ライフサイエンスコーパス: thymine dimer

1 her undamaged or contained a single cis, syn thymine dimer.

2 corporates two adenines opposite the thymine-thymine dimer.

3 on of the complex leads to the repair of the thymine dimer.

4 5'-GT<>TG-3' tetrad only in the presence of thymine dimer.

5 isruption in the base stack generated by the thymine dimer.

6 GC), where TT denotes a cis, syn cyclobutane thymine dimer.

7 cription bubble terminating at a cyclobutane thymine dimer.

8 observed during bypass of a cis-syn thymine-thymine dimer.

9 tiated by H atom abstraction from C-6 of the thymine dimer.

10 cates that the photoproduct is a cyclobutane thymine dimer.

11 lectronic coupling to acceptor states of the thymine dimer.

12 y to analyze simulations of DNA containing a thymine dimer.

13 lesions such as a UV-induced cis-syn thymine-thymine dimer.

14 olymerase II and RNA polymerase I stalled at thymine dimers.

15 e 1,25(OH)(2)D(3)-induced protection against thymine dimers.

16 rations shown to block decreases in post-UVR thymine dimers.

17 esions, such as abasic sites and cyclobutane thymine dimers.

18 ng DNA synthesis through cis-syn cyclobutane thymine dimers.

19 olymerase when the template contains thymine-thymine dimers.

20 were stained with a monoclonal antibody for thymine dimers.

21 n vitro and assessed their ability to bypass thymine dimers.

22 uggesting a possible mechanism for bypassing thymine dimers.

23 ry in which the major UV photoproduct is the thymine dimer 5-thyminyl-5,6-dihydrothymine (spore photo

24 V-irradiated Bacillus subtilis spores is the thymine dimer 5-thyminyl-5,6-dihydrothymine [spore photo

25 V-irradiated dormant bacterial spores is the thymine dimer 5-thyminyl-5,6-dihydrothymine, commonly re

26 uct in UV-irradiated spore DNA is the unique thymine dimer 5-thyminyl-5,6-dihydrothymine, commonly re

27 d in UV-irradiated bacterial endospores is a thymine dimer, 5-thyminyl-5,6-dihydrothymine, i.e., the

28 (6)-MeG, 8-oxoG, an abasic site or a thymine-thymine dimer); a greater proofreading activity; an incr

29 mapping of the repair processes of a flavin-thymine dimer adduct with femtosecond resolution.

30 correlates with higher levels of UV-induced thymine dimer adducts being formed in cells lacking Nhp6

31 m for the low repair quantum yield of flavin-thymine dimer adducts is the short-lived excited flavin

32 ite specificity and integrity of the cis-syn thymine dimer after both primer extension and ligation w

33 surface areas are incorporated opposite the thymine dimer almost as effectively as an abasic site, a

34 nctional classes, which photo-reactivate the thymine dimer along different pathways.

35 Single- or double-thymine dimers also allow cleavage.

36 Here, dyads containing the cyclobutane thymine dimer and guanine or 8-oxoguanine are synthesize

37 and pyrene nucleotide insertion opposite the thymine dimer and its N3-methyl derivatives was determin

38 he ternary complex of RNA polymerase II at a thymine dimer and surprisingly exerts the same effect on

39 lineC/C-C stretch vibrations) of cyclobutane thymine dimer and thymine dinucleotide radical anion, th

40 rease with aging in the repair rates of both thymine dimers and (6-4) photoproducts (P<0.001).

41 Direct measurement of thymine dimers and (6-4) photoproducts by immunoassay de

42 We studied the rate of removal of thymine dimers and (6-4) photoproducts in UV-irradiated

43 We used monoclonal antibodies against thymine dimers and 6-4 photoproducts and image analysis

44 sunscreen, resulted in comparable levels of thymine dimers and 6-4 photoproducts to one minimal eryt

45 fluorescent-tagged monoclonal antibodies for thymine dimers and melanocytes.

46 suppressed the formation of cyclobutane-type thymine dimers and promoted the formation of the spore p

47 We show that Pol eta copies thymine dimers and the flanking bases with higher proces

48 to A opposite an abasic site, the 3'-T of a thymine dimer, and a normal T with almost equal efficien

49 erted opposite an abasic site, the 3'-T of a thymine dimer, and most undamaged bases by yeast DNA pol

50 d site for oxidative reaction, repair of the thymine dimer appears to be kinetically more favorable.

51 rate constants for incorporation opposite a thymine dimer are considerably slower than those measure

52 Thymine dimers are a major mutagenic photoproduct induce

53 Interloop-specific anti thymine dimers are incompatible with hybrid-type structu

54 Cis-syn thymine dimers are the major photoproducts of DNA and ar

55 lex and was approximately equal to a thymine-thymine dimer as a substrate for the former.

56 ng progressively greater numbers of KCs with thymine dimers as the dose of UV-light was increased; in

57 ication of an abasic site, a cis-syn thymine-thymine dimer, as well as acetyl aminofluorene adducted-

58 ontaining a single cyclo-dA or a cyclobutane thymine dimer at a specific site on the transcribed stra

59 at the damage site that initiates removal of thymine dimers at a physiologically relevant rate and sp

60 Oligonucleotide-treated adult cells removed thymine dimers at least as rapidly as diluent treated ne

61 n the presence of Na(+) results in a cis,syn thymine dimer between two adjacent Ts in a TTA loop and

62 a TTA loop and a mixture of nonadjacent anti thymine dimers between various loops.

63 IDS, at concentrations that had no effect on thymine dimers, blocked UVR-induced upregulation of p53.

64 f the bacteriophage enzyme is activated by a thymine dimer but not by an abasic site.

65 ly opposite an abasic site and the 3'-T of a thymine dimer but not opposite undamaged DNA.

66 istance between intercalated rhodium and the thymine dimer, but it diminished with disruption of the

67 oride currents help protect from UVR-induced thymine dimers, but further increases in p53 or reductio

68 ls against UVR-induced DNA damage, including thymine dimers, but the mechanism is unknown.

69 ions responsible for recognition of cis, syn thymine dimers by repair enzymes is not sensitive to the

70 UV-irradiated Bacillus spore DNA is a unique thymine dimer called spore photoproduct (SP, 5-thyminyl-

71 relevant supercoiling densities and forces, thymine dimers can preferentially segregate to the tips

72 and imino proton signals of an (15)N-labeled thymine dimer-containing decamer duplex were assigned by

73 alent UV photoproduct, a cis-syn cyclobutane thymine dimer (cs CTD), was chemically synthesized and i

74 which contained a single cis-syn cyclobutane thymine dimer (CTD) at one of six different sites in the

75 Cyclobutane-thymine dimers (CTDs), the most common DNA lesion induce

76 We found that, like the cyclobutane thymine dimer, cyclo-dA is a strong block to gene expres

77 A dodecamer containing a cis-syn cyclobutane thymine dimer d(GCACGAAT[cs]TAAG).d(CTTAATTCG TGC) and i

78 of epidermal cells with DNA strand breaks or thymine dimers decreased markedly between 12 and 36 h.

79 the presence of both a 5'-GG-3' site and the thymine dimer diminished the dimer repair efficiency by

80 ms error-free bypass of the 8-oxoguanine and thymine dimer DNA lesions, though with a 10(3) and 10(2)

81 s simulations of the solvated protein with a thymine dimer docked in its active site.

82 cently built a computer molecular model of a thymine dimer docked to photolyase catalytic site and st

83 ase eta (Pol eta) bypasses a cis-syn thymine-thymine dimer efficiently and accurately, and inactivati

84 de Pol eta, which bypasses a cis-syn thymine-thymine dimer efficiently and accurately.

85 rase eta (Poleta) bypasses a cis-syn thymine-thymine dimer efficiently and accurately.

86 y of DNA polymerases which is able to bypass thymine dimers efficiently and in a relatively error-fre

87 nary 8-oxo-2'-deoxyguanosine and cyclobutane thymine dimers following ultraviolet exposure of healthy

88 dark (1)npi* excited states does not lead to thymine dimer formation.

89 antioxidant formulation efficiently reduced thymine dimer formation.

90 me products, a large amount of specific anti thymine dimers formed between either T in loop 1 and the

91 or without XPC, compared with the removal of thymine dimer from a base paired duplex by the entire se

92 o 5'-GG-3' doublets in DNA and the repair of thymine dimers from a remote site on the DNA duplex.

93 C-HHR23B complex is required for excision of thymine dimers from DNA in a human excision nuclease sys

94 ion of dAMP opposite the 3'-T of the cis-syn thymine dimer happens by way of a loosely held dimer in

95 transfer (ET) from the excited flavin to the thymine dimer in 79 ps.

96 d correctly replicate past a cis-syn-thymine-thymine dimer in template DNA.

97 Furthermore, the thymine dimer in the bubble-containing substrate was rem

98 ing the adenovirus major late promoter and a thymine dimer in the template strand downstream of the t

99 ur data show that UVB and UVA readily induce thymine dimers in melanocytes at levels that are compara

100 assay is convenient for monitoring repair of thymine dimers in oligonucleotides.

101 On day 12, there were more thymine dimers in skin type IV than skin type II, again

102 d 19, however, showed a much greater loss of thymine dimers in skin type IV, suggesting better thymin

103 It was recently shown that thymine dimers in the all-thymine oligonucleotide (dT)(1

104 Here, we introduce a model of thymine dimers in the oxDNA forcefield, parametrized by

105 e is an enzyme that catalyses photorepair of thymine dimers in UV damaged DNA by electron transfer re

106 y bypasses UV-associated cis-syn cyclobutane thymine dimers in vitro and contributes to normal resist

107 adenines during efficient bypass of thymine-thymine dimers in vitro, has led to the description of p

108 leave SP but not cyclobutane cis,syn thymine-thymine dimers in vitro.

109 eater opposite the 5'-T than the 3'-T of the thymine dimer, in accord with previous work suggesting t

110 l-2,2'-bipyridine) catalyzed the repair of a thymine dimer incorporated site-specifically in a 16-bas

111 TP nick end labeling-positive cells) or with thymine dimers increased to maximal levels within 30 min

112 periments and structural measurements of the thymine dimer induced bend angle.

113 Thymine dimer-induced tip-bubbles also pin plectonemes,

114 contrast, binding of a nucleotide opposite a thymine dimer is directly correlated with the overall pi

115 lecule carrying a single cis,syn-cyclobutane thymine dimer is replicated in vitro by human cell extra

116 The cyclobutane thymine dimer is the major DNA lesion induced in human s

117 This suggests that formation of thymine dimers is not the sole mechanism of ARB inactiva

118 The formation of cyclobutane thymine dimers is one of the most important DNA carcinog

119 godeoxynucleotide (ODN) containing a cis-syn thymine dimer labeled at the N3 of both T's with 15N by

120 DNA-mediated repair of a thymine dimer lesion by charge transfer from the tethere

121 ciently but cannot trigger the repair of the thymine dimer lesion.

122 Similarly, cyclobutane thymine dimer levels peaked 3 d postexposure, before ret

123 Compared to undamaged DNA, the presence of a thymine dimer lowers the supercoiling densities at which

124 ltheta is unable to bypass a cis-syn thymine-thymine dimer, nor does it bypass a (6-4) photoproduct o

125 The footprint of RNAP II stalled at the thymine dimer, obtained using DNase I, lambda exonucleas

126 n vitro replication of duplex DNA containing thymine dimers occurs by translesion synthesis.

127 de currents in osteoblasts, had no effect on thymine dimers on its own but prevented the 1,25(OH)(2)D

128 Cyclobutane thymine dimer, one of the major lesions in DNA formed by

129 The presence of a thymine dimer or a cisplatin diadduct in the context of

130 ynthesized from a mixture of [3-15N]-labeled thymine dimer phosphoramidites after which the cis-syn d

131 If these unique nonadjacent anti thymine dimer photoproducts also form in vivo, they woul

132 e crucial aspects of the overall cyclobutane thymine dimer photoreductive repair triggered by the nuc

133 ne dimers in skin type IV, suggesting better thymine dimer repair.

134 However, rates of thymine-dimer repair and UV-induced apoptosis were signi

135 uences lacking either the guanine doublet or thymine dimer, respectively.

136 Dpo3 bypassed uracil and cis-syn cyclobutane thymine dimer, respectively.

137 s out TLS to bypass abasic sites and thymine-thymine dimers resulting from UV radiation.

138 y of highly bent and denatured states at the thymine dimer site, which may facilitate repair enzyme b

139 oproducts as determined by reacting DNA with thymine dimer-specific antibodies: 40+/-5% vs. 20+/-9% a

140 ct lyase (SPL) repairs a covalent UV-induced thymine dimer, spore photoproduct (SP), in germinating e

141 lease were required for dual incision of the thymine dimer substrate.

142 ne, and either uracil or cis-syn cyclobutane thymine dimer, suggesting their catalytically limited ro

143 prevalent UV-derived DNA lesion, the cis,syn-thymine dimer (T x T), we have recently found that a T x

144 d with DNA duplexes containing a cyclobutane thymine dimer (T<>T), here we probe the electrochemistry

145 mid containing a single cis, syn-cyclobutane thymine dimer (T[c,s]T) 385 base pairs from the center o

146 s (TLS) of site-specific cis-syn cyclobutane thymine dimers (T (wedge)T).

147 ctly, leading to lesions such as cyclobutane thymine dimers (T<>T), or indirectly, via photosensitize

148 Cyclobutane thymine dimers (T-T) comprise the majority of DNA damage

149 synthetic primers past template cyclobutane thymine dimers (T[CPD]T) or undamaged T-T under physiolo

150 DNA damage (thymine dimers: T-T dimers) and vitamin D (25(OH)D) synt

151 s a base excision repair enzyme that removes thymine dimers (TD) from damaged DNA.

152 PL) repairs 5-thyminyl-5,6-dihydrothymine, a thymine dimer that is also called the spore photoproduct

153 UV light causes the formation of thymine dimers that can be misreplicated to induce mutag

154 staining with a monoclonal antibody against thymine dimers that were quantitated by image analysis.

155 s value is comparable to that of cyclobutane thymine dimers (the major UV-induced lesions) in genomic

156 structed an SV40 vector containing a cis-syn thymine dimer, the major DNA photoproduct induced by UVB

157 ucture-activity relationships of the cis-syn thymine dimer, the major photoproduct of DNA, has been g

158 nd non-natural nucleotides paired opposite a thymine dimer through exonuclease degradation or pyropho

159 Pol eta replicate through a cis-syn thymine-thymine dimer (TT dimer) by inserting two As opposite th

160 st skin cancer caused by cyclobutane thymine-thymine dimers (TTDs), a frequent form of DNA damage ari

161 nduces cyclobutane pyrimidine dimers, mainly thymine dimers (TTs), and pyrimidine (6-4) pyrimidone ph

162 m was highly efficient, removing >30% of the thymine dimers under optimal conditions.

163 In this system the thymine dimer was excised independent of XPC.

164 nary 8-oxo-2'-deoxyguanosine and cyclobutane thymine dimers was by competitive enzyme-linked immunoso

165 oach involving monoclonal antibodies against thymine dimers we provide direct evidence for the presen

166 tand the nature of base pairing with cis-syn thymine dimers, we have synthesized a decamer oligodeoxy

167 lculated distortions of DNA structure by the thymine dimer were qualitatively and quantitatively simi

168 Protection factors for erythema and thymine dimers were calculated and shown to be about 2 i

169 Thymine dimers were found at a potential of about 1.1 V

170 Thymine dimers were quantified by image analysis.

171 A by converting two adjacent thymines into a thymine dimer which is potentially mutagenic, carcinogen

172 induces the formation of a novel cyclobutane thymine dimer which lacks an intradimer phosphodiester b

173 An enlarged active site accommodates the thymine dimer with excellent stereochemistry for two-met

174 Exonuclease-deficient pol gamma bypassed thymine dimers with low relative efficiency; bypass was

175 f <310 nm wavelength to photo-reactivate CPD thymine dimers within a substrate DNA.