ライフサイエンスコーパス: tick

1 e, is transmitted by the bite of an infected tick.

2 ly restricted to developmental stages of the tick.

3 , persist and, at the optimal time, exit the tick.

4 y conforms to the territory of the lone star tick.

5 ortant for B. burgdorferi persistence in the tick.

6 e and transmitted by Ornithodoros verrucosus ticks.

7 f LB and other disease agents borne by these ticks.

8 ted by feeding with DC-microinjected nymphal ticks.

9 n water uptake by type I acini in desiccated ticks.

10 and Francisella-like endosymbionts found in ticks.

11 of 2n = 20 chromosomes for Ornithodoros spp. ticks.

12 f unfed uninfected Ixodes scapularis nymphal ticks.

13 in comparison to the genomes of the parental ticks.

14 ansmitted to vertebrate hosts by Ixodes spp. ticks.

15 mans, mammalian commensals can be harmful to ticks.

16 e to nymphal stage was also evident in these ticks.

17 inst an acute challenge by Borrelia-infected ticks.

18 profiles of POWV-infected versus uninfected ticks.

19 g due to lower encounter rates with infected ticks.

20 targets for rickettsiae after inoculation by ticks.

21 f acquired pathogens and transmissibility by ticks.

22 pirochetes are transmitted by Ixodes species ticks.

23 g-term prescribed fire significantly reduced tick abundance at sites with varying burn regimes (burne

24 of parasitized erythrocytes decreased during tick acquisition feeding.

25 d has been related to bites of the lone star tick (Amblyomma americanum).

26 port for the first time that adult lone star ticks, Amblyomma americanum, also actively drink nutrien

27 ly transmitted through a bite of an infected tick and blood transfusions in human.

28 ype of POWV (DTV) is transmitted by the deer tick and is the likely cause of the increase in the numb

29 life cycles involving multiple stages in the tick and the mammalian host.

30 tted to vertebrate hosts via infected Ixodes ticks and are the etiologic agents of Lyme disease.

31 s study suggest that the rickettsial load in ticks and during transmission may be an important elemen

32 The relationships between ticks and hosts are relevant to capture the ecological b

33 find strong support for monophyletic Acari (ticks and mites), which when considered as a single grou

34 ern-most site of refuge giving rise to those ticks and pathogens now fueling the epidemic.

35 mutants were successfully acquired by larval ticks and persisted through fed nymphs.

36 itted by the bite of infected mosquitoes and ticks and regularly cause outbreaks.

37 s support a phylogenetic association between ticks and their microbiota across evolution; this is kno

38 aluable resource for research and control of ticks and tick-borne diseases.

39 feeding system that facilitates the study of ticks and tick-borne pathogens.

40 ating possible nonlinear responses of vector ticks and transmission dynamics to projected climate cha

41 the major tick marks (rather than the minor ticks), and in Fig. 1b, the arrows at the top and bottom

42 2n = 28 chromosomes for parental Ixodes spp. ticks, and both increase and decrease in chromosome numb

43 sticide currently sold for control of fleas, ticks, and mites on companion animals and poultry.

44 Ixodid ticks are ectoparasites that feed exclusively on blood a

45 Ticks are hematophagous arachnids that parasitize mammal

46 Ticks are important vectors that transmit several pathog

47 Infected Haemaphysalis longicornis ticks are the major source of human SFTSV infection.

48 Hard ticks are widely distributed across temperate regions, s

49 Ticks, as blood-sucking parasites, have developed a comp

50 ed to a human host, that is, within hours of tick attachment, which is distinctive when compared to o

51 This tick behavior can be exploited to target important physi

52 Salivary evasins from ticks bind multiple chemokines to overcome redundancy an

53 enome with a largely unexplored influence on tick biology and pathogen transmission.

54 ght how the study of the epigenetic basis of tick biology and vectorial capacity will enrich our know

55 International experts from the fields of tick biology, allergy, immunology, infectious disease, a

56 s increased and supports microbial impact on tick biology.

57 DIA3 modulates inflammatory responses at the tick bite site, potentially facilitating spirochete surv

58 manifestation called erythema migrans at the tick bite site.

59 cut with encephalitis, who had a recent deer tick bite, were evaluated by the relevant serologic test

60 ansmitted within just 15 minutes following a tick bite.

61 oinfections that most commonly occur after a tick bite.

62 The connection between tick bites and alpha-Gal sensitization was further suppo

63 ly acquired in adulthood as a consequence of tick bites and has a regional distribution that largely

64 History of tick bites and tick-related febrile illness were assesse

65 E to alpha-Gal and also the association with tick bites have been increasing worldwide.

66 Of note, the duration of the tick bites in both cases was very short.

67 o food and medication in patients at risk of tick bites including travellers.

68 They appear to be stimulated only by tick bites which induce production of alpha-gal specific

69 ht additional evidence for the connection to tick bites.

70 l, 881 specimens were positive for bacterial tick-borne agents.

71 een neglected in discovery efforts targeting tick-borne agents.

72 epresenting a 100% increase in the number of tick-borne bacteria identified compared to what was poss

73 Taxonomic predictions for tick-borne bacteria were exceptionally accurate, as inde

74 In three blood specimens, two tick-borne bacteria were simultaneously detected.

75 Twelve tick-borne bacterial species were detected, including tw

76 Lyme borreliosis is a tick-borne disease caused by the Borrelia burgdorferi se

77 Human granulocytic anaplasmosis (HGA) is a tick-borne disease caused by the obligate intracellular

78 Tick-borne disease pathogen identification remains a dia

79 ine trials and public health surveillance of tick-borne disease patterns.

80 Tick-borne diseases (TBD) are common across the United S

81 cycle and efficient pathogenesis.IMPORTANCE Tick-borne diseases have become a growing threat to publ

82 Tick-borne diseases, due to a diversity of bacterial pat

83 hogenesis and on the polymicrobial nature of tick-borne diseases.

84 source for research and control of ticks and tick-borne diseases.

85 Tick-borne encephalitis (TBE) is a viral infection of th

86 Southern Sweden is endemic for tick-borne encephalitis (TBE), with Stockholm County as

87 Tick-borne encephalitis virus (TBEV) is the causative ag

88 ia, Bartonella, Francisella, Powassan virus, tick-borne encephalitis virus, and Colorado tick fever v

89 diated transport.IMPORTANCE Nairoviruses are tick-borne enveloped RNA viruses that include several pa

90 for Powassan virus (POWV), a North American tick-borne flavivirus that is the causative agent of a s

91 al samples from patients suspected of having tick-borne illness and >1,000 controls.

92 a burgdorferi sensu lato, is the most common tick-borne illness in the Northern Hemisphere and the nu

93 to samples from persons suspected of having tick-borne illness.

94 drome (PTLDS), and (3) clinical suspicion of tick-borne illnesses (TBI).

95 Lyme disease is a tick-borne infection caused by the bacteria Borrelia bur

96 erranean spotted fever is a reemerging acute tick-borne infection produced by the alpha-proteobacteri

97 occurrence and the clinical implications of tick-borne infections in immunosuppressed patients livin

98 The incidence of tick-borne infections in the United States has risen sig

99 including Rocky Mountain spotted fever, are tick-borne infections with frequent neurologic involveme

100 torial capacity will enrich our knowledge of tick-borne infections.

101 Babesia species are tick-borne intracellular parasites that infect the red b

102 ic ability to kill Borrelia burgdorferi, the tick-borne Lyme disease bacterial pathogen.

103 RUO) nine-target high-definition PCR (HDPCR) tick-borne pathogen (TBP) panel using 379 retrospective,

104 n-Congo hemorrhagic fever virus (CCHFV) is a tick-borne pathogen causing a febrile illness in humans,

105 Collectively, 279 distinct unique tick-borne pathogen derived peptides were identified.

106 mass spectrometry is a new tool for studying tick-borne pathogen infections.

107 Neoehrlichia (N.) mikurensis is an emerging tick-borne pathogen of humans that is closely related to

108 ed by 100% amino acid sequence identity with tick-borne pathogen proteins, evolutionary taxonomic ver

109 ing was performed to confirm the presence of tick-borne pathogens by real-time PCR, and a subset of s

110 The occurrence of tick-borne pathogens in the blood of patients (n=163) wi

111 Nonetheless, the full range of tick-borne pathogens is unknown.

112 ication testing for B. burgdorferi and other tick-borne pathogens.

113 stem that facilitates the study of ticks and tick-borne pathogens.

114 is and accelerate the discovery of bacterial tick-borne pathogens.

115 Little is known about the ability of tick-borne phleboviruses to reassort.

116 rn equine encephalitis virus, as well as the tick-borne Powassan virus.

117 current postexposure prophylaxis regimen for tick-borne relapsing fever (TBRF) consists of 5 days' do

118 Tick-borne relapsing fever (TBRF) is a neglected zoonoti

119 e Lyme disease, syphilis, leptospirosis, and tick-borne relapsing fever.

120 China, South Korea, and Japan caused by the tick-borne SFTS virus (SFTSV).

121 The tick-borne spirochete, Borrelia miyamotoi, is an emergin

122 Lyme neuroborreliosis (LNB), caused by the tick-borne spirochetes of the Borrelia burgdorferi sensu

123 Since 2000, the reported prevalence of tick-borne spotted fever rickettsiosis has increased con

124 s the causative agent of the most widespread tick-borne viral infection in humans.

125 fever (CCHF) is the most widely distributed tick-borne viral infection in the world.

126 fever is the most geographically widespread tick-borne virus, with infection resulting in mortality

127 Kyasanur Forest disease (KFD) is a tick-borne, acute, febrile viral illness endemic in sout

128 istinct from the established mosquito-borne, tick-borne, insect-only, and unknown-vector flavivirus g

129 rounding prioritises data collection through tick boxes or a prescriptive and structured recording of

130 sation of prescribed methods of recording or tick boxes rather than relational, individualised patien

131 only to generate A. phagocytophilum-infected ticks but also provides a tool to understand acquisition

132 evasin ACA-01 from the Amblyomma cajennense tick can be posttranslationally sulfated at two tyrosine

133 Ticks can transmit a variety of pathogens, including bac

134 Tick cell cultures are often continuously cultivated, as

135 Tick cell lines are an easy-to-handle system for the stu

136 Thus, highly passaged tick cell lines can be used for research purposes, but p

137 All studied tick cell lines had a larger genome size in comparison t

138 we investigated karyotype and genome size of tick cell lines.

139 However, the long-term cultivation of tick cells can influence their genome stability.

140 In contrast, the profile of TBEV grown in tick cells showed that paucimannose (Man(3-4) GlcNAc(2)F

141 virus egress in mammalian cells, but not in tick cells.

142 compare it to the profile of virus grown in tick cells.

143 nd bacterial infections and other aspects of tick cellular processes.

144 the origin, maintenance, and spread of these ticks contributes much to our understanding of the sprea

145 veloping novel, sustainable technologies for tick control.

146 lts under an ecological perspective in which ticks could track its environmental niche associating to

147 Secreted into the saliva and gut of ticks, Dae2 limits skin-associated staphylococci in tick

148 eruginosa to drinking water quickly leads to tick death.

149 fornia, and how land use change shifts human tick-encounter risk across the state.

150 nts treated with biologicals and living in a tick-endemic area seem to have a high risk of contractin

151 tions in immunosuppressed patients living in tick-endemic areas is limited.

152 n should be considered in patients living in tick-endemic areas of Europe and northern Asia who prese

153 se two actions are known to alternate during tick engorgement.

154 istic insight into how CXC-chemokine-binding tick EVAs achieve class specificity but also engage in p

155 Tick evasins (EVAs) bind either CC- or CXC-chemokines by

156 Ticks exist across diverse environments and transmit num

157 hogen acquisition from blood meal during the tick feeding process.

158 orm needle inoculations in naive animals for tick feeding studies.

159 strain, we demonstrated that the artificial tick feeding system is a suitable tool to study tick-pat

160 In this study, we describe a new in vitro tick feeding system that facilitates the study of ticks

161 rk demonstrates the utility of an artificial tick feeding system to directly study the association be

162 ttachment rates between the first and second tick feeding.

163 several spirochete genotypes introduced via tick feeding.

164 tick-borne encephalitis virus, and Colorado tick fever virus.

165 We collected 1232 Ixodes scapularis ticks from 17 east coast sites ranging from New Hampshir

166 BUB and UBB sites, respectively) compared to ticks from control sites (unburned, surrounded by unburn

167 specimens to understand three key aspects of ticks: genetic diversity, population structure, and path

168 ave decreased spirochete colonization of the tick gut after engorging on B. burgdorferi-infected mice

169 ected vertebrate host, spirochetes enter the tick gut along with the bloodmeal and colonize the vecto

170 ring infection, as well as interactions with tick gut and salivary gland proteins important for estab

171 enhances B. burgdorferi colonization of the tick gut.

172 as it exits the vertebrate host to enter the tick gut.

173 ecognition of novel pathogens transmitted by ticks, has made accurate diagnosis of these infections c

174 a glycoprotein precursor variant, present in ticks, has severely impaired function in human cells.

175 supports the existence of a species-specific tick hologenome with a largely unexplored influence on t

176 vestigated how environmental suitability for tick host-seeking changes seasonally, how the magnitude

177 heir hosts in the Neotropics to approach the tick-host relationships using a network-based construct.

178 is transmitted through the bite of infected ticks; however, little is known about the response of th

179 es scapularis genome and characterization of tick immune defence pathways, such as the JAK-STAT, immu

180 A burgeoning area of research is tick immunity as it can unlock mechanistic pathways that

181 been bitten by the Haemaphysalis longicornis tick in the United States, which occurred in New York St

182 vere febrile illness transmitted by Hyalomma ticks in endemic areas, handling of infected livestock o

183 thod to generate A. phagocytophilum-infected ticks in laboratory conditions.

184 zoonosis and is dependent on transmission by ticks in the genus Ixodes.

185 table, and genetically diverse population of ticks in the Southeastern US, that is rarely infected wi

186 I. scapularis ticks in which ispdiA3 has been knocked down using RNA i

187 We explored the genetic basis common to ticks, including heme and hemoglobin digestion, iron met

188 pathogen to determine the effect of dose on tick infection rate.

189 rrelia burgdorferi, transfers from a feeding tick into a human or other vertebrate host, the bacteriu

190 on of KUNDV and KARYV isolated from Hyalomma ticks is critical for the development of specific serolo

191 lore the response of the western blacklegged tick (Ixodes pacificus), the primary Lyme disease vector

192 ere, we discover that a toxin in blacklegged ticks (Ixodes scapularis) horizontally acquired from bac

193 fferent components of the mouthparts of hard ticks (Ixodidae) enable these parasites to penetrate hos

194 present heritable, contrasting phenotypes of tick loads, taurine breeds carrying higher loads of the

195 s in Fig. 3h should appear next to the major tick marks (rather than the minor ticks), and in Fig. 1b

196 owledge of the composition and complexity of tick microbial communities has increased and supports mi

197 Tick midgut and salivary glands were infected with A. ma

198 as KH(2)PO(4) + NaCl+KNO(3) resulted in 100% tick mortality within 3 days.

199 P ((R))) showed positivity for shrimp, crab, ticks, moths, and mosquitoes, while ImmunoCAP((R)) tests

200 n animated model of the orchestration of the tick mouthparts and associated structures during blood m

201 icephalus pulchellus lasts for days, and the tick must therefore rely on inhibitors to counter comple

202 sts that during the last glacial period such ticks occupied distinct refugia, with only the northern-

203 We used a set of 4,764 records of ticks of the genera Amblyomma, Ixodes, and Haemaphysalis

204 oscope and a fourth pathologist via manually ticking off each cell, the latter of which was deemed th

205 entified 9 clusters of interacting hosts and ticks partially connected by 22 tick species that switch

206 analytical sensitivity = 2.5 pg/mL) to study tick pathogen-specific proteins shed in the urine of pat

207 entor andersoni and Anaplasma marginale as a tick-pathogen interaction model.

208 k feeding system is a suitable tool to study tick-pathogen interactions and that A. marginale tick sa

209 the role of 6S RNA in murine infectivity and tick persistence of the Lyme disease spirochete Borrelia

210 CCHF-negative Hyalomma anatolicum tick pools were passaged for virus isolation, and two vi

211 analyses to resolve geographically distinct tick populations and compare their demographic histories

212 s and vaccines have been used to try to keep tick populations under control.

213 The contrasting geography and demography of tick populations, interpreted in the context of the geol

214 Male ticks presented the most diverse armamentarium of mediat

215 e into the pharynx through the mouth and how ticks prevent mixing the uptaken blood with secreted sal

216 Here, we show that a secreted tick protein, I. scapularis protein disulfide isomerase

217 o characterize the IgE response to lone star tick proteins administered through the skin of mice.

218 by B. burgdorferi during tick transit and on tick proteins that mediate feeding and pathogen transmis

219 n infection, B. burgdorferi induces selected tick proteins that modulate the vector gut microbiota to

220 formatics approach is used to identify seven tick proteins with putative thrombin inhibitory activity

221 bited increased estimated epigenetic mitotic tick rate as well as DNA methylation age compared with c

222 ation, sponsored a workshop on this emerging tick-related disease.

223 History of tick bites and tick-related febrile illness were assessed as part of a

224 Based on the results of testing the tick removed from case 2, this patient was infected by D

225 genome sequences of CCHFV directly from the tick reservoir.

226 These findings suggest ticks resist their own pathogens while tolerating symbio

227 The blood-meal of the tick Rhipicephalus pulchellus lasts for days, and the ti

228 The cattle tick, Rhipicephalus microplus, is a monoxenous tick that

229 m neural signaling pathways arising from the tick's central nervous system.

230 been learned about the basic anatomy of the tick's mouthparts and in the broad outlines of how they

231 Moreover, the tick's mouthparts represent a key route for saliva-assis

232 Nomacopan, a drug originally derived from tick saliva, has dual functions of sequestering leukotri

233 e have identified a class of inhibitors from tick saliva, the CirpT family, and generated detailed st

234 erent to previously described anaphylaxis to tick saliva.

235 Ixolaris is a potent tick salivary anticoagulant that binds coagulation facto

236 -pathogen interactions and that A. marginale tick salivary gland infection is dose dependent.

237 Regulatory factors controlling tick salivary glands (SGs) are direct upstream neural si

238 ay suggest that the differentially expressed tick salivary miRNAs could act in regulating POWV replic

239 o evasins may provide a strategy to optimize tick salivary proteins for antiinflammatory applications

240 Ticks secrete numerous salivary factors that enhance hos

241 ere collected daily to determine if infected ticks secreted viable A. marginale.

242 07 ul) and most likely due to differences in tick size.

243 assembled high-quality genomes of six ixodid tick species and further resequenced 678 tick specimens

244 ucture and pathogen composition in different tick species are mainly shaped by ecological and geograp

245 entation, pathomechanism and role of various tick species in the development of AGS.

246 ng hosts and ticks partially connected by 22 tick species that switch their host range according to t

247 to detect B. burgdorferi DNA extracted from tick species, showing comparable results to real-time PC

248 rgic signaling pathway in the SG of two hard tick species.

249 CDS to the NCBI database for this important tick species.

250 t (p > 0.15) but if examined individually 63 tick species/stages (59%) displayed such clustering, sug

251 We identified a single tick-specific amino acid variant in the viral glycoprote

252 did tick species and further resequenced 678 tick specimens to understand three key aspects of ticks:

253 Although ticks spend most of their life off the host, until now i

254 ent when switching between the mammalian and tick stages.

255 In addition, larval ticks successfully acquired A. phagocytophilum from mice

256 These ticks successfully transmitted A. phagocytophilum to the

257 sociating to vertebrates that would maximize tick survival under the range of abiotic traits.

258 Thus, just as tick symbionts can be pathogenic to humans, mammalian co

259 Ticks target this process by secreting glycoproteins cal

260 ck, Rhipicephalus microplus, is a monoxenous tick that co-evolved with indicine cattle on the Indian

261 included molecular testing of an adult deer tick that had been removed from one of the patients.

262 hosts and subsequent cascade extinctions of ticks: the robustness of the network slightly changed wh

263 nt discovery of numerous Evasins produced by ticks, their classification into two structural and func

264 Far less is known about pathogens of ticks themselves.

265 In particular, the recent spread of this tick to over 12 states in the United States has increase

266 Phylogenetic clustering of ticks to hosts at cluster level was not significant (p >

267 and has developed complex interactions with ticks to successfully colonize, persist and, at the opti

268 It is transmitted by Ixodes ticks, transfusion of blood and blood products, organ do

269 n proteins produced by B. burgdorferi during tick transit and on tick proteins that mediate feeding a

270 Ticks transmit a diverse array of microbes to vertebrate

271 Among arthropod vectors, ticks transmit the most diverse human and animal pathoge

272 Seven bacteria, not known to be tick transmitted, were also confirmed to be unique to sa

273 the mammalian immune pathways engaged during tick-transmitted B. burgdorferi infection would further

274 nown as Lyme borreliosis, is the most common tick-transmitted disease in the Northern Hemisphere.

275 dorferi causes Lyme disease, the most common tick-transmitted illness in North America.

276 h is distinctive when compared to other deer tick-transmitted infections such as Lyme disease.

277 Ehrlichia chaffeensis, a tick-transmitted obligate intracellular rickettsial agen

278 Powassan virus (POWV) is a tick-transmitted pathogen that may cause severe encephal

279 es to capture the patterns of circulation of tick-transmitted pathogens, a topic still unaddressed in

280 Recent data suggest spread of the Ixodes tick vector and increasing incidence of Lyme disease in

281 n gene expression as it transits between its tick vector and vertebrate host.

282 al significance of the miRNA response of the tick vector Ixodes scapularis in response to Anaplasma p

283 o stimulate bacterial replication within the tick vector.

284 The life cycles of the tick vectors and spirochete pathogen are highly sensitiv

285 Tick vectors are capable of transmitting several rickett

286 evity of some reservoir hosts and the Ixodes tick vectors' life cycle, long-term studies are required

287 The deer tick virus subtype of POWV (DTV) is transmitted by the d

288 tant physiological systems, which would make ticks vulnerable to dehydration and microbial dysbiosis.

289 Subsequent field studies confirmed that this tick was present in multiple geographic locations near t

290 cline taken up to 72 hours after exposure to ticks was 100% effective in preventing the disease.

291 ng as a delivery route of toxic reagents for ticks, we also show that adding Pseudomonas aeruginosa t

292 Ticks were collected between 1999 and 2010 in three ecol

293 Ticks were fed on bovine blood containing 10-fold diluti

294 In the current study, these ticks were tested for pathogens to more directly investi

295 After feeding on infected blood, ticks were transferred to uninfected blood to stimulate

296 d the ability of spirochetes to colonize the tick when feeding on these animals.

297 en isolated from fruit bats, mosquitoes, and ticks, whereas all other known New World mammarenaviruse

298 Dae2 limits skin-associated staphylococci in ticks while feeding.

299 suppressed forced water uptake by desiccated ticks, while injection of atropine, an mAChR-A antagonis

300 the bloodstream and for transmission to the tick, with an emphasis on the role of phosphorylation- a