ライフサイエンスコーパス: titration

1 spectrum recorded in nanodiscs via detergent titration.

2 f 6-MR paired Al sites, quantified by Co(2+) titration.

3 c absorption spectrometry and complexometric titration.

4 (81%) had mUFC normalisation by end-of-dose titration.

5 ith bolus doses of insulin and rapid insulin titration.

6 data supporting increased activity with dose titration.

7 ed blood glucose target, and gradual insulin titration.

8 on fraction receiving aggressive vasodilator titration.

9 train, and post-mortem by qPCR and bacterial titration.

10 by Job's plot and ESI-MS as well as (1)H NMR titration.

11 administration and the timing of vasopressor titration.

12 of Na(2)EDTA by both UV-Vis and fluorometric titration.

13 g affinity based on pK(a) shifts using UV-pH titration.

14 ich is hyper-reactive according to the CpHMD titration.

15 thyroxine or matching placebo with mock dose titration.

16 Ln(3+) ions, as determined by potentiometric titrations.

17 ng separate potentiometric or conductometric titrations.

18 changes and fluorescence anisotropy binding titrations.

19 ed by BVS, solubility experiments, and redox titrations.

20 s been demonstrated in solution by (13)C NMR titrations.

21 ed guidelines are needed for optimal prozone titrations.

22 (MDS-UPDRS-I) underwent open-label nabilone titration (0.25 mg once daily to 1 mg twice daily, phase

23 The uneven titration across binding sites differs from KcsA, where

24 o identify patients who may benefit from AAM titration after CTO PCI and develop strategies to adjust

25 ts weak Bronsted acidity, as demonstrated by titrations, alcohol dehydration, and dehydra-decyclizati

26 rotein nanodiscs revealed lipid binding, and titrations allowed measurement of the optimal lipid comp

27 have comparable accuracy to the conventional titration (American Oil Chemists' Society) and UV-Vis sp

28 mass spectroscopy, UV-Vis spectroscopy, and titration analysis.

29 PERK inhibitor-titration and -time course experiments showed that the d

30 C tablet results to those obtained by iodine titration and by HPLC-UV; all three methods were within

31 creening, continuity of care, and medication titration and disproportionally impact women and older p

32 Our results from titration and pull-down studies revealed that miR-124 bi

33 Patient characteristics associated with AAM titration and the variation in postprocedure AAM managem

34 on symptoms were rated at timepoints of dose titration and weekly.

35 nd the monoanions was elucidated by (1)H NMR titrations and (1)H-(1)H NMR NOESY supported by molecula

36 py, cyclic voltammetry, fluorescence spectra titration, and (1)H DOSY NMR.

37 Moisture sorption studies, Karl Fischer titration, and differential scanning calorimetry were al

38 otein-ligand interactions in solution by MS, titration, and H/D exchange (PLIMSTEX); and native MS) p

39 in the pH range 1.50-6.40, ESI-MS, (1)H NMR titration, and ROESY experiments were performed to chara

40 m clones, 3D7, HB3, and IT4/FCR3 by promoter titration, and then isolated individual IEs binding IgM

41 microscale thermophoresis measurements, NMR titrations, and computational docking calculations, as w

42 eady-state, pulse-chase, equilibrium-binding titrations, and stopped-flow binding studies.

43 etin may be used as an alternative to a dose-titration approach to minimize transfusions, with less c

44 Insulin therapy is most effective if dosage titrations are done regularly and frequently, which is s

45 on, and other mutants in conjunction with pH titration as an in vitro surrogate of phosphorylation.

46 slated to the in vivo mouse serum inhibitory titration assay, with administration of coumestan 48 at

47 Initial dose was 5 mg daily with 1 dose titration at week 6.

48 mechanical support therapy requiring ongoing titration but without widely accepted variables to guide

49 anges in G86R GCAP1 detectable by isothermal titration calorimetry (ITC) also became less sensitive t

50 w was explored successfully using isothermal titration calorimetry (ITC) analysis.

51 t crystal structures, competitive isothermal titration calorimetry (ITC) and NMR, hydrogen-deuterium

52 er known LsrB-type receptors, and isothermal titration calorimetry (ITC) assays showed that binding o

53 Isothermal titration calorimetry (ITC) binding studies with a range

54 rface plasmon resonance (SPR) and isothermal titration calorimetry (ITC) can provide quantitative bin

55 ductometric methods as well as by isothermal titration calorimetry (ITC) in acetonitrile at 20 degree

56 Isothermal titration calorimetry (ITC) is a powerful method to dete

57 Isothermal titration calorimetry (ITC) is conventionally used to ac

58 azurin have been quantified with isothermal titration calorimetry (ITC) measurements and analysis, p

59 Isothermal titration calorimetry (ITC) measurements indicated negat

60 From the isothermal titration calorimetry (ITC) results, we propose that the

61 hibitors of both human CAMKKs and isothermal titration calorimetry (ITC) revealed that binding to som

62 Herein we describe the use of isothermal titration calorimetry (ITC) to establish proton involvem

63 udy, we used NMR spectroscopy and isothermal titration calorimetry (ITC) to investigate the cooperati

64 Herein, we add isothermal titration calorimetry (ITC) to our arsenal of techniques

65 combination of NMR spectroscopy, isothermal titration calorimetry (ITC), and computational methods.

66 characterized by crystallography, isothermal titration calorimetry (ITC), and molecular dynamics (MD)

67 d micellar breakdown of STC using isothermal titration calorimetry (ITC), dynamic light scattering an

68 tic Resonance spectroscopy (NMR), Isothermal Titration Calorimetry (ITC), Microscale Thermophoresis (

69 g was evaluated in solution using isothermal titration calorimetry (ITC), native nano-electrospray io

70 s, with liposomes were studied by isothermal titration calorimetry (ITC), tryptophan (Trp) fluorescen

71 on which were characterized using isothermal titration calorimetry (ITC), turbidity, and zeta-potenti

72 By crystallography and isothermal titration calorimetry (ITC), we studied a series of d-Ph

73 at increasing temperatures, using isothermal titration calorimetry (ITC).

74 -tranfer difference (STD)-NMR and isothermal titration calorimetry (ITC).

75 scopy (TFS) and, as a comparison, isothermal titration calorimetry (ITC).

76 eptide, and TTR stabilizers using isothermal titration calorimetry (ITC).

77 Isothermal titration calorimetry analyses suggested that saponins i

78 Isothermal titration calorimetry analysis confirmed high-affinity b

79 egmatis orthologues, results from isothermal titration calorimetry and analytical ultracentrifugation

80 ABD to human serum albumin using isothermal titration calorimetry and assess the structural integrit

81 Using isothermal titration calorimetry and CBD-mimetic peptides, as well

82 Isothermal titration calorimetry and CD experiments revealed that t

83 Solution-phase isothermal titration calorimetry and density functional theory (DFT

84 Finally, a combination of isothermal titration calorimetry and dynamic light scattering exper

85 Isothermal titration calorimetry and multiphoton microscopy showed

86 CATH-2 and affected its function, isothermal titration calorimetry and solid-state nuclear magnetic r

87 Isothermal titration calorimetry and spectral data show that Cu(II)

88 Isothermal titration calorimetry and two-dimensional lineshape anal

89 bioactivity, flow cytometry, and isothermal titration calorimetry assays, we found that heparin-depe

90 findings are further supported by isothermal titration calorimetry binding assays as well as modeling

91 Isothermal titration calorimetry data indicated that the assembly i

92 the surface plasmon resonance and isothermal titration calorimetry data, apparently at least two KN-9

93 Isothermal titration calorimetry disclosed that the highest affinit

94 Isothermal titration calorimetry experiments further revealed that

95 Extensive isothermal titration calorimetry experiments reveal that the lectin

96 Finally, isothermal titration calorimetry experiments showed distinct entrop

97 Thanks to isothermal titration calorimetry experiments, we show that this com

98 microbalance with dissipation and isothermal titration calorimetry measurements reveal the mechanism

99 edicted-and confirmed by in vitro isothermal titration calorimetry measurements-specific mutations ab

100 inity using cysteine labeling and isothermal titration calorimetry provide evidence for allosteric co

101 Isothermal titration calorimetry revealed that Ca(2+)/CaM has highe

102 Isothermal titration calorimetry showed that these nucleobases had

103 Additionally, isothermal titration calorimetry suggested that tannic acid modifie

104 We confirmed by isothermal titration calorimetry that JMS-053 binds to human serum

105 nsferase (Tv4AGT), and show using isothermal titration calorimetry that this protein binds HS.

106 rface plasmon resonance, NMR, and isothermal titration calorimetry to characterize this presumed inte

107 w secondary structure changes and isothermal titration calorimetry to investigate the impact of varia

108 Isothermal titration calorimetry was also utilized to evaluate the

109 r dichroism and fluorescence, and isothermal titration calorimetry was used to evaluate the interacti

110 tagenesis, deuterium-exchange MS, isothermal titration calorimetry, and computational methods in conj

111 nd poly-l-proline was measured by isothermal titration calorimetry, and involved more hydrogen bondin

112 pectroscopy ((1)H and (31)P NMR), isothermal titration calorimetry, and optical spectroscopies (UV/vi

113 Using affinity pulldown assays, isothermal titration calorimetry, and thermal denaturation CD spect

114 we show using mass spectrometry, isothermal titration calorimetry, and x-ray crystallography that a

115 al techniques have been employed, isothermal titration calorimetry, circular dichroism spectroscopy a

116 Isothermal titration calorimetry, circular dichroism, and NMR studi

117 leads to loss of binding shown by isothermal titration calorimetry, explaining the specificity of the

118 The method, based on isothermal titration calorimetry, is the first universal, reporter-

119 Isothermal titration calorimetry, scanning electron microscopy, and

120 Isothermal titration calorimetry, sedimentation velocity, size-excl

121 pitation assays, native state MS, isothermal titration calorimetry, single-channel conductance measur

122 graphy, differential scanning and isothermal titration calorimetry, surface plasmon resonance spectro

123 Using isothermal titration calorimetry, we also demonstrate direct bindin

124 Using isothermal titration calorimetry, we find that substitution of the

125 Using isothermal titration calorimetry, we found that Munc18c, like Munc1

126 and cell-based assays along with isothermal titration calorimetry, we investigate KU-32, a derivativ

127 nally, using NMR spectroscopy and isothermal titration calorimetry, we map a region of the phosphopro

128 lecular dynamics simulations, and isothermal titration calorimetry, we show how the three structural

129 Using isothermal titration calorimetry, we show that BK1.3 directly binds

130 luding in vitro kinase assays and isothermal titration calorimetry, we show that Lpg2603 is an active

131 alectin-3, using a combination of isothermal titration calorimetry, X-ray crystallography, NMR relaxa

132 membrane-to-micelle transition by isothermal titration calorimetry.

133 es, via (1)H NMR spectroscopy and isothermal titration calorimetry.

134 (d) = 180 nM) was demonstrated by isothermal titration calorimetry.

135 trometry, cyclic voltammetry, and isothermal titration calorimetry.

136 says, biolayer interferometry and isothermal titration calorimetry.

137 nstant of 3.0 muM, as measured by isothermal titration calorimetry.

138 gh-resolution crystallography and isothermal titration calorimetry.

139 ange of 5-33 muM, as evaluated by isothermal titration calorimetry.

140 nce FRET ratio and validated with isothermal titration calorimetry.

141 w the pK(a) value can be determined based on titrations carried out at two different compound concent

142 ctroscopy technique using an electrochemical titration cell to change the oxygen nonstoichiometry of

143 Docking and isothermal calorimetry titration confirmed interaction between lumefantrine and

144 ection against co-transfection, showing that titration curves for commonly-used regulators agree betw

145 Titration curves of hyperimmune sera were included on as

146 NMR titration curves of residues in the Ca(2+)-binding regio

147 l, to our knowledge, approach to analyze NMR titration curves was proposed.

148 quilibrium concentrations of typical binding titration curves, but also the lineshapes of NMR spectra

149 Equilibrium Ca(2+) titrations demonstrate that the Syt-7 C2AB tandem binds

150 tic analysis and the absorption spectroscopy titration, displays a high degree of similarity of the s

151 e versus dosing based on a hemoglobin-based, titration-dose algorithm in such patients might reduce r

152 dministered according to a hemoglobin-based, titration-dose algorithm, for up to 2 years.

153 n monthly dose of 30.9 ug) compared with the titration-dose group (53.6 ug median monthly dose).

154 The titration-dose group achieved significantly higher media

155 ffer (24.1% and 24.4% for the fixed-dose and titration-dose group, respectively), with similar time t

156 ized to the fixed-dose group, and 377 to the titration-dose group.

157 ncidence of red blood cell transfusion for a titration-dose strategy versus a fixed-dose strategy for

158 starting dose of 5 mg twice daily with dose titration every 14 days in 1 mg increments (ie, 5 mg twi

159 etermine affinities for each UIM region by a titration experiment.

160 cids was investigated by IR, NMR, and UV-vis titration experiments and by computational methods, shed

161 NMR titration experiments and density functional theory (DFT

162 ationic species was assessed by calorimetric titration experiments and hyperpolarized (129)Xe NMR.

163 the crystal structures of the complexes, NMR titration experiments and IC(50) measurements reveal the

164 We performed RNase titration experiments for low-input samples to identify

165 NMR titration experiments reveal that the first helical segm

166 Titration experiments reveal that the methoxy substituen

167 NMR titration experiments revealed that PSHCP has only a wea

168 Finally, titration experiments with cyclic voltammetry provided v

169 UV/vis titration experiments with eight anions in acetonitrile

170 nt of 1200 M(-1) was extracted from (1)H NMR titration experiments, indicating that efficient fluorid

171 (a) = 8.04 M(-1)), as determined by (1)H NMR titration experiments.

172 newly developed method named LITPOMS (ligand titration, fast photochemical oxidation of proteins and

173 etry (MS)-based method named LITPOMS (ligand titration, fast photochemical oxidation of proteins and

174 -anisyl)phosphine) have been investigated by titrations followed by photometric or conductometric met

175 ded to improve guideline-directed medication titration for HFrEF.

176 e RESTORE (Randomized Evaluation of Sedation Titration for Respiratory Failure) trial.

177 udies included (1)H-(1)H ROESY NMR, (1)H NMR titration, Fourier-transform infrared spectroscopy, cycl

178 (1)H NMR titrations, Fourier transform infrared (FTIR) studies, e

179 for most clinicians, resulting in an insulin titration gap.

180 Here we establish the analytical method of titration gas chromatography to quantify the contributio

181 The combination of automated insulin titration guidance with support from health-care profess

182 in in aqueous solution, revealed by (1)H NMR titrations, has produced binding constants in the order

183 spectroscopy, and galvanostatic intermittent titration have been also used to study the crystallograp

184 ution facilitated safe and effective insulin titration in a large group of patients with type 2 diabe

185 hese findings do not support PES-guided PEEP titration in ARDS.

186 UV-vis titration in MeCN reveals that all hosts exhibit a prefe

187 residues differ from those identified by NMR titration in solution, suggesting that packaging motors

188 Titration in the presence of the Egr1 target DNA sequenc

189 electrode placement and careful stimulation titration in the prevention of neuropsychiatric side-eff

190 rgo outpatient diagnostic procedures and PAP titration in the sleep laboratory (ideally within 2-3 mo

191 m in the presence of an indicator and a back-titration in which an analyte/indicator mixture is depro

192 High-throughput UV-vis titrations in combination with chemical double-mutant cy

193 Isothermal calorimetry titrations indicate that this molecular recognition is d

194 ed a structured protocol enabling medication titration, laboratory ordering, and booking urgent clini

195 NMR titrations mapped 3-O-S binding sites to the microtubule

196 By stimulating mouse macrophages with a titration matrix of TLR ligand pairs, we identified dist

197 monstrate how an apparently simple chaperone-titration mechanism produces diversified transcriptional

198 s in their HSA binding proved that the UV-pH titration method combined with an in silico support can

199 The titration method is then applied to VDAC, a 19-stranded

200 ecognition of chiral carboxylates, using the titration method under (1)H NMR control.

201 The back-titration method was applied to measure pK(a) values of

202 Langmuir isotherm formulation and Isothermal Titration Microcalorimetry (ITC).

203 s had adverse events (AEs) during open-label titration, most of them were transient.

204 can be, for example, used for multiparameter titrations, multiplexed biological and chemical assays,

205 Isothermal titration nanocalorimetry (ITC), molecular docking (DC),

206 The degree to which titration occurs in contemporary U.S. practice is unknow

207 The assay accuracy was validated by titration of 10-80% mixture of acetylated/nonacetylated

208 with heart failure in whom initiation and up-titration of ACE inhibitors or ARBs and beta blockers wa

209 oral hydralazine for 48 hours, and rapid up-titration of angiotensin-converting enzyme inhibitors, a

210 is has important clinical implications since titration of antihypertensive therapy is currently based

211 axon growth is distinct in most regards from titration of axonal regenerative growth after adult CNS

212 Here, we showed that the titration of BMPQ-1 shifted the conformational ensemble

213 Homeostatic feeding (i.e. titration of caloric intake), is typically associated wi

214 Titration of catalyst hexafluoroacetylacetonate salt wit

215 biomarker for CO exposure and for potential titration of dosage to allow precision testing of therap

216 method affords a library-based, bidirection titration of gene expression across all major metabolic

217 gonucleotide for time-release activation and titration of gene expression in living cells.

218 exist in the routine initiation and dose up-titration of guideline-directed medical therapies (GDMT)

219 NMR titration of H(MQ(+))H with O(NH)O in 0.1 M NBu(4)PF(6)/

220 is study sought to characterize longitudinal titration of HFrEF medical therapy in clinical practice

221 the timing of blood glucose measurements and titration of insulin infusion, continuous glucose monito

222 e, a DHP antagonist (R)-(+)-Bay K8644, and a titration of its agonistic enantiomer (S)-(-)-Bay K8644

223 Time-delay titration of Mn(V) further revealed that MnO(x) produced

224 ion and establishment of normal size through titration of myonuclear numbers during mouse neonatal de

225 domain adopted alpha-helical structure upon titration of Nterm and Nterm-ACB with RNA hairpins conta

226 ecause of nonlinear production chemistry and titration of ozone in winter, reduced nitrogen oxides re

227 Titration of PF74 against the integrase inhibitor ralteg

228 tor molecules and do not require the tedious titration of reagents into a sample.

229 vergence of mechanisms that ensure the exact titration of RNA molecules in a spatiotemporally control

230 Initiation and titration of sacubitril/valsartan led to variable change

231 substantially increased with initiation and titration of sacubitril/valsartan, more than doubling by

232 d mouse model of TSC and FCD that allows for titration of seizure frequency and generation of a mild

233 Titration of small ssDNA oligonucleotides to Mycobacteri

234 strength of BCR signal transduction via the titration of surface CD45 expression, we demonstrate tha

235 Titrations of increasing peptide concentration and colli

236 for their functions in vivo Here, using NMR titrations of methyl-labeled TGF-beta2 with BG's C-termi

237 inoculated with limiting dilutions (endpoint titration) of ovine AS isolates.

238 M BID, or to pharmacokinetically guided dose titration (OM-PK) for 20 weeks.

239 to 30% oxygen and to base subsequent oxygen titration on oxygen saturation targets.

240 asopressor dosing intensity varies by dosing titration pattern.

241 200 mg two times a day (BID), preceded by a titration period, and ended by a tapering period.

242 The study included a 6-week titration phase and 12-week maintenance phase.

243 ketoconazole in a 2-21 week incremental dose-titration phase starting at 150 mg twice daily (150 mg i

244 In an open-label titration phase, increasing doses of apomorphine subling

245 re determination; and (v) paramagnetic probe titration (PPT) to characterize the membrane partition o

246 the Heart And Lung Failure-Pediatric INsulin Titration protocol developed hypoglycemia, including 25

247 ocnemius, and used a comprehensive substrate titration protocol to examine the function of muscle mit

248 use is still limited because of its complex titration protocols.

249 ttings was non-inferior to intensive insulin titration provided by physicians from specialized academ

250 Comparison of virus titration results to reverse transcriptase quantitative

251 Titration results were used to track changes in the MgOH

252 NMR oxidation titrations reveal the presence of a global paratropic ri

253 g studies with fluorescence anisotropy-based titrations revealed that Mtf1 with an intact C-tail has

254 Base titration reveals a significant increase in the acid con

255 but these data show that this individualised titration scheme is feasible and has robust clinical act

256 e porphyrin for double-tweezer behavior, NMR titrations show exclusive formation of 1:1 adducts.

257 Time-dependent redox titrations show that reorganization occurs as a multiste

258 nd two-dimensional lineshape analysis of NMR titration spectra are used to characterize the thermodyn

259 decremental positive end-expiratory pressure titration (steps of 2 cm H2O starting from >/= 26 cm H2O

260 (15)NH(4)(+) titration studies allowed us to determine the dissociati

261 We previously reported that titration studies are a consistent and accurate means of

262 To test whether titration studies can also predict which patients are be

263 NMR titration studies in DMSO revealed an anion affinity ord

264 X-ray crystallographic and NMR titration studies indicate distinct interaction of the L

265 he quantitative analysis of the fluorescence titration studies of TL18 with picric acid proved that t

266 bine sedimentation velocity and fluorescence titration studies to examine nearest-neighbor cooperativ

267 Stopped-flow kinetic and spectroscopic titration studies, along with isothermal calorimetry, we

268 Rationale: Guidelines for vasopressor titration suggest a universal target-mean arterial press

269 The galvanostatic intermittent titration technique (GITT) analysis provides voltage-dep

270 ther supported by galvanostatic intermittent titration technique (GITT) and electrochemical impedance

271 xperimental approach based on potentiometric titrations to determine solubility limits of various org

272 the Heart And Lung Failure-Pediatric INsulin Titration trial to determine the association of hypoglyc

273 derwent two positive end-expiratory pressure titration trials by randomized cross-over design to find

274 Infrared Thermometric Titration (TT-IR) was utilized, with simple analyzers an

275 otonation state of histidine throughout a pH titration using Raman difference spectroscopy, thereby p

276 etween 3 and 2 was achieved through spectral titrations using a derivatized phosphazene base.

277 s were determined by UV-vis-NIR denaturation titration, using pyridine as a competing ligand, and coo

278 A dose titration was performed after 2 weeks.

279 mine the accuracy of this method, iodometric titration was used; results were in close agreement with

280 trial of prazosin (16 mg/day, with a 2-week titration) was conducted in community-recruited adults w

281 n potentials by spectroelectrochemical redox titration, we observed values of -420 +/- 10 and -330 +/

282 Through a series of titrations, we show that a cooperative interaction, invo

283 ochromic studies and spectrophotometric acid titrations were performed and indicate the possibility o

284 Dose titrations were permitted after 1 week (patiromer) and 3

285 Potentiometric titrations were used to determine the protonation consta

286 lly still measured by time consuming complex titrations, were measured with MALDI and (1)H NMR and we

287 the polyester bulk in contrast to acid-base titrations where those monomers severely distort the res

288 Further titration with Ca(2+), or adding excess regulatory prote

289 Upon titration with D(2)O, little change was observed until ~

290 values of weak acids are described, a direct titration with dimsyl potassium in the presence of an in

291 Different binding stoichiometries found upon titration with metal ions correlate with their specific

292 ACB, Nterm structure remained unaffected by titration with single-stranded RNAs.

293 Using redox titrations with [Ir(IV)Cl(6)](2-), we have determined th

294 (19) F NMR titrations with chloride highlight that the HBeXB analog

295 Spectral titrations with cholesterol, in the presence of EFV or l

296 Titrations with molecular redox species show that this r

297 using transient absorption, EPR, and optical titrations with NADH or inorganic reductants with and wi

298 sites were determined using in situ chemical titrations with NO.

299 Here, titrations with the purified ACCase biotin attachment do

300 including dye leakage assays, NMR-monitored titrations, X-ray and neutron diffraction, oriented CD,