ライフサイエンスコーパス: tight control

1 formance within or across institutions under tight control.

2 oliferation and tumorigenesis, is subject to tight control.

3 ial energetic response at a time of normally tight control.

4 amily members to keep hTERT expression under tight control.

5 ostimulatory ligands is believed to be under tight control.

6 ween those with usual control and those with tight control.

7 nd molecular mechanisms responsible for this tight control.

8 ke growth factor I receptor (IGF1R) is under tight control.

9 gamma synthesis or that such cells are under tight control.

10 ent immune response, they must be kept under tight control.

11 tantial reduction of future stroke risk with tight control (0.49; 0.34-0.69), but those with establis

12 id not experience stroke risk reduction with tight control (0.92; 0.83-1.03).

13 llow-up, 286 patients (12.7%) who maintained tight control, 249 (12.6%) who had usual control, and 43

14 less-tight control and 488 women assigned to tight control (31.4% and 30.7%, respectively; adjusted o

15 vere Crohn's disease who were managed with a tight control algorithm, using clinical symptoms and bio

16 ere similar among 493 women assigned to less-tight control and 488 women assigned to tight control (3

17 s for irreversible degradation must be under tight control and is often regulated at the level of sub

18 Tight control and mutual balance of their antagonistic a

19 ntigen-presenting cells (APCs) is subject to tight control and responds to inflammatory stimuli such

20 e and function of the cardiac wall are under tight control and, when the control is upset, can result

21 is and activity of the regulators, to ensure tight control and, where required, irreversible commitme

22 cose metabolic rates while glucose was under tight control as compared with loose control (3.2 +/- 0.

23 d for treatment, such as treat to target and tight control based on therapeutic monitoring and early

24 not surprising that these channels are under tight control by a series of inhibitory extracellular io

25 This process is under tight control by arginase 1 and is of functional importa

26 As such, MOMP is subject to tight control by Bcl-2 family proteins.

27 ecursors with high avidity to NY-ESO-1 under tight control by CD4(+)CD25(+) regulatory T (Treg) cells

28 tro and in vivo These results establish that tight control by ESE3/EHF over the Lin28/let-7 axis is a

29 ow matriptase activates prostasin under this tight control by HAI-1.

30 eals AD as a metabolic disease that is under tight control by JNK3.

31 ein abundance suggests this process is under tight control by miRNAs at the onset of fertilization.

32 The BMP-initiated signaling pathway is under tight control by processes including regulation of the l

33 PRR complexes are under tight control by protein phosphatases, E3 ligases, and o

34 that pluripotency and self-renewal are under tight control by specific molecular networks.

35 gastric cancer (GC) and, therefore, requires tight control by suppressive counter mechanisms.

36 ulates iNKT cell autoreactivity based on the tight control by the APC cytoskeleton of the sizes and d

37 noxin mRNA and protein levels are under tight control by the cell cycle.

38 folded protein domains, are also subject to tight control during evolution.

39 ation of these activators, chaperones ensure tight control, dynamic range, and rapid reversible trans

40 icantly higher proportion of patients in the tight control group achieved the primary endpoint at wee

41 105 (86%) of 122 patients in the tight control group and 100 (82%) of 122 patients in the

42 ients (25 events in 14 [14%] patients in the tight control group and eight events in six [6%] patient

43 ure criteria, which differed between groups (tight control group before and after random assignment:

44 anagement group and 32 (26%) patients in the tight control group discontinued the study, mostly becau

45 CR20 response at 48 weeks were higher in the tight control group than in the standard care group (odd

46 inical management group, 0.9 years [SD 1.7]; tight control group, 1.0 year [2.3]) were randomly assig

47 s (18 [15%]), and headache (18 [15%]) in the tight control group, and worsening Crohn's disease (35 [

48 -control group and 27.5% of the women in the tight-control group (P<0.001).

49 developed in 40.6% of the women in the less-tight-control group and 27.5% of the women in the tight-

50 c blood pressure that was higher in the less-tight-control group by 4.6 mm Hg (95% CI, 3.7 to 5.4).

51 he all-cause mortality rate was 11.0% in the tight-control group vs 10.2% in the usual-control group

52 e care units did not confirm the benefits of tight control, however, and the most recent study sugges

53 Patients were categorized as having tight control if they could maintain their systolic BP a

54 Despite the normally tight control in cell numbers in this region in adults,

55 nonreceptor tyrosine kinases are kept under tight control in cells, but exposure to several differen

56 isone in an MTX-based treatment strategy for tight control in early RA improves patient outcomes.

57 f the host, suggesting the requirement for a tight control in the regulation of transposable element

58 ver, and the most recent study suggests that tight control increases mortality rates.

59 This tight control indicates that maintenance of a cell type-

60 The mechanism underlying this tight control is not fully understood.

61 Such tight control may be due to the incorporation of Drosoph

62 S gene transcription and further underscores tight control mechanisms regulating the expression of th

63 occurs during myogenesis and highlights the tight control mechanisms that are utilized for the regul

64 re enrolled and randomly assigned to receive tight control (n=101) or standard care (n=105).

65 Tight control of 8-oxoG bypass during DNA replication is

66 bly transfected with p14(ARF) cDNA under the tight control of a doxycycline-inducible promoter.

67 ma) cells expressing wild-type p53 under the tight control of a tetracycline-responsive promoter was

68 In the striatum, the sparse firing and tight control of action potential timing is in contrast

69 Advantages of this setup include tight control of all bilayer components, which is compel

70 Tight control of antigen-receptor gene rearrangement is

71 ng to signal transduction and suggest that a tight control of ATPase activity by the CARDs prevents R

72 The consistent vertebral count indicates a tight control of axial patterning by Hox genes during de

73 Tight control of B cell differentiation into plasma cell

74 Tight control of blood glucose concentration in people w

75 xtent to which intensive insulin therapy and tight control of blood glucose improve outcome after isc

76 Many studies of tight control of blood glucose in critically ill patient

77 tremely elevated blood glucose levels, early tight control of blood glucose may permit this insulin-h

78 g overfeeding may improve outcomes more than tight control of blood sugars.

79 The tight control of both biosynthesis of, and cellular resp

80 A tight control of BR homeostasis is vital for modulating

81 This study reveals that tight control of brain volume is exerted through a large

82 l, and post-translational levels, suggesting tight control of C/EBPdelta content and function.

83 Our results thus show that the tight control of Ca(2+) influx by the TRPM4 channel is c

84 They also point to the importance of the tight control of calcium and pH during different stages

85 nd alpha7-nAChR offers a novel mechanism for tight control of calcium dynamics in neurons.

86 Here, we report tight control of cardiomyocyte hypertrophy through miR-3

87 Tight control of cardiomyocyte proliferation is essentia

88 he underlying molecular mechanism behind the tight control of CD86 is not completely understood.

89 e neural crest cell (NCC) migration requires tight control of cell adhesions, cytoskeletal dynamics a

90 Tight control of cell proliferation is essential for pro

91 One means by which signaling is regulated is tight control of cell surface CD70, which is expressed o

92 Tight control of cell/tissue identity is essential for a

93 nscription into the operon, thereby ensuring tight control of cellular NusA levels.

94 Tight control of centriole duplication is critical for n

95 Tight control of charge transport from a visible light s

96 terior-to-anterior cytokinesis, suggesting a tight control of CIF2 protein abundance.

97 termination efficiency demonstrated loss of tight control of conjugation function.

98 Our data suggest that tight control of CYCD activity in the central cell and i

99 rborization is highly regulated and requires tight control of dendritic growth, branching, cytoskelet

100 These data clearly point to the need for tight control of disease activity without reliance on co

101 ts with rheumatoid arthritis--for sustained, tight control of disease activity--compared with routine

102 Our findings support the importance of tight control of DNA metabolism for beta-cell integrity

103 en dATP and ribonucleotide reductase ensures tight control of dNTP concentration.

104 Treatment strategies for tight control of early rheumatoid arthritis (RA) are hig

105 st anti-oxidant defence system and maintains tight control of EGSH despite substantial oxidative chal

106 Our findings indicate tight control of eIF4E phosphorylation through modulatio

107 We propose that tight control of ERK signalling strength by MKP3 is impo

108 autoinhibitory switch mechanism that allows tight control of ESCRT-III assembly.

109 s fire near the peak of CA1 theta, under the tight control of excitatory inputs that arise at a speci

110 esponses, including autoimmunity; therefore, tight control of expression is critical for proper homeo

111 ranslational organization of RNase H1 allows tight control of expression of RNase H1 in mitochondria,

112 Tight control of extracellular and intracellular inorgan

113 These results indicate that the tight control of FtsA, and probably FtsQ, by cell cycle

114 ystem that affords for modular, tunable, and tight control of gene expression in vivo.

115 ulation is a powerful mechanism that enables tight control of gene expression, via integration of mul

116 providing a novel mechanism for maintaining tight control of gene expression.

117 rough an indirect control mechanism ensuring tight control of gene expression.

118 evelopment and function of the brain require tight control of gene expression.

119 crucial roles, mGluR5 signaling is under the tight control of glutamate release machinery mediated th

120 imeric repressor system was shown to exert a tight control of green fluorescent protein expression in

121 Also, tight control of HbA1c levels in patients with type 2 di

122 The tight control of heat shock gene expression has prompted

123 Thus, tight control of Hedgehog pathway activity throughout em

124 Our results indicate that the tight control of HIF transient dynamics has important fu

125 ults in embryonic lethality, indicating that tight control of Hif-mediated adaptive responses to hypo

126 -1 gene transcription and contributes to the tight control of HO-1 gene regulation in the setting of

127 Understanding such tight control of host defense requires the elucidation o

128 hat Y. pestis YopJ and YopM can both exert a tight control of host IL-1beta/IL-18 production to benef

129 e observations suggest a role for E47 in the tight control of HSC proliferation and energy metabolism

130 hTERT promoter are known to be important for tight control of hTERT in normal tissues, but the molecu

131 ) is driven by a RHO-like GTPase that allows tight control of hydrogen peroxide (H(2)O(2)) production

132 ether an insulin infusion should be used for tight control of hyperglycemia in critically ill childre

133 The effects of less-tight versus tight control of hypertension on pregnancy complications

134 Based on these findings, we propose that tight control of IkappaBbeta protein by p65 is necessary

135 We conclude that tight control of IL23 mRNA stability by TTP is critical

136 Early intervention and tight control of inflammation optimise outcomes in rheum

137 ility to switch between treatments to ensure tight control of inflammation.

138 This tight control of iTreg differentiation dictated by Ag do

139 hysiological processes in plants, making the tight control of its endogenous levels and spatiotempora

140 ost defense and tumor surveillance, requires tight control of its expression.

141 ance, in terms of interaction with the host, tight control of its in vivo expression might be particu

142 expressed without slowing growth, suggesting tight control of its powerful protein-remodeling activit

143 These effects are mediated through tight control of lipid localization, as overexpression o

144 inally, we show that this is achieved by the tight control of local excitation and inhibition by peri

145 or catabolic inactivation of RA required for tight control of local RA concentrations, is significant

146 ts and solubilisation rates might indicate a tight control of LytB activity to prevent unrestrained b

147 We propose that the tight control of mDia2 expression and ubiquitin-mediated

148 ion is an energy-demanding process requiring tight control of metabolism and redox state.

149 The tight control of metal homeostasis in cells depends on t

150 thway upstream of DNMT1, thus disturbing the tight control of methylation-sensitive genes, which are

151 Not surprisingly, a tight control of miR-155 expression is required to avoid

152 ubation times that are not compatible with a tight control of MLF.

153 Synaptic plasticity requires a tight control of mRNA levels in dendrites.

154 ulatory pathway or both, we demonstrate that tight control of MutS levels in stationary phase contrib

155 ion of digital and analogue processes allows tight control of Myc expression at the population and si

156 ivated K(+) channel activity, thus providing tight control of myogenic tone in the microcirculation.

157 and substrate adaptors cooperatively provide tight control of neddylation and cullin-RING-ligase acti

158 Therefore, tight control of niche number, size and function is nece

159 Tight control of nodulation and infection is required to

160 eath areas also were found, highlighting the tight control of organ growth within and between phytome

161 d shed light on the mechanisms mediating the tight control of p100 processing.

162 Finally, we show that tight control of ParA filament dynamics is essential for

163 1 protein, play key role in proteostasis via tight control of partitioning and recycling of misfolded

164 nt role for various TLRs in cooperation with tight control of pathogens penetrating into Peyer patche

165 ticentre trials contradicted the benefits of tight control of patients' blood glucose and results sho

166 as well as the PDCD4 transcript to maintain tight control of PDCD4 levels.

167 Tight control of peripheral vitamin C concentration is p

168 Therefore, tight control of PKR activity is essential for regulated

169 opment of postsurgical fibrosis is under the tight control of positive and negative T cell costimulat

170 Thus, our results demonstrate tight control of PP2A expression, and provide an explana

171 ur studies suggested mechanisms of LCMT-1 in tight control of PP2A function, important for the cell c

172 ly regulate T and B cell responses to ensure tight control of productive T-B cell interactions.

173 HSC function depends on the tight control of proliferation and the balance between s

174 This approach offers tight control of protein functions and improved detectio

175 ase of GDP from eIF2gamma and thereby ensure tight control of protein synthesis initiation.

176 Tight control of psoriatic arthritis disease activity th

177 These functions rely on a tight control of RA distribution within embryonic tissue

178 ion of the pancreatic field are dependent on tight control of RA signaling.

179 wardly rectifying potassium channels enforce tight control of resting membrane potential in excitable

180 The Tight Control of Rheumatoid Arthritis study previously d

181 communicate damage by using S1P release and tight control of S1PR1 and 2.

182 ganization of cAMP signaling begins with the tight control of second messenger synthesis.

183 n yeast, mitochondrial function requires the tight control of several metabolic processes such as coe

184 rowth, metabolism, and cell division through tight control of signaling via two complexes, TORC1 and

185 as a strategy to define nanostructures with tight control of size, shape and orientation has been wi

186 Tight control of Smad level and activity is critical for

187 E regulation by Ca(2+) ions not only enables tight control of SOCE by the SR membrane, but also provi

188 the Na(+),K(+)-ATPase activity leading to a tight control of sodium reabsorption.

189 es a unique mechanistic insight into how the tight control of spatial segregation is critical in the

190 ncover a new feature of BIR and propose that tight control of ssDNA accumulated during this process i

191 These data suggest that a tight control of Std fimbrial expression mediated by Ros

192 Our insights explain the tight control of STING signaling given varying backgroun

193 remove SUMOs from targets, contributing to a tight control of SUMOylated proteins.

194 Tight control of synapse formation ensures that neurons

195 Tight control of systolic BP among patients with diabete

196 Tight control of T follicular helper (Tfh) cells is requ

197 Tight control of T(FH) numbers maintains self tolerance.

198 Tight control of T-cell proliferation and effector funct

199 the bacterial heat shock response where the tight control of the amount of heat shock proteins is ac

200 oredoxin (aptamers) were expressed under the tight control of the arabinose-inducible P(BAD) promoter

201 ir normal controls by placing each under the tight control of the arabinose-regulated P(araB) promote

202 arbon dioxide into organic matter requires a tight control of the ATP/NADPH ratio which, in other pho

203 mote neural development and signaling, hence tight control of the concentration of cellular DISC1 in

204 ential function of BER not only necessitates tight control of the continuous availability of basic co

205 comprise an unusual operon in which separate tight control of the distal gene (kilB) by the KorB repr

206 d arrestin binding may more generally permit tight control of the duration of GPCR activity.

207 f-renewal of embryonic stem cells requires a tight control of the expression of several key stemness

208 s unique transcriptional mechanism assures a tight control of the homeostasis of VLDL-derived fatty a

209 pombe, the regulatory logic that governs the tight control of the key meiosis-inducing genes in these

210 the cell devotes many genes/proteins to keep tight control of the level of intracellular free Ca(2+).

211 eractions in three-dimensions while allowing tight control of the microenvironment and real-time moni

212 egulation of chromatin remodelers allows for tight control of the naive-to-primed pluripotency transi

213 Tight control of the number and distribution of crossove

214 oreactor system, which allowed for rapid and tight control of the operating conditions.

215 These findings show that the tight control of the protein environment allows drastic

216 High light-induced PCD thus results from a tight control of the relative activities of these regula

217 The mechanism for tight control of the robust catalytic potential of PARP-

218 Many of these processes require tight control of the size and shape of cytoskeletal stru

219 erfering RNA expression system that allows a tight control of the specific gene silencing by RNAi.

220 taphase plate formation and thinning require tight control of the state of the mechanical linkage bet

221 nducible cell lines expressing PS2 under the tight control of the tetracycline-responsive transactiva

222 These data provide the first indication that tight control of the turnover of positive as well as neg

223 s a highly dynamic environment that requires tight control of the various inputs to maintain homeosta

224 onal roles speak to the need for maintaining tight control of their concentration within cells.

225 lex network of transcription factors ensures tight control of their expression.

226 The tight control of their fusion and fission, a process ter

227 ve unique homeostatic abilities, maintaining tight control of their local environment through interco

228 re very unstable, which is important for the tight control of their temporal and spatial expression p

229 bute to HSV latency and reactivation through tight control of these LAT-encoded miRNAs and their vira

230 pregnancy, but underscore the necessity for tight control of this signaling molecule to avoid unwarr

231 e reactivation by deubiquitination, allowing tight control of thyroid hormone action.

232 However, the mechanisms that ensure the tight control of tissue-specific alternative splicing ar

233 caution is required for vector spillover and tight control of tissue-specific gene expression.

234 for its function, and suggest a mechanism of tight control of TLR3 signaling and thus immunity.

235 ns within individual sensory ganglia despite tight control of total number in all ganglia.

236 Tight control of transposon activity is essential for th

237 eat domains and highlights the importance of tight control of TRIO-RAC1 signaling in neuronal develop

238 A tight control of viral replication by the host innate im

239 Ocean's 'organic carbon pump' has exerted a tight control on atmospheric CO2, and thus global climat

240 The forest canopy exerts a tight control on biotic N input at a period of high prod

241 We aimed to assess the effect of tight control on early psoriatic arthritis using a treat

242 ression of COX subunits exerted a relatively tight control on oxidative phosphorylation.

243 K approximately = 10(12) M(-1)) and exerts a tight control on the CB7 concentration available to inte

244 nts were randomly assigned at a 1:1 ratio to tight control or clinical management groups, stratified

245 from dephosphorylation in vitro, suggesting tight control over activity in vivo.

246 To ensure a quick response yet maintain tight control over AP-1 target genes, AP-1 activity is l

247 systems that gel only on mixing, which gives tight control over assembly.

248 eed to develop sustainable synthesis routes, tight control over chemical releases during production,

249 Adipocytes maintain tight control over circulating plasma levels, suggesting

250 ts suggest that TGF-beta signaling may exert tight control over COL7A1 by offsetting the balance betw

251 Thus, cells exert tight control over cytosolic metal concentrations, even

252 programming its in vivo retention, providing tight control over embedded drug release kinetics.

253 lators in multi-input motifs (MIMs) provides tight control over expression of target genes.

254 ession of the genes that encode the enzymes, tight control over gene expression and consistent expres

255 These mutations cooperate to deregulate the tight control over gene expression that is otherwise see

256 S. aureus must ensure tight control over its cellular levels as both high leve

257 The intraerythrocytic parasite itself exerts tight control over its internal Na(+), K(+), Cl(-), and

258 onsequently, metabolic factors impose a very tight control over kisspeptin synthesis and release.

259 th intergenic regions and introns suggests a tight control over length expansion of non-coding region

260 ung volume changes, emphasizing the need for tight control over lung volume when performing hyperpola

261 ins are all important variables in providing tight control over many biological paradigms.

262 Additionally, Ptc(+/-) NSCs maintain tight control over mitosis and do not further augment pr

263 of regulation to prevent leakiness and allow tight control over neoantigen expression.

264 eous fraction, but they exert a powerful and tight control over neuronal activity and consequently mo

265 We propose that, rather than exerting tight control over parameters, the auditory system uses

266 In conjunction with a tight control over pore sizes, inverse opal scaffolds ha

267 ring a number of different Ag particles with tight control over shape, as well as a wide variety of A

268 udy indicates that GABA(B) receptors exert a tight control over spatial learning by modulating neuron

269 , we developed a class of stimuli that grant tight control over statistical relations among object ve

270 Mitochondria must maintain tight control over the electrochemical gradient across t

271 tions as a negative regulator that imposes a tight control over the level of innate immune response a

272 epts of triterpene biosynthesis, which posit tight control over the mechanistic pathway through catio

273 as well as better LE and LipE by exercising tight control over the molecular weight and lipophilicit

274 Nervous system function requires tight control over the number of synapses individual neu

275 Tight control over the segregation of endoderm, mesoderm

276 Immune homeostasis is dependent on tight control over the size of a population of regulator

277 with subnanometer precision and allow for a tight control over their biochemical functionality, e.g.

278 synthesize intermetallic nanocrystals with a tight control over their size and shape.

279 Both systems rely on tight control over triggering the concerted refolding of

280 our three-dimensional microtumor model with tight control over tumor size, we recapitulated the tumo

281 We postulated that such tight control permits a paracrine function of vitamin C.

282 in nucleation by the Arp2/3 complex is under tight control, remaining inactive until stimulation by n

283 Furthermore, tight control significantly increases episodes of hypogl

284 A tight control strategy for RA implies monthly visits to

285 ents were randomly assigned to an MTX-based, tight control strategy starting with either MTX and pred

286 l for proper function, and evolution of this tight control system may have been favored by reduction

287 Women were randomly assigned to less-tight control (target diastolic blood pressure, 100 mm H

288 rget diastolic blood pressure, 100 mm Hg) or tight control (target diastolic blood pressure, 85 mm Hg

289 Developmental errors are minimized by the tight control that imprinted genes have on regulation of

290 These include the tight control that somatic support cells exert on every

291 normal growth, these proteins are subject to tight control through at least two mechanisms.

292 oles and its plasma level in humans requires tight control to avoid bone loss (insufficiency) or vasc

293 such a multiplicity of interfaces requires a tight control to ensure the desired phenotype.

294 h, the regulation of these pathways requires tight control to prevent DNA errors and potentially onco

295 The sigma(54)-factor imposes tight control upon the RNAP by creating a regulatory swi

296 risk of all-cause mortality was 22.8% in the tight control vs 21.8% in the usual control group (adjus

297 verall maternal complications, although less-tight control was associated with a significantly higher

298 To test this action in vivo, normal oral tight control was bypassed by parenteral ascorbate admin

299 ly assigned in a 1:1 ratio to receive either tight control (with review every 4 weeks and with escala

300 t, bNAb treatment beginning at 48 h leads to tight control without adaptive immune responses in half