 n nanotubes (CNTs) in pure form continues to thwart efforts by scientists to use these ultrathin mate

121 ordial germ cells (PGCs) in the mouse embryo thwart efforts to investigate molecular mechanisms of ge

122 6d and other conduction electron states, has thwarted efforts for fully understanding this class of c

123 on, but the apparent instability of MD-2 has thwarted efforts to more fully separate and characterize

124 rapidly undergoes O-O bond cleavage, thereby thwarting efforts to trap it using rapid mixing methods.

125 key contributor in multidrug resistance that thwarts efforts to combat malaria-mediates H(+)-coupled

126 parum underlies its transmission success and thwarts efforts to control disease caused by this parasi

127 asite, a strict preference for reticulocytes thwarts efforts to maintain it in vitro.

128 mediated cell cycle activity specifically by thwarting EGF-mediated Tcf/Lef transcriptional activity,

129 bsorption of iron, calcium, and vitamin B12; thwarts enteric infection; and prevents bacterial overgr

130 ) display intrinsic drug resistance that may thwart eradication of a malignancy by chemotherapy.

131 We hypothesize that accelerating assembly thwarts error-correction, so that the assembling particl

132 nism by which many soft biological materials thwart excessive deformation to protect tissue integrity

133 nd only the corresponding predictions of the thwarted expectations.

134 r, these data indicate that Pla functions to thwart fibrin-dependent T cell-mediated defense against

135 ic and granulomatous inflammation capable of thwarting fungal growth.

136 chanisms may reveal unique opportunities for thwarting GATA-2-dependent processes in a therapeutic co

137 n often differs among individuals, which can thwart generalization.

138 f RESV treatment after SE is efficacious for thwarting glutamatergic neuron degeneration, alleviating

139 2020) demonstrate that resident microbes can thwart gut colonization by the enteric bacterial pathoge

140 roportion of F-cells that have enough HbF to thwart HbS polymerization is the most critical predictor

141 arge and often complex genome structure have thwarted HGT studies of eukaryotes.

142 A second variant, 45-46m7, designed to thwart HIV-1 resistance to NIH45-46(G54W) arising from m

143 e efficient expression of viral genes and to thwart host cell protein synthesis.

144 ive regulators of innate immune signaling or thwart host cell proteins that are activated by ubiquiti

145 selects for a cuckoo plumage polymorphism to thwart host detection.

146 overed a novel means by which bacteriophages thwart host immunity.

147 o strategies used by pathogenic bacteria for thwarting host defenses and surviving in human blood.

148 Understanding how KSHV thwarts host defense responses is necessary to help deve

149 es C3b binding and their antigenic variation thwarts host immunological defences.

150 and lack of studies across MASLD/MASH stages thwart identification of stage-specific immunological ta

151 These efforts can, however, be thwarted if exploitation is compensated demographically

152 emplified by the many BCR/ABL mutations that thwart imatinib activity in patients with chronic myelog

153 Chronic viruses and cancers thwart immune responses in humans by inducing T cell dys

154 e of highly pathogenic viruses, which either thwart immune- and small molecule-based therapies or lac

155 The Epstein-Barr virus thwarts immune surveillance through a Gly-Ala repeat (GA

156 ide a nuanced understanding of how our brain thwarts impulsive actions while nonetheless enabling beh

157 While we were ultimately thwarted in using the ammonium ylide/rearrangement casca

158 By virtue of specific adaptations that thwart individual innate or adaptive immune mechanisms,

159 consideration of lectin-based approaches to thwart infection by present and future viral threats, al

160 striction factors target the viral capsid to thwart infection.

161 nological or chemical interventions that may thwart infectious disease.

162 e active kinase complexes to synergistically thwart innate immunity.

163 ion (42% versus 28% isolated yield), thereby thwarting installation of the isocyclic ring (ring E, sp

164 unction and the mechanisms viruses employ to thwart its effects.

165 ine-rich domain structure within Pfs230 have thwarted its recombinant expression and characterization

166 are still possible, realizing these gains is thwarted largely by economic rather than scientific conc

167 n adenylated ligase complex and consequently thwarted ligation.

168 thogen, which may lead to new strategies for thwarting Lyme disease.

169 Multiple factors have thwarted molecular identification of this channel, inclu

170 es rapid and sustained BTK inhibition, while thwarting more slowly accumulating off-target reactivity

171 of gene transcription, a mechanism that has thwarted most efforts to inhibit MYC function as potenti

172 These standard cages may thwart mouse ability to segregate resting areas from are

173 everal key cells of the human immune system, thwarting multiple arms of the host immune response, and

174 a clinically important DNA glycosylase that thwarts mutations by initiating base-excision repair at

175 duals then act to fortify or replenish their thwarted need or needs.

176 ght to improve visibility during fixation by thwarting neural adaptation to unchanging stimuli, but h

177 If parental choice thwarts offspring's evolved mate preferences from being

178 y, activating inflammation through TNFR1 and thwarting opsonization by trapping IgG Fc domains, while

179 ameters could identify optimal strategies to thwart or redirect assembly to block infection.

180 class A beta-lactamases (ESBLs) continue to thwart our best clinical efforts.

181 een a largely unrecognized confound that has thwarted our ability to identify the biological basis fo

182 nderstanding of cancer's diversity currently thwarts our goal of a cure for every patient, but recent

183 We categorize the former as "thwarted oxygenases".

184 argets for therapeutic intervention aimed at thwarting parasite transmission and pathogenesis.

185 appreciation of the complexities of RAS that thwarted past efforts, and armed with new technologies a

186 ial of using components of the microbiota to thwart pathogen transmission.

187 To thwart pest resistance, some transgenic crops produce 2

188 y excluding infection of heterologous phage, thwarting phage production and further infection.

189 flammation, but chemokine network redundancy thwarts pharmacological intervention.

190 don states, computational burden has largely thwarted phylogenetic reconstruction under codon models,

191 Steric limitations thwarted plans to prepare the naphthalene analogue of 10

192 onentially with distance from the source and thwarting prediction.

193 to develop resistance to antimalarial drugs, thwarting present efforts to control it.

194 n different detergent environments that have thwarted previous native MS studies.

195 mocystis spp. outside the mammalian lung has thwarted progress toward understanding their basic biolo

196 ession of NF-kappaB target genes and thereby thwarted progression of disseminated HL-60 leukemia.

197 loid cells drive human cancer progression by thwarting protective immunity and could lead to immunoth

198 tic, the dosage at which bacterial growth is thwarted, provides an effective quantitative measure for

199 other words, crossover to the polar manifold thwarts rather than enables ethylene formation.

200 ached B cell tolerance to DNA, apparently by thwarting receptor editing.

201 to the most broadly neutralizing antibodies thwart recognition by transitioning to the activated sta

202 inhibitory signals produced by CNS glia that thwart regenerating axons.

203 immune MRL-Fas(lpr) mice could exacerbate or thwart renal injury.

204 These properties may underlie its ability to thwart replicative senescence and, not surprisingly, hav

205 platforms for screening drug combinations to thwart resistance at the individual patient level, and (

206 ptic knockdown of the fly homologue of LRRK2 thwarts retrograde, homeostatic synaptic compensation at

207 nd presumably quantitatively, bind siRNAs to thwart RNA-interference-mediated degradation.

208 analog antivirals such as remdesivir, which thwarts RNA synthesis by inhibiting viral polymerase (Rd

209 versarial topology reconnaissance, including thwarting RTT-based fingerprinting attempts.

210 ds the SOZ during seizure onset, possibly to thwart seizure activity.

211 Such knowledge is needed to thwart serious threats to human health and calls to mind

212 ural networks to reduce handover latency and thwart several types of cyberattacks, the proposed 5G Se

213 generates intrinsic stimulatory capacity and thwarts signal blockade strategies.

214 This arrangement has thwarted standard genetic approaches to generate an Hsp7

215 beneficial for restraining seizures, cannot thwart status epilepticus (SE) induced neurodegeneration

216 conserved elements of the target epitope, by thwarting strain-specific and distracted lineages.

217 Pleiomorphy has thwarted structural analysis by image reconstruction of

218 arrangements of this multimeric protein have thwarted structural study of the full-length form for de

219 o tick bites develop an immune response that thwarts subsequent tick feeding.

220 ue two-stage translation silencing mechanism thwarts synthesis of a male-specific transcription activ

221 clusion protein that provides a mechanism to thwart T-even phage infection.

222 The discovery that Y. pestis thwarts T cell defense by promoting fibrinolysis suggest

223 a protease that promotes fibrin degradation, thwarts T cell-mediated defense against fully virulent Y

224 trace explosives is crucial in the effort to thwart terrorist explosives attacks.

225 crophages by IL-4 as a possible mechanism of thwarted Th17 vaccination responses by underlying helmin

226 foundation for future approaches designed to thwart the aging phenotype.

227 HTLV-1) has evolved a remarkable strategy to thwart the antiviral effects of the cellular cytidine de

228 Fierce maternal-aggression to thwart the attack/threat of male-conspecific/intruder is

229 d toxin-producing bacteria, GBS may actively thwart the autophagic pathway.

230 ar environment may provide an opportunity to thwart the cell death initiated by the loss of dystrophi

231 stantial ethical governance risks that could thwart the delivery of these anticipated benefits.

232 homeostasis, are co-opted by cancer cells to thwart the development of effective antitumor responses.

233 gical drug development strategy is needed to thwart the development of metastatic disease at every st

234 even dangerous treatments, for example, and thwart the discovery of real solutions for society.

235 The brain microenvironment can thwart the effectiveness of drugs against primary brain

236 processes may facilitate HCC progression and thwart the efficacy of immunotherapeutic interventions.

237 ble, and parallel (or redundant) pathways to thwart the expected emergence of drug resistance.

238 ble, and parallel (or redundant) pathways to thwart the expected emergence of drug resistance.

239 nother strategy utilized by this pathogen to thwart the host immune response.

240 six effector proteins into the host cells to thwart the host innate immune response.

241 ts of granuloma-specific bacterial genes may thwart the host's attempt to completely eradicate the ba

242 d carotenoid (shield), act in partnership to thwart the immune phagocytic defenses.

243 we suggest a role that allows B. cepacia to thwart the immune response and a model of the events tha

244 l to females, and female countermeasures may thwart the interests of males, which can lead to an arms

245 al for survival and enables C. neoformans to thwart the mammalian immune system.

246 d/or aggregation is an appealing strategy to thwart the onset and progression of this disease.

247 t can pose considerable difficulties or even thwart the preparation of specific derivatives for furth

248 s suggested that GATA2 may be upregulated to thwart the proliferative signal generated by PML-RARA an

249 go extensive replication, it might therefore thwart the purpose of MRT In order to improve the safety

250 of the U.S. educational system continues to thwart the search for a straightforward answer to the qu

251 and vaccine development will be essential to thwart the staggering worldwide impact of this disease;

252 tives for the pursuit of AR treatments, have thwarted the ability to understand AR pathology and mech

253 revealed that higher dose hMSC-EV treatment thwarted the chronic activation of the p38 mitogen-activ

254 41 and the methylene amino acrylate ester 48 thwarted the completion of the synthesis of lysergic aci

255 s resulting from error-prone replication has thwarted the discovery of a universal prophylactic vacci

256 while maintaining chemical specificity have thwarted the emergence of general approaches.

257 Ultimately, undesired C-N cyclization thwarted the final projected C-C bond forming ring closu

258 e a diol underwent subsequent reactions that thwarted the generation of the desired PMPs.

259 rtunately, however, a failed decarboxylation thwarted the total synthesis of curvulamine.

260 -based dietary small RNAs in circulation has thwarted the use of dietary RNA therapeutics.

261 This has thwarted the use of FM dyes in systems more intact than

262 ocratic Republic of the Congo (DRC) has been thwarting the case isolation, treatment, and vaccination

263 apoptosis in sepsis is beneficial; however, thwarting the development of secondary necrosis through

264 esponses could improve drug effects, thereby thwarting the emergence of acquired resistance.

265 ractions in which the virus is successful in thwarting the host's defense systems, here the human gen

266 gests a novel role for gram-positive pili in thwarting the innate defenses of phagocyte killing.

267 ctions of these pathways in AML are unclear, thwarting the rational application of targeted therapeut

268 n latently infected individuals survives and thwarts the attempts of eradication by the immune system

269 s the numerous mechanisms by which the virus thwarts the cells from expressing its genes after infect

270 hose components may favor a selfishness that thwarts the evolution of cooperation.

271 an enigmatic microbial virulence factor that thwarts the host immune surveillance system to cause dis

272 n important mechanism by which H. capsulatum thwarts the host immune system.

273 An electron-deficient phosphine thwarts the reduction step but, based on the Ru-S cataly

274 Proliferative vitreoretinopathy (PVR) thwarts the repair of rhegmatogenous retinal detachments

275 ming these TAMs toward an M1 phenotype could thwart their pro-cancer activities and unleash anti-tumo

276 ity favoured the generation of MDR cells and thwarted their loss within communities with multiple pla

277 lecules with substantial off-target effects, thwarting their use as specific modulators of endogenous

278 the complexity of these molecular structures thwarts their accessibility.

279 inherent and acquired antibiotic resistance thwarts therapy.

280 ns and the strategies employed by viruses to thwart these defenses.

281 et of mutations dominating the picture, have thwarted this approach.

282 Thwarting this accelerated grass-fire cycle is at the fo

283 Thwarting this process would prevent HIV transmission or

284 m (chemokine receptors, adhesion molecules), thwarting tissue retention and recirculation into the ti

285 This enabled thwarting TKI resistance by using the hypomethylating ag

286 However, significant barriers have thwarted translation of these approaches to true therapi

287 Furthermore, loss of GCN2 thwarted translational control, normal epidermal differe

288 st in the host, facilitate transmission, and thwart treatment of infected patients.

289 llular senescence or apoptosis, which act to thwart tumor development.

290 suggests that driving pyruvate oxidation can thwart tumor growth in BRAF-driven melanoma by inducing

291 potently impeded KSHV lytic replication and thwarted tumorigenesis of primary effusion lymphoma (PEL

292 We also elucidate how yeast cells thwart Ty3/Gypsy proliferation by blocking translation o

293 nized the expression of DECTIN-2 family CLR, thwarting vaccine responses and possibly increasing infe

294 t evidence may benefit vaccine strategies to thwart variants of concern, including the omicron varian

295 , host cells have also evolved strategies to thwart viral immune escape.

296 lved not primarily to prevent cancer, but to thwart viral infection.

297 One way to thwart virus infection is to inhibit interaction with ce

298 cellular and therapeutic interventions that thwart virus-cell membrane fusion.

299 Repression can be thwarted when stable transcription preinitiation complex

300 This additional layering is thwarted when the PE conformation is constrained.