ライフサイエンスコーパス: to generate

1 itively expensive, and are often complicated to generate.

2 omplex (GPC) and murine hybridoma technology to generate 25 mouse monoclonal antibodies (MAbs) agains

3 le them with human skeletal muscle spheroids to generate 3D cortico-motor assembloids.

4 n applications, we use nanographenes in SMLM to generate 3D super-resolution images of silica nanocra

5 ss spectrometry (LA-ICP-MS) to tooth samples to generate 500 temporally sequential measurements of el

6 elax linearity assumptions and bootstrapping to generate 95% confidence intervals.

7 We used Monte Carlo simulations to generate 95% uncertainty intervals (UIs) around our p

8 s from previous studies provided a framework to generate a 10-minute video that featured registered o

9 with a Hi-C-based proximity guided assembly to generate a 15.87 Mb assembly of the Y chromosome.

10 We exploit this to generate a biosensing platform with a limit of detect

11 This phenomenon led to generate a blue color of the solution that enabled vi

12 First, we used single-cell RNA sequencing to generate a cellular landscape of basal TSPO gene expr

13 a nearby field laboratory and used the data to generate a chromosome-scale draft genome sequence.

14 nge conformation data for single individuals to generate a chromosome-scale phased assembly within 1

15 or a neutral binding surface, are sufficient to generate a classifier able to identify polyreactive a

16 olution into 2D and 3D COF shapes as well as to generate a COF ink that can be directly printed onto

17 ding of early events in eukaryotic evolution to generate a coherent picture.

18 To generate a comprehensive metabolic map of genes and p

19 We designed this registry to generate a comprehensive picture of clinical presenta

20 e consider the similarities between features to generate a concise feature map in the form of a two-d

21 ry synapses can be tuned from weak to strong to generate a family of models that spans a continuum fr

22 her with RHD3 to move the ER on microtubules to generate a fine ER network.

23 dent size fluctuations, which are sufficient to generate a full repertoire of synaptic sizes at corre

24 ufacturer's instructions using a cube reader to generate a galactomannan index (GMI).

25 stages, we extend the original Protocol used to generate a GEM for a single strain to enable multi-st

26 We utilized a reverse genetics system to generate a GFP reporter virus to explore severe acute

27 tivation of a bicyclic iminoglycal carbamate to generate a highly reactive acyliminium cation.

28 de cyclization of homopropargyl sulfonamides to generate a highly reactive dihydropyrrole intermediat

29 etween a reference strain and target strains to generate a homology matrix; (iii) generate draft stra

30 Results were used to generate a mechanism to define aspergillosis in futur

31 and Fezf2 knockout mouse lines were crossed to generate a model that expresses a mutant of the murin

32 H bonds via proton-coupled electron transfer to generate a mu-amide product.

33 apidly disaggregated by addition of a ligand to generate a nearly synchronized cargo wave.

34 new polymer was utilized for modifying a GCE to generate a new electrochemical sensor.

35 ven-step method of translation and synthesis to generate a novel conceptual model.

36 This study aimed to generate a novel epigenetic clock in rats-a model wit

37 Pathogens usurp host pathways to generate a permissive environment for their propagati

38 An enzymatic approach was also developed to generate a previously undescribed co-factor, carboxy-

39 ed by the addition of fermentable substrates to generate a reducing environment, the presence of arse

40 ) or single-nucleus RNA-seq (snRNA-seq) data to generate a reference expression profile and learn gen

41 By using photoaffinity probes to generate a relationship between chemical structure an

42 To generate a robust multicellular map of gene expressio

43 na, and this specific pool of MAD1 is needed to generate a robust SAC response.

44 (FdltB(r)) strain demonstrated its capacity to generate a similar inflammatory response to a wild-ty

45 Here we apply machine learning to generate a spatial embedding (multidimensional ordina

46 l Protein Identification Technology (MudPIT) to generate a transcriptome from whole larvae and saliva

47 to copper particles, and process parameters to generate a variety of microporous coatings possessing

48 noviral and Modified Vaccinia Ankara vectors to generate a viral-vectored vaccine, referred to as Nou

49 We then used local illumination to generate a virtual array of electrochemical sensors f

50 he results of this and an earlier experiment to generate a weighted average of [Formula: see text] Ou

51 yase (ACLY) enzyme cleaves cytosolic citrate to generate acetyl-CoA, and is upregulated after consump

52 ast to VTA, SNc DaNs engage calcium channels to generate action potentials, which lead to oxidant str

53 sted for high-dimensional propensity scores, to generate adjusted hazard ratios (aHR).

54 to sustain stem cell pools and differentiate to generate all types of blood cells.

55 he initial step of the amyloidogenic pathway to generate amyloid-beta (Abeta).

56 The slag was dissolved in nitric acid to generate an acid solution containing 23.5 g/L Fe, 4.4

57 urons to Lgmn decreased the current required to generate an action potential through PAR(2) Inhibitor

58 ene undergoes extensive alternative splicing to generate an array of splice variants.

59 of 2-substituted anilines has been developed to generate an electrophilic N-aryl nitrenoid intermedia

60 s of two neural networks: (i) an autoencoder to generate an embedding that can reconstruct original m

61 he initial formation of a C(benzylic)-O bond to generate an Fe-alkoxide species, which is observed in

62 ors at room temperature and ambient pressure to generate an ink.

63 h both of these mechanisms have been invoked to generate an intermediate that catalyzes oxidative rin

64 69% accuracy) This work provides an approach to generating an accurate and interpretable group-level

65 ly accessible, there is a need for new tools to generate and analyze large data sets of mitochondrial

66 The aim of this study was to generate and characterize atabecestat(metabolite)-res

67 ures, they serve to camouflage and insulate, to generate and help detect sound, and even to disintegr

68 chromatin stability and the ability of cells to generate and inherit epigenetic transcriptional state

69 Assays were established to generate and purify both naturally occurring and in s

70 ng of terrestrial locomotion has been on how to generate and stabilize around near-steady-state movem

71 carbon nanotube network contacts can be used to generate and study electroluminescence from a variety

72 Here, we report a method to generate antibody-siRNA (1:2) conjugates (ARCs) that

73 his biological data, there is a crucial need to generate appropriate gene annotation repositories and

74 were coupled with 1,1-disubstituted alkenes to generate arenes with beta-stereogenic centers.

75 volved current natural marine snow protocols to generate 'artificial' marine snow, into which bacteri

76 ed Ni(II) complexes can undergo Ni homolysis to generate aryl radicals and Ni(I), both of which are s

77 d different assembly algorithms, we are able to generate assemblies whose protein annotations are sta

78 primarily utilizes oxygen during respiration to generate ATP.

79 to disentangle confounders from true signals to generate biologically informative embeddings.

80 This design was leveraged to generate biosensors with specificity for different he

81 resident stem-cell population can be induced to generate cartilage for treatment of localized chondra

82 vitro selections are the only known methods to generate catalytic RNAs (ribozymes) that do not exist

83 d attributes and their antecedent conditions to generate changes in lake physical and chemical enviro

84 The growing demand for tools to generate chemical information in decentralized settin

85 s, preserving their pluripotency and ability to generate chimeric mice.

86 and combined these combined these estimates to generate choices.

87 We optimized a protocol to generate choroid plexus organoids from hiPSCs and sho

88 Subsequently, we use the fitted model to generate circa 143 million grain yield data points fo

89 ve tissue-specific molecular information and to generate classification models using machine learning

90 The objective of this study was to generate clozapine-specific T cell clones (TCC) and c

91 rom separate features.SIGNIFICANCE STATEMENT To generate coherent percepts, sensory systems integrate

92 tiation protocol that uses transwell filters to generate columnar polarized HLCs with clearly defined

93 he plasma and urine metabolome, and in order to generate comparable data across laboratories and coho

94 ives for pharmaceutical and device companies to generate comparative data on drugs and devices and as

95 Developing reactions to generate complex and modular building blocks in a con

96 ts into the unique chemistry that plants use to generate complex, bioactive metabolites from simple a

97 l solution for site-selective cross-coupling to generate complex, highly substituted arenes.

98 eed structured illumination microscopy (SIM) to generate continuous gigapixel panoramas of the fresh

99 nabled reactive therapeutics (PERx) approach to generate covalent protein drugs.

100 We used multinomial logistic regression to generate covariates of care and viral load status and

101 mon microbes from RefSeq, and an online tool to generate custom probe libraries.

102 limiting auto-oxidation, but is also thought to generate cytosolic hydrogen peroxide (H(2)O(2)).

103 ctured frameworks and reduces Ti(4+) in situ to generate defects during calcination, giving rise to t

104 dies, the FAST-DOSE biomarker panel was able to generate delivered dose estimates at days 1, 2 and 3

105 This approach has been used mostly to generate deoptimized viruses used as vaccine candidat

106 This study utilized a Master Protocol to generate diagnostic performance data for multiple ass

107 We have used the model to generate district-level maps for the probability that

108 cessed as they transit the secretory pathway to generate diverse glycans on cell surface and secreted

109 To generate diversified SMs that enable different functi

110 linked sugars and enzymatic glycan extension to generate donor and acceptor substrates using purified

111 A diastereoselective synthesis was developed to generate (E)-1-cyano-1,3-butadiene (1) (10:1 E/Z) via

112 es is only one part of the selective process to generate effective immune responses.

113 d to anticipate their zoonotic potential and to generate effective vaccines and antiviral compounds.

114 nd sequestered, H(2) and/or O(2) may be used to generate electric power via fuel cells or combustors,

115 solar thermoelectric generators, the ability to generate electricity at both the daytime and nighttim

116 s a remarkable Stokes shift of 15 000 cm(-1) to generate emission at 633 nm.

117 n of 1,1-bisboryl-1,3-butadiene is developed to generate enantioenriched 3,6'-bisboryl-anti-1,2-oxabo

118 s work, a cross-metathesis reaction was used to generate end-functionalized acetoxy ionizable oligome

119 We demonstrate how Medusa can be used to generate ensembles and perform ensemble simulations,

120 its local excitatory circuits are sufficient to generate epileptiform activity.

121 lial cells undergo coordinated morphogenesis to generate epithelial folds (secondary septa) to form a

122 Field studies are required to generate evidence about UAS lifespan, failure rates,

123 We aimed to generate evidence on the feasibility of integrating c

124 How MutLgamma acts to generate expansions is unclear given its normal role

125 f gene expression and applied this framework to generate expression models for 43 human tissues from

126 cture of the lever in each head is competent to generate force upon activation.

127 chemical bonds within a polymer backbone or to generate force-responsive materials.

128 ating negative pressure along their surfaces to generate forward thrust (i.e., suction thrust).

129 -Net was trained on four different databases to generate four different models: (a) 375 neuroradiolog

130 7) function as catalytically active hexamers to generate free amino acids from human hemoglobin and a

131 , different cell types need to work together to generate functional multicellular structures.

132 n PM-activated DCs, impairing their capacity to generate functional Treg cells.

133 1 (B4GALNT1) encodes the key enzyme B4GALNT1 to generate gangliosides GM2/GD2.

134 It takes ~2-4 weeks to generate GBOs and 5-7 d to perform CAR T cell co-cult

135 gle-crystal-to-single-crystal transformation to generate Gd-IHEP-8.

136 Here we report two methods to generate gene-edited dicotyledonous plants through de

137 In recent years, the ability to generate genomic data has increased dramatically alon

138 s, and by consumers like bison and elephants to generate grazing lawns: dependable sources of sodium.

139 , potentially interfering with their ability to generate group consensus.

140 l activity when participants were attempting to generate hand opening either supported on a table or

141 Sexually reproducing organisms use meiosis to generate haploid gametes and faithfully transmit thei

142 thermogenesis occurs in brown adipose tissue to generate heat in response to cold ambient temperature

143 CRISPR/CRISPR-associated protein 9 was used to generate HeLa cell lines in which ENT expression was

144 magneto-patterned in hydrogels and cultured to generate heterogeneous tissues.

145 To generate HFrEF, Sprague-Dawley (SD) rats underwent pe

146 ilding a training dataset (D-COID) that aims to generate highly compelling decoy complexes that are i

147 The SH3 domain tends to generate homodimers through a domain swap.

148 Hence, we sought to generate human norovirus-specific T cells (NSTs) that

149 PC) differentiation, we optimized a protocol to generate human pluripotent stem cell-derived Purkinje

150 e protein side chains in these contact pools to generate hundreds of thousands of energetically favor

151 strate that females of both species are able to generate hybrids with males of the other species.

152 rs derivatised with a pendant bisphosphonate to generate hydrogels with enhanced mechanical propertie

153 with each other, and then used path analyses to generate hypotheses about the mechanistic connections

154 rus exploited paracrine purinergic signaling to generate ICWs that amplified the dysregulation of hos

155 ion did not trigger the mechanisms necessary to generate immunological memory able to induce long-ter

156 established for Chinese cynomolgus macaques to generate in vitro MCM embryos.

157 ur objective was to develop a novel approach to generate individual maps of white matter (WM) innate

158 ematic measurements of Eigenmannia were used to generate individualized estimates of each fish's loco

159 ing and air travel flows, and use this model to generate influenza forecasts in conjunction with inci

160 ious research applications, where the aim is to generate insights into the relations between a set of

161 We knocked out the Fndc5 gene to generate irisin-lacking mice.

162 cow immunisations harness the immune system to generate knob domains with affinities in the picomola

163 g from the distinct capacity of camera traps to generate large datasets from multiple species with mi

164 The ability to generate large panels of peptides and subsequently la

165 These cytoskeletal structures are able to generate large scale forces that can extensively remo

166 s have enabled significant leaps in capacity to generate large volumes of DNA sequence data, which ha

167 of the interneurons to the training odorants to generate learned olfactory behavior.

168 in previous membrane models that were prone to generating leucine-rich designs.

169 l product and synthetic chemistry approaches to generate libraries of compounds, with some ending as

170 he lipid bilayers of the NE and suggest ways to generate lipid asymmetry across the NE despite its di

171 elivery to the endothelium has the potential to generate localized therapeutic effects at the blood-t

172 that microwave-frequency photons may be used to generate long-range two-qubit gates between spatially

173 sulfur acceptor, revealing MPST's potential to generate low-molecular-weight persulfides.

174 The use of charge-reducing reagents to generate lower-charge ions has gained popularity in t

175 recombinase and Pdgfra-floxed mice were bred to generate Lrat-CrePdgfra-/- (knockout) animals, which

176 the ability of a population of cancer cells to generate, maintain, and propagate this heterogeneity

177 contexts and thus manipulate female behavior to generate mating opportunities.

178 s among progenitor cells with their capacity to generate mature cell types.

179 to the skin, and these stimuli are proposed to generate mechanical strain within sensory neurons.

180 tively repressed CD127 expression and failed to generate memory precursors and long-lived memory T ce

181 ce of acetic acid and other carboxylic acids to generate methyl and alkyl radicals, respectively, wit

182 , with the latter undergoing decarboxylation to generate methyl radicals.

183 owing to their biocompatibility and ability to generate microscale force gradients.

184 , it is unclear how Atg11 concentrates Atg32 to generate mitophagy initiation sites.

185 pplied different machine learning approaches to generate models for predicting different classes of k

186 -chip double emulsion method was implemented to generate monodisperse VEGF encapsulated microcarriers

187 This context-dependence is expected to generate more variation in the sign and magnitude of

188 roles for Y RNAs in mammals, we used CRISPR to generate mouse embryonic stem cells lacking one or bo

189 Purpose To generate multiparametric response map (mPRM) measurem

190 ctive and respiratory syndrome virus (PRRSV) to generate multiple proteins from overlapping reading f

191 analogous condensation of Asmic with imines to generate N-substituted dihydroimidazoles.

192 m proliferative to differentiative divisions to generate neurons.

193 ssues and organs rely on resident stem cells to generate new cells that replenish damaged cells.

194 Unable to generate new enzyme paradigms and metabolic networks

195 ality between different ethnic groups is set to generate new health care disparities through data-dri

196 have evolved that demonstrate the potential to generate new myocytes and thereby fulfill an essentia

197 rotease responsible for triggering anaphase, to generate newly near-tetraploid cells.

198 dvanced data science approaches, can be used to generate novel biological insights.

199 d complex with native and non-native systems to generate novel functional materials.

200 er of guiding synthetic strategies available to generate novel NP-inspired scaffolds, limiting both t

201 d the anatomically informed decisions needed to generate numbers that are not only valid in theory.

202 Single-genome amplification (SGA) was used to generate partial HIV-1 polymerase genomes in paired C

203 term memory of the membrane potential allows to generate persistent firing when clusters of cooperati

204 data demonstrated that HT-DBP could be used to generate personalized pharmacotypes.

205 s high-throughput reaction discovery in flow to generate pharmaceutically relevant compound libraries

206 ody reengineering (e.g. affinity maturation) to generate potential therapeutic candidates.

207 Yet, the network plasticity mechanisms to generate predictive signals in these distributed circ

208 we derived and compared different approaches to generating predictive polygenic risk scores (PRS) fro

209 or centromedial thalamus (n = 32) were used to generate probabilistic tractography to form a normati

210 is assumed to be combusted alongside lignin to generate process heat and electricity.

211 en-experienced CD4(+) T cells are sufficient to generate protection.

212 for development of highly effective vaccines to generate protective antiviral Ab responses.

213 itopes to link inductive and effector phases to generate protective immunity.

214 Acetonitrile is trimerized to generate protonated 2,4,6-trimethyl-s-triazine tautom

215 e progress, we are still far from being able to generate PSC-derived cardiomyocytes with adult-like p

216 a greater arrhythmic history) were selected to generate pseudo-time series according to their collec

217 This work provides a framework to generate purified N(0) and incorporate it with RNA in

218 h for using EHR data and clinical prediction to generate quantitative measures from binary phenotypes

219 alitative abiotic proxy, glendonite calcite, to generate quantitative temperature estimates for north

220 that uses a front-end glow discharge source to generate radical fluoranthene reagent cations.

221 CRISPR-Cas9 methods have been applied to generate random insertions and deletions, large delet

222 Basically, the inherited ability of TiO(2) to generate reactive oxygen species is used as a strateg

223 With the ability to generate reads tens to thousands of kilobases in leng

224 The end points were further used to generate reasonable intermediate structures of the re

225 antibody drugs (alemtuzumab and adalimumab) to generate recombinant single chain GloBodies, which re

226 of the NSP3 ORF showed that it was possible to generate recombinant viruses encoding 2 heterologous

227 involving the sequential chemical treatment to generate reduced graphene oxide (rGO) within 3D-print

228 matched samples and can be successfully used to generate reference maps for the human cell atlas.

229 nt types of information to be bound together to generate representations of experiences.

230 The correlated networks were then used to generate 'reverse' tractography to parcellate the tot

231 rain reward networks form a reinforcing loop to generate reward prediction coding.

232 circuit function by their intrinsic ability to generate rhythmic bursts of action potential.

233 romatic compounds as modular building blocks to generate richly substituted, three-dimensional compou

234 ces OPA1 cleavage, we show that cells unable to generate S-OPA1 are more sensitive to this stress und

235 of etheric, alcoholic, and esteric C-O bonds to generate saturated alkanes via a tandem dehydroalkoxy

236 e marked by Sca1, but upon injury are unable to generate Sca-1(+)/Clu(+) revSCs and could not regener

237 To generate scMNase-seq libraries, single cells are isol

238 ontrolled by afferent and intrinsic activity to generate sensory cue and prediction error signals tha

239 biomolecular capping ligands, has been used to generate sequence-specific morphologies in various me

240 c pathways, including anaerobic fermentation to generate short-chain fatty acids.

241 s into a PreB cell receptor complex (PreBCR) to generate signals to initiate this transition and supp

242 their interpretability and opening up a way to generate similarity estimates from object dimensions

243 can serve as an entry site for Exo1 in vitro to generate single-stranded DNA, which would be suscepti

244 analyze the efficacy of molecular constructs to generate siRNAs against specific gene targets.

245 ture at elevated temperature, which was used to generate six-membered phosphorus heterocycles via het

246 n both academia and pharmaceutical companies to generate small-molecule protein inhibitors and drug c

247 PrP(C) may be shed from the cell surface to generate soluble derivatives.

248 sly designed a library of lentiviral vectors to generate somatic-transgenic rodents to monitor signal

249 at embedding in Matrigel induces gastruloids to generate somites with the correct rostral-caudal patt

250 opinocytosis depends on the ability of cells to generate specialized cup-shaped protrusions.

251 tion is a fundamental strategy used by cells to generate specialized functions at specific stages of

252 es propagate to the lipid bilayer components to generate specific nanomechanical responses.

253 3 locus can be epigenetically edited ex vivo to generate stable therapeutic iTregs.

254 ecifically interact with sufficient strength to generate stable, dense, and highly ordered monolayers

255 ng the hydrolysis of GTP have been suggested to generate stress and drive depolymerization.

256 em repeats (STRs) contain sufficient entropy to generate strong encryption keys, and that only one te

257 his problem, we have developed a methodology to generate structural ensembles that faithfully reprodu

258 mized by a simple gradient descent algorithm to generate structures without complex sampling procedur

259 of the RNH folding intermediate is required to generate sufficient force to release a stall induced

260 ETPY assemblies could activate aerial oxygen to generate superoxide for completing the vital proton a

261 To generate suppressor iTreg cells, cells were then diff

262 mals use similar fluid dynamic relationships to generate swimming thrust.

263 e permanent magnet arrays have been proposed to generate switchable magnetic fields for pre-polarisat

264 smission can propagate within the BC network to generate synchronous inhibition of Purkinje cells, wh

265 By using the MiCRM to generate synthetic data with different environmental

266 f deep convolutional neural networks (DCNNs) to generate synthetic MRI ventilation scans from free-br

267 ween the two eyes' images, is a powerful cue to generate the 3D depth percept known as stereopsis.

268 molytic reductive cleavage of the S-C5' bond to generate the 5'-dAdo. radical.

269 t for reconstruction are those that are used to generate the acoustic speech signal.

270 econd model is trained on remaining lifespan to generate the AFRAID (Analysis of Frailty and Death) c

271 for each brain region across the sample used to generate the atlas, and a statistical comparison of a

272 zes the C19 hydroxylation of SiTPS8 products to generate the corresponding diterpene alcohols.

273 We here apply comparative genomic approaches to generate the first genome-wide estimates of genetic d

274 currently in use rely on image registration to generate the fused data and therefore can suffer from

275 We were also able to generate the H(inact) state anaerobically via both ch

276 Addition of the KAP subunit to generate the heterotrimeric FLA8/10/KAP relieved this

277 ediment sources with sediment fingerprinting to generate the knowledge base to improve land managemen

278 This protocol takes 2-3 weeks to generate the labeling cells and 1-2 weeks to test the

279 dent studies and meta-analyzed these results to generate the largest genome-wide association study of

280 HVT079 and HVT096 genes from the HVT genome to generate the mutant HVT-DeltavNr-13 to gain insights

281 e response to inductive signals is modulated to generate the proper transcriptional output in target

282 isms by which they regulate dendritic growth to generate their characteristic coverage and connectivi

283 However, the time required to generate them poses a bottleneck.

284 kidney biopsy, blood and urine samples used to generate these different types of molecular data are

285 The (FSF)TGFbeta(CA) allele was created to generate this model, and functionally validated by in

286 nd state-of-the-art scaffolding protocols(1) to generate, to our knowledge, the first reference-quali

287 s energy from the transmembrane ion gradient to generate torque at the interface between stator units

288 though repeat expansion has been established to generate toxic products, mRNAs encoding the C9ORF72 p

289 burn injury (>= 20% total body surface area) to generate training and test datasets for ML applicatio

290 ggered photolysis of silver trifluoroacetate to generate trifluoromethyl radicals, confined only to t

291 charge for numerous individual protein ions to generate true mass spectra.

292 ctivating ESR1 mutation, Y537S-ER, were used to generate tumor xenografts in ovariectomized female im

293 used Monte Carlo and optimization algorithms to generate two different intensity-modulation patterns,

294 vides asymmetrically, like many other cells, to generate two distinct progeny cells.

295 ich bacterial redox systems can be exploited to generate "unnatural" polymers in the presence of "hos

296 y investigated potential uses of the bycatch to generate value-added products.

297 ies, suggesting that there are multiple ways to generate variation in migration.

298 did not penetrate the renal vascular network to generate vessels; only administering them into the ki

299 ce on choosing ML workflows and their tuning to generate well-calibrated CP estimates for precision d

300 ve reactions are a highly desirable approach to generate well-defined functional macromolecules.