ライフサイエンスコーパス: tissue distribution

1 locking activities that vary in strength and tissue distribution.

2 ciency did not affect in vivo MC numbers and tissue distribution.

3 f catalytic activity as well as cellular and tissue distribution.

4 equivalence (NEQ) were also investigated for tissue distribution.

5 ives higher peripheral numbers and increased tissue distribution.

6 elf-renewal and differentiation with a broad tissue distribution.

7 incipal regulator of iron absorption and its tissue distribution.

8 ts in GDR, fasting glucose, FFAs and adipose tissue distribution.

9 iral gene expression and restricted in their tissue distribution.

10 ers are ubiquitous while others show limited tissue distribution.

11 als, toxicity, limited efficacy, and limited tissue distribution.

12 eacetylase complex with a broad cellular and tissue distribution.

13 in parallel to affect drug cytotoxicity and tissue distribution.

14 sential for T(reg) cell migration and normal tissue distribution.

15 l cell types, while others have a widespread tissue distribution.

16 howed rapid plasma clearance (0.021 L/h) and tissue distribution.

17 eas PDK3 and PDK4 displayed a rather limited tissue distribution.

18 abolic pathways, kinetics of elimination and tissue distribution.

19 ted with amounts of JCV DNA in urine and its tissue distribution.

20 RDye) 800CW to study its tumor targeting and tissue distribution.

21 their metabolic stability and improves their tissue distribution.

22 NAs, like messenger RNAs, display restricted tissue distributions.

23 s but have different physiological roles and tissue distributions.

24 d exhibit dissimilar physiological roles and tissue distributions.

25 lower injection volumes, and facilitate drug-tissue distributions.

26 essed in adult liver and has broader age and tissue distributions.

27 rface receptors with different functions and tissue distributions.

28 meters (5 mum and 20 mum) to investigate the tissue distribution, accumulation, and tissue-specific h

29 ) weight maintenance, and 3) compare adipose tissue distribution after 1-y maintenance with that of c

30 previously reported abnormalities in adipose tissue distribution after acute weight restoration in ad

31 2L(hi), CD27(hi), KLRG-1(low)) and function (tissue distribution, Ag-driven proliferation, cytokine p

32 XVIIIA, MyoIIA, and SP-R210 have overlapping tissue distribution, all being highly expressed in myelo

33 This tissue distribution allows these bipotent uterine epithe

34 Interestingly, tissue distribution analysis identified miR-378 to be hi

35 An extensive tissue distribution analysis of 1 in wild-type animals w

36 cific Vgamma2Vdelta2 T cells regarding their tissue distribution, anatomical localization, and correl

37 692/29 has a more restricted normal tissue distribution and a higher antigen threshold for k

38 pharmacokinetics characterized by extensive tissue distribution and a long terminal half-life.

39 d healing protein fibronectin shows distinct tissue distribution and abundance kinetics in AGMs.

40 t, the first of which is characterization of tissue distribution and access to the site of action; th

41 simultaneous modulation of serum half-life, tissue distribution and activity of a given human IgG1.

42 t in discrepancies due to variation in prion tissue distribution and assay sensitivities that limit d

43 ships between visceral adiposity and adipose tissue distribution and beta cell function, insulin resi

44 Although its wide tissue distribution and biological functions have been w

45 Pharmacokinetic studies investigated the tissue distribution and blood clearance of the (225)Ac-E

46 al fat, liver and heart ectopic fat, adipose tissue distribution and cell size as predictors of cardi

47 racellular proteins, which facilitates their tissue distribution and cellular uptake in animals.

48 ding live-animal imaging capability to track tissue distribution and clearance of the injected polyme

49 we further demonstrate marked divergence in tissue distribution and developmental expression.

50 rties led to the discovery of compounds with tissue distribution and duration of action suitable for

51 se compounds demonstrate preferential ocular tissue distribution and efficacy after oral administrati

52 y evaluated the impact of conjugate on siRNA tissue distribution and efficacy.

53 Mdr1a (Abcb1a) had a profound effect on the tissue distribution and especially the brain accumulatio

54 n (humans, ABCB1; rodents, Abcb1a/b) affects tissue distribution and excretion of (11)C-erlotinib and

55 sion (MATE) transporter 1 contributes to the tissue distribution and excretion of many drugs.

56 However, given their complex tissue distribution and expression patterns, their role

57 tracted from cartilage; and investigated its tissue distribution and extracellular assembly by immuno

58 Sex differences in adipose tissue distribution and function are associated with sex

59 atrix protein whose isoforms differ in their tissue distribution and function.

60 g is accompanied by major changes in adipose tissue distribution and function.

61 Studies of the tissue distribution and gene regulation of ACAD9 and ver

62 olate/antifolate transporter with the widest tissue distribution and greatest activity is the reduced

63 (ILCs), increased the understanding of their tissue distribution and has established essential functi

64 The tissue distribution and histopathology in mice challenge

65 ed corepressor variants that differ in their tissue distribution and in their biochemical properties.

66 of this kind of agent for monitoring in vivo tissue distribution and in vivo stability of a biologica

67 Tissue distribution and in vivo therapeutic activity wer

68 o determine the relationship between adipose tissue distribution and incident hypertension.

69 membrane permeability resulting in enhanced tissue distribution and intracellular drug delivery of m

70 Identifying the diverse tissue distribution and intracellular location of NeuPSA

71 UDA is distinct from UAA in its differential tissue distribution and its lower expression levels and

72 T and high quality cDNA (hq-cDNA) sequences, tissue distribution and likely intron position inferred

73 emory subset displayed a distinct pattern of tissue distribution and localization within the spleen,

74 een associated with abnormalities in adipose tissue distribution and metabolism.

75 parent conjugate exhibited relatively broad tissue distribution and only modest elimination via excr

76 NA polymerase III transcript with restricted tissue distribution and orthologs in chimpanzee but not

77 D50 data, we dissected the kinetics of viral tissue distribution and pathology in mice challenged wit

78 ical MHC class Ia molecules but with limited tissue distribution and polymorphism.

79 ng expression of CD115, scavenging function, tissue distribution and poor capacity for Ag presentatio

80 nsus on many aspects of HLA-G, including its tissue distribution and receptor binding.

81 is a critical determinant of healthy adipose tissue distribution and remodeling in obesity.

82 Tissue distribution and residence time in normal organs

83 1 (11betaHSD1(-/-)) have "healthier" adipose tissue distribution and resist metabolic disease with di

84 e its cellular function, we investigated its tissue distribution and subcellular location.

85 The normal and tumor tissue distribution and the cell line reactivity of AOC3

86 The tissue distribution and transcriptional regulation of ut

87 eta subunits (beta1-beta4) show differential tissue distribution and unique functional modulation, re

88 iseases is associated with abdominal adipose tissue distribution and varies between ethnic groups.

89 nografts, [(131)I]MIP-1145 exhibited diffuse tissue distribution and washout from all tissues except

90 evelopment remain unresolved, their distinct tissue distributions and differential activities in coop

91 These Treg subsets have unique tissue distributions and diverse roles in maintaining or

92 er clinical disorders, as indicated by their tissue distributions and inheritance patterns.

93 r studies related to phylogenetic relations, tissue distribution, and biological activity point to CK

94 y available about their antigen specificity, tissue distribution, and biological relevance in chronic

95 l protein hepcidin regulates the absorption, tissue distribution, and extracellular concentration of

96 To assess AMI bioconcentration factors, tissue distribution, and metabolite formation in fish, w

97 n summary, we have determined the structure, tissue distribution, and molecular function of the carti

98 by a determination of drug pharmacokinetics, tissue distribution, and multiple functional measures of

99 decitabine, severely limiting its half-life, tissue distribution, and oral bioavailability.

100 el that accounts for coating dissolution and tissue distribution, and predicts the concentration of d

101 ing in a high tumor uptake, highly favorable tissue distribution, and promising therapeutic profile i

102 tro and in vivo metabolic stability, in vivo tissue distribution, and rates of release of the active

103 ntial as antibiotics, their size, stability, tissue distribution, and toxicity have hampered attempts

104 rious concentrations and infusion durations; tissue distribution; and methods for optimizing delivery

105 For adipose tissue distribution assessment to be clinically useful,

106 bly compromising the prediction of erlotinib tissue distribution at therapeutic doses from PET with a

107 of (11)C-erlotinib PET to predict erlotinib tissue distribution at therapeutic doses.

108 lymphoid organs and subsequent non-lymphoid tissue distribution but also their phenotypic diversity.

109 MHHAV has wide tissue distribution but shows tropism for the liver.

110 We believe that given the broad tissue distribution, but contrasting signaling profiles,

111 labeled allogeneic splenocytes and monitored tissue distribution by in vivo bioluminescence imaging.

112 easures pulmonary perfusion and corrects for tissue distribution by measuring regional proton density

113 rformed serial necropsies to assess PrP(CWD) tissue distribution by real-time quaking-induced convers

114 get activity, favorable pharmacokinetics and tissue distribution characterize VFV as a promising new

115 xhibited improved pharmacokinetics and liver tissue distribution compared with unmodified oligonucleo

116 ion and pharmacokinetics indicated favorable tissue distribution, controlled pharmacokinetic paramete

117 valuated using measured bioconcentration and tissue distribution data collected in two previous studi

118 both the morphology of guard cells and their tissue distributions differ substantially between Arabid

119 n the gill, heart, and brain, representing a tissue distribution distinct from that found in teleosts

120 al bioavailability (F = 56%) and a favorable tissue distribution drug profile, with high liver to pla

121 fically examined Se assimilation efficiency, tissue distribution, efflux rate, and maternal transfer

122 and mouse resistin have distinct patterns of tissue distribution, experiments were performed using hu

123 afish (Danio rerio), and characterized their tissue distribution, expression levels, and biochemical

124 endowed with unique antigen recognition and tissue distribution features.

125 d a favorable pharmacokinetic profile, broad tissue distribution following different routes of admini

126 ractions governing iNKT cell development and tissue distribution have been uncovered recently, buildi

127 reconstruction; analysis of RNA and protein tissue distribution; immunofluorescent and electron micr

128 tional study of dietary patterns and adipose tissue distribution in 74 overweight adolescents (aged:

129 ight for approximately 1 y, visceral adipose tissue distribution in AN patients was not different fro

130 nt properties and, based on apparent limited tissue distribution in Arabidopsis, should be considered

131 TUSC3) but that each protein has a different tissue distribution in humans.

132 To determine the plasma clearance and tissue distribution in mice of the versatile capsid of b

133 The ex vivo tissue distribution in mice was determined at 4 and 24 h

134 (18)F-fluorothymidine ((18)F-FLT) uptake and tissue distribution in mouse models of cancer.

135 er, no studies have extensively analyzed the tissue distribution in other species or compared evoluti

136 ater than 50-fold liver-to-pancreas ratio of tissue distribution in rodent and non-rodent species.

137 The tissue distribution in the healed state was then used as

138 ate the two models: (1) observed patterns of tissue distribution in the laboratory and field, (2) the

139 ncreased energy expenditure; altered adipose tissue distribution, including reduced white adipose acc

140 Tissue distribution indicated preferential partitioning

141 diffusion-weighted images for complimentary tissue distribution information to address the difficult

142 of beta5-tubulin, a minor isotype with wide tissue distribution, inhibits cell division.

143 on process coupled with biologic insights on tissue distributions into account by comparing in vivo r

144 .5 (chBP2) and E11.5 (chBP1), although their tissue distribution is similar (skin = intestine>lung>he

145 different memory T-cell subsets with diverse tissue distributions is largely unknown.

146 ormone that controls iron absorption and its tissue distribution, is the cause of iron overload in ne

147 e in vivo, demonstrating drug absorption and tissue distribution leading to pharmacological efficacy.

148 g indicated extensive systemic clearance and tissue distribution, leading to a half-life of 6.6 h.

149 europathic pain and its limited cellular and tissue distribution makes PI16 an attractive target for

150 For each query, a hierarchically-clustered tissue distribution map, a peptide coverage map, and a l

151 x (BMI) is associated with CVD risk, adipose tissue distribution may better identify patients with a

152 n tumor standardized uptake value and normal tissue distribution may determine the most appropriate c

153 Measures of adipose tissue distribution may help identify high-risk patients

154 1 breast carcinoma cells and in paired-label tissue distribution measurements in mice bearing subcuta

155 gesting a link between the heart and adipose tissue distribution mediated through natriuretic peptide

156 Studies examining the tissue distribution of (1)(4)C-Dp44mT injected intraveno

157 CsA effect on tissue distribution of (11)C radioactivity (AUC ratios)

158 sue)/AUC(plasma)) served as a measure of the tissue distribution of (11)C radioactivity.

159 Tissue distribution of (123)I-MIP-1072 was determined on

160 f accelerator mass spectrometry to trace the tissue distribution of (14)C-labeled proanthocyanidins i

161 On the basis of the measured amounts and tissue distribution of (210)Po, it was estimated that th

162 ve biomarkers, enabling visualization of the tissue distribution of (potentially modified) therapeuti

163 prehensive investigation of the steady-state tissue distribution of 8c2 in wild-type mice versus thos

164 highest level of Tmem86b, which agreed with tissue distribution of activity.

165 The relative tissue distribution of AMI was consistent at both doses,

166 no major effect on the induction or overall tissue distribution of antigen-specific T cells during a

167 orescent protein fluorescence resembling the tissue distribution of APPb mRNA requires both the intro

168 rovides the first information on the precise tissue distribution of CD8 T cells in pancreata from T1D

169 ors in prime-boost immunization to shape the tissue distribution of CD8(+) T cell responses.

170 etics, effects on arterial NO signaling, and tissue distribution of cell-free Hb and its scavenger pr

171 d long-term in vivo imaging of viability and tissue distribution of cellular grafts in large animals.

172 emical phenotype determines the severity and tissue distribution of clinical features.

173 ignal transduction and the regulation of the tissue distribution of cytokines/growth factors.

174 ATP1 activation and that FATPs determine the tissue distribution of dietary lipids.

175 latory effect might be due to differences in tissue distribution of DPAT.

176 ffect of P-gp activity and inhibition on the tissue distribution of drugs in a more representative an

177 The potency and tissue distribution of FAAH inhibitors can be imaged in

178 mice and specific antiserum to determine the tissue distribution of FcRn in the adult mouse.

179 Low-density maps of tissue distribution of HBV peptides, such as secapin, ma

180 Tissue distribution of human, mouse, and rat P518/Qrfp a

181 on MR- and MPR-mediated plasma clearance and tissue distribution of infused phosphorylated (P) and no

182 This study investigated the expression and tissue distribution of inositol monophosphatase (IMPA1)

183 The widespread tissue distribution of ion channels, coupled with the pl

184 cidin controls plasma iron concentration and tissue distribution of iron by inhibiting intestinal iro

185 control the dietary absorption, storage, and tissue distribution of iron.

186 In this study, the transport and tissue distribution of lutein and zeaxanthin were examin

187 fficient production, delivery, and effective tissue distribution of lysosomal enzymes.

188 Concerning the strategic tissue distribution of MC and the presence of degranulat

189 tical role in modulating the development and tissue distribution of memory cells induced by parasite

190 le in the clinical assessment of the spatial tissue distribution of metabolites.

191 As the tissue distribution of MiHA affects the clinical outcome

192 quantitative analysis of the composition and tissue distribution of multiple cell populations in lymp

193 specialized mammalian cells, the ubiquitous tissue distribution of NHA2 suggests that H(+)-coupled t

194 BPK model to estimate the toxicokinetics and tissue distribution of PFOA in male rats.

195 successfully predicts the toxicokinetics and tissue distribution of PFOA in rats following exposure v

196 n important role for CXCR3 and CXCL10 in the tissue distribution of preimmune MP cells.

197 exposed deer to CWD prions and monitored the tissue distribution of PrP(CWD) over the first 4 months

198 Together, the tissue distribution of RDH12 and its catalytic propertie

199 However, the cellular and tissue distribution of Se remains largely unknown becaus

200 nd immunohistochemistry was used to evaluate tissue distribution of selected proteins.

201 al signal transduction and regulation of the tissue distribution of signaling molecules.

202 Results indicate that limited tissue distribution of silver detected from AgNPs is due

203 f AgNPs and AgNO3 to mice, and characterized tissue distribution of silver in the sinonasal mucosal e

204 Tissue distribution of small proline-rich proteins (SPRR

205 examined the homing receptor expression and tissue distribution of T reg cells in the steady state a

206 onal data coupled with the restricted normal tissue distribution of testisin and its overexpression i

207 nsgene expression (luciferase) and the local tissue distribution of the labeled plasmid at the inject

208 haracterize the discovered miRNAs, including tissue distribution of the precursors and mature sequenc

209 by PET and CT 4 and 24 h later, and measured tissue distribution of the radiohybridization probes.

210 influence of vitamin D(3), as defined by the tissue distribution of the VDR, has broadened at least 9

211 ss of function of PUT3 demonstrated that the tissue distribution of these metabolites is altered with

212 e-dependent manner because of the dissimilar tissue distribution of these proteins.

213 leotide Polymorphism) and information on the tissue distribution of these proteins.

214 uantitative RT-PCR method, we determined the tissue distribution of these SDF-1 isoforms.

215 ngly limited phenotype, given the widespread tissue distribution of tricellulin in epithelial cells.

216 nd ST revealed altered expression levels and tissue distribution of TSP-1.

217 This reflects the tissue distribution of TTP lesions in vivo.

218 Thus, by determining the subcellular and tissue distribution of two isoforms, alternative splicin

219 S1P1 receptor also dictates the distinctive tissue distribution of V alpha14-J alpha18 natural kille

220 prevalence (particularly in the UK), altered tissue distribution of vCJD, and the failure of decontam

221 ts as a basis for determining the levels and tissue distribution of vector, noninvasively in living a

222 protein in the heart but does not modify the tissue distribution of wild type beta2-microglobulin.

223 n be used to simulate the toxicokinetics and tissue distribution of xenobiotic substances, such as pe

224 amine the infection potential, kinetics, and tissue distribution of XMRV in an animal model, we inocu

225 This study presents the first whole-body tissue distributions of dissolved (Ag(I)) and 20 nm silv

226 a coupled with the overlapping, but distinct tissue distributions of FAAH-1 and FAAH-2 suggest that t

227 of 21 HIV positive men, we observed similar tissue distributions of Th and Tc cell subsets, although

228 The tissue distributions of the three antimicrobials, especi

229 Although the cell and tissue distributions of the three kindlins differ, there

230 he underlying mechanisms may include altered tissue distribution or increased catabolism via pyridoxa

231 wn about the kinetics of the generation, the tissue distribution or the underlying mechanism of clona

232 novel gene is expressed in a more restricted tissue distribution, particularly kidney and brain.

233 or algal toxins and have provided details on tissue distribution, pathways of trophic transfer, and s

234 n these mice, hCD1d is expressed in a native tissue distribution pattern and supports NKT cell develo

235 The tissue distribution pattern of ALT1 and ALT2 proteins la

236 These data correlate well with the tissue distribution pattern of cocaine as visualized wit

237 Similar to the tissue distribution pattern of rat CXCR1, we found murin

238 e identified distinct hepatic expression and tissue distribution patterns of ISGs that segregated wit

239 Tissue distribution patterns of organochlorine pesticide

240 oforms of ACSL and FATP exist with different tissue distribution patterns, intracellular locations, a

241 iNKT functional subsets showed distinct tissue distribution patterns.

242 monkeys, respectively, as well as favorable tissue distribution properties with a liver to plasma ex

243 and possesses favorable pharmacokinetic and tissue distribution properties.

244 imilar intracellular distribution, and broad tissue distribution, Rap1a and 1b are not functionally r

245 h the molecular mechanisms that ensure IL-22 tissue distribution remain poorly understood.

246 ion patterns of SOX9, MITF, and OTX2 yielded tissue distribution remarkably similar to that of BEST1.

247 cells: (i) antiretroviral drugs have limited tissue distribution, resulting in insufficient tissue co

248 SPECT/CT images and tissue distribution results revealed that (166)Ho-MSNs a

249 SPECT/CT imaging corroborated the tissue distribution results, demonstrating uptake only i

250 puted tomography imaging was consistent with tissue distribution results.

251 rison of the (132)La-NM600 and (225)Ac-NM600 tissue distributions revealed a similar biodistribution

252 ncomplexed protein; however, the analysis of tissue distribution reveals that the interaction with th

253 An assessment of tissue distribution showed the Cas-PMCA transcript to be

254 ITF isoforms was expressed in a sequence and tissue distribution similar to that observed in mice.

255 Ts) have been identified as important to the tissue distribution, species-specific accumulation, and

256 These data suggest that a combination of tissue distribution, specificity, and kinetic difference

257 Tissue distribution studies 30 min after [(18)F]10 admin

258 Post mortem and real-time tissue distribution studies did not reveal increased cis

259 Tissue distribution studies in hamsters suggest, rather,

260 Tissue distribution studies in mice showed 17.3 +/- 6.3%

261 Tissue distribution studies in mice showed the highest e

262 Tissue distribution studies in mice using [(14)C]-labele

263 On the basis of imaging and tissue distribution studies in several rodent tumor mode

264 Tissue distribution studies in the rat using radiolabele

265 Tissue distribution studies of a series of analogues ([1

266 Tissue distribution studies show that JNJ-28871063 cross

267 Tissue distribution studies were performed at the end of

268 as their in vitro stability and the ex vivo tissue distribution studies.

269 of a cassette dosing strategy for label-free tissue distribution studies.

270 In a preliminary PK/tissue distribution study in healthy mice, the parent co

271 rate recognition, SCF complex formation, and tissue distribution suggest that FBA proteins play diver

272 In keeping with its broad tissue distribution, taurine serves as a modulator of nu

273 SSmuLC-MS/MS) was explored as a quantitative tissue distribution technique for probing compound prope

274 a CDC42 splice variant that has a ubiquitous tissue distribution, termed here as CDC42u, specifically

275 creased replication efficiency and a broader tissue distribution than nonlethal isolates from the sam

276 ata provide evidence that MMP-20 has a wider tissue distribution than previously acknowledged.

277 properties such as biotransformation rate or tissue distribution that differ from those of legacy con

278 activated and recruited into the lung with a tissue distribution that differs from that of convention

279 sence of overt inflammation, with a specific tissue distribution that includes the kidney, gastrointe

280 Vitamin D receptors have a broad tissue distribution that includes vascular smooth muscle

281 encoded by the VWA2 gene, has a very similar tissue distribution to the Fraser complex proteins in bo

282 s transmembrane proteins restricted in their tissue distribution, to act as coreceptors along with cl

283 lations that exhibit similar degradation and tissue distribution upon injection but have differential

284 detected as an increase in [(11)C]flumazenil tissue distribution volume (VT).

285 Adipose tissue distribution was assessed at baseline and at the

286 okinetics were determined in monkeys and its tissue distribution was evaluated in rats.

287 ssfully applied to two case studies in which tissue distribution was instrumental in advancing projec

288 Its normal tissue distribution was largely restricted to moderate s

289 portantly, in mosquito-infected animals ZIKV tissue distribution was limited to hemolymphatic tissues

290 After the last time point, the ex vivo tissue distribution was measured to corroborate the in v

291 he suppression of de novo Th1 generation and tissue distribution was mediated by chronic type I IFN (

292 Tissue distribution was non-uniform, with greatest densi

293 Tissue distribution was similar but not identical betwee

294 Tissue distribution was studied by PET imaging, ex vivo

295 prepared in high specific activity, and its tissue distribution was tested in vivo.

296 ity, body composition, and abdominal adipose tissue distribution were assessed with a frequently samp

297 The pharmacokinetic profile and the tissue distribution were investigated by beta-radio imag

298 Epsin 1 and 2 have broad tissue distribution with high-level expression in the br

299 3) each have PAP activity, but have distinct tissue distributions, with lipin 1 being the predominant

300 led highly restricted and mutually exclusive tissue distributions, with striking resolution of layere