ライフサイエンスコーパス: tighten

1 the prediction intervals cannot possibly be tightened.

2 s regulations on other emissions sources are tightened.

3 ated inside the implants, and abutments were tightened.

4 he NMR spectrum indicative of conformational tightening.

5 becomes less dynamic and exhibits structural tightening.

6 sterior lamella as spacer graft, and canthal tightening.

7 stinct from nucleosome breathing, sliding or tightening.

8 the membrane was largely responsible for the tightening.

9 ased constraints on the first conformational tightening.

10 ntubation (transient or permanent) or eyelid tightening.

11 tress fiber formation and induces junctional tightening.

12 302 orthopaedic surgeons tightened 10 non-locking screws to what they determined

13 SL annular (SLAC) or inter-PM (PAPS) suture tightening (4 to 5 mm of cinching for 5 seconds during i

14 pknotted protein, it is possible to untie or tighten a knotted polypeptide and even convert a slipkno

15 eatherization efforts targeted solely toward tightening a building envelope led to 20% more serious a

16 Hyptiotes stretches its web by tightening a separate anchor line over multiple cycles o

17 The latter tightens a monolayer of airborne contaminants to yield l

18 As funding for science tightens across the United States, attention has turned

19 NADP+ binding in the reductase also tightened affinity of these inhibitors for P-450 BM3 (Kd

20 partially dehydrating phosphate oxygens and tightening all interfaces to form RO.

21 th biplane videofluoroscopy before and after tightening an adjustable Paneth-type mitral annuloplasty

22 As hospital budgets tighten and justification of staffing becomes a necessit

23 These bonds must be tightened and highlighted as we work toward our common g

24 erve that the fibre-soil interfacial bond is tightened and the measurement range of the fibre is exte

25 ingency is a tactile sensation of puckering, tightening and dryness in the oral cavity, commonly indu

26 ID domain protein confers position-dependent tightening and loosening of guide-strand-target interact

27 terium exchange experiments have highlighted tightening and loosening of protein structures upon liga

28 mes, with minimal hysteresis during both the tightening and loosening processes.

29 Tightening and loosening show that ligand binding respec

30 ositions, ensuring fast response during bolt tightening and loosening.

31 ss based on the trade-off between structural tightening and restraint of conformational mobility.

32 tructure of DNA knots, without spurious knot tightening and sliding.

33 After AFR, skin tightening and symptomatic relief were reported.

34 sic dependence: a force-induced entanglement tightening and then splitting and a force-induced cataly

35 asmic funnel of SecY, and by the coordinated tightening and widening of SecA's clamp above the SecY p

36 onine, the inhibitor of N-glycan processing, tightens and stabilizes cell-cell junctions as detected

37 It also predicts that Arg(73) tightens and stabilizes the actin and that Glu(73) cause

38 66 and GFP is longer than 36 residues, ClpXP tightens and translocates the knot before it reaches GFP

39 pulled by the termini, the knot can only get tightened, and any attempt at untying results in failure

40 The pore opens upon tightening, and closes upon disengagement, of the cataly

41 lation of histone tails results in chromatin tightening, and therefore, HDACs are generally regarded

42 P complex (K(D)(GDP) = 9.4 +/- 3.2 mM) which tightened approximately 500-fold in the presence of Mn2+

43 P hydrolysis, while the clamp domain of SecA tightens around the polypeptide, preserving progress of

44 and susceptibility to neutralizing sera, and tightened association of the S1 subunit with the trimer.

45 to test whether such non-consumptive effects tightened behavioural trait correlations in wild-caught

46 investigation as it was previously found to tighten binding to both dihydrofolate and NADPH by appro

47 tructures, closes around the product further tightening binding.

48 Addition of these Q67H mutations tightens binding 40-fold, and the catalytic efficiency (

49 ons to determine if the Q67H mutation, which tightens binding approximately 100-fold to both dihydrof

50 ecosystem health, unless steps are taken to tighten biosecurity worldwide.

51 ltaneously loosening lymphatic junctions and tightening blood vessel junctions.

52 2.3+/-0.1 to 2.3+/-0.1), and decreased after tightening both sutures (STRING-1+2, 2.3+/-0.2 to 1.3+/-

53 es the setup of the catalytic triad but also tightens both subsites to achieve better binding.

54 accurate energies even with the drastically tightened bound.

55 However, here we tighten bounds showing that certain first-quantized quan

56 s in leading markets have been progressively tightened, but current diesel vehicles emit far more NOx

57 f release sites and MVR events are similarly tightened by buffering intracellular calcium.

58 le microtubules into loose bundles that are "tightened" by the other.

59 This phosphorylation tightens CAR interacting with ERalpha and to activates t

60 of Mertk synergized with interferon-beta to tighten cell junctions and prevent virus transit across

61 Histone deacetylases (HDACs) tighten chromatin structure and repress gene expression

62 and Pro102, in turn, not only stabilize the tightened conformation of the [2Fe-2S] cluster binding l

63 er complex formation followed by two slower, tightening conformational changes.

64 derived calcium signals to the mitochondria, tightened connections, synthetic or naturally observed u

65 ly attributable to allosteric conformational tightening, consistent with IM-MS data.

66 We hypothesized that tTS would tighten control of transgene expression in rtTA-based sy

67 ations of the membrane-permeant dB-cAMP 1 mM tightened coupling in almost all cell pairs.

68 Prolonged hypobaric hypoxia significantly tightened coupling modes GC/NE, NE/GC, and NE/NE but red

69 many model is more informative and generally tightens credible intervals over models that do not inco

70 -0.1 to 1.2+/-0.1; P<0.05) when STRING-1 was tightened, did not change after tightening STRING-2 (2.3

71 Paneth suture tightening during circumflex occlusion also decreased en

72 ures in terms of modular fragments: the TEF (Tightened End Fragments), and the calculation at each po

73 matrix, junctions between nanoparticles are tightened, enhancing electrical performance during trans

74 This progressively increases writhe and tightens entanglements, causing a macroscopic contractio

75 C strategies is further demonstrated against tightening environmental standards (to the strictest lev

76 traditional treatment methods to comply with tightening environmental standards.

77 Though CD73 tightens epithelial barriers, its role in the ischemic b

78 Tightened equilibrium climate sensitivity estimates pair

79 te that overexpression of VAPB or PTPIP51 to tighten ER-mitochondria contacts impairs, whereas small

80 ss-border university research relationships, tightened export controls on technologies, and strengthe

81 past 2 decades and recent recommendations to tighten federal regulation of electroconvulsive therapy

82 This work motivates tightened feedstock regulations and adds a reduction in

83 ion by serving among all of the factors that tighten gene expression.

84 e, and whether owners experience facilitated tightened glycaemic control, and wider psychosocial bene

85 2+-binding affinity of S100A1 is found to be tightened (greater than threefold) when TRTK12 is bound.

86 st that the closed conformation results from tightened hydrophobic interactions that exclude water fr

87 e sharp cristae edges, whereas trimeric OPA1 tightens ICS outlets.

88 onal estimates of climate sensitivity can be tightened if reconstructions of Northern Hemisphere temp

89 K(D) 1.45 +/- 0.30 mm, and this binding was tightened in the T.SOS.HCII complex, characterized by K(

90 This undergoes conformational tightening in line with the solution Tmelt = 348 K befor

91 ociation constant (8.48 +/- 1.22 nM) and its tightening in the presence of GTP (3.69 +/- 0.65 nM), at

92 ture cardiomyocytes, the linker expanded and tightened individual mitochondria-junctional SR contacts

93 high-throughput environment, to reduce bias, tighten insert size distribution and reliably obtain hig

94 structural analysis identified an extensive, tightened intramolecular H-bonding network in bound PMI

95 tic vesicles corral a central exocytic zone, tightening it to a vertex that establishes the polarity

96 he contrast of a focal spot to 6 x 10(6) and tightened its spatial resolution to 0.5 micrometers, res

97 15 degree bending in the inner bundle gate, tightening its diameter and shifting the narrowest point

98 of tumors associated with KSHV/HHV8, further tightens its association with malignancy, and suggests a

99 In a tightening job market, early-career researchers may cons

100 As hospital budgets tighten, justification of staffing becomes a necessity.

101 proved systematic uncertainties, this result tightens KATRIN's previous bound by a factor of almost t

102 s off the free terminus, or one in which the tightened knot enters the translocation pore of ClpXP.

103 ation of the polymer backbone induced by the tightening knot activates otherwise unreactive covalent

104 which has particularly benefited workers in tightening labor markets.

105 in monomer; an effect that may contribute to tightening lateral interactions between protofilaments a

106 Golic+ incorporates genetic modifications to tighten lethality-based selection while simultaneously b

107 t be the key to improved N retention through tightening linkages between plants and microbes and redu

108 Recently, a strongly and optimally tightened lower bound on the exchange energy was proved

109 wn to disrupt blood vessel junctions instead tightened lymphatic cell-cell junctions and impeded lymp

110 Therefore, an overall structural tightening mechanism is not supported by the data.

111 sion of two VL domains into a single protein tightens MG binding over 1000-fold to low picomolar affi

112 rs' budgets for helping to fight the disease tighten, national governments and external funding partn

113 t of the second wave in both countries, with tightening non-pharmaceutical interventions (NPIs) and s

114 The potential of soil biota to tighten nutrient cycles by improving plant nutrition and

115 r mechanism of mechanical unfolding and knot tightening of AFV3-109.

116 lthough these findings have helped lead to a tightening of air-quality standards, their validity with

117 een receiving increased attention due to the tightening of ambient air quality standards.

118 Tightening of any STRING sutures did not affect anterior

119 tor protein(s) evolved to provide allosteric tightening of Ca(2+) and simultaneously determine how sp

120 e and during acute ischemia before and after tightening of each STRING using transesophageal echocard

121 onin is enhanced by more than 2000-fold upon tightening of EI to form EI*, from K(i) = 530 nM (EI) to

122 ased inflammatory response is accompanied by tightening of endothelial cell junctions and reduction i

123 Interestingly, we discovered that tightening of ER-mitochondria contacts by overexpression

124 vo model for organogenesis, we show that the tightening of hindgut curvature that normally occurs bet

125 (cat) for isomerization of GAP, suggesting a tightening of interactions between the side chain of Lys

126 g of Ca(2+) to carbonyl groups and/or strong tightening of interlipid H-bonds to levels beyond those

127 IL-15-mediated tightening of intestinal epithelial monolayers correlate

128 ect of phosphite was accompanied by apparent tightening of its interactions within the active site at

129 bound to PIP 2 in lipid bilayers indicate a tightening of ligand-protein interactions relative to th

130 Such mutual tightening of metal and substrate binding suggests the f

131 ket, and the underlying mechanism could be a tightening of Na(+) binding at Na(+) site II, possibly v

132 route to improved air quality than continued tightening of new vehicle emissions standards.

133 anatomical imbalance reveals a reproducible tightening of structural covariance by age 25 y, which l

134 bouquet formed through a gradual, continuous tightening of telomeres over approximately 6 h.

135 trate binding to ProT(QQQ) caused allosteric tightening of the affinity of most SC(1-246) variants, c

136 Tightening of the annuloplasty sutures, even beyond the

137 ll three measurements gave rise to a similar tightening of the apparent Kd value compared with pure P

138 Here we show that tightening of the ascending branch of the Hadley Circula

139 a short "synthetic linker" (<5 nm) leads to tightening of the associations.

140 These results imply selective tightening of the barrier in patients exposed to the wid

141 mpositional shift in soil biota, preceded by tightening of the belowground networks, corresponds with

142 the brain endothelial cells and promoted the tightening of the blood-brain barrier (BBB) thereby cont

143 Entropy of activation may reflect tightening of the contact between the associated protein

144 ackbone amide nitrogen atoms that results in tightening of the Cys39-Cys48 metal cluster binding loop

145 ssion on Zoological Nomenclature, advocate a tightening of the definition of "species diagnosis" in f

146 derived largely from changes associated with tightening of the dimer interface.

147 residue I174 to serine results in an overall tightening of the hinge region, resulting in aberrant pr

148 with a two-step binding mechanism, in which tightening of the initial encounter complex (EI) results

149 ow which the structure is compressed through tightening of the inter-tetrahedral bond angle, resultin

150 Our results imply a tightening of the interaction between L7 and L10 relativ

151 Diminished cavity size and tightening of the LAA orifice may play a role in the red

152 derived largely from changes associated with tightening of the ligand-antibiotic interface.

153 ajor mode of MT stabilization by MSAs is the tightening of the longitudinal interactions between two

154 = 21 microM) and PRPP each caused a 2.5-fold tightening of the other's binding.

155 s before and during circumflex ischemia, and tightening of the Paneth suture.

156 This is consistent with the substantial tightening of the particulate matter emission limit valu

157 This indicates that the pain-related tightening of the patients orbits was matched by partici

158 arctation of the aorta (CoA) is a congenital tightening of the proximal descending aorta.

159 s occur in vivo, the present results imply a tightening of the selective blood-brain barrier with chr

160 thus appears that the binding of heme and a tightening of the structure around the heme stabilize th

161 mechanism of stabilization, resulting in the tightening of the tertiary and quaternary hexamer struct

162 o or beta(nuc) values, indicating a putative tightening of the usual S(N)2 transition states (anti-Ha

163 ded by FasIII can be sufficient to drive the tightening of tube curvature observed.

164 the former Soviet Union, and the progressive tightening of U.S. sanctions, Cuba's model health care s

165 in recent years-key reasons appear to be the tightening of vessel transformation limits and the centr

166 r Zn(II) concentration, we show how a modest tightening of Zn(II) affinity, plus weakened DNA affinit

167 ion to the enthalpy of binding derived from "tightening" of the protein structure.

168 -Ca(2+)-channel topology whose developmental tightening optimizes synaptic transmission.

169 Instead, dipolar torque activity may either tighten or unwind the cholesteric helix and if tuned, ca

170 emic infection, we identify bottlenecks that tighten or widen with higher inoculum sizes, revealing t

171 anges in cell-substrate adherence, cell-cell tightening or cytoskeletal remodeling.

172 t previously been considered in terms of the tightening, or loosening, of receptor structures that re

173 ents are the equilibrium between relaxed and tightened organizations of the hydrogen-bonding network

174 assisting CRISPR-Cas engineering to relax or tighten PAM requirements for subsequent applications.

175 range, with a cholesteric state arising with tightening pitch as temperature deviates from this point

176 tent permanently; 34% (n = 22) had an eyelid-tightening procedure with 50% success, and 15% (n = 10)

177 e intensity, bilateral location, pressing or tightening quality, and no aggravation by routine physic

178 State governments can tighten regulation of profit-driven abuses, and the medi

179 m from recreational use of nitrous oxide and tightening regulations on suppliers are essential in mit

180 the data that are consistent with structural tightening relate to defined regions and are close to th

181 In 2014, Assembly bill 2109 tightened requirements for obtaining a personal belief e

182 onents of these traits, or because predators tighten residual correlations by causing environmental h

183 They imply that the barriers are tightened selectively (efflux transporter upregulation)

184 proper orientation in the epithelium, and a "tightened" Sertoli cell TJ permeability barrier, support

185 slipknot was untied during unfolding, and no tightened slipknot conformation was observed.

186 ing it from shrinking and the formation of a tightened slipknot conformation.

187 s with broadened specificity, receptors with tightened specificity, and receptors that lack activatio

188 er complex is followed by two conformational tightening steps reported by fluorescence quenches.

189 Forward and reverse rates for both tightening steps were unaffected by 6-aminohexanoic acid

190 STRING-1 was tightened, did not change after tightening STRING-2 (2.3+/-0.1 to 2.3+/-0.1), and decrea

191 anges in network connectivity strengthen and tighten synchronous connectivity near foci-a mechanism t

192 the rapidly progressive painful, itchy skin tightening that characterizes dcSSc is the symptom that

193 been proposed to operate through structural tightening that improves all of the functional group int

194 ature, whereby the DNA reduces the degree of tightening that is observed in its absence, thereby prom

195 h between distinct open and closed states to tighten the active site and avail catalysis.

196 e transmembrane helices of LptFG and LptC to tighten the cavity, with the closure of two lateral gate

197 Many TJ proteins are known to tighten the cell structure and maintain a barrier.

198 In addition, it is also necessary to tighten the co-occurrence network into smaller modules t

199 neracy by identifying a lensing object would tighten the constraints on the mass in MACHOs.

200 We suggest that Cra helps to tighten the control of adhE transcription under aerobic

201 ate (vitamin C) has previously been shown to tighten the endothelial barrier and maintain barrier int

202 opose that, via PTGS, disiRNAs could help to tighten the expression of epigenetically activated TEs a

203 e of prior information that could be used to tighten the focus of a range of health-related research

204 A new generation of humanized mice aims to tighten the gap between mouse and human, such that MS-as

205 interdomain bonds are critical, because they tighten the interaction with ATP in the E2.P phosphoryl

206 residues in the interstices of the TtCM x S tighten the intersubunit hydrophobic interactions compar

207 d data and alternative surveys that can help tighten the link between surveillance activities and int

208 nd Trp436, Gln440, Glu443 and Arg444 tend to tighten the nucleotide-binding pocket when non-cognate n

209 e at the cell membrane, which contributes to tighten the PI3Kalpha Ras binding domain/K-Ras4B interac

210 marily from diffuse structural changes which tighten the protein structure around the 8-oxo-nucleotid

211 omeric carbon while transition state analogs tighten the reaction coordinate to place the nucleophile

212 a similar induction of P-glycoprotein, which tightened the BBB, thereby increasing the neuroprotectio

213 icated that, with both isozymes, Mg(2+) ions tightened the binding of NADH, and by binding to the coe

214 n vivo increased P-glycoprotein activity and tightened the blood-brain barrier to methadone, reducing

215 Apical S1P treatment of BMECs tightened the endothelial barrier in vitro, whereas baso

216 uring restitution, both CXCL12 and TGF-beta1 tightened the monolayer by decreasing the paracellular s

217 Mechanistically, PFKFB3 inhibition tightened the vascular barrier by reducing VE-cadherin e

218 mechanism by which BVM disrupts maturation, tightening the 6-helix bundle pore and quenching the mot

219 Future distributions may result in tightening the acceptance levels of quantification and t

220 corporations, which they could accomplish by tightening the active site of the TLS Pol.

221 oth the wild-type and mutant structures thus tightening the active site.

222 g baseline conditions, then before and after tightening the annuloplasty suture during proximal left

223 on in response to inflammatory cues, thereby tightening the border to limit the number of activated T

224 of MurA with PEP fulfills dual functions by tightening the complex with UNAM for the efficient feedb

225 escribe some of these new functions that are tightening the connection between autophagy and acquired

226 yme fail to undergo immortalization, further tightening the connection between telomere maintenance a

227 e inactivated conformation of the channel by tightening the cytosolic juxtamembrane segments, while C

228 On tightening the degree of confinement, a transition is ob

229 le external stimulation is held constant are tightening the experimental link between consciousness a

230 Tightening the grid of microsatellite markers under this

231 ng that health benefits would be achieved by tightening the guidelines and regulatory limits of NO(2)

232 led chromophores in condensed phase systems, tightening the inferred relations between the spatial an

233 on and ischemia due to coronary occlusion by tightening the link between cardiac systolic performance

234 We demonstrate that tightening the mtDNA bottleneck increases heteroplasmic

235 .1+/-0.4 to 0.4+/-0.4, mean+/-SD, P<0.05) by tightening the Paneth annuloplasty suture.

236 It is also found that substrate binding tightens the active site and restricts the conformationa

237 The gamma-rotation tightens the ATP-bound alphabetaTP interface, as require

238 mechanism in which binding of one substrate tightens the binding of the other substrate to produce a

239 auses concerted movement of SDL2 and thereby tightens the binding pocket for the internal ligand.

240 Addition of 9-deazaadenine tightens the binding to 0.10 microM whereas added adenin

241 Thus, CAR activation selectively tightens the blood-brain barrier by increasing transport

242 ngthens the interaction between subunits and tightens the catalytic site loops.

243 an elbow connecting S4 to the S4-S5 linker, tightens the collar around the S6 activation gate, and p

244 Using simulations, we found that the method tightens the depth of focus even for systems with a narr

245 ed rotation of an invariant Tyr residue that tightens the intracellular gate.

246 DNA binding further tightens the narrow distal pocket and slightly weakens t

247 geal joints (MTPJs) prior to push off, which tightens the plantar soft tissues to convert the foot in

248 the glutenin network during pasta processing tightens the protein network and results in lower cookin

249 Fourth, ISW1a tightens the spacing to canonical repeat lengths.

250 This established CFA chronology tightens the timespan of phosphatization events and refi

251 This network tightens the transition-state ensemble, which induces a

252 nded length of this tail suggests that ClpXP tightens the trefoil knot against GFP, which prevents GF

253 an increase of transcription factor binding tightens the variability of gene expression around the m

254 On activation, outward S4 motion tightens the VSD-pore linker, perturbing linker-S6-helix

255 chinery and hijack the actin cytoskeleton to tighten their interaction with the gut epithelium, while

256 creased aridity and/or drought frequency may tighten them.

257 n of either the larger Ser (22) or Met (108) tightens this interaction, pulling alpha2 and alpha5 tow

258 ulated E-cadherin localization and monolayer tightening through Rho-associated protein kinase activat

259 ro substrate concentration (K(a)Mn2+), which tightened to 0.32 +/- 0.18 mM when extrapolated to infin

260 tic abutments were fixed to the implants and tightened to 20 Ncm without counter torque.

261 ope of 1.6) is indicative of further complex tightening to the closed conformation.

262 ation site binds with a Kd of 3.2 microM and tightens to 0.75 microM in the presence of 9-deazaadenin

263 /unwinding in helical propensity as the knot tightens to secure the SAM cofactor.

264 The difference between loosening and tightening torque value was also measured.

265 onse of AML patients to therapy; however, to tighten treatment correlates within genetically defined

266 he underwent cosmetic plasma fibroblast skin tightening treatment at her local salon four hours earli

267 Plasma fibroblast skin tightening treatment is a relatively novel and growing m

268 eye injury following plasma fibroblast skin tightening treatment secondary to EMLA cream.

269 omplication following plasma fibroblast skin tightening treatment.

270 n preparation for the plasma fibroblast skin tightening treatment.

271 otted protein AFV3-109 is transformed into a tightened trefoil knot by applied pulling force.

272 s and the slipknot can be transformed into a tightened trefoil knot involving approximately 13 amino

273 Addition of SAM tightened up the cosubstrate pocket in both proteins and

274 t binding of two distinct Ca(2+) ions causes tightening up of the regions that surround the anion hol

275 1 cm(-1) upon magnesium binding is due to a "tightening up" (in the sense of a more rigid molecule wi

276 ition mechanism is proposed, wherein slower "tightening up" of the initial encounter complex occurs.

277 A further 10 screws were tightened, using an augmented screwdriver that indicated

278 fficient) for thermodynamic feasibility; 2), tighten V(max) and V(min) constraints to enclose the rem

279 suture annuloplasty that could be reversibly tightened was anchored to each fibrous trigone and exter

280 negatively charged lipid indicated that the tightening was largely electrostatic.

281 dface lift, buccal mucosal graft and canthal tightening) was an effective procedure to correct cicatr

282 ine and the bilayers, while this interaction tightened when POPE (1-hexadecanoyl-2-(9-Z-octadecenoyl)

283 crevice, and that this crevice is closed or tightened when S1 is in the S1** MgADP.Pi state.

284 a cage around the distally bound anion that tightens when substrate binds and an active site loop cl

285 the pressing need to implement the recently tightened WHO air quality guidelines.

286 By contrast, genetic correlations did not tighten with exposure to risk.

287 ot in the unfolded state that can be further tightened with higher forces.

288 in the United States have been dramatically tightened with the goal of reducing urban air pollution.

289 ctivates dermal lymphatic capillary junction tightening (zippering) and lymph node lymphangiogenesis,