ライフサイエンスコーパス: tip cell

1 e, thereby modulating wall stress within the tip cell.

2 m cells are controlled by the somatic distal tip cell.

3 amyloplasts sediment along the length of the tip cell.

4 muli inducing cytosolic Ca(2+) rises in root tip cells.

5 nt at the apical plasma membranes of growing tip cells.

6 n the retraction of filopodia in endothelial tip cells.

7 s and diminished the directionality of their tip cells.

8 g the retraction of filopodia in endothelial tip cells.

9 figuration of strain vectors in the ECM near tip cells.

10 g and helps to restrict the proliferation of tip cells.

11 s required for RanGAP NE association in root tip cells.

12 hairs, but only five were expressed in root tip cells.

13 mpaired front-rear polarization of sprouting tip cells.

14 nsure its correct localization within hyphal tip cells.

15 y are rate-limiting for the growth of hyphal tip cells.

16 ion of microtubule disassembly within hyphal tip cells.

17 ended bead-like structure in interphase root tip cells.

18 and inducing adrenocorticotropin in rostral tip cells.

19 ns of two specific gonadal cells, the distal tip cells.

20 gonad, in the spermatheca and at the distal tip cells.

21 retention of exogenously added auxin in root tip cells.

22 rain in immunofluorescence assays using root tip cells.

23 L to the cell plate in dividing soybean root tip cells.

24 prouting as a result of increased numbers of tip cells.

25 r outgrowth, without affecting the number of tip cells.

26 eaved CLEC14A binds to sprouting endothelial tip cells.

27 ks due to increased elongation of protonemal tip cells.

28 nts and divisions of individual ureteric bud tip cells.

29 elial cell motility, driving cells to become tip cells.

30 ltaneous cell extension and expansion in the tip cells.

31 in endothelial cells, including endothelial tip cells.

32 matrix and transfer Dll4 protein to distant tip cells.

33 ing in stalk cells is induced by DLL4 on the tip cells.

34 staining in TIPS mesenchymal cells and peri-TIPS cells.

35 type III procollagen mRNA compared with peri-TIPS cells.

36 ative to type I, collagen compared with peri-TIPS cells.

37 prouting, in which a subset of cells, termed tip cells, acquires motile, invasive behaviour and exten

38 progenitors that secrete VEGF-A to stimulate tip cell activity and the pro-angiogenic macrophages tha

39 ed due to cell elastic distortion, offset by tip-cell adhesion, and indeed such a model fits the bare

40 Tip cells also undergo most cell proliferation, daughter

41 TIPS cells also expressed high levels of type III procol

42 the pro-angiogenic macrophages that promote tip cell anastomosis.

43 we find defects in the generation of distal tip cells, anchor cells, and spermatheca; three of the f

44 Tip cell anchorage antagonizes forward-directed, TGF-bet

45 Defects in these features obliterate tip cell anchorage, producing misshapen and misplaced tu

46 Interactions between the distal tip cell and germline stem cells maintain a proliferativ

47 ctive interaction between the somatic distal tip cell and the germ line.

48 ic relies on induction by the somatic distal tip cell and the glp-1 signal transduction pathway.

49 caused rapid disassembly of microtubules in tip cells and a 10x reduction in growth rate.

50 l macrophages localize between Dll4-positive tip cells and at vascular branchpoints, and that these m

51 led vegfr3) is expressed in segmental artery tip cells and becomes ectopically expressed throughout t

52 ects caused by a perturbed directionality of tip cells and by loss of cell contacts between tip and s

53 formation of significantly more endothelial tip cells and capillary bridges-some with loops-near the

54 d on astrocytes (ACs), which guide sprouting tip cells and deposit a provisional matrix for sprouting

55 During sprouting, tip cells and ensuing stalk cells migrate collectively i

56 ialisation of endothelial cells into leading tip cells and following stalk cells.

57 Notch regulation, is present on endothelial tip cells and is critical to sprouting angiogenesis.

58 is highly expressed in capillary endothelial tip cells and is involved in suppressing neighboring sta

59 duced vessel length and increased density of tip cells and perpendicular sprouts.

60 -coenzyme A dehydrogenase activity in villus tip cells and plasma beta-hydroxybutyrate values in port

61 epothilone B, completely interferes with EC tip cells and sprouting behavior, while allowing for EC

62 ls and regulates the differentiation between tip cells and stalk cells of neovasculature.

63 including stress fibers in migratory distal tip cells and the proximal gonad sheath, where it become

64 the sEH significantly delayed angiogenesis, tip cell, and filopodia formation, a phenomenon associat

65 stalks, verified that the stalks are free of tip cells, and assessed the ability of tip-free stalks t

66 wild type, inhibition of endocytosis in root tip cells, and cell death in the adjacent elongation zon

67 ing induces sprouty expression in the nearby tip cells, and sprouty acts nonautonomously and in a com

68 s of A. nidulans and in multinucleate hyphal tip cells, and we used a green fluorescent protein-alpha

69 lly "over" existing sprout cells to form new tip-cells; and (2) loss of VE-cadherin activity prevents

70 We found that normal tip cells are bipotential, contributing to both tips and

71 alpha-primase may be isolated from pea shoot tip cells as a large (1.25 x 10(6) Da) multi-protein com

72 ptin mutants affect morphology of the distal tip cells, as well as their migration and guidance durin

73 ced the formation of specialized endothelial tip cells at the edges of the repairing capillary networ

74 ndothelial cells exist in one of two states: tip cells at the growing front and stalk cells in the va

75 ind that, in normal kidneys, most individual tip cells behave as self-renewing progenitors, some of w

76 as a unique function in regulating migratory tip cell behavior during sprouting angiogenesis.

77 Finally, miR-221 promoted tip cell behavior through repression of two targets: cyc

78 arly all sprouting endothelial cells exhibit tip-cell behaviour, leading to excessive numbers of cell

79 is just an occasional instance of groups of tip cells being "left behind" by error in a mainly stalk

80 cells-cells that directly contact the distal tip cell body-relative to cells further proximal, a diff

81 During the pseudoglandular stage, the tip cells both self-renew and contribute descendents to

82 ontrast, Spry2 overexpression eliminated the tip cell branching in the intersegmental vessels.

83 reporter sorted to peroxisomes in lon2 root tip cells but was largely cytosolic in more mature root

84 ssion leads to overproduction of endothelial tip cells by both morphologic and molecular criteria.

85 ation studies indicate that CD45(+) liver SP tip cells can be generated from BM HSCs, suggesting a re

86 In addition, individual Id2(+) tip cells can self-renew and contribute descendents to b

87 rotein, directed biosynthesis only in apical-tip cell clusters of short, procumbent glandular trichom

88 ting cytoskeleton remodelling, migration and tip cell competitiveness.

89 demonstrate that microtubules help balancing tip cell contraction, which is driven by myosin, and is

90 ssing protein 46), phenocopied bcd1-mediated tip cell death.

91 le) and its fast neutron-derived Bgh-induced tip cell death1 mutant, bcd1.

92 ociated cell dispersal." Premitotic ureteric tip cells delaminate from the epithelium and divide with

93 ion of sprouting activity (e.g., endothelial tip cell density, filopodia number) can be obtained.

94 Ablation of the peripheral cap cells and tip cells did not alter root curvature.

95 The growth rate of hyphal tip cells did not change significantly in mitosis.

96 Tip cell differentiation is inhibited through lateral No

97 During angiogenic sprouting, endothelial "tip cells" directionally branch from existing vessels in

98 ip in comparison to experiments in which the tip-cell distance is a constant irrespective of cell siz

99 Ret expression defines a population of UB "tip cells" distinct from cells of the tubular "trunks,"

100 ages of vasculogenesis, during canalogenesis tip cells divide and form branched chains prior to vesse

101 n addition, when notch signaling is blocked, tip cells divide, and both daughter cells take on a tip

102 The distal tip cell (DTC) caps a blind-ended tube; only the distal

103 iche exit in the canonical C. elegans distal tip cell (DTC) germ stem cell niche mediated by previous

104 Analysis of distal tip cell (DTC) migration during gonadogenesis in Caenorh

105 nscription factor required for proper distal tip cell (DTC) migration.

106 Notch pathway signaling from the distal tip cell (DTC) niche to the germline maintains the proge

107 ferative fate is specified by somatic distal tip cell (DTC) niche-germline GLP-1 Notch signaling thro

108 The Caenorhabditis elegans distal tip cell (DTC) provides a niche for germline stem cells

109 single-celled mesenchymal niche, the distal tip cell (DTC), employs GLP-1/Notch signaling and an RNA

110 neurons, vulval precursor cells, the distal tip cell (DTC), intestine, and the lateral hypodermal se

111 TNT-like cellular protrusions of the distal tip cell (DTC), the germline stem cell niche in the gona

112 etaR signaling cascade in the gonadal distal tip cell (DTC), the germline stem cell niche, where it n

113 only its distal daughter generates a distal tip cell (DTC), which is required for stem cell maintena

114 f which was strikingly similar to the distal tip cell (DTC)-germ stem cell niche.

115 ific expression of HA-betatail in the distal tip cells (DTC), the cells that direct gonad morphogenes

116 n the gonadal lineage both to specify distal tip cells (DTCs) and in DTC differentiation and function

117 The two specialized C. elegans distal tip cells (DTCs) provide an in vivo model system for the

118 n is found in the hypodermis, muscle, distal tip cells (DTCs), and in neurons.

119 ms are determined by migration of the distal tip cells (DTCs).

120 nd the gonad arm migration led by the distal tip cells (DTCs).

121 Like axon guidance, the tuning of vascular tip cells during angiogenesis is an intriguing but puzzl

122 uppressing neighboring stalk cells to become tip cells during angiogenesis.

123 with heterozygous deletion of Dll1 had fewer tip cells during angiogenic sprouting of the superficial

124 train to lineage trace the distal epithelial tip cells during either the pseudoglandular or canalicul

125 lay in the retraction and fusion of the tail tip cells during L4 morphogenesis, such that retraction

126 hese pathways might interact to generate new tip cells during retinal angiogenesis.

127 l derived factor-1, was also identified as a tip cell-enriched gene, and we provide evidence for a no

128 n (termed CD45(+) liver side population [SP] tip cells), exhibit a surface phenotype similar to that

129 Distinctive tip cell exploratory behavior, adhesion, and basement me

130 ies, particularly in kidney, have shown that tip cells express a set of genes distinct from those in

131 nocopied defects associated with loss of the tip cell-expressed Flt4 receptor.

132 ngiogenic switch on by promoting endothelial tip cell fate and sprouting and it promotes venous diffe

133 ole of miR-27b in the control of endothelial tip cell fate, branching, and venous specification and d

134 ns are critical for formation of endothelial tip cell filopodia and EC migration.

135 postnatal angiogenesis impaired endothelial tip cell filopodia protrusion, resulting in incomplete f

136 , leads to aberrant extension of endothelial tip cell filopodia, excessive vessel branching and abnor

137 provide an opportunity to selectively target tip cell filopodia-driven angiogenesis to restrict tumor

138 ect in astrocytes, the number of endothelial tip cell filopodias, and the rate of developing retinal

139 filopodia-like protrusions characteristic of tip cells, following stalk cells exhibiting apical-basal

140 found that transposition of RescueMu in root-tip cells follows the cut-and-paste type of transpositio

141 VEGFR-1 deficiency promoted tip cell formation and endothelial cell proliferation an

142 )-directed Notch signaling induces excessive tip cell formation and endothelial proliferation resulti

143 uced retinal endothelial cell proliferation, tip cell formation and neovascularization in vivo.

144 uced retinal endothelial cell proliferation, tip cell formation and neovascularization.

145 ugh in most endothelial beds hypoxia induces tip cell formation and sprouting angiogenesis, here we d

146 e reduced microglial activation and enhanced tip cell formation by A2AR-dependent and -independent me

147 essels, where Dll1 expression coincided with tip cell formation in a spatiotemporal manner.

148 ted signaling was required for the lymphatic tip cell formation in both FGF-2- and VEGF-C-induced lym

149 e VEGFR-3-induced lymphatic endothelial cell tip cell formation is a prerequisite for FGF-2-stimulate

150 and HEY2, thereby repressing VEGF signaling, tip cell formation, and endothelial sprouting.

151 ata identify SYNJ2BP as a novel inhibitor of tip cell formation, executing its functions predominatel

152 Interestingly, increased angiogenesis, tip cell formation, vascular permeability, VEGFR-2 accum

153 of new connections by regulating endothelial tip cell formation.

154 tivity promotes vessel maturation and limits tip cell formation.

155 giopoietin-2, ESM1, and Apelin, and impaired tip cell formation.

156 type needs to be actively repressed to allow tip-cell formation.

157 enes that distinguish uniplanar protonematal tip cells from multiplanar gametophore bud cells in the

158 s demonstrate that NRP1 promotes endothelial tip cell function during angiogenesis.

159 Notch signaling regulates tip cell function, and we find that TNF also induces the

160 To identify genes critical to tip cell function, we have developed a method to isolate

161 othelial cells activate a previously dormant tip cell gene expression program, which likely underlies

162 TNF induces the known tip cell genes platelet-derived growth factor B (PDGFB)

163 ro, culture of ECs on DLL1 induced essential tip cell genes, including Dll4, VEGF receptor 3, and eph

164 In Caenorhabditis elegans, the distal tip cell/germline interaction promotes a mitotic fate an

165 Hyphal tip cells grew approximately 5 times faster than binucle

166 study develops a quantitative framework for tip cell growth and characterizes mechanisms of force ge

167 s results in a shared defect in gametophytic tip cell growth.

168 f dense microvessels emerged without obvious tip cell guidance and reliance on blood endothelial cell

169 The hermaphrodite distal tip cell (hDTC) also provides "leader" function to contr

170 In hyphal tip cells, however, microtubules disassembled through mo

171 f UB tip markers, suggesting a shift towards tip cell identity.

172 ments are spatially segregated within hyphal tip cells in a manner that depends upon the integrity of

173 in the brain, we observed a lower number of tip cells in addition to reduced brain EC proliferation,

174 ary to restrict angiogenic cell behaviour to tip cells in developing segmental arteries in the zebraf

175 of C. albicans cell growth and to the hyphal tip cells in growing filaments.

176 ted with filopodia of angiogenic endothelial tip cells in invasive bladder cancer.

177 r cells (OPCs) contact sprouting endothelial tip cells in mouse, ferret, and human neonatal white mat

178 anosensitive ion channel in guiding vascular tip cells in pathfinding.

179 cell sprouting from spheroids, formation of tip cells in the sprouting assay, expression of alphavbe

180 Genes enriched in tip cells include ESM-1, angiopoietin-2, and SLP-76.

181 Six genes with expression in ureteric tip cells, including Wnt11, were downregulated, whereas

182 se of alternative oxidase levels in the root tip cells indicated that the reduction of mitochondrial

183 a suggested feedback loop that links VEGF-A tip cell induction with delta-like 4 (Dll4)/notch-mediat

184 cting system of the mature kidney, while the tip cells interact with the adjacent cells of the metane

185 esion, and indeed such a model fits the bare-tip/cell interaction, in agreement with earlier work.

186 and impairs differentiation of ureteric bud tip cells into trunk cells.

187 angiogenesis initially depend on endothelial tip cell invasion, which is followed by a series of matu

188 The putative posterior distal tip cell is then eliminated in all but one species by pr

189 zed subtype of endothelial cell known as the tip cell is thought to be involved in the detection and

190 wing blood vessels, sprouting of endothelial tip cells is inhibited by Notch signaling, which is acti

191 ination, thought to be regulated by anterior tip cells, is selectively suppressed by mild hypoxia by

192 Moreover, our analysis of the tip cell lamellipodia revealed the diversity in their in

193 orphogenetic process that involves polarized tip cells leading stalk cells to form new capillaries.

194 The outgrowth of multipotent tip cells leaves behind differentiated progeny that form

195 or (EGF) signalling from the distally placed tip cell lineage, which sets up a distal-to-proximal gra

196 on the anterior tubules, we demonstrate that tip cells make transient contacts with alary muscles at

197 rrelates with decreased expression of the EC tip cell markers apelin and Dll4 and is associated with

198 Therefore, the male distal tip cell (mDTC) serves as a niche but not as a leader.

199 s an important regulatory node through which tip cell migration and proliferation are controlled duri

200 ic ring assay indicated that TLR9 suppressed tip cell migration and recruitment of mural cells and ad

201 n ADAMTS family protease required for distal tip cell migration in C. elegans.

202 In this study we examine the contribution of tip cell migration rate and stalk cell proliferation rat

203 properties of FN and HS promote directional tip cell migration, whereas FN integrin-binding function

204 onger intersegmental vessels and exacerbated tip cell migration.

205 unctions are required for nuclear and distal tip cell migrations, but only one is required for nuclea

206 lin signaling exhibit defects in endothelial tip cell morphology and sprouting.

207 a novel role for this receptor in mediating tip cell morphology and vascular patterning in the neona

208 Third, the distal tip cell niche extends processes that nearly encircle ad

209 /Notch signaling from the mesenchymal distal tip cell niche maintains GSCs in the distal gonad of bot

210 , whether Dll4-containing exosomes influence tip cells of existing capillaries is unknown.

211 CLAVATA pathway genes are expressed in the tip cells of filamentous tissues, regulating cell identi

212 synthesize protective acylated sugars in the tip cells of glandular trichomes on stems and leaves.

213 e Arp2/3 complex subunit ARPC1 in elongating tip cells of protonemal filaments of the moss Physcomitr

214 Here, we show that the tip cells of Six1(-/-) UB fail to form an ampulla for br

215 reticulum (ER) and cell cycle arrest in root tip cells of stt3a seedlings, as determined by expressio

216 Hyphal tip cells of the fungus Aspergillus nidulans are useful

217 tium and in the migrations of the two distal tip cells of the gonad.

218 lial growth factor A (VEGF-A) in endothelial tip cells of the mouse retina.

219 ere abundant throughout the length of hyphal tip cells of the mutant.

220 gene are expressed in the sheath and distal tip cells of the somatic gonad, the gut and other non-go

221 In Drosophila development, tip cells of the tracheal system lead the migration of e

222 n receptor UNC5B is expressed by endothelial tip cells of the vascular system.

223 with one gene (named Sl-ASAT3) expressed in tip cells of type I trichomes where acylsugars are made.

224 lastid displacement and induced curvature in tip cells of WT and wwr protonemata.

225 riving GFP expression showed fluorescence in tips cells of long, slender trichomes that is consistent

226 ter canalicular stage, the distal epithelial tip cells only contribute descendents to the alveoli.

227 by being either positioned at the sprouting tip cells or tethered along the vessel walls.

228 ur key findings are that when an endothelial tip cell penetrates BrM: 1) RPE with normal epithelial j

229 TNF promotes angiogenesis by inducing an EC tip cell phenotype and the expression of jagged-1, a lig

230 mental data illustrate that induction of the tip cell phenotype is dependent on the protein VEGF-A; h

231 Addition of Dll4 exosomes confers a tip cell phenotype on the endothelial cell, which result

232 hrough VEGFR2, but in addition by inducing a tip cell phenotype through an NFkappaB-dependent pathway

233 ls divide, and both daughter cells take on a tip cell phenotype, resulting in increased branching thr

234 ELTD1 specifically regulates the endothelial tip-cell phenotype through yet undefined signalling path

235 posit that endothelial cells default to the tip-cell phenotype when Notch is inactive.

236 providing spatial and temporal control over "tip cell" phenotype during angiogenic sprouting.

237 tes angiogenesis by inducing an endothelial "tip cell" phenotype.

238 show that Kif26b and Daam1 depletion impairs tip cell polarization and destabilizes extended vascular

239 expression, which suggests an increase in EC tip cell population.

240 P1-expressing endothelial cells attained the tip cell position when competing with NRP1-negative endo

241 ing has been activated are excluded from the tip-cell position.

242 lial cells did not efficiently contribute to tip cell positions in developing sprouts.

243 cell proliferation and migration, as well as tip cell potential in mosaic blood vessels.

244 ithin this cluster of cells to segregate the tip cell precursor, in which proneural gene expression s

245 s exposed in its monomer form on endothelial tip cells prior to adherens junction formation.

246 These distal tip cell processes are likely to play a critical role in

247 Furthermore, miR-221 was required for tip cell proliferation and migration, as well as tip cel

248 were found within dividing cells in the root tip cell proliferation zone.

249 g, and also regulates migration of capillary tip cells, proliferation of trunk cells, and gene expres

250 ssion of angiogenic factors, failed to adopt tip cell properties, and displayed reduced sprouting, le

251 a-miR-132 to developing mouse eyes disrupted tip cell Ras activity and prevented angiogenic sprouting

252 endothelial sprout, it causes filopodia and tip cell retraction.

253 ar endothelial growth factor (VEGF)-mediated tip cell selection and subsequent angiogenic sprouting.

254 ood vessel formation starts with endothelial tip cell selection and vascular sprout migration, follow

255 ving Delta-4 and Jagged-1 ligands determines tip cell selection and vessel branching.

256 the protein VEGF-A; however, the process of tip cell selection is not fully understood.

257 al (Semaphorin3E-Plexin-D1) that accelerates tip cell selection rate, yielding a dense network.

258 environments; (2) a VEGF gradient increases tip cell selection rate.

259 Dll1 acts as an extrinsic cue involved in tip cell selection, which directs vessel sprouting and b

260 ive imaging, we demonstrate that the rate of tip-cell selection determines the length of linear sprou

261 Reiterations of endothelial-tip-cell selection, sprout extension and anastomosis are

262 Anterior portions of the tail tip cells show the first evidence of retractions and fus

263 ngly, proper oocyte growth depends on distal tip cell signaling involving the redundant function of G

264 noma, the presence of a migration-associated tip-cell signature correlated with poor clinical outcome

265 ption-polymerase chain reaction (qRT-PCR) of tip cells sprouting in vitro.

266 or more factors that promote the endothelial tip cell state and inhibit angiogenesis.

267 nhibited the expression of genes enriched in tip cells, such as angiopoietin-2, ESM1, and Apelin, and

268 overlap is more extensive than predicted for tip cell switching, and it sets up a longitudinal cell-c

269 vessel branching (angiogenesis), endothelial tip cells (TCs) lead sprouting vessels, extend filopodia

270 including in neurons, as well as the distal tip cell that plays a crucial role in signaling to germl

271 s harbor distinct stem cell types, including tip cells that divide in single planes to generate filam

272 forming sprouts are composed of specialized tip cells that guide the sprout and trunk cells that pro

273 specification of endothelial cells into the tip cells that lead new blood vessel sprouts is coordina

274 In interphase root tip cells, the fluorescent protein fusions labeled micro

275 step of the migration is the ability of the tip cell to carry out proteolysis, we have estimated cel

276 st time that Dll4-containing exosomes causes tip cells to lose their filopodia and trigger capillary

277 but the molecular signaling pathways used by tip cells to mediate tissue vascularization remain large

278 gous bridging phenomenon linking endothelial tip cells together during formation of polygonal endothe

279 these ceRNAs appears to reduce PTEN levels, tipping cells toward cancer progression.

280 e host's mid-region, whereas donor allantoic tip cells typically returned to the tip, often colonizin

281 time-lapse analysis reveals that endothelial tip cells undergo a stereotypical pattern of proliferati

282 ates the cell-fate decision between vascular tip cells versus stalk cells.

283 NDINGS: Experimental data extends beyond the tip cell vs. stalk cell paradigm, and involves numerous

284 ibutions, particularly the conversion of the tip cell wall to a more shaft-like state.

285 growth rate and a decreased thickness of the tip cell wall, causing tip bursts.

286 etailed analysis of pea (Pisum sativum) root tip cell walls.

287 Enrichment of jagged-1 in tip cells was confirmed by immunofluorescent staining as

288 ibition to antagonize filopodia formation in tip cells was context-dependent, suggesting a mechanism

289 ature and, the appearance and density of the tip cells were similar in bim+/+ and bim-/- mice.

290 located from the NE in undifferentiated root-tip cells, whereas NE targeting in differentiated root c

291 py was used to directly visualize the distal tip cell which extends tentacle-like processes that dire

292 Each first gives rise to one distal tip cell (which promotes arm growth and germ line prolif

293 ptins are also expressed in migrating distal tip cells, which are leaders for gonad arm extension.

294 ated at the tip of branches, consistent with tip cells, which emerged from established vessels to for

295 om a specialised subset of tubule cells, the tip cells, which express the protease Rhomboid and are t

296 cyclin cDNA clone, cycZm2w, from maize root tip cells, which fits best into group A2 of current plan

297 L4-Notch signaling controls the selection of tip cells, which guide new sprouts, and trailing stalk c

298 types of cells make up the new vasculature: tip cells, which migrate in response to gradients of vas

299 ily is required for RanGAP targeting in root tip cells, while both families are dispensable in other

300 comparison of RNA extracted from endothelial tip cells with that of endothelial stalk cells using mic