ライフサイエンスコーパス: thymopoiesis

1 Of the six autopsies, one had evidence of thymopoiesis.

2 receptors, and exposure to androgen inhibits thymopoiesis.

3 se of thymic size, and impairing increase of thymopoiesis.

4 sts that this hormone is required for normal thymopoiesis.

5 ration of KGF to young and old mice enhanced thymopoiesis.

6 c stroma, which may be involved in defective thymopoiesis.

7 llografts long-term, with evidence of normal thymopoiesis.

8 g traits and/or cytokine milieu during adult thymopoiesis.

9 TREC)-positive T cells, indicating increased thymopoiesis.

10 oGEF to inhibit Galpha12 and Galpha13 during thymopoiesis.

11 trast, normal STAT5 is dispensable for adult thymopoiesis.

12 regeneration of T cells was due to enhanced thymopoiesis.

13 do not contribute to age-related declines in thymopoiesis.

14 Galpha13, but not Galpha12, is required for thymopoiesis.

15 en used as an indicator of ongoing or recent thymopoiesis.

16 of Notch1 to study surface expression during thymopoiesis.

17 taken as an absolute indication of previous thymopoiesis.

18 re present in the absence of current or past thymopoiesis.

19 s that orchestrate CD4 expression throughout thymopoiesis.

20 ng the thymic microenvironment and affecting thymopoiesis.

21 ity resulted from a progressive cessation of thymopoiesis.

22 IV can be generated at high frequency during thymopoiesis.

23 elial cells (TECs) and impairing recovery of thymopoiesis.

24 rved adverse effects of cytotoxic therapy on thymopoiesis.

25 he CD4 gene is tightly controlled throughout thymopoiesis.

26 (TREC) levels, a molecular marker for active thymopoiesis.

27 s appeared in the thymic medulla, indicating thymopoiesis.

28 mediate signals at both major transitions in thymopoiesis.

29 is and plays an important regulatory role in thymopoiesis.

30 provides an estimate of the level of ongoing thymopoiesis.

31 ative (DN) to double positive (DP) stages of thymopoiesis.

32 mune system that is not directly involved in thymopoiesis.

33 iency, bone marrow hypoplasia, and defective thymopoiesis.

34 D-hu Thy/Liv mice, an in vivo model of human thymopoiesis.

35 ral T cells as a result of an early block in thymopoiesis.

36 ted human thymic implants to support renewed thymopoiesis.

37 py is limited by an age-dependent decline in thymopoiesis.

38 of the CD3/TCR complex necessary for normal thymopoiesis.

39 es a resource for the further study of human thymopoiesis.

40 by IL-7, a critical gammac cytokine in early thymopoiesis.

41 8) of murine survivin during early stages of thymopoiesis.

42 trol of metabolic circuit, may contribute to thymopoiesis.

43 have posed a barrier to understanding human thymopoiesis.

44 Dll4 expression and more rapid promotion of thymopoiesis.

45 ansplant and does not solely require de novo thymopoiesis.

46 :CD8 ratio in which T cells are generated by thymopoiesis.

47 es describe a multilayered role for IL-21 in thymopoiesis.

48 y expressed protein that is important during thymopoiesis.

49 n with antiretroviral therapy alone, without thymopoiesis.

50 anisms that control Notch1 expression during thymopoiesis.

51 thymus allograft tissue was able to support thymopoiesis.

52 und in 25 of 30 biopsies, 23 of which showed thymopoiesis.

53 ined by immunohistochemistry for evidence of thymopoiesis.

54 1) the damaging effect of pulse steroids on thymopoiesis; 2) the need for adequate immunosuppression

55 IV can be generated at high frequency during thymopoiesis, a process where previously activated cells

56 ymus are not capable of supporting long-term thymopoiesis, a successful transplant is thought to requ

57 SCF together failed to significantly improve thymopoiesis above that shown by IL-7 alone.

58 With the enhanced thymopoiesis after KGF treatment, the number of naive CD

59 e data suggest that long-term suppression of thymopoiesis after sublethal irradiation was primarily d

60 germline mutation of FoxP3 caused defective thymopoiesis, although its potential contribution to aut

61 Thymopoiesis analyses with mouse models and reaggregate

62 contrast, Cxcr4(+/1013) mice show defective thymopoiesis and B-cell development, accounting for circ

63 Reduced thymopoiesis and continuous mobilization of naive T cell

64 transplant resulted in increased recovery of thymopoiesis and development of new thymus-derived perip

65 acologic interventions capable of preserving thymopoiesis and facilitating the recovery of a diverse

66 toimmune counterparts, but they show reduced thymopoiesis and generate a more restricted T-cell reper

67 al investigation into its in vivo effects on thymopoiesis and HIV infection.

68 herapy may be clinically useful in improving thymopoiesis and immune function in the elderly.

69 may complement the approaches to rejuvenate thymopoiesis and immunity in elderly.

70 gamma chain receptor cytokine implicated in thymopoiesis and in peripheral expansion and survival of

71 ymus regeneration characterized by increased thymopoiesis and increased naive T cell output.

72 essential mediator of T cell survival during thymopoiesis and indicate that its loss deregulates p56L

73 s as physiologically important precursors of thymopoiesis and indicate that they instead belong to a

74 he ability of such VTL allografts to support thymopoiesis and induce transplantation tolerance across

75 or plays a crucial role in the regulation of thymopoiesis and lymph node organogenesis.

76 and cytokines, including IL-7, regulate both thymopoiesis and maintenance of naive T cells in the per

77 uctural requirements of SLP-76 for mediating thymopoiesis and mature T cell function remain largely u

78 tion of hrIL-7/HGFalpha efficiently restores thymopoiesis and naive T-cell reconstitution in mice aft

79 Furthermore, KGF enhanced thymopoiesis and normalized TEC organization in klotho (

80 I discuss the contributions of thymopoiesis and other renewal mechanisms, lymphatic hom

81 new techniques to focus on the interplay of thymopoiesis and peripheral expansion that defines T-cel

82 mpact of premature thymic involution on both thymopoiesis and peripheral immune niches likely contrib

83 sed to a failure in regular and regenerative thymopoiesis and peripheral T-cell homeostasis in the ad

84 w transplantation (BMT) resulted in enhanced thymopoiesis and peripheral T-cell numbers in middle-age

85 Defective thymopoiesis and peripheral T-cell reconstitution were f

86 he provision of human IL-6 not only enhanced thymopoiesis and periphery T-cell engraftment, but also

87 nction of thymic epithelial cells (TECs) and thymopoiesis and postulated that these effects would be

88 T cells are produced through 2 mechanisms, thymopoiesis and proliferative expansion of postthymic T

89 spanning key differentiation events in human thymopoiesis and provide a resource for the further stud

90 teroids, and their removal promotes enhanced thymopoiesis and recovery from immune injury.

91 delay and underline a crucial role of HS in thymopoiesis and skeletal and brain development.

92 ymic epithelial cells (TECs) are crucial for thymopoiesis and T cell generation, how TEC development

93 hymoproteasome dysfunction leads to impaired thymopoiesis and the development of severe combined immu

94 In adults, both impaired recipient thymopoiesis and the lack of transferred memory cells co

95 Thymopoiesis and thymic output were supranormal, leading

96 regenerated via a dynamic interplay between thymopoiesis and thymic-independent homeostatic peripher

97 x 1 (mTORC1) in TECs plays critical roles in thymopoiesis and thymus function.

98 4% CR for 2 years in healthy humans improved thymopoiesis and was correlated with mobilization of int

99 pre-existing viral infections without having thymopoiesis, and 1 late death occurred from autoimmune

100 f CD4(+)CD45RA(+) T cells, reconstitution of thymopoiesis, and attainment of T-cell receptor rearrang

101 integrated into SwTHY grafts, enhanced human thymopoiesis, and increased peripheral CD4(+) naive T-ce

102 ts (CD3(+), CD4(+), and CD8(+)), evidence of thymopoiesis, and sustained T-cell proliferative capacit

103 We prospectively measured T-cell numbers, thymopoiesis, and T-cell memory in 73 children undergoin

104 mic epithelial cells (TECs) help orchestrate thymopoiesis, and TEC differentiation relies on bidirect

105 homeostatic peripheral expansion, promoting thymopoiesis, and the use of adjuvant-targeted cellular

106 constitution is related to both increases in thymopoiesis as well as a direct increase in the magnitu

107 ses, and correlated with decreased levels of thymopoiesis, as determined by either decreased keratin-

108 wed good graft development, with evidence of thymopoiesis, as indicated by positive CD1 and host-type

109 tration of IL-7 maintained the first step of thymopoiesis at a level far higher than was seen in age-

110 fficient for CD4(+) T-cell regeneration, and thymopoiesis becomes critical in this process.

111 e major selection processes occurring during thymopoiesis: beta-selection, positive selection, and ne

112 nsulin-like growth factor 1 (IGF-1) enhances thymopoiesis but given the broad distribution of IGF-1 r

113 ngement is not only to minimize waste during thymopoiesis, but also to simultaneously allow proper ex

114 er transplantation, before reconstitution of thymopoiesis, but fail to clear CMV viremia.

115 GF-beta signaling is not required for normal thymopoiesis, but is essential for regulating the expans

116 We studied thymopoiesis by CD31(+) naive T cells (recent thymic emi

117 he BM of immunodeficient mice, sustain human thymopoiesis by generating circulating T-cell progenitor

118 In the absence of conditioning, long-term thymopoiesis by semiallogeneic progenitors was detected

119 ymic lobe transplantation and the support of thymopoiesis by such transplants in a large animal model

120 During thymopoiesis, c-Myb appears to regulate immature cell nu

121 Thymopoiesis can be assessed by quantification of recent

122 pheral lymphoid homeostasis and suggest that thymopoiesis can be negatively regulated by the accumula

123 A combination of functional assays and thymopoiesis comparisons enabled a categorization of div

124 ed by increased cytokine responsiveness, and thymopoiesis complement each other as mechanisms of T-ce

125 mplete T-cell repertoire renewal and reduced thymopoiesis contribute to a proautoimmune state after a

126 hich disrupted bone marrow hematopoiesis and thymopoiesis contribute to the development of lymphoma i

127 ll receptor excision circle (TREC) assays of thymopoiesis, cytokine-flow cytometry assays of T-cell f

128 n thymus increases in volume during aging as thymopoiesis declines.

129 c CD4+ T cells from engrafted donor HSCs was thymopoiesis dependent.

130 During postnatal life, thymopoiesis depends on the continuous colonization of t

131 depleted of CD4(+) cells can support renewed thymopoiesis derived from both endogenous and exogenous

132 mice that lacked ZFP36L1 and ZFP36L2 during thymopoiesis developed a T cell acute lymphoblastic leuk

133 Evidence of thymopoiesis developed from 5 to 6 months after transpla

134 functional thymus tissue, and when present, thymopoiesis did not prevent prolonged lymphopenia.

135 Consistent with reduced thymopoiesis, dietary obesity led to reduction in periph

136 Ghrelin-induced thymopoiesis during aging was associated with enhanced e

137 genic signaling in thymus via CR may promote thymopoiesis during aging.

138 While donor-derived thymopoiesis during the early post-transplant period is

139 R-205, an epithelial-specific miR, maintains thymopoiesis following inflammatory perturbations.

140 nt T cell recovery involves an uncoupling of thymopoiesis from thymic tolerance, which results in aut

141 l systems that recapitulate the full span of thymopoiesis, from hematopoietic stem and progenitor cel

142 e thymic architecture, with a single wave of thymopoiesis generating long-term peripheral T-cell func

143 hymus grafts support robust murine and human thymopoiesis, generating a diverse T cell repertoire tha

144 lls in thymic biopsies, implying that baboon thymopoiesis had begun to occur in the porcine thymic xe

145 Renewed thymopoiesis has been found to play a critical role in t

146 The role of IL-7 during thymopoiesis has led to it being the focus of a number o

147 n early bone marrow hemopoiesis, its role in thymopoiesis has not been thoroughly examined.

148 t extent these cells genuinely contribute to thymopoiesis has remained obscure.

149 Thymopoiesis immediately recovered following cessation o

150 topsy data, allogeneic thymus tissues showed thymopoiesis in 24 of 29 (86%) evaluable transplants.

151 We examined thymopoiesis in adults up to 56 years of age and found a

152 Leptin also enhanced thymopoiesis in aged but not young mice.

153 f Foxn1 expression in the thymus ameliorates thymopoiesis in aged mice and offer a strategy to combat

154 ting the elimination of thymic ILCs improved thymopoiesis in an IL-22-dependent fashion.

155 IL-7 is a critical component of thymopoiesis in animals and has recently been shown to p

156 In this study, we find that reduced thymopoiesis in Carm1(-/-) mice is due to a defect in th

157 class I barrier can engraft and support host thymopoiesis in euthymic miniature swine.

158 enogeneic barriers, and to support long-term thymopoiesis in immunodeficient hosts.

159 une-based therapies could be used to enhance thymopoiesis in immunodeficient individuals.

160 on of hrIL-7/HGFalpha significantly enhanced thymopoiesis in mice after syngeneic BMT by increasing t

161 Interleukin-7 (IL-7) is important for thymopoiesis in mice and humans because IL-7 receptor al

162 In vivo analyses of thymopoiesis in mice defective in signaling through Kit

163 dy, we found that the impact of radiation on thymopoiesis in mice varied by sex and dose but, overall

164 them into SwTHY tissue, which supports human thymopoiesis in NOD severe combined immunodeficiency IL2

165 them into SwTHY tissue, which supports human thymopoiesis in NOD severe combined immunodeficiency IL2

166 IL-7/mAb complexes also increased thymopoiesis in normal mice and restored thymopoeisis in

167 istration induced weight loss and stimulated thymopoiesis in ob/ob mice, but did not stimulate thymop

168 Defects in thymopoiesis in obese mice were related with decrease in

169 ent that can reverse age-related declines in thymopoiesis in rodents.

170 Thymopoiesis in the absence of AIRE is implicated in bot

171 Our data suggest that thymopoiesis in the Foxn1Delta/Delta adult thymus procee

172 of atypical subjects; and 3) the presence of thymopoiesis in the presence of ongoing immunosuppressio

173 ion from hDAF swine to baboons induced early thymopoiesis in the recipients and donor-specific cellul

174 evaluated the capacity for rhIL-7 to enhance thymopoiesis in the setting of allogeneic T cell-deplete

175 As a consequence, thymopoiesis in this xenogeneic setting began by weeks 4

176 functional T cell progenitors, evidenced by thymopoiesis in thymic organ cultures.

177 The apoptotic phenotype is mirrored during thymopoiesis in transgenic mice expressing dominant inte

178 By examining thymopoiesis in vivo and in vitro, diverse abnormalities

179 uiescent lymphocytes can be generated during thymopoiesis in vivo in the SCID-hu mouse system.

180 this study, the ability of leptin to promote thymopoiesis in wild-type C57BL/6 and BALB/c mice, as we

181 poiesis in ob/ob mice, but did not stimulate thymopoiesis in wild-type C57BL/6 nor BALB/c mice.

182 o the thymus and reconstituting a functional thymopoiesis in young recipients is presently unknown.

183 f histocompatible HSCs can sustain long-term thymopoiesis in ZAP-70-immunodeficient mice.

184 that MG itself or treatment for MG decreased thymopoiesis independent of thymectomy.

185 blish thymic mesenchyme prior to recovery of thymopoiesis-inducing epithelial compartments.

186 tional and molecular properties of embryonic thymopoiesis-initiating progenitors (T-IPs) before their

187 hese results indicate that reconstitution of thymopoiesis is critical for long-term clinical outcome

188 enhance immune reconstitution by increasing thymopoiesis is critical to solving this problem.

189 cell lineage and subsequent stages of early thymopoiesis is critically regulated by Notch.

190 Unfortunately, thymopoiesis is highly susceptible to damage by physiolo

191 Collectively, these data suggest that thymopoiesis is inhibited by GVHD.

192 hese implants with antiretroviral drugs, new thymopoiesis is initiated.

193 static peripheral expansion, especially when thymopoiesis is insufficient, as is often the case in hu

194 only the memory T cell compartment, whereas thymopoiesis is required for the reconstitution of the n

195 have previously shown that the first step of thymopoiesis is specifically blocked in aging.

196 ne mechanism by which sex steroids influence thymopoiesis is through direct inhibition in cortical th

197 conditioning, and/or augment the recovery of thymopoiesis may improve outcomes after CBT.

198 hat TCR signaling during the early stages of thymopoiesis mediates an oncogenic signal, and therefore

199 y and imply that therapeutic potentiation of thymopoiesis might either prevent or reverse this outcom

200 Despite an initial burst of thymopoiesis, most recovering regulatory T cells were pe

201 y provided a mechanism for both the abnormal thymopoiesis observed after BMT and the previously obser

202 (BMT), we found that efficient donor-derived thymopoiesis occurred before the pool of ETPs had been r

203 Initial results suggest that baboon thymopoiesis occurs in vascularized porcine thymus xenog

204 In addition, thymopoiesis of aged mice improved with a single intrath

205 Transplanted VTL grafts supported early thymopoiesis of recipient-type immature thymocytes, and

206 All patients had thymopoiesis on allograft biopsy.

207 All 19 survivors with thymopoiesis on biopsy developed naive T cells and T cel

208 Two of seven patients also had areas of thymopoiesis; one of these patients had peripheral blood

209 r by enhancement of the demonstrably reduced thymopoiesis or by peripheral TN expansion.

210 sociated with thymic involution and impaired thymopoiesis, particularly in pediatric patients.

211 overy of an additional age-sensitive step in thymopoiesis, proliferation of the DN4 population, which

212 these 2 populations, only CLPs reconstitute thymopoiesis rapidly after intravenous injection.

213 We show here that human thymopoiesis releases a large population of clustered CD

214 lineage potential of the cells that initiate thymopoiesis remain controversial.

215 in mice varied by sex and dose but, overall, thymopoiesis remained suppressed for >/=12 mo after a si

216 ported, their impact on protein function and thymopoiesis remains unclear for most variants.

217 Ongoing thymopoiesis requires continual seeding from progenitors

218 Thus, in MG, removal of a thymus with active thymopoiesis resulted in a significant fall in PB TREC(+

219 is the major Src family member required for thymopoiesis, since there is a severe deficit of CD4+CD8

220 llectively, these data indicate that, during thymopoiesis, stage-specific surface translocation of TM

221 s an oncogene and precisely map the stage in thymopoiesis susceptible to ThPOK-dependent tumor initia

222 Interleukin-7 (IL-7) is fundamental for thymopoiesis, T-cell homeostasis, and survival of mature

223 as a loss of naive cell input due to reduced thymopoiesis, the present data suggest that the aged mic

224 ntly traffic to the thymus and contribute to thymopoiesis under normal conditions because of the lack

225 or CD8 T cell TREC concentrations most when thymopoiesis was active before thymectomy (six of six pa

226 Thymopoiesis was assessed in mouse lines genocopying sev

227 In intrathymic-transplanted mice, ongoing thymopoiesis was associated with a 10-fold higher level

228 Furthermore, we demonstrated that renewed thymopoiesis was critical for the restoration of periphe

229 Enhanced thymopoiesis was maintained for about 2 months after a s

230 nts), but had little effect in patients when thymopoiesis was minimal (four of four patients).

231 of full lymphoid maturation, suggesting that thymopoiesis was not affected.

232 etic stem cell transplantation; in contrast, thymopoiesis was reduced and clonal renewal of T-cell re

233 Histologic confirmation of thymopoiesis was seen in 7 of 11 patients undergoing bio

234 Epithelium without thymopoiesis was seen in two of 25 biopsies in which thy

235 In this time period, thymopoiesis was similar between the three treatment gro

236 hymus-derived stromal cells, but its role in thymopoiesis was unknown.

237 To determine the cellular basis for impaired thymopoiesis, we examined the number and function of fet

238 hether Galpha12 and Galpha13 are involved in thymopoiesis, we expressed the regulator of G protein si

239 lopmental pattern of human prothymocytes and thymopoiesis, we used NOD-scid/gammac(-/-) mice grafted

240 epsilon delta P mice with CD3 zeta-/- mice, thymopoiesis were arrested at the CD44-CD25+ DN stage as

241 Graft survival and thymopoiesis were assessed by histology, immunohistochem

242 ecific for that lineage, as myelopoiesis and thymopoiesis were normal in dwarf and hypothyroid mice.

243 s able to replicate in the thymus and impact thymopoiesis were present in all infants, regardless of

244 We present a model for human thymopoiesis which includes gammadelta development as a

245 at the FoxP3(sf) mutation leads to defective thymopoiesis, which is caused by inactivation of FoxP3 i

246 ion of Trpm7 in the T cell lineage disrupted thymopoiesis, which led to a developmental block of thym

247 They are selected during thymopoiesis, which releases a repertoire of about 10(8)

248 ein) transgenic zebrafish revealed defective thymopoiesis, which was rescued by injection of wild-typ

249 -expressing progenitor cells showed impaired thymopoiesis with a block at the CD4-CD8-CD44-CD25+ (DN3

250 ES) volume decreases progressively with age, thymopoiesis with active T-cell receptor gene rearrangem

251 adiation dose also caused synchronization of thymopoiesis, with a periodic thymocyte differentiation

252 common lymphoid progenitors, boosted de novo thymopoiesis without affecting haematopoietic stem cell

253 f Ikaros-deficient mice that exhibit ongoing thymopoiesis without B lymphopoeisis revealed near-norma

254 enforce the beta-selection checkpoint during thymopoiesis, yet their molecular targets remain largely