ライフサイエンスコーパス: thymocyte

1 lopment and supporting survival of SP CD8(+) thymocytes.

2 an important role in the survival of CD8(+) thymocytes.

3 , Nur77 upregulation in TCR-stimulated mouse thymocytes.

4 mbers but reversed the loss of mature CD4(+) thymocytes.

5 gression, and proliferation of beta-selected thymocytes.

6 ent, and is limited to immature CD4(-)CD8(-) thymocytes.

7 evated in TCR(hi)CD4(+)CD8(+) (TCR-signaled) thymocytes.

8 l strength and MHC specificity of developing thymocytes.

9 n a similar manner to the clonal deletion of thymocytes.

10 tive RAG locus chromatin hub in CD4(+)CD8(+) thymocytes.

11 mune responses and develop from CD4(+)CD8(+) thymocytes.

12 actor, IL-2, produced by self-reactive CD4SP thymocytes.

13 ulted in decreased phagocytosis of apoptotic thymocytes.

14 evelopment of committed (CD73(+)) gammadelta thymocytes.

15 ative fates of autoreactive MHCII-restricted thymocytes.

16 age commitment of MHCII-specific Thpok (-/-) thymocytes.

17 e for presenting self-antigens to developing thymocytes.

18 nt proliferation and differentiation into DP thymocytes.

19 acts with RORgammat in Th17 cells but not in thymocytes.

20 hed the generation of CD8(+) single-positive thymocytes.

21 ocytes and CD8(+) and CD4(+) single-positive thymocytes.

22 T cells and prevents escape of high-affinity thymocytes.

23 aks on CD3(high)CD4(+)CD8(+) double-positive thymocytes.

24 iated the developmental block in Themis(-/-) thymocytes.

25 ade as double-negative (DN) TCRalphabeta(hi) thymocytes.

26 ely regulates CXCL12-induced migration in DN thymocytes.

27 ancers and promoters in NOD, but not C57BL/6 thymocytes.

28 cient for complete deletion of TRP1-specific thymocytes.

29 dritic cells and the deletion of Ag-specific thymocytes.

30 ras with increased deletion of TRP1-specific thymocytes.

31 ous tissue-restricted antigen (TRA)-specific thymocytes.

32 sequent oncogenic transformation of immature thymocytes.

33 mental stage-specific regulation of SATB1 in thymocytes.

34 nd differentiation into double positive (DP) thymocytes.

35 ession signature in immature Lmo2 transgenic thymocytes.

36 nregulation of Bcl-xl and Bcl2 expression in thymocytes.

37 ed Nur77 overexpression (Nur77(tg)) in mouse thymocytes abrogates iNKT cell development.

38 ce develop postnatal thymic hyperplasia with thymocyte accumulation.

39 ise pre-leukaemic, differentiation inhibited thymocytes allowing us to provide a profile of the LIC s

40 e of the G-proteins Galphai2 and Galphai3 in thymocyte and T cell function, we developed several mous

41 By directly imaging interactions between thymocytes and APCs, while monitoring intracellular sign

42 finity signaled CD4(+)CD8(+) double-positive thymocytes and CD8(+) and CD4(+) single-positive thymocy

43 rent alternative promoters of Satb1 in mouse thymocytes and characterized them.

44 To test this, thymocytes and fresh serum were separately obtained and

45 d in increased negative selection of OTII(+) thymocytes and in increased thymic and peripheral T regu

46 omatin organizer SATB1 is highly enriched in thymocytes and is essential for T-cell development.

47 resses the cytotoxic program in the signaled thymocytes and is shown to be necessary and sufficient f

48 f the T cell receptor (TCR) within activated thymocytes and peripheral T cells.

49 opmental block at the DN3 stage of alphabeta thymocytes and pro-B stage of early B cells at which the

50 gnaling increased the expression of Foxp3 in thymocytes and promoted thymic T(reg) (tT(reg)) cell dev

51 s the expression signature of immature human thymocytes and provides a resource for the further study

52 d organ weights, flow cytometric analysis of thymocytes and splenocytes, and histologic/transcriptomi

53 hymus are mature CD4 single-positive (CD4SP) thymocytes and that continuous IL-2 production sustained

54 ression was induced during development of SP thymocytes and that IKK was required to prevent RIPK1-ki

55 rkhead box protein O1 (Foxo1) and Klf2 in DP thymocytes and the accumulation of postselection interme

56 r lineage choice of MHCII- and MHCI-specific thymocytes and the role of TCR signaling in this process

57 ion of immature CD4(+)CD8(+) double-positive thymocytes and their commitment to the CD4(+)CD8(-) sing

58 ry depends on positive/negative selection of thymocytes and thus on the dynamics of antigen degradati

59 e, we isolated TCR libraries from unselected thymocytes and upon reexpression of these random TCR rep

60 is of mature naive T cells without affecting thymocytes and/or recent thymic emigrants remains unknow

61 ocytes undergoing beta-selection, gammadelta thymocytes, and also B cell progenitors by regulating th

62 l1, and Nfe2) in preleukemic Lmo2 transgenic thymocytes, and binding of both Ldb1 and Lmo2 at these s

63 ediated positive selection into CD4+ or CD8+ thymocytes, and constituted up to 10% of TCRdelta+ cells

64 itic cells (DC) delete self-antigen-specific thymocytes, and drive development of Foxp3-expressing im

65 se Pggt1b is up-regulated in single-positive thymocytes, and loss of Pggt1b leads to marked defects i

66 is mainly restricted to developing cortical thymocytes, and neither CD34(+) progenitors nor T cells

67 molecular crosstalk between stroma, ECM and thymocytes, and offer practical prospects for treating c

68 Wnk1 is highly expressed in thymocytes, and since migration is important for thymocy

69 pattern of chemokine receptors on developing thymocytes, and the interaction of the chemokine recepto

70 HCT AIC, mismatched donor, alemtuzumab, anti-thymocyte antiglobulin, and acute and chronic graft vers

71 Thus, S. suis induced thymocyte apoptosis through a p53- and caspase-dependent

72 later stage of positive selection, inducing thymocyte apoptosis.

73 and RNA-seq reveals that HDAC3-deficient DP thymocytes are biased towards the CD8 lineage prior to p

74 Autoreactive thymocytes are eliminated during negative selection in t

75 thymic epithelial cells (TEC) and developing thymocytes are essential for T cell development, but mol

76 Preselection thymocytes are normally retained in the thymic cortex, b

77 Whereas CD4(+) thymocytes are positively selected in wild-type AND TCR-

78 lymphocytes, we find that mature CD5(low) DN thymocytes are precursors to peripheral DN T cells.

79 ence of HDAC3, MHC Class II-restricted OT-II thymocytes are redirected to the CD8 cytotoxic lineage,

80 Temporally, Padi4-specific thymocytes are subject to a developmental stage-specific

81 Thus, these findings reveal TGF-beta in thymocytes as crucial for negative selection with implic

82 expression of which is tightly regulated in thymocytes, as well as in mature T cells both at steady

83 lly, the CCR4-NOT complex is up-regulated in thymocytes before initiation of positive selection, wher

84 The alphabeta thymocyte block is accompanied by massive apoptotic depl

85 gammac/STAT5 signaling in HDAC3-deficient DP thymocytes, blocking IL-21R does not restore CD4 lineage

86 d CD4 helper lineage choice of MHCI-specific thymocytes but was still substantially less efficient th

87 Thymic phagocytes serve to remove dead thymocytes, but whether they play additional roles durin

88 sor populations among TCRbeta(+)CD4(-)CD8(-) thymocytes by dependence on the kinase TAK1 and rigorous

89 shaping of the TCR repertoire of developing thymocytes by intestinal luminal Ags.

90 vels of SATB1 mRNA and protein in developing thymocytes can be explained by the differential translat

91 We also found that wild-type immature thymocytes can be separated into distinct populations ba

92 th respect to the numbers of double-positive thymocytes, CD4(+)CD8(-) T cells, regulatory T cells, CD

93 e report that, despite being dispensable for thymocyte clonal deletion, RasGRP1 is critical for agoni

94 e-positive stage, and within single-positive thymocytes, complement binding gradually decreased with

95 eukemic NHD13/NP23 mice demonstrated that DN thymocytes could transmit AML, and limiting dilution stu

96 pport negative selection of antigen-specific thymocytes depending on antigen dose.

97 ation of RAG gene expression in CD4(+)CD8(+) thymocytes depends on Ikaros and occurs with disassembly

98 ag1 and Rag2 gene expression in CD4(+)CD8(+) thymocytes depends on Rag1 and Rag2 promoter activation

99 thymic regeneration following stress, while thymocyte-derived LXRalphabeta limits cell disposal duri

100 and is sustained in immature single-positive thymocytes, despite the strong decrease in Themis mRNA l

101 sults delineate a role for Galphai2 in early thymocyte development and for Galphai2/3 in multiple asp

102 pLckCre drives recombination early in thymocyte development and is frequently used to delete g

103 considered critical for single positive (SP) thymocyte development because loss of upstream activator

104 Thus, Bcl6 is required in thymocyte development for efficient differentiation from

105 al TCR-proximal signaling events and impairs thymocyte development in retrogenic mice.

106 ables their regulation of specific stages of thymocyte development is poorly understood.

107 this process, their involvement during early thymocyte development often precludes direct analysis of

108 iologic mechanism of GC resistance in normal thymocyte development that is retained during leukemogen

109 onal mechanisms have been well documented in thymocyte development, co-/post-transcriptional modifica

110 -defined molecular process programmed during thymocyte development, requires myriad pre-T cell recept

111 signaling largely induces cell death during thymocyte development, whereas weak TCR signals induce p

112 ne encephalomyelitis (EAE), it also disrupts thymocyte development, which could lead to lethal thymic

113 atural product of TCR gene rearrangement and thymocyte development.

114 NF-kappaB transcription, had no impact upon thymocyte development.

115 role in supporting HSC homeostasis and early thymocyte development.

116 h SRC1, impairs Th17 differentiation but not thymocyte development.

117 ntal autoimmune encephalomyelitis but normal thymocyte development.

118 on, we investigated a role for WNK1 in mouse thymocyte development.

119 but is not essential for RORgammat-dependent thymocyte development.

120 in type 2 immunity, norovirus infection, and thymocyte development.

121 ally' disrupted TH17 differentiation but not thymocyte development.

122 s impairs selective T cell functions but not thymocyte development.

123 g ion homeostasis is a critical regulator of thymocyte development.

124 of p53 was not primarily responsible for the thymocyte developmental defects observed in the Smarca5

125 ing, we identified mouse and human alphabeta thymocyte developmental trajectories.

126 CD4((+))CD8((+)) "double positive" (DP) thymocytes differentiate into diverse alphabeta T cell s

127 or into ZAP-70(-/-) mice resulted in a rapid thymocyte differentiation associated with the developmen

128 er identified a non-coding RNA named ThymoD (thymocyte differentiation factor).

129 hronization of thymopoiesis, with a periodic thymocyte differentiation profile persisting for at leas

130 te this, migration defects of WNK1-deficient thymocytes do not account for the developmental arrest.

131 bolism-fueled protein prenylation pathway in thymocyte egress and immune homeostasis.

132 nd loss of Pggt1b leads to marked defects in thymocyte egress and T cell lymphopenia in peripheral ly

133 of protein farnesylation, is dispensable for thymocyte egress but contributes to peripheral T cell ho

134 Thymocyte egress is a critical determinant of T cell hom

135 lphai2 interactions are essential for normal thymocyte egress, T cell trafficking, and homeostasis.

136 Absence of IL-4Ralpha limits thymocyte emigration, leading to an intrathymic accumula

137 the roles of G protein-coupled receptors in thymocyte emigration, the downstream signaling mechanism

138 As they differentiate, thymocytes encounter spatially restricted cues critical

139 study, HDAC3-deficient double-positive (DP) thymocytes exhibit a severe decrease in numbers.

140 inally, we evaluated CD4/CD8 double positive thymocytes expressing surface MR1.

141 Neonatal thymocytes expressing T cell receptors that engage IA(b)

142 y less efficient than that of MHCII-specific thymocytes expressing the same amount of ThPOK.

143 Here, we discuss how thymocyte-intrinsic and thymocyte-extrinsic determinants may specify the choice

144 resent self-peptides is a key determinant of thymocyte fate.

145 Highly autoreactive thymocytes first escape cortical negative selection and

146 (TECs) use LXRalphabeta for self-renewal and thymocytes for negative selection.

147 required to restrain CD8-lineage genes in DP thymocytes for the generation of CD4 T cells.

148 Further thymocyte fractionation demonstrated that DN1 and DN2, b

149 previous model posited that THEMIS prevents thymocytes from inappropriately crossing the positive/ne

150 stically, NCoR1 protects positively selected thymocytes from negative selection by suppressing Bim ex

151 at IKK was required to protect Rel-deficient thymocytes from RIPK1-dependent cell death, underscoring

152 XCR4-CXCL12 engagements release preselection thymocytes from the thymic cortex.

153 While RIPK1 protects thymocytes from TNFalpha-induced apoptosis, TRADD promot

154 mitochondria, synaptosomes, fibroblasts, and thymocytes from WT and MCU KO mice and the isolated work

155 in distinct populations of normal developing thymocytes, GCs paradoxically induced their own resistan

156 opment of CD4 T cells, as HDAC3-deficient DP thymocytes generate only CD8SP thymocytes in mice.

157 tion that is not impacted by rituximab, anti-thymocyte globulin (after absorption), or autoantibodies

158 p previously demonstrated that low-dose anti-thymocyte globulin (ATG) (2.5 mg/kg) preserved beta-cell

159 stem cell transplantation (AHSCT) with anti-thymocyte globulin (ATG) conditioning as treatment of ac

160 The use of anti-thymocyte globulin (ATG) has represented the standard of

161 l, particularly regarding concerns that anti-thymocyte globulin (ATG) might increase HCV-related comp

162 heart allograft recipients treated with anti-thymocyte globulin (mATG) critically depends on B cells

163 s; 84% received alemtuzumab (n = 14) or anti-thymocyte globulin (n = 8) as serotherapy.

164 signed 203 eligible patients to receive anti-thymocyte globulin (n=101) or no additional treatment (n

165 induction immunosuppression: (1) Rabbit anti-thymocyte globulin (rATG); (2) Alemtuzumab (C1H); (3) IL

166 nts received rabbit-derived intravenous anti-thymocyte globulin 0.5 mg/kg on day -9 and 2 mg/kg on da

167 ients were randomly assigned to receive anti-thymocyte globulin 4.5 mg/kg plus standard GVHD prophyla

168 S-D) scores were 10.40 (SD 9.88) in the anti-thymocyte globulin group and 14.62 (SD 12.26) in the sta

169 ths was 26.3% (95% CI 17.5-35.1) in the anti-thymocyte globulin group and 41.3% (31.3-51.3) in the st

170 5) occurred in 38 (38%) patients in the anti-thymocyte globulin group and in 49 (51%) in the standard

171 1 patient), fludarabine, thiotepa, and anti-thymocyte globulin or alemtuzumab conditioning were used

172 with scores of 13.27 (SD 10.94) in the anti-thymocyte globulin plus GVHD prophylaxis group and 20.38

173 ths was 70.6% (95% CI 60.6-78.6) in the anti-thymocyte globulin plus GVHD prophylaxis group compared

174 apse was 16.3% (95% CI 8.9-23.7) in the anti-thymocyte globulin plus GVHD prophylaxis group compared

175 One patient in the anti-thymocyte globulin plus GVHD prophylaxis group died of E

176 8 (38%) of 99 evaluable patients in the anti-thymocyte globulin plus GVHD prophylaxis group were free

177 analysis suggest that pretreatment with anti-thymocyte globulin provides clinically meaningful benefi

178 Anti-thymocyte globulin should be included in the preparative

179 In this trial of anti-thymocyte globulin, we measured treatment-independence a

180 tis, but no deaths were attributable to anti-thymocyte globulin.

181 clophosphamide, fludarabine, and rabbit anti-thymocyte globulin.

182 tially lower in T cells, and double-positive thymocytes had a notably higher response to TAM.

183 Although CD31 expression on human thymocytes has been reported, a detailed analysis of CD3

184 protein with high expression in CD4(+)CD8(+) thymocytes, has a crucial role in positive selection and

185 ro models and the heterogeneity of alphabeta thymocytes have hampered analyses of their intrathymic d

186 elios, which are upregulated in TCR-signaled thymocytes, have been implicated in negative selection.

187 e we found that, unlike postnatal gammadelta thymocytes, human fetal gammadelta thymocytes were funct

188 selection/maturation of CD8 single-positive thymocytes in a thymocyte-intrinsic manner.

189 ced T-ALL by conditional deletion of Ldb1 in thymocytes in an Lmo2 transgenic mouse model of T-ALL.

190 trophy of the thymus and induce apoptosis of thymocytes in mice, thus likely suppressing host immunit

191 nced the negative selection of TRP1-specific thymocytes in mice.

192 -deficient DP thymocytes generate only CD8SP thymocytes in mice.

193 ctions during the maturation of CD4(+)CD8(+) thymocytes, including downstream stages of iNKT and alph

194 nching is required for positive selection of thymocytes, inhibiting both death by neglect and negativ

195 a two-photon microscopy approach to observe thymocytes interacting with intact APCs presenting TRAs.

196 rogram, failed to redirect all MHCI-signaled thymocytes into the CD4 helper lineage, resulting in the

197 is sufficient in redirecting MHCI-restricted thymocytes into the CD4 helper lineage.

198 rects MHCII- and MHC class I (MHCI)-signaled thymocytes into the CD8 cytotoxic and CD4 helper lineage

199 to allow escape of preselection TCR(-)CD8(+) thymocytes into the periphery.

200 The diversion of MHC class II-restricted thymocytes into the regulatory T (T(reg)) cell lineage i

201 limiting agonist selection of self-reactive thymocytes into the Treg cell lineage.

202 Here, we discuss how thymocyte-intrinsic and thymocyte-extrinsic determinants

203 ation of CD8 single-positive thymocytes in a thymocyte-intrinsic manner.

204 CR4 expression by CD4(+)CD8(+) pre-selection thymocytes is progressively downregulated following both

205 anges were substantially more modest than in thymocytes lacking all Tcf1 isoforms.

206 K induction in MHC class II (MHCII)-signaled thymocytes leading to the CD4 helper lineage commitment.

207 Adaptive immunity depends on mature thymocytes leaving the thymus to enter the bloodstream a

208 es in thymic-epithelial cell ( P < 0.01) and thymocyte markers ( P < 0.01) were observed in both grou

209 ctified the dysregulated gene expression and thymocyte maturation in Gfi1-deficient mice.

210 ocytes, and since migration is important for thymocyte maturation, we investigated a role for WNK1 in

211 endent regulatory T-cell differentiation and thymocyte maturation, which progressed to a failure in r

212 illuminate the dynamics of chemokine-driven thymocyte migration, localization, and interactions with

213 PRRSV-induced apoptosis in CD4(pos)CD8(pos) thymocytes modulates cellular immunity against PRRSV and

214 Thymocytes must pass both positive and negative selectio

215 Thus, wild-type thymocytes naturally acquire the ability to protect them

216 roles in setting the signaling threshold for thymocyte negative selection.

217 es shapes the TCR repertoire by antagonizing thymocyte negative selection.

218 dendritic cells (DCs) required for effective thymocyte negative selection.

219 g Growth Factor beta (TGF-beta) signaling in thymocytes, negative selection is significantly impaired

220 Thymocyte numbers fell subsequent to the stromal changes

221 is associated with only a mild reduction of thymocyte numbers, contrasting with a more pronounced im

222 maps of linear and 3D genome organization in thymocytes of NOD mice, a model of type 1 diabetes (T1D)

223 mutation affects B cell development but not thymocyte or T cell development.

224 n signals to allow migration of TCR-signaled thymocytes out of the thymic cortex into the medulla.

225 scRNA-seq) to examine the immature postnatal thymocyte population in humans.

226 alpha expression skewed the insulin-specific thymocyte population toward greater regulatory T (Treg)

227 mocytes without any defects in the SP CD4(+) thymocyte population.

228 Thus, THEMIS facilitates thymocyte positive selection by enhancing the T cell ant

229 led a critical requirement for THEMIS during thymocyte positive selection, implicating THEMIS in sign

230 Although preselection BDC2.5 thymocytes possess higher affinity than splenic BDC2.5 T

231 1 in Lmo2-induced thymocyte self-renewal and thymocyte radiation resistance and for the transition of

232 Although thymocyte reconstitution was transient, gene-corrected p

233 Conditional deletion of Bcl6 from thymocytes reduced pre-TCR-induced differentiation to DP

234 complement protein C3 to wild-type immature thymocytes required the lectin but not the classical pat

235 ts that RORgammat inhibition in CD4(+)CD8(+) thymocytes resulted in skewed T cell repertoire, contrib

236 ntation of tissue-specific Ags to developing thymocytes, resulting in deletion of self-reactive T cel

237 and forced expression of ARID5B in immature thymocytes results in thymus retention, differentiation

238 arginine deiminase type IV (Padi4)-specific thymocytes reveal disparate fate choices.

239 3D genome mapping of NODxC57BL/6 F1 thymocytes revealed that genomic misfolding in NOD mice

240 fy a previously unknown function for Copa in thymocyte selection and demonstrate that a defect in cen

241 r data demonstrate that CD70 ablation alters thymocyte selection and increases circulating T cell lev

242 ein 2 is not involved in CD8 single-positive thymocyte selection or ERK signaling.

243 t with very high levels of expression during thymocyte selection, followed by massive down-regulation

244 ns of exhausted T cells in mice requires the thymocyte selection-associated high mobility group box (

245 Moreover, thymocyte selection-associated high mobility group box p

246 creased CDR3beta sharing was observed during thymocyte selection.

247 ritical requirement for Ldb1 in Lmo2-induced thymocyte self-renewal and thymocyte radiation resistanc

248 Glucocorticoid (GC) signaling in thymocytes shapes the TCR repertoire by antagonizing thy

249 p45(-/-) thymocytes showed increased apoptosis and alterations in

250 at the immature CD24(+)CD45RB(lo) gammadelta thymocyte stage, which revealed a critical checkpoint in

251 the immature CD4(+)CD8(+) (double-positive) thymocyte stage.

252 V8, AAV9, and AAV10 serotypes all transduced thymocyte subsets after in situ gene transfer, with tran

253 ssociated virus (AAV) serotypes to transduce thymocyte subsets and correct the T-cell immunodeficienc

254 , single-cell RNA sequencing analysis of CD4 thymocyte subsets revealed that IL-2 was expressed in se

255 erefore, HDAC3 is a critical regulator of DP thymocyte survival and is required to suppress P2X7 rece

256 expression responses to LPS and could impact thymocyte survival and trafficking, and thereby contribu

257 Instead, we found that IKK controlled thymocyte survival by repressing cell-death-inducing act

258 Thus, CCR4-NOT might control thymocyte survival during two-distinct stages of positiv

259 sitive selection by promoting post-selection thymocyte survival in part through stabilization of the

260 tenin interaction is necessary for promoting thymocyte survival to maintain thymic output.

261 of NF-kappaB as the IKK target required for thymocyte survival.

262 eased by macrophages that clear apoptotic DP thymocytes that fail to undergo positive selection.

263 tial subset of semimature (CD45RA(-)) CD4 SP thymocytes that lack CD31 expression.

264 In contrast to CD5(high) DN thymocytes that preferentially yield TCRalphabeta(+) CD8

265 ends on interactions between double-positive thymocytes that provide key homotypic interactions betwe

266 e pre-T cell receptor (pre-TCR) guides early thymocytes through maturation processes within the thymu

267 d for the transition of double negative (DN) thymocytes through the beta-selection checkpoint and sub

268 s diminished in p45(-/-) mice, transition of thymocytes through the maturation stages was unaffected,

269 cell fate decisions in double-positive (DP) thymocytes through the sequential suppression of MAF and

270 The ordered migration of immature thymocytes through thymic microenvironments generates bo

271 In anti-thymocyte/Thy-1 autoreactive BCR knock-in mice lacking s

272 t binding decreased from the double-positive thymocyte to the single-positive stage, and within singl

273 chemokine receptor expression on developing thymocytes to allow escape of preselection TCR(-)CD8(+)

274 gnal transduction is required for developing thymocytes to differentiate from CD4(-)CD8(-) double-neg

275 n the thymus, alphabeta TCRs signal immature thymocytes to differentiate into mature T cells by bindi

276 present tissue-restricted antigens (TRA) to thymocytes to induce central tolerance, but the relative

277 stance and for the transition of preleukemic thymocytes to overt T-ALL.

278 where THEMIS enhances TCR signaling enabling thymocytes to reach the threshold for positive selection

279 autoimmune disease relies on tolerization of thymocytes to self-antigens whose expression and present

280 CR4 expression normally anchors preselection thymocytes to the thymic cortex via interaction with its

281 s ligand adheres TCR-unsignaled preselection thymocytes to the thymic cortex.

282 oforms are adequate in supporting developing thymocytes to traverse through maturation steps and in r

283 2 and Pak signaling and mevalonate-dependent thymocyte trafficking.

284 Highly autoreactive thymocytes undergo an atypical maturation program, subst

285 , using a murine thymic slice model in which thymocytes undergo negative selection in situ, we demons

286 arca5 plays a key role in the development of thymocytes undergoing beta-selection, gammadelta thymocy

287 n expression is increased in double-positive thymocytes undergoing positive selection and is sustaine

288 HDAC3-deficient DP thymocytes upregulate the P2X7 receptor, increasing sens

289 The decrease in SP CD8(+) thymocytes was not caused by a block in differentiation

290 Upregulation of Helios in TCR-stimulated thymocytes was unaffected by deletion of Nur77, indicati

291 While IKK-deficient thymocytes were acutely sensitive to tumor necrosis fact

292 ammadelta thymocytes, human fetal gammadelta thymocytes were functionally programmed (e.g., IFNgamma,

293 e (WT) and DKO mice, CD3(+) alphabeta TCR(+) thymocytes were significantly reduced in DKO mice, imply

294 splantation of CD4-CD8- double negative (DN) thymocytes (which were also negative for Mac1 and Gr1) f

295 at IL-2 was expressed in self-reactive CD4SP thymocytes, which also contain T reg precursor cells.

296 heir presentation and encounter with passing thymocytes, while maintaining mTEC identity.

297 Mature thymocytes with a Galphai2 mutation that disables RGS pr

298 ing to an intrathymic accumulation of mature thymocytes within medullary perivascular spaces and redu

299 educed number of single-positive (SP) CD8(+) thymocytes without any defects in the SP CD4(+) thymocyt

300 Instead, we show that in DN thymocytes WNK1 transduces pre-TCR signals via OXSR1 and