ライフサイエンスコーパス: thymidine

1 cleosides: cytidine, uridine, adenosine, and thymidine.

2 ine triphosphatelation of [(3)H]TMP to [(3)H]thymidine.

3 cy by re-examining the SP formation using d3-thymidine.

4 is hypersensitivity is reversed by exogenous thymidine.

5 fic TP/PyNP inhibitor (TPI), or by exogenous thymidine.

6 in, including ethanols, propionic acids, and thymidine.

7 re we report Peroxy-Caged-[(18)F]Fluorodeoxy thymidine-1 (PC-FLT-1), an oxidatively immolative positr

8 +2] cycloaddition reaction with the opposing thymidine, 2'-deoxycytidine, or 2'-deoxyadenosine.

9 y cleavage of the C3'-O bond of TpT, whereas thymidine 3'-monophosphate (TMP3') and 2',5'-dideoxythym

10 radioactive DNA replication marker tritiated thymidine ([(3)H]dT, or TdR) at early embryonic ages wer

11 iphospho-beta-l-rhamnose (UDP-beta-l-Rha) or thymidine 5'-diphospho-beta-l-rhamnose (TDP-beta-l-Rha).

12 The formation of thymidine 5'-monophosphate (TMP5') together with 2',3'-d

13 Analogues 1-3 at 100 muM inhibited thymidine 5'-monophosphate p-nitrophenyl ester hydrolysi

14 eration and isolation of various thymine and thymidine 5,6-epoxides from the corresponding trans-5,6-

15 phenylalanine, as well as nucleosides (e.g. thymidine, 5'-methylthioadenosine, xanthosine), the orga

16 rivatives of UV-induced DNA lesions, namely, thymidine (6-4) photoproducts.

17 kylation of DNA, and the resulting alkylated thymidine (alkyldT) lesions were found to be poorly repa

18 20, 455 nm) light led to the release of free thymidine along with the competitive generation of a thy

19 ncorporation and fluorescent labeling of the thymidine analog 5-ethynyl-2'-deoxyuridine (EdU) into na

20 Using the thymidine analog 5-ethynyl-2'-deoxyuridine to monitor DN

21 Using a low-dose thymidine analog incorporation assay, we examine whether

22 nd an AZT-resistant (AZT(R)) RT containing a thymidine analog mutation set-D67N, K70R, D215F, and K21

23 ith preferential tenofovir activity, >/= two thymidine analog mutations (TAMs) or Q151M, occurred in

24 oexisted unlinked with variants carrying 2-5 thymidine analog mutations at frequencies of 1.6%-23.0%.

25 dividuals and are highly associated with the thymidine analog mutations D67N and K70R, which confer d

26 with nucleoside resistance including type 2 thymidine analog mutations, K65R, a T69del, and M184V.

27 owing for reporter-specific detection with a thymidine analog probe.

28 ntrols, received 10 weekly injections of the thymidine analog, bromodeoxyuridine (BrdU) to mark new c

29 (ts)T is thereby a "smart" thymidine analog, exhibiting a 28-fold brighter fluoresc

30 5-ethynyl-2'deoxyuridine (EdU)-a thymidine analog-containing minipumps were inserted at t

31 ntate gyrus (DG) were labeled with different thymidine analogs (EdU, IdU, and CldU) at 4, 8, and 21 d

32 malian cells have the ability to incorporate thymidine analogs along with the natural A, T, G and C b

33 of cells in the entire retina employing the thymidine analogs and also determined their phenotype by

34 ed alpha-cells, we sequentially administered thymidine analogs and quantified their incorporation int

35 full agreement with previous findings using thymidine analogs and retroviral labeling, thus providin

36 e Technologies MinION to detect 11 different thymidine analogs including CldU, BrdU, IdU as well as E

37 ronal death was induced by standard doses of thymidine analogs, but disappeared when low doses were u

38 and three cell cycle analysis methods using thymidine analogs, we determined the proliferation dynam

39 ration imaging mainly based on (18)F-labeled thymidine analogs.

40 The thymidine analogue (DMA)T was used for the first fluores

41 ficiency virus (HIV)-positive individuals on thymidine analogue backbone antiretroviral therapy (ART)

42 The synthesis of a novel bicyclic thymidine analogue carrying a beta-fluoro substituent at

43 , i.e., mitotic quiescence with retention of thymidine analogue label and activation by injury.

44 94% vs 44%), M184V/I (94% vs 26%), and >/= 1 thymidine analogue mutations (47% vs 18%), all P = .01;

45 % acquired DRMs were found, including M184V, thymidine analogue mutations (T215F, D67N, K70R, K219Q),

46 investigate the prevalence and correlates of thymidine analogue mutations (TAM) in patients with viro

47 The thymidine analogue mutations, M184V/I and the tenofovir-

48 The subsequent identification of thymidine analogue nucleoside reverse transcriptase inhi

49 BMS-986001 is a thymidine analogue nucleoside reverse transcriptase inhi

50 HIV-1 drug resistance to older thymidine analogue nucleoside reverse transcriptase inhi

51 Among PWH without thymidine analogue or didanosine exposure, time since in

52 e incorporations of our previously published thymidine analogue, 5-(1-phenyl-1H-1,2,3-triazol-4-yl)-2

53 A thymidine analogue, bromodeoxyuridine (BrdU), was added

54 At least 1 thymidine-analogue mutations was present in 2.7% of pati

55 ver, the presence of common TDRMs, including thymidine-analogue mutations/T215rev, showed no impact o

56 such as M41L, D67N, K70R, or S215Y (known as thymidine-analogue resistance mutations (TAMs)) are rare

57 e in the range of +1-2 degrees C compared to thymidine and +1-3 degrees C compared to a standard bc-T

58 provide insights into the pathogenic role of thymidine and deoxyuridine imbalance in mitochondrial ne

59 ked elevations of the pyrimidine nucleosides thymidine and deoxyuridine in plasma and tissues, and so

60 phosphorylase activity deficiency, elevated thymidine and deoxyuridine in tissues, mitochondrial DNA

61 Mutant mice treated with exogenous thymidine and deoxyuridine showed reduced survival, body

62 stressed double knockout mice with exogenous thymidine and deoxyuridine, and assessed clinical, neuro

63 Elevated plasma and urine thymidine and deoxyuridine, and genetic testing for TYMP

64 nd matrix cells (M cells) in cats with (3) H-thymidine and followed their distributions during fetal

65 tion forks, which reduces the consumption of thymidine and increases resistance to trimethoprim under

66 h a noncompetitive inhibition mode with both thymidine and inorganic phosphate substrates.

67 production were measured by using tritiated thymidine and Luminex MagPix, respectively.

68 ased on labelling of nascent DNA with 4-thio-thymidine and nucleoside conversion chemistry.

69 the mitochondrial isoform required exogenous thymidine and purine but not glycine for optimal growth

70 Here we show that dietary thymidine and serine enhance 5-fluoro 2'deoxyuridine (FU

71 re the first CpG motif is preceded by the 5'-thymidine and the elongated poly-thymidine tail at the 3

72 in pH, calcium, magnesium, zinc, potassium, thymidine, and polysorbate 80 levels were tested by BMD

73 n its structure and reactivity have utilized thymidine as a precursor, which limits quantitative prod

74 (3)H]TTP than the amount observed with [(3)H]thymidine as the precursor.

75 Tritiated thymidine based lymphocyte proliferation assays and inte

76 e along with the competitive generation of a thymidine-bearing recombination product.

77 -thymidine with varying amounts of unlabeled thymidine before the SP photochemistry is performed.

78 A protein peaked 12 hours after release from thymidine block, corresponding to M-phase.

79 nucleotide radical anion, thymidylyl(3'-->5')thymidine, can be directly probed with femtosecond stimu

80 ulator cytosine-cytosine-adenosine-adenosine-thymidine (CCAAT)/enhancer-binding protein homologous pr

81 g properties displayed by two coumarin-caged thymidine compounds, each conjugated with (2) or without

82 nografts, which was accompanied by low tumor thymidine concentrations, suggesting that tumor thymidin

83 on, efficiently spliced lincRNAs have higher thymidine content in the polypyrimidine tract (PPT) comp

84 High frequency of cytidine to thymidine conversions was identified in the genome of se

85 ffects of uracil incorporation into DNA from thymidine-deficient nucleotide pools.

86 variants detected in these participants were thymidine dependent.

87 1.33-3.57; p=0.0021), whereas those with non-thymidine-dependent small-colony variants did not.

88 Children with thymidine-dependent small-colony variants had significan

89 with small-colony variants, and particularly thymidine-dependent small-colony variants, was common in

90 Small colony variants of the thymidine-dependent subtype had the strongest associatio

91 liferation arrest is characterized by severe thymidine depletion, and supplying exogenous thymine res

92 A thymidine-derived bicyclic monomer, 3',5'-cyclic 3-(3-bu

93 affinity of RecA binding to DNAs carrying a thymidine dimer than to those with an abasic site.

94 The length polymorphism of guanosine thymidine dinucleotide repeats in the heme oxygenase-1 g

95 nalyzed the allelic frequencies of guanosine thymidine dinucleotide repeats in the heme oxygenase-1 g

96 In conclusion, a greater number of guanosine thymidine dinucleotide repeats in the heme oxygenase-1 g

97 The DNA nucleoside, thymidine, does not self-assemble into stable adlayers b

98 coli thyA mutants growing in the absence of thymidine (dT) is preceded by a substantial resistance p

99 cells avoid lethal replication stress after thymidine (dT)-induced inhibition of DNP dCTP synthesis

100 marked reduction in intracellular levels of thymidine, due to suppression of both uptake and de novo

101 as the platform for the chiral resolution of thymidine enantiomers.

102 he resulting poly(3',5'-cyclic 3-(3-butenyl) thymidine ethylphosphate)s with low dispersities (D < 1.

103 bicyclic monomer, 3',5'-cyclic 3-(3-butenyl) thymidine ethylphosphate, was synthesized in two steps d

104 ent with the photolysis of 2, which released thymidine exclusively with higher quantum efficiency.

105 Thymidine exudation could be attributed to ABCG36 functi

106 levels were imageable with [(18)F]-fluoro-L-thymidine (FLT)-positron emission tomography (PET).

107 some agar types and also with potassium and thymidine for S. pneumoniae For all other variations, ge

108 Diastereomeric mixtures of thymidine glycol and the corresponding 5-hydroxperoxides

109 osure times to LPS, lipoteichoic acid (LTA), thymidine homopolymer phosphorothioate oligonucleotide [

110 ed distribution must be co-determined by the thymidine hydroxylases (JBP1 and JBP2) that catalyze the

111 ces the sole intracellular de novo source of thymidine (i.e., the DNA base T) and thus is a common ta

112 ron spectroscopy is performed on thymine and thymidine in aqueous solution to study the excited-state

113 addition between an alkyne-functionalized C5-thymidine in DNA and an azide-containing 10-mer peptide.

114 se there is no interaction between OPV3T and thymidine in solution, the liquid/solid interface acts a

115 n is highly sensitive to the trace protiated thymidine in the starting material.

116 ntigens using proliferation assays (based on thymidine incorporation and carboxyfluorescein succinimi

117 knock-out (P4KO) mice showed impaired [(3)H]thymidine incorporation and G1 phase arrest as compared

118 Proliferation was measured by (3)H-thymidine incorporation and TGF-beta by RT-PCR and ELISA

119 or determining T cell responses (i.e., [(3)H]thymidine incorporation and the use of cell proliferatio

120 ocyte proliferation was demonstrated by (3)H thymidine incorporation assay and carboxyfluorescein suc

121 Tritiated thymidine incorporation assay revealed that Cu(GTSC) and

122 ed Ki-67 mRNA expression levels and enhanced thymidine incorporation in Wnt6-treated macrophage cultu

123 Liver regeneration peaked at 24 h ([(3)H]-thymidine incorporation into hepatic DNA and mitotic ind

124 rtial hepatectomy and peaked at 32 h ([(3)H]-thymidine incorporation into hepatic DNA and mitotic ind

125 Liver regeneration was evaluated by [(3)H]-thymidine incorporation into hepatic DNA, the mitotic in

126 transgenic OT-II) was measured via a [(3)H]-thymidine incorporation proliferation assay.

127 cytometry), T-cell proliferative responses (thymidine incorporation), and cytokine expression (Fluor

128 id not prevent the GH stimulatory effects on thymidine incorporation, collagen X, and IGF-1 expressio

129 mM peptides for 7 days) was assessed by (3)H-thymidine incorporation.

130 tometry and lymphocyte proliferation by (3)H-thymidine incorporation.

131 eus-specific T-cells were quantified by (3)H-thymidine incorporation; cytokine release was measured b

132 Parallel [3H]-leucine and [3H]-thymidine incubations indicated active protein and DNA s

133 ine nucleosides uridine, 2'-deoxyuridine and thymidine inhibited mycoplasma-associated dFdC deaminati

134 yme assay and by the inhibition of precursor thymidine into DNA during cell growth.

135 Out of the five randomized bases, a 5' thymidine is present in most of the top ranking elements

136 limits quantitative product analysis because thymidine is readily reformed from 1.

137 Thymidine is the major product (33%) from 1 at pH 7.2.

138 N3-Methyl-thymidine is, however, the major product and is produced

139 f dual specific vector, herpes simplex virus thymidine kinase (HSV-TK) gene was introduced for cancer

140 rthermore, an unrelated herpes simplex virus-thymidine kinase (HSV-TK) promoter was strongly represse

141 We also co-express Herpes Simplex Virus thymidine kinase (HSV-tk) with the transposase.

142 cent cells expressing herpes simplex virus 1 thymidine kinase (HSV-TK).

143 s a truncated form of herpes simplex virus 1 thymidine kinase (HSV-TK).

144 The herpes simplex virus type 1 thymidine kinase (HSV1-tk) gene has previously been tran

145 onverting enzyme herpes simplex virus type 1 thymidine kinase (HSV1-tk) into the genomes of cancer ce

146 an engineered cyclic herpes simplex virus 1-thymidine kinase (HSV1-TK) PET reporter whose kinase act

147 nt (hdCKDM), and herpes simplex virus type 1 thymidine kinase (hsvTK) reporter genes.

148 ssing the suicide gene, herpes simplex virus thymidine kinase (HSVtk), driven by the promoter of stim

149 es Cre/lox-assisted cell fate mapping with a thymidine kinase (sr39tk) reporter gene for cell detecti

150 cation of the pht genes between the putative thymidine kinase (tdk) and phosphopentomutase (deoB) gen

151 pendent prognostic impact was found for FCR, thymidine kinase (TK) >/=10 U/L, unmutated IGHV, 11q del

152 Paradoxically, the thymidine kinase (TK) encoded by Kaposi sarcoma-associat

153 ncrease in mutation frequency as detected by thymidine kinase (TK) gene mutation assay.

154 Thymidine kinase (TK) is a key enzyme in the pyrimidine

155 Mutagenicity was assessed at the thymidine kinase (TK) locus, CYP1A activity was determin

156 We investigated thymidine kinase (tk) mutants isolated during multiple e

157 AT(+) virus had higher levels of ICP0, ICP4, thymidine kinase (TK), and PD-1 ligand 1 (PD-L1) transcr

158 ncode ribonucleotide kinase B subunit (RRB), thymidine kinase (TK), and UL9-like origin binding prote

159 ynthesis and salvage, such as those encoding thymidine kinase (TK), cytidylate kinase, and purine nuc

160 KSHV thymidine kinase (TK), the ORF21 gene product, can enhan

161 ORF21 encodes KSHV thymidine kinase (TK), which increases the pool of dTTP

162 clin B1-interacting protein 1 (Ccnb1ip1) and thymidine kinase (TK1).

163 er into the VC2 vector in place of the HSV-1 thymidine kinase (UL23) gene.

164 y regulate other 5-FU targets, such as TYMS, thymidine kinase 1 (TK-1) and thymidine phosphorylase (T

165 d expression of thymidylate synthase (TYMS), thymidine kinase 1 (TK-1), and equilibrative nucleoside

166 ed in both models, which was correlated with thymidine kinase 1 (TK1) expression.

167 ilibrative nucleoside transporter 1 (hENT1), thymidine kinase 1 (TK1), thymidylate synthase, and thym

168 he fact that (18)F-FLT uptake is mediated by thymidine kinase 1 expression, which is higher in active

169 o deoxynucleoside treatment in patients with thymidine kinase 2 (TK2) deficiency and compared it to F

170 Mitochondrial DNA depletion caused by thymidine kinase 2 (TK2) deficiency can be compensated b

171 Thymidine kinase 2 (TK2), a critical enzyme in the mitoc

172 requires thymidine salvage by mitochondrial thymidine kinase 2 (TK2).

173 the mitochondrial nucleotide salvage enzyme thymidine kinase 2 (TK2).

174 Thymidine kinase 2, encoded by the nuclear gene TK2, is

175 , a phylogenetic tree is constructed for the thymidine kinase 2-like dNK gene family in metazoa.

176 ) and genotypically (sequencing of the viral thymidine kinase and DNA polymerase genes).

177 ters, the mutant herpes simplex virus type I thymidine kinase and the human sodium-iodide symporter.

178 KSHV thymidine kinase can phosphorylate zidovudine and gancic

179 Thymidine kinase catalyzes the first step in the nucleot

180 Our results suggest that thymidine kinase contributes to several DNA repair pathw

181 Tg) mice expressing the herpes simplex virus thymidine kinase gene (HSV-Tk) driven by the mouse GFAP

182 the model plant Arabidopsis thaliana has two thymidine kinase genes (AtTK1a and AtTK1b) and microarra

183 Of note, exogenous expression of HSV-1 thymidine kinase increased the incorporation efficiency

184 V also inhibited the replication of an HSV-1 thymidine kinase mutant resistant to nucleoside analogue

185 -mediated microglial ablation on tga20/CD11b-thymidine kinase of Herpes simplex virus (HSVTK) cerebel

186 We show that thymidine kinase provides a route to thymidine monophosp

187 adult neurogenesis in naive transgenic GFAP-thymidine kinase rats resulted in social behavior simila

188 uction of new neurons in socially naive GFAP-thymidine kinase rats showed that loss of 6-week-old neu

189 p21-driven truncated herpes simplex virus-1 thymidine kinase sr39 mutant (ttksr39) in vitro and in v

190 In mammals thymidine kinase supplies deoxyribonucleotides for DNA r

191 rferon response independent of its canonical thymidine kinase target.

192 ed to deliver the human Herpes simplex virus thymidine kinase type-1 (HSVtk) gene, which has a dual f

193 acterial maltodextrin transporter, bacterial thymidine kinase, antibiotics, antimicrobial peptides, b

194 ates, including securin, cyclin A, cyclin B, thymidine kinase, geminin, and many others.

195 drug converting enzyme, herpes simplex virus thymidine kinase, into therapeutic S-TRAIL secreting ste

196 found that thymidine uptake correlated with thymidine kinase-1 protein levels and that thymidine lev

197 ild-type CEM/O cells and more importantly in thymidine kinase-deficient CD4(+) T-cells (CEM/TK(-)).

198 e CD4(+) CEM T-cells and more importantly in thymidine kinase-deficient CD4(+) T-cells (CEM/TK(-)).

199 infected CEM/0 cells and more importantly in thymidine kinase-deficient CD4(+) T-cells.

200 ounds were highly active against HIV even in thymidine kinase-deficient CEM cells.

201 Initial inoculation with thymidine kinase-deficient HSV-1 (TK(del)) completely ab

202 struct provides a potential combination with thymidine kinase-mediated gene therapy to optimize the t

203 status, serum beta2-microglobulin, and serum thymidine kinase.

204 ses and phosphorylation to ddTMP by the host thymidine kinase.

205 cade, various enzyme/prodrug systems such as thymidine kinase/ganciclovir (TK/GCV), yeast cytosine de

206 al scars, respectively; therefore, we used a thymidine kinase/ganciclovir paradigm to ablate both div

207 It is trapped in cells in proportion to thymidine-kinase 1 enzyme expression, which is upregulat

208 paired when the minimum EBE was fused with a thymidine-kinase promoter but could be restored by fusio

209 O(2)- and O(4)-alkylated thymidine lesions are known to be poorly repaired and pe

210 also suggested that these carboxymethylated thymidine lesions may constitute efficient substrates fo

211 Clinicians should consider measuring plasma thymidine levels in suspected Crohn's disease to rule ou

212 midine concentrations, suggesting that tumor thymidine levels influence (18)F-FLT uptake in the tumor

213 Thymidine levels were determined by liquid chromatograph

214 h thymidine kinase-1 protein levels and that thymidine levels were imageable with [(18)F]-fluoro-L-th

215 these compounds are the first reports of non-thymidine-like inhibitors of Mtb TMK.

216 First, in broth cultures that mimicked thymidine limitation or starvation, L. pneumophila exhib

217 Galactose-modified thymidine, LNA-T, and 2'-amino-LNA-T nucleosides were sy

218 However, this thymidine maps to a region outside of the Pax half site

219 thway by transferring a phosphate group to a thymidine molecule.

220 melting probe embedded with a single locked thymidine monomer (tL) can reliably differentiate the fo

221 biochemical processes, including purine and thymidine monophosphate (dTMP) biosynthesis, mitochondri

222 e of ATP to 2'-deoxythymidine (dThd) forming thymidine monophosphate (dTMP).

223 g a colorimetric assay with p-nitrophenyl 5'-thymidine monophosphate (p-Nph-5'-TMP) as an artificial

224 ow that thymidine kinase provides a route to thymidine monophosphate in the absence of DHFR-TS.

225 Second, in medium that lacked thymidine, multicopy phtC(+) or phtD(+) alleles enhanced

226 anti-folate that inhibits de novo purine and thymidine nucleotide synthesis.

227 ization of this pathway and the transport of thymidine nucleotides are not well understood.

228 Model studies using thymidine nucleotides to lock in i-motif loop lengths su

229 showed that the minor-groove O(2)-alkylated thymidine (O(2)-alkyldT) lesions are poorly repaired and

230 O(2)- and O(4)-[4-(3-pyridyl)-4-oxobut-1-yl]-thymidine (O(2)-POBdT and O(4)-POBdT).

231 reasing the immobilization efficiency of the thymidine oligonucleotide, oligo(dT)25, and providing a

232 DarT is an enzyme that specifically modifies thymidines on single-stranded DNA in a sequence-specific

233 We investigated the metabolism of [(3)H]thymidine or [(3)H]TMP as precursors of [(3)H]TTP in iso

234 Proliferation was estimated using (3) H-thymidine or CFSE labeling and ICAM-1 blocking.

235 olic FPGS required exogenous glycine but not thymidine or purine, whereas cells expressing the mitoch

236 ficient diets and supplemented with uridine, thymidine, or deoxyuridine were bred, and litters (n = 1

237 ion with the pyrimidine nucleosides uridine, thymidine, or deoxyuridine with and without folate defic

238 e-1-phosphate, 2'-deoxyuridine/phosphate and thymidine/phosphate were analyzed.

239 Overexpressed human thymidine phosphorylase (hTP) has been associated with c

240 ne kinase 1 (TK1), thymidylate synthase, and thymidine phosphorylase (TP) were analyzed by Western bl

241 by mutations in TYMP gene, encoding nuclear thymidine phosphorylase (TP).

242 Platelets contain abundant thymidine phosphorylase (TYMP), which is highly expresse

243 such as TYMS, thymidine kinase 1 (TK-1) and thymidine phosphorylase (TYMP).

244 Here, we now identify thymidine phosphorylase (TYMP; previously known as endot

245 several features of these patients including thymidine phosphorylase activity deficiency, elevated th

246 Thymidine phosphorylase activity rose from undetectable

247 ccur later in life, and may reflect residual thymidine phosphorylase activity.

248 ve TYMP mutations cause severe reductions of thymidine phosphorylase activity; marked elevations of t

249 Thymidine phosphorylase and uridine phosphorylase double

250 disease due to TYMP mutations that result in thymidine phosphorylase deficiency.

251 oietic stem cell transplantation can restore thymidine phosphorylase enzyme function in patients with

252 Based on high thymidine phosphorylase expression in the liver, a 25-ye

253 mine and deoxyribose-1-phosphate by the host thymidine phosphorylase greatly increases the sensitivit

254 Thymidine phosphorylase replacement has been achieved by

255 ase caused by mutations in the gene encoding thymidine phosphorylase, leading to reduced enzymatic ac

256 istant from substrate binding sites, reduced thymidine phosphorylation 10-20-fold, and acyclovir phos

257 was evaluated using flow-cytometry and (3)H-thymidine proliferation assays, respectively.

258 Thymidine promotes microbial conversion of the prodrug F

259 Thymidine radical cation (1) is produced by ionizing rad

260 n contrast, in undamaged 2'-deoxyuridine and thymidine, reactions at elevated temperatures lead to th

261 de-modified 523 bp PCR amplicon with all 335 thymidines replaced by AHP dU was shown to be a perfect

262 ing radiation damage to 2'-deoxycytidine and thymidine, respectively, under anoxic conditions.

263 thway of TTP synthesis in the heart requires thymidine salvage by mitochondrial thymidine kinase 2 (T

264 ed that the phtC and phtD loci contribute to thymidine salvage in L. pneumophila.

265 these data, taken together, suggest that the thymidine salvage pathway is compartmentalized so that T

266 s death, the phenomenon of cell death due to thymidine starvation.

267 Using double-thymidine synchronization and immunoblotting, we observe

268 MTX inhibits thymidine synthesis by targeting dihydrofolate reductase

269 Folate one-carbon units support purine and thymidine synthesis, and thus cell growth.

270 2'-alpha-fluoro analogue of thymidylyl(3',5')thymidine, synthesized to probe the effect of a minimum

271 activity on both (5m)C (major activity) and thymidine (T) (minor activity) in all DNA forms tested,

272 methyluracil), an epigenetic modification of thymidine (T) confined to pathogenic protozoa such as Tr

273 eoside, we previously replaced around 75% of thymidine (T) with 5'-hydroxymethyl-2'-deoxyuridine (5hm

274 d by the 5'-thymidine and the elongated poly-thymidine tail at the 3' end of the ODN.

275 sis was initially studied with the tritiated thymidine technique, later replaced by the injection and

276 analogs (lamivudine and emtricitabine) and L-thymidine (telbivudine) have been widely used as antivir

277 for dyads containing BP covalently linked to thymidine, the aim of this work is to investigate whethe

278 trum from an absorption maximum at 267 nm in thymidine to 363 nm in 2,4-dithiothymine (DeltaE = 9905

279 We also show that cleavage of thymidine to thymine and deoxyribose-1-phosphate by the

280 we could introduce site-specific cytidine to thymidine transitions in the absence of targeted genomic

281 fatty acids, NADPH, NADP+, some amino acids, thymidine, trigonelline, nicotinic acid, 5,6-dihydrourac

282 chia coli); when fed food with a low uridine/thymidine (U/T) level, germline proliferation is arreste

283 5' or TMP3', and even further in the case of thymidine, underlining the critical role of the phosphat

284 ration of astrocytes based on increased (3)H-thymidine update.

285 n occurs between the coumarin moiety and the thymidine upon 350 nm irradiation forming both syn- and

286 We found that thymidine uptake correlated with thymidine kinase-1 prot

287 -cell and cytokine responses were studied by thymidine uptake, carboxyfluorescein diacetate succinimi

288 tion of alkyne- or azide-modified analogs of thymidine, uridine, methionine, and glucosamine to label

289 , was synthesized in two steps directly from thymidine, via butenylation and diastereoselective cycli

290 In broken mitochondria, [(3)H]thymidine was readily converted to [(3)H]TMP, but furthe

291 The results demonstrated that [(3)H]thymidine was readily metabolized by the mitochondrial s

292 Trifluoromethyl-1H-1,2,3-triazol-1-yl)methyl]thymidine was synthesized and incorporated as a phosphor

293 ryonic day [E]27-E35 following E24-E28 (3) H-thymidine) was characterized by a transient medial accum

294 contained all amino acids and low amounts of thymidine were treated with trimethoprim under aerobic a

295 tion-specific information for the nucleoside thymidine, where five of eight carbon positions were mea

296 iothymine, respectively, relative to that of thymidine, whereas the triplet yield increases 60-fold t

297 Thymidine, which is incorporated into DNA but not RNA, h

298 Replacement of thymidine with AHP dU increases duplex stability, accoun

299 We spiked the d3-thymidine with varying amounts of unlabeled thymidine be

300 es effectively convert specific cytidines to thymidines with 13% efficiency in Escherichia coli and 2