ライフサイエンスコーパス: thymidylate synthase

1 dihydropyrimidine dehydrogenase and targets thymidylate synthase.

2 e signaling molecules that can down-regulate thymidylate synthase.

3 ct as rTS signaling mimics and down-regulate thymidylate synthase.

4 docked against a conformational ensemble of thymidylate synthase.

5 not interfere with intermediate formation at thymidylate synthase.

6 with the enzymes dihydrofolate reductase and thymidylate synthase.

7 sential KSHV genes, the viral polymerase and thymidylate synthase.

8 e next enzyme in the dTTP synthetic pathway, thymidylate synthase.

9 Compound 3 was also a weak inhibitor of rh thymidylate synthase.

10 rch Institute against Toxoplasma gondii DHFR-thymidylate synthase.

11 phate, a tight binding covalent inhibitor of thymidylate synthase.

12 ate deoxyuridine and coupled the reaction to thymidylate synthase.

13 ompound, thereby enhancing the inhibition of thymidylate synthase.

14 ion of antiproliferative agents that inhibit thymidylate synthase.

15 than one site of action; the primary site is thymidylate synthase.

16 dium falciparum, dihydrofolate reductase and thymidylate synthase activities are conferred by a singl

17 BCG thyA mutants have reduced thymidylate synthase activity and are resistant to known

18 study we demonstrated that Escherichia coli thymidylate synthase activity could be restored complete

19 gs is the suggestion that the restoration of thymidylate synthase activity is due to a separation of

20 The manner in which thymidylate synthase activity is restored from the mutan

21 rpose, we employed two mutants with marginal thymidylate synthase activity, Y(94)A and R(126)E.

22 piens that has been implicated in regulating thymidylate synthase activity.

23 . coli NDP kinase interacts directly with T4 thymidylate synthase, aerobic ribonucleotide reductase,

24 of both endogenous and ectopically expressed thymidylate synthase alleles revealed that the mRNA-bind

25 s applied to generate a potent inhibitor for thymidylate synthase, an essential enzyme in pyrimidine

26 and is a major supplier of the substrate for thymidylate synthase, an important enzyme in DNA synthes

27 negatively charged dihydrofolate produced at thymidylate synthase and a series of lysine and arginine

28 nse-expressing dones exhibited a decrease in thymidylate synthase and an increase in thymidine phosph

29 FdUMP inhibits thymidylate synthase and causes the accumulation of urac

30 enzymes in its biosynthetic pathway, namely thymidylate synthase and cytoplasmic thymidine kinase.

31 by the fact that a 100-fold up-regulation of thymidylate synthase and dihydrofolate reductase (known

32 and trimethoprim (TOP), potent inhibitors of thymidylate synthase and dihydrofolate reductase, respec

33 thesis was linked to decreased expression of thymidylate synthase and dihydrofolate reductase.

34 thought to kill cells via the inhibition of thymidylate synthase and increased use of dUTP in place

35 Overexpression of thymidylate synthase and its adjacent gene, c-Yes, was d

36 f the basis of half-the-sites reactivity for thymidylate synthase and providing an example of such a

37 apeutics, including dihydrofolate reductase, thymidylate synthase and ribonucleotide reductase, while

38 Isozyme differences in thymidylate synthase and rTSbeta also exist in the two c

39 and cellular morphology between H630 and the thymidylate synthase and rTSbeta-overproducing, 5-FU-res

40 y established determinants of 5-FU response: thymidylate synthase and thymidine phosphorylase activit

41 ovo thymidylate biosynthesis pathway, cSHMT, thymidylate synthase, and dihydrofolate reductase, all c

42 sferase 1 and 2alpha (SHMT1 and SHMT2alpha), thymidylate synthase, and dihydrofolate reductase.

43 e equivalent inhibition of the target enzyme thymidylate synthase, and instead accumulate progressive

44 sical thymidylate synthases, including human thymidylate synthase, and is instrumental in mechanism-b

45 ential markers were assessed (TGF-BRII, p53, thymidylate synthase, and Ki67).

46 sporter 1 (hENT1), thymidine kinase 1 (TK1), thymidylate synthase, and thymidine phosphorylase (TP) w

47 n complexes with their in vivo target, human thymidylate synthase, and with the structurally best-cha

48 tide reductase, dihydrofolate reductase, and thymidylate synthase are coordinately regulated to ensur

49 leic acids but act as prodrugs by inhibiting thymidylate synthase as 5F-dUMP.

50 Flux through thymidylate synthase, as measured by 3H release from [3H

51 use the enzyme activities of dThd kinase and thymidylate synthase, as well as the levels of triphosph

52 protein structure of dihydrofolate reductase/thymidylate synthase at 1.95 A resolution.

53 Its primary target is thymidylate synthase but it also inhibits folate-depende

54 Thymidylate synthase catalyzes the reductive methylation

55 By also deleting the gene encoding thymidylate synthase (CDC21) we have constructed strains

56 privation in thymidylate synthase-deficient (thymidylate synthase-) cells.

57 rom TM0423 glycerol dehydrogenase and TM0449 thymidylate synthase-complementing protein are presented

58 One mutant, K282E/R283E, was found to be thymidylate synthase-dead because of an impaired ability

59 es examined, as did thymidine deprivation in thymidylate synthase-deficient (thymidylate synthase-) c

60 luorouracil in colon cancer, is regulated in thymidylate synthase-deficient (TS(-)) human colon carci

61 In thymidylate synthase-deficient (TS-) colon carcinoma cel

62 luated both in vivo, by complementation of a thymidylate synthase-deficient Escherichia coli mutant,

63 uman enzyme with the ability to complement a thymidylate synthase-deficient Escherichia coli strain a

64 al targets including dihydrofolate reductase-thymidylate synthase (DHFR-TS) and inosine monophosphate

65 crystal structure of dihydrofolate reductase-thymidylate synthase (DHFR-TS) from Cryptosporidium homi

66 of the bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) gene.

67 ckout (DKO) lines of dihydrofolate reductase-thymidylate synthase (DHFR-TS) of bloodstream Trypanosom

68 bifunctional enzyme dihydrofolate reductase-thymidylate synthase (DHFR-TS), the experimentally obser

69 s in drug binding to dihydrofolate reductase-thymidylate synthase (DHFR-TS).

70 ate cycle (encoding dihy-drofolate reductase-thymidylate synthase, dhfr-ts, and serine hydroxymethylt

71 pend on the presence of intact gp32, notably thymidylate synthase, dihydrofolate (DHF) reductase, rib

72 tic methods to characterize the bifunctional thymidylate synthase-dihydrofolate reductase (TS-DHFR) e

73 Plasmodium falciparum thymidylate synthase-dihydrofolate reductase (TS-DHFR) i

74 ate reductase activity from the bifunctional thymidylate synthase-dihydrofolate reductase (TS-DHFR) i

75 hat substrate channeling in the bifunctional thymidylate synthase-dihydrofolate reductase enzyme from

76 ing thymidine kinase (TK) and the second via thymidylate synthase-dihydrofolate reductase.

77 ions of rTS signaling mimics as enhancers to thymidylate synthase-directed chemotherapy, evidence tha

78 an have great influence over the efficacy of thymidylate synthase-directed chemotherapy, thereby enha

79 tification and the dihydrofolate produced by thymidylate synthase during DNA synthesis to the reduced

80 2-associated protein), nucleotide synthases (thymidylate synthase), early intermediate genes (early g

81 Thymidylate synthase (EC 2.1.1.45) (TS) catalyzes the co

82 strate is the pyrimidine biosynthetic enzyme thymidylate synthase (EC 2.1.1.45), which catalyzes the

83 regulators of antigen presentation, EZH2 and thymidylate synthase, enhanced DLBCL MHC-I presentation.

84 Polymorphisms in the thymidylate synthase enhancer region (TSER) have been re

85 domain of the human estrogen receptor with a thymidylate synthase enzyme (TS).

86 Several potential candidates, such as thymidylate synthase, excision repair complementation gr

87 Flavin-dependent thymidylate synthase (FDTS) catalyzes the final step in

88 man pathogens, thyX-encoded flavin-dependent thymidylate synthase (FDTS) catalyzes the last step in t

89 hyX gene, which codes for a flavin-dependent thymidylate synthase (FDTS), and is present in several h

90 gens rely on an alternative flavin-dependent thymidylate synthase (FDTS), which differs from the huma

91 an alternative thyX-encoded flavin-dependent thymidylate synthase (FDTS).

92 In thymidylate synthase, four conserved arginines provide t

93 ium tuberculosis and dihydrofolate reductase/thymidylate synthase from Babesia bovis, against 48 diff

94 ium tuberculosis and dihydrofolate reductase/thymidylate synthase from Babesia bovis.

95 crystal structure of dihydrofolate reductase-thymidylate synthase from Cryptosporidium hominis and a

96 We demonstrate this approach on thymidylate synthase from Escherichia coli, a homodimeri

97 Thymidylate synthase from Pneumocystis carinii (PcTS) is

98 Polymorphisms in the thymidylate synthase gene (TYMS) had previously defined

99 ation of a targeted region of the P. carinii thymidylate synthase gene by PCR over the 8-week study p

100 present study, we identified an orthologous thymidylate synthase gene in the relapsing fever (RF) ag

101 L. major promastigotes or with dihydrofolate-thymidylate synthase gene locus (DHFR-TS) gene knockout

102 homing endonuclease I-TevI that targets the thymidylate synthase gene of phage T4, we readily isolat

103 orphism in the 3'-untranslated region of the thymidylate synthase gene was shown to influence mRNA st

104 ich targets a different cleavage site in the thymidylate synthase gene, recapitulating the evolution

105 of a plant DHFR-TS (dihydrofolate reductase-thymidylate synthase) gene family that implements the pe

106 interleukin-6, dihydrofolate reductase, and thymidylate synthase genes were identified, along with a

107 Expression of a series of six markers (p53, thymidylate synthase, glutathione s-transferase pi [GST-

108 therapeutic drug pemetrexed, an inhibitor of thymidylate synthase, has an important secondary target

109 Allosteric peptide inhibitors of thymidylate synthase (hTS) bind to the dimer interface a

110 ntiangiogenic effects and also inhibit human thymidylate synthase (hTS) for cytotoxic effects in sing

111 Although thymidylate synthase (hTS) is an important anticancer ta

112 Loop 181-197 of human thymidylate synthase (hTS) populates two conformational

113 Crystal structures of human thymidylate synthase (hTS) revealed that the protein exi

114 Human thymidylate synthase (hTS) was targeted through a virtua

115 Human thymidylate synthase (hTS), a target for antiproliferati

116 ta suggest that BGC 945 selectively inhibits thymidylate synthase in alpha-FR-overexpressing tumors a

117 Inhibition of thymidylate synthase in tissues leads to increased incor

118 tive mechanism was proposed based on that of thymidylate synthase, in which the thiol(ate) group of a

119 ionality has been demonstrated for classical thymidylate synthases, including human thymidylate synth

120 titute for the IDR and the hA helix of human thymidylate synthase, indicating that the degradation-pr

121 nd FdU misincorporation sites resulting from thymidylate synthase inhibition and thymine depletion.

122 Cell-based thymidylate synthase inhibition studies show that, in co

123 r, naphthoquinone 3b has an IC(50) value for thymidylate synthase inhibition that is comparable to FU

124 ng gemcitabine uptake or gemcitabine-induced thymidylate synthase inhibition, and only reflected grow

125 nt CDK inhibition in cytotoxicity induced by thymidylate synthase inhibition.

126 5-FU) is generally considered to result from thymidylate synthase inhibition.

127 NG depletion does not sensitize cells to the thymidylate synthase inhibitor (raltitrexed), which indu

128 The thymidylate synthase inhibitor 5-fluorouracil (5-FU) is

129 ed by single exposures to a low level of the thymidylate synthase inhibitor 5-fluorouracil (5-FU) or

130 These agents include the thymidylate synthase inhibitor capecitabine (which is po

131 The RFC-mediated thymidylate synthase inhibitor plevitrexed also increase

132 FdUMP[10] as well as to FdUMP, FdU, and the thymidylate synthase inhibitor raltitrexed (Tomudex).

133 BGC 945 is a cyclopenta[g]quinazoline-based, thymidylate synthase inhibitor specifically transported

134 nses (i.e. G(2) arrest and lethality) to the thymidylate synthase inhibitor, Tomudex, and a greater l

135 rouracil combined with leucovorin and to the thymidylate synthase inhibitor, ZD9331, dependent on thy

136 key determinant of tumor cell sensitivity to thymidylate synthase inhibitors such as 5-fluoro-2'-deox

137 positively regulates the cytotoxic action of thymidylate synthase inhibitors, negatively regulates th

138 f cytotoxicity resulting from treatment with thymidylate synthase inhibitors.

139 '-deoxyuridine 5'-monophosphate (FdUMP), the thymidylate synthase inhibitory metabolite of 5-fluorour

140 The K(i) for isolated thymidylate synthase is 1.2 nmol/L and the IC(50) for in

141 Thymidylate synthase is an attractive target for antibio

142 Thymidylate synthase is an attractive target for antipro

143 e labeled cofactor in mechanistic studies of thymidylate synthase is demonstrated by measuring the tr

144 owed that intracellular proteolysis of human thymidylate synthase is directed by a degron at the poly

145 nophages, but also by all 27 T4-like phages (thymidylate synthase); its evolutionary history suggests

146 tease, dihydrofolate reductase, HIV Tar RNA, thymidylate synthase, kinesin, insulin receptor, tyrosin

147 For HAI patients with thymidylate synthase levels in tumor less than or > or =

148 site CC genotype (OR, 4.5; P =.045), and the thymidylate synthase low activity 2/2 enhancer repeat ge

149 amples for the detection of polymorphisms in thymidylate synthase, methylenetetrahydrofolate reductas

150 be converted to thymidine to enable a thyA (thymidylate synthase) mutant to grow.

151 The thyX gene for thymidylate synthase of the Lyme borreliosis (LB) agent

152 lethal to E. coli harboring either wild-type thymidylate synthase or constructs encoding previously c

153 rent chemical cascade than that of classical thymidylate synthases or any other known biological meth

154 sites located immediately upstream of ORF70 (thymidylate synthase), ORF19 (tegument protein), and ORF

155 lasmodium falciparum dihydrofolate reductase-thymidylate synthase (P. falciparum DHFR-TS) with the ob

156 HFR mRNA, while unrelated proteins including thymidylate synthase, p53 and glutathione-S-transferase

157 e and folinic acid indicates the role of the thymidylate synthase pathway also.

158 tide reductase, dihydrofolate reductase, and thymidylate synthase promoters in the absence of SWI/SNF

159 n cyclin A, Cdc2, topoisomerase IIalpha, and thymidylate synthase promoters.

160 actone (3-oxo-C12-(L)-HSL) can down-regulate thymidylate synthase protein at 10 micromol/L and reduce

161 was specific, because thymidylate kinase and thymidylate synthase protein levels were not decreased n

162 iosynthesis and altered amounts of SHMT1 and thymidylate synthase protein.

163 The thymidylate synthase reaction remains an important targe

164 exocyclic methylene-dUMP intermediate in the thymidylate synthase reaction was recently obtained by d

165 ase is required to significantly inhibit the thymidylate synthase reaction, consistent with experimen

166 All known thymidylate synthases rely on an active site residue of

167 ar hormone receptors with a highly sensitive thymidylate synthase reporter, yield simple sensors that

168 te cycle (mainly dihydrofolate reductase and thymidylate synthase, respectively).

169 ourses (R(2) = 0.043; P < .001), whereas the thymidylate synthase rs34743033 tandem repeat polymorphi

170 ThyX is an essential thymidylate synthase that is mechanistically and structu

171 ybaK for its ability to suppress the E. coli thymidylate synthase thyA:146CCA missense mutant strain,

172 were derived from three different antigens: thymidylate synthase (ThyA(30-38)), RNA polymerase beta-

173 cobacterium bovis BCG with insertions in the thymidylate synthase (thyA) gene, a critical determinant

174 ptamers that interfered with the activity of thymidylate synthase (ThyA) in vivo.

175 eles enhanced the survival of L. pneumophila thymidylate synthase (thyA)-deficient strains, which can

176 nt in humans, which depend upon an unrelated thymidylate synthase, ThyA.

177 nucleotide salvage, such as flavin-dependent thymidylate synthase, thymidylate kinase, ribonucleotide

178 valent inhibitors of the essential bacterial thymidylate synthase ThyX in a cellular context.

179 In many bacteria the flavoenzyme thymidylate synthase ThyX produces the DNA nucleotide de

180 The novel flavin-dependent thymidylate synthase, ThyX, is absent in humans but seve

181 A novel FAD-dependent thymidylate synthase, ThyX, is present in a variety of e

182 se thymine depends on activity of the enzyme thymidylate synthase to catalyse the methylation of the

183 zation of dihydrofolate reductase, SHMT, and thymidylate synthase to the nuclear lamina, indicating t

184 se (CBS exon 8, 68-base-pair insertion), and thymidylate synthase (TS enhancer region and 3' untransl

185 uced folate carrier (RFC) 80A allele and the thymidylate synthase (TS) 3'-untranslated region (3'-UTR

186 the presence of adequate dTTP pools, normal thymidylate synthase (TS) activity, persistence of incre

187 ymidine to overcome the potent inhibition of thymidylate synthase (TS) and deoxycytidine monophosphat

188 nclassical analogues 5- 15 as potential dual thymidylate synthase (TS) and dihydrofolate reductase (D

189 onclassical analogues 5-17 as potential dual thymidylate synthase (TS) and dihydrofolate reductase (D

190 and synthesized as potent dual inhibitors of thymidylate synthase (TS) and dihydrofolate reductase (D

191 rotozoal parasites are unusual in that their thymidylate synthase (TS) and dihydrofolate reductase (D

192 nd synthesized as a potent dual inhibitor of thymidylate synthase (TS) and dihydrofolate reductase (D

193 Thymidylate synthase (TS) and dihydrofolate reductase (D

194 ues 2a-2m were synthesized as potential dual thymidylate synthase (TS) and dihydrofolate reductase (D

195 gues 5-13 were synthesized as potential dual thymidylate synthase (TS) and dihydrofolate reductase (D

196 lls resulted in corresponding high levels of thymidylate synthase (TS) and resistance to 5-fluoropyri

197 NHF-HRAS(G12V) cells underexpressed thymidylate synthase (TS) and ribonucleotide reductase (

198 FdUMP[10] inhibited thymidylate synthase (TS) and trapped topoisomerase I cl

199 llus casei, Escherichia coli, and rat and rh thymidylate synthase (TS) and were found to be weak inhi

200 Drug-resistant variants of thymidylate synthase (TS) can potentially be used in gen

201 The enzyme thymidylate synthase (TS) catalyzes a complex reaction t

202 Thymidylate synthase (TS) catalyzes methylation of dUMP

203 Thymidylate synthase (TS) catalyzes the production of th

204 The enzyme thymidylate synthase (TS) catalyzes the reductive methyl

205 Thymidylate synthase (TS) catalyzes the substitution of

206 Two crystal structures of rat thymidylate synthase (TS) complexed with dUMP and the an

207 rements for I-TevI, which binds a stretch of thymidylate synthase (TS) DNA that codes for functionall

208 Human and other mammalian thymidylate synthase (TS) enzymes have an N-terminal ext

209 s have investigated the relationship between thymidylate synthase (TS) expression and survival in col

210 e thyX gene and depend upon the conventional thymidylate synthase (TS) for their dTMP requirements.

211 Thymidylate synthase (TS) functions as an RNA-binding pr

212 oded by a group I intron that interrupts the thymidylate synthase (TS) gene (thyA) of Bacillus mojave

213 Thymidylate synthase (TS) gene expression is modulated b

214 The thymidylate synthase (TS) gene, which is induced at the

215 folate compounds, developed as inhibitors of thymidylate synthase (TS) in a strategy to circumvent dr

216 The role of Ser 167 of Escherichia coli thymidylate synthase (TS) in catalysis has been characte

217 nd possibly more effective way of inhibiting thymidylate synthase (TS) in cells than through the use

218 s to investigate the utility of quantitating thymidylate synthase (TS) in the primary tumor as a surr

219 PYD expression by p53 is augmented following thymidylate synthase (TS) inhibition and DPYD repression

220 Although thymidylate synthase (TS) inhibition by FP is necessary,

221 now known as ONX 0801), is a small molecule thymidylate synthase (TS) inhibitor discovered at the In

222 sing levels of dUTPase on sensitivity to the thymidylate synthase (TS) inhibitor fluorodeoxyuridine (

223 and toxicity of clinically used folate-based thymidylate synthase (TS) inhibitors that require folylp

224 lovir (HSV-tk/GCV) system by the addition of thymidylate synthase (TS) inhibitors.

225 Thymidylate synthase (TS) is a key enzyme in folate meta

226 Thymidylate synthase (TS) is a major target in the chemo

227 Thymidylate synthase (TS) is a major target in the chemo

228 to fluoropyrimidines and other inhibitors of thymidylate synthase (TS) is a serious problem often ass

229 Thymidylate synthase (TS) is a target for antifolate-bas

230 Thymidylate synthase (TS) is a target for pemetrexed and

231 Thymidylate synthase (TS) is a target in the chemotherap

232 The ThyA gene that encodes for thymidylate synthase (TS) is absent in the genomes of a

233 Thymidylate synthase (TS) is an essential enzyme for DNA

234 Thymidylate synthase (TS) is the sole enzyme responsible

235 Thymidylate synthase (TS) is the sole enzyme responsible

236 ur laboratory have shown that translation of thymidylate synthase (TS) mRNA is controlled by its own

237 Translation of thymidylate synthase (TS) mRNA is controlled by its own

238 The translational initiation codon for thymidylate synthase (TS) mRNA is located in a unique st

239 eported to be associated with alterations in thymidylate synthase (TS) mRNA protein levels.

240 ies have shown that the repressive effect of thymidylate synthase (TS) mRNA translation is mediated b

241 antimetabolite radiosensitizers may inhibit thymidylate synthase (TS) or ribonucleotide reductase, a

242 R) and antifolate-resistant mutants of human thymidylate synthase (TS) that contain single residue su

243 encoding dihydrofolate reductase (DHFR) and thymidylate synthase (TS) was cloned from a Zea mays cDN

244 esidues on the RNA binding activity of human thymidylate synthase (TS) was investigated by mutating e

245 8-bp tandem repeat in the promoter region of thymidylate synthase (TS) were studied and found to modu

246 Mutant forms of thymidylate synthase (TS) with substitutions at the cons

247 Thymidylate synthase (TS), a half-the-sites reactive enz

248 Thymidylate synthase (TS), a key cancer chemotherapeutic

249 factor LSF that regulates the expression of thymidylate synthase (TS), a target of 5-FU.

250 tifolates on dihydrofolate reductase (DHFR), thymidylate synthase (TS), and folylpolyglutamate synthe

251 Previous studies showed that thymidylate synthase (TS), as an RNA binding protein, re

252 e LY231514 were synthesized as inhibitors of thymidylate synthase (TS), dihydrofolate reductase (DHFR

253 Inhibitors of the enzyme thymidylate synthase (TS), such as the fluoropyrimidines

254 irreversible inactivator of Escherichia coli thymidylate synthase (TS), which covalently modifies Tyr

255 onucleases that bind a homologous stretch of thymidylate synthase (TS)-encoding DNA but use different

256 A thymidylate synthase (TS)-ribonucleoprotein (RNP) comple

257 degraded siRNAs reversed the cytotoxicity of thymidylate synthase (TS)-targeted siRNAs and other TS i

258 man dihydrofolate reductase (DHFR) and human thymidylate synthase (TS).

259 ide ribonucleotide transformylase (ATIC) and thymidylate synthase (TS).

260 cleotide reductase (RNR) subunits R1/R2, and thymidylate synthase (TS).

261 nt of cytotoxicity mediated by inhibitors of thymidylate synthase (TS).

262 antifolate nonpolyglutamatable inhibitors of thymidylate synthase (TS).

263 dUMP), a tight binding covalent inhibitor of thymidylate synthase (TS).

264 wn translationally regulated mRNA transcript thymidylate synthase (TS).

265 athway is the pyrimidine biosynthetic enzyme thymidylate synthase (TS; EC 2.1.1.45), which catalyzes

266 Based on crystal structures of bacterial thymidylate synthases (TS), a glutamine corresponding to

267 Thymidylate synthase (TSase) catalyzes a complex reactio

268 Thymidylate synthase (TSase) catalyzes the intracellular

269 Thymidylate synthase (TSase) is a clinically important e

270 Thymidylate synthase (TSase) produces the sole intracell

271 es are involved in the reaction catalyzed by thymidylate synthase (TSase), which provides the sole de

272 Thymidylate synthase (TSase)-based de novo biosynthesis

273 l organisms and is synthesized by the enzyme thymidylate synthase (TSase).

274 n the hydride transfer reaction catalyzed by thymidylate synthase (TSase).

275 enetetrahydrofolate reductase (MTHFR) 677TT, thymidylate synthase (TSER) *2/*2 (variable number of ta

276 s examined and haplotypes generated included thymidylate synthase (TYMS 28-bp triple repeat [3R]-->do

277 , where they form a multienzyme complex with thymidylate synthase (TYMS) and dihydrofolate reductase

278 hylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase (TYMS) are known to play a role in

279 uiescence through the cell cycle, regulating thymidylate synthase (Tyms) expression at the G(1)/S bou

280 ng required for activating expression of the thymidylate synthase (Tyms) gene at the G1/S transition.

281 erest because it contained the gene encoding thymidylate synthase (TYMS), a molecular target of 5-FU.

282 ial serine hydroxymethyltransferase (SHMT2), thymidylate synthase (TYMS), and a novel human mitochond

283 ymes serine hydroxymethyltransferase (SHMT), thymidylate synthase (TYMS), and dihydrofolate reductase

284 he transcriptional status of four key genes, thymidylate synthase (TYMS), MORF-related gene X (MRGX),

285 On the basis of increased expression of thymidylate synthase (TYMS), thymidine kinase 1 (TK-1),

286 d to elevated expression of the main target, thymidylate synthase (TYMS), which catalyses the de novo

287 targeting dihydrofolate reductase (DHFR) and thymidylate synthase (TYMS).

288 seem, based on accumulated literature, to be thymidylate synthase (TYMS, TS) expression levels, TS ge

289 Thymidylate synthase (TYMS; EC 2.1.1.15) catalyzes the r

290 yed in their appearance included viral DHFR, thymidylate synthase, vMIP I, G protein-coupled receptor

291 me's specific activity, it was proposed that thymidylate synthase was a half-of-the-sites activity en

292 A novel flavin-dependent thymidylate synthase was identified recently as an essen

293 Using mutants of the C-terminal residue of thymidylate synthase, we found that the ratio of HETM-dU

294 s, rely on the thyA- or TYMS-encoded classic thymidylate synthase, whereas, certain microorganisms, i

295 olypeptide (DHFR-TS, dihydrofolate reductase-thymidylate synthase) which assembles into a functional

296 By analogy to thymidylate synthase, which also uses CH(2)-H(4)folate a

297 ide thymidylate is synthesized by the enzyme thymidylate synthase, which catalyzes the reductive meth

298 trexed that combines enzymatic inhibition of thymidylate synthase with alpha-folate receptor-mediated

299 Thymidylate synthase X (ThyX) represents an attractive t

300 late-reductase (MTX, aminopterin, PT523) and thymidylate synthase (ZD1694, ZD9331).