ライフサイエンスコーパス: tight

1 sely related systems such as the type IV and tight adherence pilus systems.

2 th specific chemistries are known to promote tight adhesion between adjacent membranes via the format

3 , a trait transmitted by the mother during a tight age window after birth but stable for life, resist

4 We find tight alignment between the model and human performance

5 mina propria perivascular macrophages into a tight anatomical barrier that might function to prevent

6 s both types of oxidation as a result of the tight and "sleeved in" physical arrangement, rather than

7 rading the intercellular barrier proteins at tight and adherens junctions, triggering epithelial alar

8 Indeed, the very tight and closed microstructure of pastes containing Col

9 Tight and coordinate regulation of virulence determinant

10 Nano-structural analysis exhibited tight and ordered lamellar structures for SA compared wi

11 To combine extremely tight and reversible binding, we have introduced disulfi

12 molecules of the opposite handedness to form tight and specific 'cross-chiral' interactions with each

13 d characterized four nanobodies that present tight and specific binding and internalization into PSMA

14 sual information from the ocelli converge in tight apposition in the PS.

15 ulation bottleneck, the bottleneck is not so tight as to universally prevent the transmission of with

16 average, 10 kinesin-2 motors "line up" in a tight assembly on the trains [3], provoking the question

17 l introns and large duplications, suggesting tight assimilation into host genomes.

18 nates vs.broncho alveolar lavages implicated tight association of these bacteria with the host tissue

19 Cyclin/Cdk1 activity normally declines in tight association with increasing N/C and is regulated b

20 Antibodies isolated for tight association with MUC16 (MUC16-eluted antibodies) s

21 channels, whose activation depends on their tight association with presynaptic calcium channels.

22 The epithelial-mesenchymal plasticity, in tight association with stemness, contributes to the mamm

23 es FERM interdomain contacts and assures the tight association with the beta3-integrin cytoplasmic se

24 s that are protected from lysis due to their tight association with the protein, and enables their ch

25 ee diffusion observed, but new interactions (tight attachment and tethered rotation) were also discov

26 des hemodynamic perturbation, showing that a tight balance in the Wnt-Adamts19-Klf2 axis is required

27 nterfollicular epidermis (IFE) forms a water-tight barrier that is often disrupted in inflammatory sk

28 l animals, the intestinal epithelium forms a tight barrier to the environment.

29 ingle layer of epithelial cells that forms a tight barrier, separating luminal antigens and microbes

30 ploy density functional theory-based (DFT-b) tight binding and funnel metadynamics to advance our ear

31 This tight binding comes with retention of crystallinity and

32 These structures revealed an atypically tight binding conformation of 3TC-TP, where the Met184 s

33 e enzymatic assay to evaluate the potency of tight binding inhibitors.

34 ex as ~0.7 mum, consistent with a relatively tight binding interaction.

35 Extensions of these ideas from current tight binding models to continuum theories for realistic

36 according to the knock-off mechanism, while tight binding of Gd(3+) to the aspartate ring blocks the

37 Ca(2+) induces tight binding of synaptotagmin-1 to PIP(2)-containing na

38 eric compression and electronic effects in a tight binding site, as opposed to solvent exclusion.

39 served spatial resolution is associated with tight binding, which was confirmed by the slower diffusi

40 ed), thus explaining why H2 is necessary for tight binding.

41 rst-principles density-functional theory and tight-binding calculations.

42 Synthetic efforts resulted in a tight-binding inhibitor with a K(i) value of 12.0 nM.

43 red the possibility that the drug is a slow, tight-binding inhibitor.

44 e optimal conditions, warfarin inhibits with tight-binding kinetics.

45 re investigated by employing the generalized tight-binding model to calculate the energy bands.

46 Sn, which can be well described by a minimal tight-binding model with single-orbital hopping in Co ka

47 Using Wannier tight-binding models based on first-principle calculatio

48 e show that certain asymmetric non-Hermitian tight-binding models with a [Formula: see text] symmetry

49 le dynamic covalent polymer that facilitates tight bonding to itself and other surfaces, as a soft, e

50 duction reaction is severely hampered by the tight-bonding of active centers with hydroxyl group inte

51 While a tight bottleneck operates in human influenza transmissio

52 We show that some of these constraints are tight, by constructing explicit local models (i.e. where

53 he affected shoulder to stretch and tear the tight capsule while the participant was under general an

54 er stroke in substrate translocation and the tight chemomechanical coupling in these molecular machin

55 ng by the ~20,000 SCN cells is welded into a tight circuit-wide ensemble oscillation.

56 ghly clustered across plants, which predicts tight co-clustering with putative phytopathogens across

57 The tight coevolution of the beak and the remainder of the s

58 Full-length LGR4 formed a tight complex with ZNRF3 and RNF43 even without RSPO, wh

59 OSTEROID INSENSITIVE1, HAESA and ERECTA form tight complexes with endogenous SERK coreceptors in the

60 crucial in facilitating migration across the tight confined tracts.

61 However, such tight confinement inevitably increases optical losses th

62 yonic diapause, dormancy that interrupts the tight connection between developmental stage and time, i

63 Thus, in theory there should be a tight connection between how much people value future re

64 bodies and their component parts result from tight constraints on growth.

65 ernal stress, be it during migration through tight constrictions or compressive pressure by the actin

66 ll has identified a target cell, they form a tight contact zone, the immunological synapse (IS).

67 This tight control indicates that maintenance of a cell type-

68 The mechanism underlying this tight control is not fully understood.

69 evelopment and function of the brain require tight control of gene expression.

70 crucial roles, mGluR5 signaling is under the tight control of glutamate release machinery mediated th

71 Synaptic plasticity requires a tight control of mRNA levels in dendrites.

72 s a highly dynamic environment that requires tight control of the various inputs to maintain homeosta

73 eat domains and highlights the importance of tight control of TRIO-RAC1 signaling in neuronal develop

74 onsequently, metabolic factors impose a very tight control over kisspeptin synthesis and release.

75 ins are all important variables in providing tight control over many biological paradigms.

76 of regulation to prevent leakiness and allow tight control over neoantigen expression.

77 , we developed a class of stimuli that grant tight control over statistical relations among object ve

78 t, bNAb treatment beginning at 48 h leads to tight control without adaptive immune responses in half

79 This requires the tight coordination, or "scaling," of mRNA and protein qu

80 cotoxicity is strong because there is such a tight correlation between defective insulin secretion an

81 We first argue that there is a tight correlation between the evolution of cumulative te

82 We observe a tight correlation between the metabolic rate and the eff

83 Our data reveal a tight correspondence between two widely studied phenomen

84 lfolobus acidocaldarius cells live to reveal tight coupling between changes in DNA condensation, segr

85 Nutrient deprivation promoted a tight coupling between glucose uptake and oxidation, G6P

86 on between stimulus and wings, pointing to a tight coupling between head and wing movements.

87 This primary transport activity depends on tight coupling between movements of the transmembrane he

88 Our study highlights the tight coupling between N and S cycling, and the implicat

89 The tight coupling between temperature, phenology and GEP ap

90 roup to winter climate change because of the tight coupling between their body temperature and metabo

91 We further show that a persistent, tight coupling existed between the variability of the IO

92 neurexin deletion significantly impaired the tight coupling of calcium influx to exocytosis, thereby

93 These results show how tight coupling of the helicase and topoisomerase activit

94 Tight coupling of transcription and translation is consi

95 chanistic isoprene emission models predict a tight coupling to photosynthetic electron transport (ETR

96 Despite their tight coupling, existing model quality estimation method

97 onstant than variable intervals, revealing a tight crossmodal link between tactile temporal expectati

98 A tight distribution of the nanofiber diameters could, how

99 ize of the interacting membrane patches upon tight docking.

100 riori adaptation events provides evidence of tight energetic coupling between metabolism and regulato

101 llecting duct, which is a typical absorptive tight epithelium, coordination between transcellular sod

102 erspectives on how recent evidence points to tight evolutionary connections between MGEs and defence

103 This approach affords tight experimental control but provides little ecologica

104 This platform, designed to mimic the tight extracellular migration tracts in brain parenchyma

105 ce 0.67 CFUs; P = .034), and subjects with a tight face mask without tape (difference 1.13 CFUs; P <

106 ross species, individuals generally maintain tight fidelity to specific foraging sites after extended

107 k, tight-fitting surgical mask without tape, tight-fitting surgical mask with adhesive tape securing

108 There was no difference between those with a tight-fitting surgical mask with tape and an N95 mask in

109 he "no-talking" scenario, subjects wearing a tight-fitting surgical mask with tape developed fewer CF

110 ing the speech scenarios, subjects wearing a tight-fitting surgical mask with tape had significantly

111 masks (no mask, loose fitting surgical mask, tight-fitting surgical mask without tape, tight-fitting

112 how how the structures funnel protons to the tight focus.

113 Exciting under tight focusing at the low frequency side of the bandgap,

114 pse to the vertices of a simplex equiangular tight frame (ETF).

115 a trade-off between fast, stable folding and tight functional DNA binding.

116 sity than influenza A virus and experience a tight genetic bottleneck during transmission.

117 e networks identify two consecutive waves of tight genetic cooperativity enriched in deregulated gene

118 Tight glucose monitoring reduces the risk of hypoglycemi

119 ultiple diabetes-related biomarkers toward a tight glycemic control.

120 ents suggest that Phe31 of ELA may bind to a tight groove distinct from that of Phe13 of Ape13, while

121 Tight Hox and the first loose ecdysozoan ParaHox homeobo

122 by loops and their cytosolic ends forming a tight hydrophobic constriction.

123 , that underlie its importance in initiating tight IC-p150(Glued) complex formation.

124 Therefore, tight immune control of the intraerythrocytic replicatio

125 Here, we describe an exquisitely tight interaction between SIRT6 and nucleosome core part

126 Our results allow insight into the tight interaction network determining AMDase selectivity

127 The tight interaction of DNA with histones represents a sign

128 lize the region of CC1B most essential for a tight interaction with IC.

129 utoinhibition is sufficient to mediate their tight interaction.

130 siveness, but they struggle with quantifying tight interactions.

131 layer is inserted between two bilayers in a tight intermembrane space of ~3 nm, implying direct inte

132 ensorimotor timing has rarely considered the tight interrelation between perception, action, and cogn

133 synthesis/metabolism (ELOVL3 and FA2H), and tight junction (CLDN8) genes were primarily seen in lesi

134 Terminal differentiation (FLG2 and LCE5A), tight junction (CLDN8), and lipid biosynthesis and metab

135 The tight junction (TJ) and barrier function of colonic epit

136 Defects in the epithelial tight junction (TJ) barrier contribute to development of

137 epithelial permeability is regulated by the tight junction (TJ) formed by specialized adhesive membr

138 Tight junction (TJ) proteins are essential for mediating

139 s in significant mislocalization of multiple tight junction (TJ) proteins.

140 TBI and PBI-BM5 disrupted colonic epithelial tight junction and adherens junction, increased mucosal

141 iptomic changes, including downregulation of tight junction and stratum corneum proteins, even in the

142 O was localized to the intestinal epithelial tight junction and within F-actin stress fibers where it

143 (BBB) opening as well as the formation of a tight junction barrier between reactive astrocytes at th

144 ult mouse RPE caused cell depolarization and tight junction breakdown, and led to inhibition of RPE65

145 Norrin, in turn, restores tight junction complex organization and BRB properties i

146 l epithelial barrier, in which intercellular tight junction complexes block the uptake of macromolecu

147 rier dysfunction with a decrease in FLG2 and tight junction components.

148 was also possible to independently confirm a tight junction disruption.

149 nd type-2 inflammation being responsible for tight junction dysfunction.

150 Type I IFN signaling caused tight junction dysregulation in IECs, promoted gut micro

151 th lower ciliary activity, cilium loss, less tight junction expression (ZO-1), and more detachment of

152 lication of shear stress is known to enhance tight junction formation and hence improve the barrier f

153 sulted in a reorientation and enhancement of tight junction formation on both coverslip and permeable

154 y diseases is dysfunctional due to disturbed tight junction formation.

155 asthma pathogenesis, tissue remodeling, and tight junction formation.

156 atin for 24 h also inhibited the increase in tight junction macromolecule permeability that occurs fo

157 ition, simvastatin inhibited the increase in tight junction macromolecule permeability that was previ

158 This event down-regulated the expression of tight junction markers, disorganized the cell-cell junct

159 d epithelial absorption without the need for tight junction opening.

160 ioavailability, and safety concerns owing to tight junction openings.

161 sms through which JAM-A expression regulates tight junction organization to control endothelial perme

162 K, the ribosome, proteasome, endocytosis and tight junction pathways.

163 ZO-1 (Zona occludens 1), encoded by the tight junction protein 1 (TJP1) gene, is a regulator of

164 cological inhibition of GCS caused levels of tight junction protein 1 (TJP1) to decrease.

165 The tight junction protein claudin-2 is upregulated in infla

166 rain barrier (BBB) integrity through loss of tight junction protein claudin-5 (cldn5) in male mice, p

167 Moreover, levels of the tight junction protein claudin-5 were increased with nor

168 ling controls junctional localisation of the tight junction protein CLDN5 and junction stability via

169 thiocyanate-labeled dextran 4kDa (FD4) flux, tight junction protein distribution, and protein abundan

170 romised blood-brain barrier permeability and tight junction protein expression in the offspring at pr

171 is played only a partial role in maintaining tight junction protein expression.

172 ecrease in the expression of the BBB-related tight junction protein, Zonula occludens-1 (ZO-1).

173 ient asthmatic mice resulted in dysregulated tight junction proteins and increased lung permeability.

174 The expression of tight junction proteins between adjacent endothelial cel

175 FD4 flux as well as increased proportions of tight junction proteins located in the plasma membrane.

176 but increased expression of the endothelial tight junction proteins ZO-1 and occludin, key mechanism

177 ns revealed that heme primarily affected the tight junction proteins zona occludens-1, claudin-1, and

178 rbated the TGF-beta-induced dysregulation of tight junction proteins, E-cadherin and N-cadherin expre

179 sed blood-brain barrier dysfunction, loss of tight junction proteins, increased endothelial stress fi

180 ericyte density, increased expression of BBB tight junction proteins, reduced brain infiltration of i

181 re we show that anionic nanoparticles induce tight junction relaxation, increasing intestinal permeab

182 the functional equivalent of the vertebrate tight junction, but proliferating follicle cells do not

183 as linked to the suppression of networks for tight junction, gap junctional intercellular communicati

184 d for enriched claudin-5 localization at the tight junction.

185 ility with significantly decreased levels of tight junction/adherens junction proteins, including ZO-

186 ther transcellular sodium transport controls tight-junction composition and paracellular permeability

187 Along with JAM3 and OCLN, JAM2 is the third tight-junction gene in which bi-allelic variants are ass

188 ates to the actin cytoskeleton and regulates tight-junction maintenance and signaling often via endos

189 ood-brain barrier permeability, with altered tight-junction messenger RNA expression, increased brain

190 or the junctional-adhesion-molecule-2, a key tight-junction protein in blood-brain-barrier permeabili

191 lly, IGF2BP1 interacted with the mRNA of the tight-junction protein occludin (Ocln), stabilizing Ocln

192 oxO1) transcriptional activity and induces a tight junctional barrier at the Glia Limitans.

193 gh the epithelium, by altering expression of tight junctional components and dynamic loosening of cel

194 istance and macromolecular flux and assessed tight junctional gene expression and protein localizatio

195 DXR treatment induced disorganization of tight junctional proteins.

196 emory loss are associated with diminution of tight junctions (TJ) in brain endothelium and pericyte c

197 rn recognition receptors are expressed below tight junctions (TJ), strongly implicating TJ disruption

198 PEA-OXA restored intestinal permeability and tight junctions (TJs) as well as reduced apoptosis in th

199 CRT localized around tight junctions (TJs) of T84 IECs.

200 Epithelial adherens junctions (AJs) and tight junctions (TJs) undergo disassembly and reassembly

201 (siTEC) that retained the abilities to form tight junctions and cilia and to differentiate at the ai

202 -layered or stratified epithelium that forms tight junctions and controls the selective transport of

203 ransport and increased protein expression of tight junctions and induce mRNA expression of several ge

204 ys, but also induced expression of important tight junctions and transporters.

205 Intercellular tight junctions are crucial for correct regulation of th

206 ding peptide for transiently opening the BBB tight junctions are expected to enhance the efficacy of

207 degradation of tight junctions between cells by extracellular calcium s

208 ls of cellular cytotoxicity and breakdown of tight junctions between cells, allowing a route for rapi

209 human beta defensin-3, mucus components and tight junctions expression in human enterocytes, and IL-

210 We found that defective adherent and tight junctions in Lztr1-depleted endothelial cells are

211 a regulatory molecular pathway through which tight junctions limit vascular permeability.

212 Tight junctions play a key role in mediating paracellula

213 ositively modulated by JAM-A, a component of tight junctions that acts through EPAC to up-regulate th

214 molecule A) is a transmembrane component of tight junctions with a role in maintenance of endothelia

215 s BBB permeability, alleviates disruption of tight junctions, and improves stroke outcomes compared t

216 188 recovered the permeability, restored the tight junctions, and suppressed the expressions of matri

217 tative trait locus for LRP2BP that regulates tight junctions, cell cycle, and apoptosis in endothelia

218 unctional integration of adherens junctions, tight junctions, gap junctions (GJ), and desmosomes.

219 binding peptide (ADTC5) to transiently open tight junctions, in combination with an external magneti

220 (zonulin), a potent regulator for intestinal tight junctions, is highly expressed in autoimmune mice

221 he device became polarized and formed mature tight junctions, that the permeability of the cholangioc

222 ction of glucosylceramide helps to stabilize tight junctions.

223 resulting from altered protein expression at tight junctions.

224 estinal permeability by impairing intestinal tight junctions.

225 via endosomal uptake of polarity proteins at tight junctions.

226 ells with good barrier properties and mature tight junctions.

227 components and dynamic loosening of cellular tight junctions.

228 asolateral and apical membranes separated by tight junctions.

229 permeability by modulation of intercellular tight junctions.

230 Caco-2 cells, and preserved the integrity of tight junctions.

231 mi-nomadic hunters and gatherers who live in tight-knit social units and collect wild foods for a lar

232 In a tight labour market with an ageing workforce, employee f

233 Transcriptomics analysis revealed a tight link between cell shape, molecular signatures, and

234 s endocytotic/exocytotic coupling requires a tight link between exocytic vesicle fusion at defined re

235 This tight link between motor actions and sensing is particul

236 Our results underline the tight link between the social structure of populations a

237 However, tight linkage between GFR and proximal tubular secretory

238 ointing the causal variant(s) among those in tight linkage disequilibrium with each associated varian

239 egions maintain alleles of multiple genes in tight linkage through suppressed recombination.

240 We found tight links between the reproducibility of embryonic geo

241 f "linear" ema(4-) to ema(4-) frozen in the "tight-loop" around single metals, and to the "looser" fo

242 t should see broad application to a range of tight macromolecular interactions.

243 lities indicates that the patients need more tight medical control of diabetes.

244 ponses to threatening stimuli and, given its tight metabolic and haemodynamic requirements, is partic

245 ed and transcriptionally adjusted to be in a tight metabolic regime.

246 ntific and technological innovations towards tight monitoring of diabetes.

247 s associated with the creation of relatively tight networks and a relatively greater tendency to retu

248 nucleus and has low activity as a result of tight nuclear tethering(14-18).

249 A, such as DNA-protein crosslinks (DPCs) and tight nucleoprotein complexes, can block replication for

250 ssive planets might also find their way into tight orbits around white dwarfs, but it is unclear whet

251 ate that giant planets can be scattered into tight orbits without being tidally disrupted, motivating

252 The tight packing of selected compounds within the enzyme co

253 rofluidic channels, mimicking aspects of the tight perivascular conduits and white-matter tracts in b

254 epidermis engage with keratinocytes (KCs) in tight physical interactions; moreover, they induce T-cel

255 The tight polymer membranes and the inward oriented enzyme c

256 While influenza A transmission involves a tight population bottleneck, the bottleneck is not so ti

257 Due to tight post-translational regulation, determination of th

258 terferENZY, that allows (i) an unprecedented tight quality control of experimental data, (ii) the aut

259 role in developmental processes that require tight regulation of actin-mediated motility.

260 he other hand, a set of miRNAs contribute to tight regulation of ATM by directly targeting the 3'-unt

261 and early seedling growth requires not only tight regulation of cell division and metabolism, but al

262 Thus, the tight regulation of endochondral ossification by TBX1 is

263 endritic cells (pDCs) require a particularly tight regulation of endosomal pH to ensure strong type I

264 Overall, we find that tight regulation of FLT3 ligand levels throughout cDC di

265 ss of cardiac homeostasis, which relies on a tight regulation of gene expression.

266 2 activity promotes tumor growth; therefore, tight regulation of IL-22 is essential.

267 Therefore, tight regulation of inositol polyphosphate metabolism is

268 The tight regulation of MNT and its functionality even witho

269 Tight regulation of NEMO is essential for host innate im

270 These findings reveal that tight regulation of NOD1 abundance prevents this sensor

271 modeler binding at regulatory regions, where tight regulation of Pol II activity is necessary for pro

272 alternative life cycles is dependent upon a tight regulation of promoters and their cognate regulato

273 ion factor-repressor feedback module employs tight regulation of Tfap2a and Kctd15 kinetics to contro

274 Tight regulation of the cellular levels and catalytic ac

275 Seemingly incongruent with the tight regulation of transcription, many biochemical and

276 NALCN activity is under tight regulation(11-14) and mutations in NALCN cause sev

277 clease activities of these complexes require tight regulation, as they are usually essential for cell

278 The tight relationship between attention and conscious perce

279 A new study describes an unexpectedly tight relationship between dopamine activity and the for

280 ean interactions and feedbacks, suggesting a tight relationship between ENSO strength and background

281 Analysis of malM 3'-UTR mutants showed that tight RNA binding by the ProQ NTD required a terminator

282 ity across metastatic lesions and identify a tight selective bottleneck preceding distant metastasis.

283 In nanoporous media such as tight-shale formations, where the typical pore size is l

284 ived neurotrophic factor/TrkB signaling with tight spatial and temporal control.

285 argeting of the small GTPase RAB13 generated tight spatial coupling of mRNA localisation, translation

286 eing particularly relevant to such movement: tight spatial focusing of exocytosis enhances the direct

287 nessing light as an on/off switch to provide tight spatio-temporal control over the release of biolog

288 (LightR) allosteric switch module to achieve tight spatiotemporal control of enzymatic activity.

289 formation is a complex process that requires tight spatiotemporal control of key myogenic factors.

290 To activate fat thermogenesis under tight spatiotemporal control without external stimuli, h

291 hat apart from the UCYN-A symbiosis, similar tight species-specific associations with PPEs are unusua

292 dependent, with shorter alkyl chains forming tight structures and longer alkyl chains forming larger

293 ires neural stem cells (NSCs) to divide with tight temporal and spatial control to produce different

294 We find that a tight transmission bottleneck limits the onward transmis

295 ission pairs suggests that IBV experiences a tight transmission bottleneck similar to that of influen

296 acterisation of materials held inside an air-tight tube furnace operated up to 250 degrees C has been

297 The tight vertical acoustic confinement releases the lateral

298 There, a tight web of aromatic amino acids grips the substrate in

299 These herbivores face a tight window for foraging activity being exposed to noct

300 f the barbs, allowing them to interlock in a tight zipper-like fashion to form vanes.