ライフサイエンスコーパス: thymic

1 of smoking (HR 3.42, 95% CI 1.40-8.45), and thymic abnormalities (HR 1.82, 95% CI 0.91-3.67).

2 e disorders, history of smoking, presence of thymic abnormalities, and medications received.

3 The role of GILT in thymic Ag processing and generation of central tolerance

4 thymic maturation, resulting in accelerated thymic aging.

5 Results revealed that: i) thymic and bone marrow output was impaired in 4 out 5 pa

6 anisms of S. suis on specific populations of thymic and immune cells in infected mice.

7 an increase in the proportion and number of thymic and peripheral Foxp3(+) regulatory T cells.

8 We also found that PRMT5 controlled thymic and peripheral homeostasis in the CD4+ Th cell li

9 stinct allelic variants of H2-A and analyzed thymic and peripheral production and TCR repertoires of

10 ociated 4 (CTLA-4) protein, but not mRNA, in thymic and peripheral Treg cells.

11 DR2b themselves, are abundant on B cells and thymic antigen-presenting cells.

12 GILT expression was enriched in thymic APCs capable of mediating deletion, namely medull

13 sion of insulin epitope B:9-23 (InsB9-23) by thymic APCs is insufficient to induce deletion of high-

14 Thus, GILT expression in thymic APCs, and mTECs in particular, preferentially fac

15 ed presentation of endogenous TRP1 by pooled thymic APCs.

16 FOXN1 deficiency leads to thymic aplasia, alopecia, and nail dystrophy, accounting

17 ogenitors promote a rapid restoration of the thymic architecture, with a single wave of thymopoiesis

18 Logically, thymic atrophy is thought to reflect senescent cell deat

19 nditional reporters to show that accelerated thymic atrophy reflects contraction of complex cell proj

20 ss of Foxn1 mRNA expression in the embryonic thymic bud.

21 hestrated by their interaction with multiple thymic cell types.

22 taste cells to ex-Aire-expressing medullary thymic cells and small-intestine cells that mediate tiss

23 s in bone marrow chimeras that reconstituted thymic cellularity developed beyond stage 0 precursors a

24 Occurring temporal to T cell exhaustion, thymic cellularity reconstituted despite ongoing viral r

25 h a defect in IL-21 signaling exhibit normal thymic cellularity, challenging the importance of this c

26 D4(+)CD8(+) cells and a 20-fold reduction in thymic cellularity.

27 molecular and cellular mechanisms mediating thymic central tolerance and prevention of autoimmunity

28 Thymic central tolerance eliminates most immature T cell

29 toire and limiting autoimmunity through both thymic clonal deletion and Treg cell generation.

30 ing that alloreactive T cell elimination and thymic clonal deletion are primary mediators of PTCy eff

31 Meanwhile, defective thymic clonal deletion due to altered B7-CD28 signaling

32 pha and TCRbeta sequences of mouse tTreg and thymic conventional CD4(+) T cells (Tconv) by high-throu

33 ration of TCR-signaled thymocytes out of the thymic cortex into the medulla.

34 The thymic cortex is rich in ATP, which is released by macro

35 mally anchors preselection thymocytes to the thymic cortex via interaction with its ligand CXCL12 on

36 tion thymocytes are normally retained in the thymic cortex, but the mechanisms responsible remain inc

37 CR-unsignaled preselection thymocytes to the thymic cortex.

38 a unique property of epithelial cells in the thymic cortex.

39 nts release preselection thymocytes from the thymic cortex.

40 otoxic effects on TECs link the rATG-induced thymic damage to the delayed T cell reconstitution, witn

41 come delayed T cell reconstitution caused by thymic damage.

42 llular MHC transfer was donor-cell specific; thymic DC readily acquired MHC from TEC plus thymic or s

43 Thymic deletion of Rank also results in impaired accumul

44 to Muc2(-/-) mice led to its presentation by thymic dendritic cells and the deletion of Ag-specific t

45 Cs regulate both iNKT-mediated activation of thymic dendritic cells, and iNKT availability in extrath

46 ng viral replication, with a rapid secondary thymic depletion following immune restoration by anti-pr

47 itis virus infection rapidly triggers severe thymic depletion, mediated by CD8 T cell-intrinsic type

48 DN T cells are a unique unconventional thymic-derived T cell subset.

49 ppressive function and lineage commitment in thymic-derived T(REG) cells and potentiating the TGF-bet

50 mab does not affect function or phenotype of thymic-derived Tregs; however, little is known about its

51 Treg cells can be generated during thymic development (called thymic Treg [tTreg] cells) or

52 we found that CD27 signaling suppresses the thymic development and effector functions of T1D-protect

53 signaling was particularly important for the thymic development and peripheral homeostasis of Foxp3(+

54 Impaired thymic development of PLZF(+) innate lymphocytes in germ

55 The thymic development of regulatory T (T(reg)) cells, cruci

56 yme (ion channel and enzyme) potentiated the thymic development of T(reg) cells in mice and led to a

57 role for beta(2) integrins in promoting the thymic development of the IFNgamma-producing CD27(+) Vga

58 ng Vgamma6Vdelta1(+) cells and promoting the thymic development of the IFNgamma-producing Vgamma4(+)

59 Thymic development of this population was normal.

60 y STIM and ORAI proteins is required for the thymic development of Treg cells, but its function in ma

61 nt factor regulating T-cell differentiation, thymic development, and cytokine signaling.

62 ably not imprinted with an IL-17 bias during thymic development, but rather acquire an IL-17 bias in

63 During thymic development, mouse gammadelta T cells commit to e

64 the precise contribution of IL-2 during Treg thymic development, peripheral homeostasis and lineage s

65 -7, which is known to be critical for T cell thymic development, the role of IL-21 in this process is

66 e IL-17 and other "type 17" cytokines during thymic development.

67 NF-kappaB-independent function of IKK during thymic development.

68 compared with alphabeta T cells during adult thymic development.

69 -type populations at different stages of the thymic development.

70 rentiation into mature effector cells during thymic development.

71 of Foxn1 function in mice results in severe thymic developmental defects and the hairless (nude) phe

72 nging the importance of this cytokine in the thymic developmental process.

73 Altogether, shared thymic differentiation processes generate "preset" NKT a

74 fector properties preprogrammed during their thymic differentiation.

75 n and unique roles of geranylgeranylation in thymic egress and highlight that the interplay between c

76 develop in a cell-intrinsic manner following thymic egress.

77 ts exhibited follicular features as early as thymic egress.

78 es also had a lower proportion of recent CD4 thymic emigrants (10.9% vs 18.6%, P = .05), a higher pro

79 ls, which are also characteristics of recent thymic emigrants (RTEs).

80 Functional assays support recent thymic emigrants as the precursors of CD4 T(SCM).

81 Within peripheral tissues iNKT cell recent thymic emigrants exhibit a different TCR repertoire than

82 Recent thymic emigrants that fail postpositive selection matura

83 of CD3(+) CD45RA(+) CD62L(+) CD31(+) recent thymic emigrants was associated with a loss of sense of

84 in newly arising T cells (so-called "recent thymic emigrants") in adults, as well as in babies.

85 ascular spaces and reduced numbers of recent thymic emigrants.

86 Collectively, we define a new axis for thymic emigration involving stimulation of the thymic mi

87 The cortical and medullary thymic epithelial cell (cTEC and mTEC) lineages are esse

88 Here we examine medullary thymic epithelial cell (mTEC) heterogeneity and its infl

89 FOXN1), a transcription factor essential for thymic epithelial cell (TEC) differentiation.

90 of B- and T-cell differentiation blocks and thymic epithelial cell defects, and induced robust cellu

91 ption factors and plays an important role in thymic epithelial cell differentiation and development.

92 r hypomorphic Rag mutations while preserving thymic epithelial cell homeostasis.

93 Cortical thymic epithelial cells (cTECs) regulate T cell lineage

94 Both medullary thymic epithelial cells (mTEC) and dendritic cells (DC)

95 o induce central T-cell tolerance, medullary thymic epithelial cells (mTEC) collectively express most

96 Medullary thymic epithelial cells (mTEC) contribute to the develop

97 able of mediating deletion, namely medullary thymic epithelial cells (mTECs) and dendritic cells, whe

98 Medullary thymic epithelial cells (mTECs) play a critical role in

99 Interactions between thymic epithelial cells (TEC) and developing thymocytes

100 e thymic epithelium and is required to prime thymic epithelial cells (TEC) for effective Treg inducti

101 FOXN1 gene dosage effect on the function of thymic epithelial cells (TECs) and thymopoiesis and post

102 The importance of thymic epithelial cells (TECs) is evidenced by clear lin

103 require LXRalphabeta for cholesterol efflux, thymic epithelial cells (TECs) use LXRalphabeta for self

104 ing bone marrow chimeras, GILT expression in thymic epithelial cells (TECs), but not hematopoietic ce

105 on cultured human thymic stroma, especially thymic epithelial cells (TECs).

106 E) critical for expression of Foxn1 in mouse thymic epithelial cells but dispensable for expression i

107 Mice deficient in Chd4 specifically in thymic epithelial cells exhibited autoimmune phenotypes,

108 Strikingly, medullary thymic epithelial cells expressing the autoimmune regula

109 g, whereas the function of individual mature thymic epithelial cells is compromised only modestly.

110 PRRSV-induced autophagy in thymic epithelial cells modulates the development of T c

111 eletion of Rank (also known as Tnfrsf11a) in thymic epithelial cells results in impaired thymic invol

112 urface of B cells, dendritic cells, cortical thymic epithelial cells, and medullary thymic epithelial

113 teraction with its ligand CXCL12 on cortical thymic epithelial cells, and that disruption of CXCR4-CX

114 in the self-antigen expression in medullary thymic epithelial cells.

115 n a manner that depends on AIRE(+) medullary thymic epithelial cells.

116 tical thymic epithelial cells, and medullary thymic epithelial cells.

117 tissue-restricted self-antigens in medullary thymic epithelial cells.

118 B7-expressing dendritic cells, B cells, and thymic epithelial cells.

119 le for MHC II ubiquitination specifically in thymic epithelial cells.

120 -lineages are thought to arise from a common thymic epithelial progenitor cell (TEPC).

121 SCLC], small-cell lung cancer, mesothelioma, thymic epithelial tumours, and other pulmonary neuroendo

122 Age-associated decreases in thymic-epithelial cell ( P < 0.01) and thymocyte markers

123 actor 4 (Irf4) is highly expressed in murine thymic epithelium and is required to prime thymic epithe

124 FOXN1 is the master regulatory gene of thymic epithelium development.

125 The depletion of Rank in the mouse thymic epithelium results in reduced accumulation of nat

126 re of presented self-peptides by B cells and thymic epithelium.

127 Importantly, normal thymic expression in DMD patients(6) should protect utro

128 In broilers, acute heat stress changed thymic expression responses to LPS and could impact thym

129 in situ CD8alphaalpha(+) T cell populations, thymic fibroblast subtypes, and activated dendritic cell

130 Thus, strategies that restore thymic function and enhance T cell reconstitution can pr

131 ions establish a FOXN1 gene dosage effect on thymic function and identify FOXN1 haploinsufficiency as

132 ng rATG treatment, partly caused by hampered thymic function, is being discussed.

133 This work establishes the relevance of thymic function, measured by sj/beta-TREC ratio, in HIV

134 LAM family receptor expression revealed that thymic gammadelta T cell subsets were each marked by dis

135 combination with STAT5 is critical for post-thymic gammadeltaT17 development and tissue-specific imp

136 levels had no notable impact on the rate of thymic generation or emigration of CD8 single-positive T

137 ssion of Myc in adult TEC similarly promotes thymic growth.

138 Neonatal life marks the apogee of murine thymic growth.

139 here that intestinal microbes influence the thymic homeostasis of PLZF-expressing cells in early lif

140 Mbnl1 129S1 knockout mice develop postnatal thymic hyperplasia with thymocyte accumulation.

141 ociated with T-cell lymphopenia and probable thymic hypoplasia in human subjects, and haploinsufficie

142 he Foxn1 compound heterozygous mutations had thymic hypoplasia, causing a T-B+NK+ SCID phenotype, whe

143 Thymic hypoplasia/aplasia occurs as a part of DiGeorge s

144 These thymic ILC2s exit the thymus, circulate in the blood, an

145 or T cells and inhibiting the elimination of thymic ILCs improved thymopoiesis in an IL-22-dependent

146 The current understanding of the nature of thymic immigrants is largely based on data from pre-clin

147 es signals emanating from the TCR to control thymic iNKT cell tolerance induction, terminal different

148 Nonetheless, the developing thymic iNKT cells that emerged in these chimeras express

149 bolism and immunity-critically contribute to thymic integrity and function.

150 opy of the native thymus, when combined with thymic interstitial cells and a natural decellularised e

151 Here, we profiled >10,000 differentiating thymic invariant natural killer T (iNKT) cells using sin

152 thymic epithelial cells results in impaired thymic involution and blunted expansion of natural regul

153 as reduced hematopoietic stem cell function, thymic involution and decreased lymphoid output with a s

154 Thymic involution and proliferation of naive T cells bot

155 eurological insults also induced significant thymic involution and rendered serum immunosuppressive.

156 Both thymic involution and serum-derived immunosuppression we

157 We determined that thymic involution was a hallmark feature of immunosuppre

158 Using parabiosis we report that thymic involution, declines in peripheral T-cell counts,

159 In addition to thymic involution, we determined that tumour growth in t

160 te effects of developmental programming upon thymic involution.

161 y have implications for the role of FOXN1 in thymic involution.

162 ommunication between intestinal microbes and thymic lymphocytes in the neonatal period that can modul

163 ts under 50 y with AChR autoantibody MG have thymic lymphofollicular hyperplasia.

164 in an FeLV isolate from naturally occurring thymic lymphoma and a mouse ERV, suggesting a common mec

165 a shorter lifespan associated with onset of thymic lymphomas, revealing a genome caretaking function

166 Although thymic macrophages require LXRalphabeta for cholesterol

167 invariant natural killer T cells through the thymic maturation process and facilitate proper host res

168 rapid postnatal growth results in premature thymic maturation, resulting in accelerated thymic aging

169 ) accessory molecule mainly expressed in the thymic medulla and B cells.

170 d IL-4-producing NKT2 cells localized to the thymic medulla, suggesting that medullary signals might

171 tiation associated with the development of a thymic medulla.

172 ntigens whose expression and presentation by thymic medullary epithelial cells (mTECs) is controlled

173 c expression of tissue-specific genes in the thymic medullary epithelium.

174 d GP2(+) mTEC were randomly dispersed within thymic medullary islands.

175 The identification of a discrete JAG1(+) thymic medullary niche enriched for DC-lineage cells exp

176 by which IL-4 and IL-13 cytokines condition thymic microenvironment to rheostat T cell selection and

177 ymic emigration involving stimulation of the thymic microenvironment via type 2 cytokines from innate

178 Thus, post-thymic modification of the TCR-repertoire underpins the

179 vascular endothelial growth factor (VEGF) on thymic morphogenesis beyond its well-known role in angio

180 egulator (AIRE) protein is the key factor in thymic negative selection of autoreactive T cells by pro

181 h peripheral NKT cells, the proliferation of thymic NKT cells was significantly impaired when CD28 en

182 require CD28-costimulation in either of the thymic NKT subsets, underlining a dichotomy between requ

183 from TEC plus thymic or splenic DC, whereas thymic or splenic B cells were poor donors.

184 thymic DC readily acquired MHC from TEC plus thymic or splenic DC, whereas thymic or splenic B cells

185 The PSC-artificial thymic organoid (ATO) system presented here is an effici

186 We describe here a serum-free, artificial thymic organoid (ATO) system that supports efficient and

187 Further evidence suggests a thymic origin of these mutant ILC2s.

188 Peak thymic output occurs in utero, during infancy, and in ea

189 nitiated by early cessation or diminution of thymic output.

190 the growth phase of the thymus and enhances thymic output; meanwhile, inducible expression of Myc in

191 Thymic phagocytes serve to remove dead thymocytes, but w

192 Importantly, perturbations in thymic PLZF(+) cells brought about by alterations in ear

193 mmadelta T cells and identify an unpolarized thymic population which is expanded in the blood and lym

194 However, detailed mechanisms underlying this thymic positive selection are not clear.

195 ol the lineage programming and maturation of thymic precursor cells.

196 l self-reactivity of a mature post-selection thymic precursor pool may likely ensure adequate control

197 Their thymic precursors (IELps) include PD-1+ type A and Tbet+

198 loping T lymphocytes, and their possible pre-thymic precursors in the early human fetus.

199 ent of central immune tolerance by promoting thymic presentation of tissue-specific molecules.

200 ination of declining peripheral division and thymic production during adulthood.

201 ed TEC subset frequency and phenotype, early thymic progenitor (ETP) cell count, and expression of FO

202 Thus, ageing disrupts thymic progenitor differentiation and impairs the core i

203 + peripheral CD4+ T cells, in keeping with a thymic progenitor-like pattern.

204 Early thymic progenitors (ETPs) are bone marrow-derived hemato

205 Early thymic progenitors (ETPs) are endowed with diverse poten

206 reservoir for AML initiating cells and that thymic progenitors can transmit AML.

207 CD34(+) thymic progenitors were comprised of a spectrum of speci

208 ifferentiation of ILC2s from bone marrow and thymic progenitors while promoting the development of B

209 However, whether such thymic programming and age-dependent generation of invar

210 ion relative to CD31 expression, a marker of thymic proximity for the CD4+ naive T-cell population.

211 IL-21 has been shown to accelerate thymic recovery in mice treated with glucocorticoids and

212 static premature involution and orchestrates thymic regeneration following stress, while thymocyte-de

213 Thymic regulatory T cells (tTreg) are critical in the ma

214 ential and enacts commitment of HR(+)ETPs to thymic resident CD11c(+)CD8alpha(+) dendritic cells (DCs

215 on to fine tune subset-specific responses by thymic resident NKT cells and contextually shape the mil

216 CD28 and CTLA-4 in driving the activation of thymic resident NKT cells.

217 A subset of mature NKT cells remain thymic resident, but their activation and function remai

218 Transcriptomic analysis of thymic RNA revealed divergence in global transcriptomic

219 Our study demonstrates that MHC-independent thymic selection can yield DN T cells that are distinct

220 e native Ags, highlighting the importance of thymic selection in determining TCR ligand specificity.

221 authors were able to demonstrate that human thymic selection is a major driver of TCR sequence shari

222 Thymic selection of MHC-independent TCR is largely uncon

223 is selected in the thymus, but the basis for thymic selection of MHC-restricted TCRs from a randomly

224 e is shaped by individual MHC context during thymic selection of naive T cells.

225 n epithelial cells of the thymus impairs the thymic selection of T cells and results in both an incre

226 ls were used as a model, as the influence of thymic selection on the T-cell repertoire directed again

227 erential effects on epitope presentation and thymic selection, thereby altering CD4 T-cell precursor

228 ipheral CD8(+) T-cell expansion and possibly thymic selection.

229 ed a reconsideration of the classic model of thymic selection.

230 study is the first to demonstrate a role for thymic selection.

231 igher rates of apoptosis and interacted with thymic self antigens with higher affinity than did Foxp3

232 for the primary outcome of the trial (infant thymic size) were described previously; here, we report

233 Here, using a murine thymic slice model in which thymocytes undergo negative

234 ur studies have identified a genomic RE with thymic-specific control of Foxn1 gene expression.

235 The release of several cytokines by cultured thymic stroma cells in response to rATG was analyzed via

236 nly used rATG preparations on cultured human thymic stroma, especially thymic epithelial cells (TECs)

237 depends on the epithelial compartment of the thymic stroma.

238 re samples to shed light on the emergence of thymic stromal cell types, the first developing T lympho

239 opment and function through their effects on thymic stromal cells and innate cell types.

240 the endothelial, mesenchymal and epithelial thymic stromal compartments, mimicking changes seen duri

241 decreased the IL-1beta-mediated increases in thymic stromal lymphopoietin (TSLP) and GM-CSF in primar

242 thelial cell-derived danger signal mediators thymic stromal lymphopoietin (TSLP) and IL-33 are consis

243 ted that this was the result of secretion of thymic stromal lymphopoietin (TSLP) by cancer cells.

244 Further, the cytokine thymic stromal lymphopoietin (TSLP) has recently been sh

245 Thymic stromal lymphopoietin (TSLP) is an epithelial-der

246 IL13, C-C motif chemokine ligand 26 (CCL26), thymic stromal lymphopoietin (TSLP), Charcot-Leyden crys

247 The epithelial cell-derived cytokines thymic stromal lymphopoietin (TSLP), IL-33, and IL-25 ar

248 ht to dissect its role, also in synergy with thymic stromal lymphopoietin (TSLP), in airway inflammat

249 fic for the epithelial-cell-derived cytokine thymic stromal lymphopoietin (TSLP), in patients whose a

250 et that expresses interleukin-33 (IL-33) and thymic stromal lymphopoietin (TSLP).

251 triggering inflammation via the induction of thymic stromal lymphopoietin (TSLP).

252 re recruited to inflamed skin via CXCL12 and thymic stromal lymphopoietin (TSLP)/IL-3-dependent upreg

253 ed nearly all the cytokine release including thymic stromal lymphopoietin and endothelin-1.

254 Thymic stromal lymphopoietin and IL-33 signaling recipro

255 17 responses, along with increased IL-36 and thymic stromal lymphopoietin expression, which were furt

256 nd activation-regulated chemokine, IL-5, and thymic stromal lymphopoietin levels were significantly i

257 Thymic stromal lymphopoietin receptor deficient mice had

258 ulate COX-2 upon IL-2, IL-25, and IL-33 plus thymic stromal lymphopoietin stimulation.

259 cytokine responses such as IL-25, IL-33, and thymic stromal lymphopoietin, and increasing the epithel

260 Their persistence in skin required IL-7 and thymic stromal lymphopoietin, and localization was depen

261 AD-related cytokines thymic stromal lymphopoietin, endothelin-1, and inflamma

262 miR-1 recruited P-selectin, thymic stromal lymphopoietin, eotaxin-3, and thrombopoie

263 d cells (ILC2s); dendritic cells primed with thymic stromal lymphopoietin, IL-25, and IL-33; and B an

264 ured in the presence of IL-3, IL-33, GM-CSF, thymic stromal lymphopoietin, or IL-25.

265 Tumor necrosis factor-alpha potentiated thymic stromal lymphopoietin-induced Ca(2+)-influx, wher

266 al keratinocytes increased the production of thymic stromal lymphopoietin.

267 The thymic structure of patients with partial DiGeorge syndr

268 ds chosen to reflect experimentally observed thymic survival rates result in near-optimal production

269 IL-15, and IL-6, cytokines being involved in thymic T cell development and proliferation.

270 It is required for normal thymic T cell development and serves as a tumor suppress

271 -21 plays an important complementary role in thymic T cell development, which, to date, has been unde

272 nization of the mucosal tract also shape the thymic T cell repertoire is unclear.

273 nd that continuous IL-2 production sustained thymic T reg cell generation and control of systemic imm

274 This IL-2-dependent scaling of thymic T reg cell generation by overall self-reactivity

275 Thus, our results suggest that the thymic T reg cell pool size is scaled by a key niche fac

276 pression of Foxp3 in thymocytes and promoted thymic T(reg) (tT(reg)) cell development.

277 on of different diverter TCRs to the nascent thymic T(reg) cell population reflected their antigen re

278 promotes the hormone-mediated development of thymic T(reg) cells during pregnancy, and expand the fun

279 cular progesterone, drive the development of thymic T(reg) cells through RANK in a manner that depend

280 r the contribution of different cytokines to thymic T(reg) development and the cellular populations t

281 the originally proposed "two-step" model of thymic T(reg) differentiation by incorporating new evide

282 Thymic T(reg) were significantly reduced in MHCIIKR(KI/K

283 The recuperated group had longer thymic telomeres than controls ( P < 0.001) at 22 d and

284 By 12 mo, recuperated offspring had shorter thymic telomeres than controls had ( P < 0.001) and redu

285 tation of hematopoietic stem cells and human thymic tissue (human BLT [Hu-BLT]).

286 aimed at generating/regenerating functional thymic tissue in vitro and in vivo.

287 Ideally, some thymic tissue should be preserved at the time of surgery

288 s, and histologic/transcriptomic analyses of thymic tissue.

289 lay aberrant phenotypes, particularly in the thymic Treg (tTreg) compartment, potentially because of

290 generated during thymic development (called thymic Treg [tTreg] cells) or derived from mature conven

291 GITR, whose stimulation is closely linked to thymic Treg cell development.

292 A20-deficient thymic Treg cells exhibit reduced dependence on IL-2 but

293 we show that IL-2R signaling is required by thymic Tregs at an early step for expansion and survival

294 IL-2R transcriptional signature is noted for thymic Tregs versus peripheral Tregs.

295 ene expression profile in peripheral but not thymic Tregs with increased expression of inhibitory rec

296 of LTbetaR is essential for the development thymic tuft cells which regulate NKT2 via IL-25, while L

297 ells, particularly dendritic cells, from the thymic tumor microenvironment support the survival and p

298 related tumors (regardless of tumor size and thymic tumor pejorative impact), large tumors over 2 cm,

299 through deletion of SAP resulted in impaired thymic Vgamma1 and Vgamma4 T cell maturation at the CD24

300 lyzed the CDR3 of the TCR of human blood and thymic Vgamma9Vdelta2 T cells from fetal until adult lif