ライフサイエンスコーパス: thymine DNA glycosylase

1 e delta but instead depends, in part, on the thymine DNA glycosylase.

2 80-fold effects were observed previously for thymine DNA glycosylase.

3 same as reported for the human G/T mismatch thymine-DNA glycosylase.

4 mination product of 5hmC could be excised by thymine DNA glycosylase and MBD4 glycosylases regardless

5 epend on two additional uracil glycosylases, thymine-DNA glycosylase and SMUG1.

6 rvation was paralleled by a compromised TDG (thymine DNA glycosylase) and TET1 (ten-eleven translocat

7 CadC, and 5-HmdU, may be cleaved from DNA by thymine DNA glycosylase, and subsequent action of base-e

8 ty differences between E. coli MUG and human thymine DNA glycosylase as well as that between the wild

9 the removal of thymine from a G.T mismatch, thymine DNA glycosylase binds tightly to the apurinic si

10 obtained by selection using mismatch repair thymine DNA glycosylase-bound beads.

11 Thymine DNA glycosylase can also remove thymine from mis

12 Thymine DNA glycosylase can further remove 5fC and 5caC,

13 regeneration-associated genes in a Tet3- and thymine DNA glycosylase-dependent fashion in DRG neurons

14 thylation, which promotes DNA damage through thymine DNA glycosylase-driven excision.

15 ibition did not correlate with p53 status or thymine DNA glycosylase expression.

16 SUMO modification of human thymine-DNA glycosylase facilitates the processing of ba

17 cantly increases the rate of dissociation of thymine DNA glycosylase from apurinic sites, presumably

18 nesium does not increase the dissociation of thymine DNA glycosylase from G.AP sites sufficiently to

19 igase III, do not affect the dissociation of thymine DNA glycosylase from the apurinic site.

20 s were fully covered by combining use of two thymine DNA glycosylases generated here.

21 The time course of removal of thymine by thymine DNA glycosylase has been measured in vitro.

22 The human thymine-DNA glycosylase has a sequence homolog in Escher

23 Human thymine DNA glycosylase (hTDG) cleaves thymine from muta

24 Human (h) DNA repair enzyme thymine DNA glycosylase (hTDG) is a key DNA glycosylase

25 Human thymine DNA glycosylase (hTDG) removes T from G.T mispai

26 rted nucleobase excision activities of human thymine DNA glycosylase (hTDG) toward duplex DNA substra

27 ipping assay to study damage search by human thymine DNA glycosylase (hTDG), which initiates BER of m

28 Knockdown of thymine DNA glycosylase increased 5caC in genome, affect

29 s not influenced by either UNG1/2, SMUG1, or thymine-DNA glycosylase knockdown, strongly suggesting t

30 Thus, thymine DNA glycosylase may play a backup role to the mo

31 t pol beta, in concert with the T:G-specific thymine DNA glycosylase, may be intricately involved in

32 The bound thymine DNA glycosylase prevents human apurinic endonucl

33 o 5-carboxylcytosine followed by excision by thymine-DNA glycosylase, raises the possibility that act

34 Each molecule of thymine DNA glycosylase removes only one molecule of thy

35 is lesion is repaired by a mismatch-specific thymine DNA glycosylase (TDG or G/T glycosylase), which

36 viously that the base excision repair enzyme thymine DNA glycosylase (TDG) acts as a potent coactivat

37 The repair enzymes thymine DNA glycosylase (TDG) and methyl-CpG-binding pro

38 a 2'-fluoroarabino-substituted nucleotide by thymine DNA glycosylase (TDG) can be directly monitored

39 easoned that the base excision repair enzyme thymine DNA glycosylase (TDG) could be such a target for

40 can be modulated in the presence of TET and thymine DNA glycosylase (TDG) enzymes.

41 lcytosine (fC), and 5-carboxycytosine (caC), thymine DNA glycosylase (TDG) excises fC or caC, and bas

42 Thymine DNA glycosylase (TDG) excises T from G.T mispair

43 The mammalian thymine DNA glycosylase (TDG) excises the mismatched bas

44 Thymine DNA glycosylase (TDG) excises thymine from G.T m

45 Tet methylcytosine dioxygenase 2 (TET2), and Thymine DNA glycosylase (TDG) genes.

46 aC), with 5fC and 5caC subject to removal by thymine DNA glycosylase (TDG) in conjunction with base e

47 nd T:G mispair, and this step is followed by thymine DNA glycosylase (TDG) initiated base excision re

48 Thymine DNA glycosylase (TDG) initiates the repair of G.

49 Thymine DNA Glycosylase (TDG) is a base excision repair

50 Thymine DNA glycosylase (TDG) is a multifaceted enzyme i

51 Thymine DNA glycosylase (TDG) is an essential enzyme inv

52 Thymine DNA glycosylase (TDG) is an essential enzyme pla

53 The mammalian thymine DNA glycosylase (TDG) is implicated in active DN

54 alytic inactivation of the DNA repair enzyme thymine DNA glycosylase (TDG) leads to embryonic lethali

55 Thymine DNA Glycosylase (TDG) performs essential functio

56 slocation (TET) enzymes (TET1/TET2/TET3) and thymine DNA glycosylase (TDG) play crucial roles in earl

57 Thymine DNA glycosylase (TDG) promotes genomic integrity

58 The base excision repair enzyme thymine DNA glycosylase (TDG) protects against mutations

59 Thymine DNA glycosylase (TDG) removes T from mutagenic G

60 Thymine DNA glycosylase (TDG) removes thymine from these

61 We describe here a novel hybrid thymine DNA glycosylase (TDG) that is comprised of a 29-

62 ated cytosine, are recognized and removed by thymine DNA glycosylase (TDG) to generate an abasic site

63 g a panel of DNA demethylases, we found that thymine DNA glycosylase (TDG) up-regulated Wnt signaling

64 relationship between chromatin structure and thymine DNA glycosylase (TDG) using chemically defined n

65 From this screen, thymine DNA glycosylase (TDG) was identified as a myocar

66 air, we characterized oxoA excision by human thymine DNA glycosylase (TDG), an enzyme known to remove

67 Herein, we report that thymine DNA glycosylase (TDG), an essential enzyme invol

68 oxylcytosine (caC), excision of fC or caC by thymine DNA glycosylase (TDG), and restoration of cytosi

69 oxylcytosine (caC), excision of fC or caC by thymine DNA glycosylase (TDG), and subsequent base excis

70 ion of 5fC and 5caC by the DNA repair enzyme thymine DNA glycosylase (TDG), followed by base excision

71 aC are selectively recognized and excised by thymine DNA glycosylase (TDG), leading to DNA demethylat

72 e bases are recognized by the monofunctional thymine DNA glycosylase (Tdg), which cleaves the glycosi

73 A key player is thymine DNA glycosylase (TDG), which excises thymine fro

74 e 5-halouracils in the context of the enzyme thymine DNA glycosylase (TDG), which is an enzyme that p

75 A prominent example is thymine DNA glycosylase (TDG), which removes T from G.T

76 ollowed by replication-dependent dilution or thymine DNA glycosylase (TDG)-dependent base excision re

77 to cytosine through iterative oxidation and thymine DNA glycosylase (TDG)-mediated base excision rep

78 luorescent probe for real-time monitoring of thymine DNA glycosylase (TDG)-mediated BER of 5-formylcy

79 veral regulatory proteins, including p53 and thymine DNA glycosylase (TDG).

80 lcytosine (5fC)/5-carboxylcytosine (5caC) by thymine DNA glycosylase (TDG).

81 oxygenases and excision of oxidized bases by thymine DNA glycosylase (TDG).

82 s that themselves contribute to AML, such as thymine DNA glycosylase (TDG).

83 excise thymine from G.T mispairs, including thymine DNA glycosylase (TDG).

84 paired to regenerate unmodified cytosines by thymine-DNA glycosylase (TDG) and base excision repair (

85 G/T mismatch-specific thymine-DNA glycosylase (Tdg) and methyl-CpG binding dom

86 A thymine-DNA glycosylase (TDG) has been described that in

87 Thymine-DNA glycosylase (TDG) plays critical roles in DN

88 Many TET2- and thymine-DNA glycosylase (TDG)-dependent 5mC and 5hmC cha

89 G mismatches may instead be initiated by the thymine DNA glycosylase, TDG.

90 repaired, following T excision by one of the thymine DNA glycosylases, TDG or MBD4.

91 ut has more recently been characterized as a thymine DNA glycosylase that interacts with the mismatch

92 e increased more than 20-fold, allowing each thymine DNA glycosylase to remove more than one uracil o

93 n of UNG1/2 but not by knockdown of SMUG1 or thymine-DNA glycosylase uracil-DNA glycosylases, proving

94 Interestingly, enforced expression of thymine-DNA glycosylase (which can excise U from U:G mis

95 li genome as a sequence homolog of the human thymine DNA glycosylase with activity against mismatched