ライフサイエンスコーパス: tolerable

1 es increasingly attractive (or at least more tolerable).

2 e survival compared with dacarbazine and was tolerable.

3 The maximum dose of topotecan plus M6620 is tolerable.

4 than accuracy, as long as the error level is tolerable.

5 tudy population is feasible, acceptable, and tolerable.

6 shorter overall survival (OS), and was less tolerable.

7 ctive agents determine which crystal size is tolerable.

8 cal internalisation of bleomycin is safe and tolerable.

9 9 in combination with FOLFIRINOX is safe and tolerable.

10 decreased (18)F-FDG uptake and is active and tolerable.

11 living with the disease more reasonable and tolerable.

12 ion consolidation was 1.3 mg/m(2) and proved tolerable.

13 mine whether STN-DBS in early PD is safe and tolerable.

14 with gemcitabine-nab-paclitaxel is safe and tolerable.

15 lotteries undesirable, adolescents find them tolerable.

16 ive non-Hodgkin lymphoma, is efficacious and tolerable.

17 athway mutations, and that this inhibitor is tolerable.

18 n 85% survival at 2 years and was clinically tolerable.

19 e third of patients by day 29 was considered tolerable.

20 Treatment is tolerable.

21 or belief-drops below a level that they find tolerable.

22 d both regimens to be safe, deliverable, and tolerable.

23 that are effective, rapid acting, safe, and tolerable.

24 Vorinostat was safe and tolerable.

25 Differences in maximum tolerable absorbed dose to normal liver between (90)Y ra

26 y has been developed to estimate the maximum tolerable activity (MTA) of (131)I that can be safely ad

27 with highly potent antitumor activity and a tolerable adverse effect profile in a cohort of patients

28 gimen of nab-paclitaxel plus gemcitabine has tolerable adverse effects with substantial antitumor act

29 This therapy stands out as a tolerable alternative to previously identified remyelina

30 stigated as potentially more efficacious and tolerable alternatives for this multiply-relapsing disea

31 MMR3 is safe and tolerable among young adults.

32 mab, olaparib, or cediranib combinations are tolerable and active in recurrent women's cancers.

33 The AALL01P2 regimen is a tolerable and active reinduction platform, suitable for

34 otecan, a selective TOP1 inhibitor, would be tolerable and active, particularly in tumors with high r

35 d durvalumab plus intermittent cediranib are tolerable and active.

36 ombination of neratinib and temsirolimus was tolerable and demonstrated antitumor activity in multipl

37 ple infusions of tremelimumab were generally tolerable and demonstrated single-agent antitumor activi

38 lzomib-lenalidomide-dexamethasone therapy is tolerable and demonstrates high rates of MRD negativity

39 utaneous injection every 28 days seems to be tolerable and effective, thus supporting the further dev

40 Even in an era of more tolerable and efficacious ART, decision making in regard

41 ncept for PS2-sparing inhibition as a novel, tolerable and efficacious gamma-secretase targeting stra

42 al B-cell receptor pathway blockade would be tolerable and efficacious.

43 he balance between offering intensive versus tolerable and function-preserving therapy has been throw

44 BV is tolerable and has activity in SR-aGVHD and merits furthe

45 mDCF with bevacizumab appears tolerable and has notable patient outcomes in patients w

46 e in continuous administration, but they are tolerable and highly effective in intermittent dosing.

47 was found to be completely inactive at both tolerable and highly toxic dose levels.

48 4 weeks before surgery in MCC was generally tolerable and induced pCRs and radiographic tumor regres

49 ximab, umbralisib, and ibrutinib seems to be tolerable and is associated with encouraging activity in

50 Conclusion BGJ398 at the MTD/RP2D had a tolerable and manageable safety profile and showed antit

51 ly improves progression-free survival with a tolerable and manageable safety profile in Asian patient

52 profile for cobimetinib and vemurafenib was tolerable and manageable, and no new safety signals were

53 inded study group, the vaccine regimens were tolerable and no safety concerns were observed.

54 revir 240 mg QD with PegIFN/RBV was safe and tolerable and produced substantial SVR rates in prior nu

55 t 12 mg/day, titrating up to a dose that was tolerable and provided adequate dyskinesia control, base

56 Carfilzomib 56 mg/m(2) +/- dexamethasone was tolerable and provided durable responses.

57 dy suggest that low-frequency stimulation is tolerable and reduces epileptiform discharges and seizur

58 ombination of TriMixDC-MEL and ipilimumab is tolerable and results in an encouraging rate of highly d

59 s small trial, IV-D after aSAH was feasible, tolerable and safe.

60 mbination with clofarabine and cytarabine is tolerable and shows activity in relapsed/refractory pedi

61 ith vemurafenib and cobimetinib was safe and tolerable and significantly increased progression-free s

62 50 mg/m(2) level, which was determined to be tolerable, and an MTD was not identified.

63 le, with a de-escalated level of 3 mg if not tolerable, and aspirin 81 mg once per day thromboprophyl

64 Impressively, 2 injections of a simple, more tolerable, and dose-sparing intradermal administration f

65 onist eltrombopag has been shown to be safe, tolerable, and effective for adults with chronic immune

66 Inosine was generally safe, tolerable, and effective in raising serum and cerebrospi

67 tion (DVI) with PfSPZ vaccine has been safe, tolerable, and feasible in adults, but safety data for c

68 tion (DVI) with PfSPZ Vaccine has been safe, tolerable, and feasible in adults, but safety data for c

69 This medication regimen was tolerable, and is therefore feasible for further studies

70 TDL are a feasible, tolerable, and novel donor cell therapy alternative for

71 which is usable across species, is quick and tolerable, and requires no training.SIGNIFICANCE STATEME

72 oxicities made the 4,370-mg dose (n = 6) not tolerable, and the next lower dose cohort (3,120 mg) was

73 It is most practical, tolerable, and tumoricidal in its most potent form treat

74 The regimen is tolerable, and use of rituximab was not associated with

75 patients and highlights the need for better-tolerable anti-CMV drugs.

76 s recommending the use of more effective and tolerable antiretroviral regimens, optimal antiretrovira

77 b plus low-dose ipilimumab was effective and tolerable as a first-line treatment of advanced/metastat

78 Low-dose naltrexone was rated equally tolerable as placebo, and no serious side effects were r

79 TPZ/CIS chemoradiotherapy was tolerable at a modified starting dose.

80 se findings suggest that IPH2101 is safe and tolerable at doses that achieve full inhibitory KIR satu

81 bination with fludarabine and cytarabine, is tolerable at doses up to 55 mg/m(2) in pediatric patient

82 Bortezomib plus Int-DAC proved tolerable at the highest dose tested.

83 ues may reflect a mechanism used to strike a tolerable balance between the requirement for efficient

84 -CDDO-trifluoroethyl amide (dh404), a rodent-tolerable bardoxolone methyl analog, in protecting the t

85 is study, 800 mug/d was considered to not be tolerable because of 1 instance each of grade 3 cytokine

86 ith indolent B-cell non-Hodgkin lymphoma was tolerable but did not lead to increased objective respon

87 et 1.3 mg/m(2) on days 5, 8, 12, and 15) was tolerable, but bortezomib-related neuropathy developed a

88 istration of TPCS2a was found to be safe and tolerable by all patients.

89 ctively induce immune activation at safe and tolerable clinical doses.

90 y; cohort 6, not even 200 mg every third day tolerable; cohort 7, not defined; cohort 8, 200 mg each

91 tion with obinutuzumab is an efficacious and tolerable combination that provides a fixed-duration, ch

92 ired resistance, and evaluation of rational, tolerable combinations with standard-of-care treatments

93 approximately 3% of the provisional maximum tolerable daily intake (PMTDI) recommended for fumonisin

94 s (TDI-iAs) exceeds the previous provisional tolerable daily intake (PTDI) value of 2.1 mug day(-1) k

95 that, in case of children, would exceed the tolerable daily intake (TDI) of 0.1mg/kg bw/day.

96 around 5 orders of magnitude lower than the tolerable daily intake (TDI) reported by the European Fo

97 the children exceeded 1 for the HI based on tolerable daily intake (TDI) values (considered as poten

98 ded the U.S. Environmental Protection Agency Tolerable Daily Intake (TDI) values and the EFSA Referen

99 out based on probable daily intake (PDI) and tolerable daily intake (TDI).

100 st erucic acid content already surpassed the tolerable daily intake established by Food Standards Aus

101 acid were at least 10-fold below the current tolerable daily intake recommended for humans.

102 eds the previous WHO recommended provisional tolerable daily intake value (2.1 mug day(-1) kg(-1) BW)

103 Law limits set fumonisins tolerable daily intake with respect to several maize bas

104 be 1-2 orders of magnitude below the current tolerable daily intake.

105 the age/gender groups of the population, the Tolerable Daily Intakes (TDIs) recommended by the EFSA w

106 were found to be lower than the provisional tolerable daily intakes proposed by Joint FAO/WHO Expert

107 1.13 mug/kg, which is above the Provisional Tolerable Daily Maximum Intake (PTDMI) of 1 mug/kg b.w.

108 Although the advent of highly effective and tolerable direct-acting antiviral therapy has paved the

109 In the animal study, a tolerable distance (<1 cm) between target and needle tip

110 ipate, and C) RAMP can identify biologically tolerable diversity of a metabolic network in an optimiz

111 igated the comparative effectiveness of more tolerable dosages of lithium as part of optimized person

112 This study determined the maximum tolerable dose (MTD) and toxicity of ch14.18 given in co

113 Primary end points were maximally tolerable dose (MTD) of LEN and progression-free surviva

114 has made it difficult to predict the maximal tolerable dose as a function of microsphere activity and

115 most damage processes, vastly increasing the tolerable dose before the specimen is destroyed.

116 count late-onset toxicities to ensure that a tolerable dose is identified for future efficacy and com

117 x 3 design was used to determine the highest tolerable dose of (90)Y-DOTATOC, with administered activ

118 fferent between the 3 conditions.The highest tolerable dose of mustard we were able to use did not el

119 ze the pharmacokinetics (PK) and determine a tolerable dose of oral sorafenib in patients with hepati

120 tration and allowed the use of a lower, more tolerable dose of tariquidar.

121 f seizures, the maximal allowable or highest tolerable dose was reached, or a criterion indicating tr

122 precision of dosimetry, validate the maximum tolerable dose, and evaluate the effectiveness of the tr

123 peptide loss 2 years after diagnosis using a tolerable dose.

124 ighest dose seems to be close to the maximum tolerable dose.

125 esource Program to derive individual maximum tolerable doses and minimum eliciting doses for objectiv

126 coln have been collecting individual maximum tolerable doses and minimum eliciting doses that produce

127 idual thresholds for food allergens (maximum tolerable doses and minimum eliciting doses) can ideally

128 alpha2b has also been evaluated at maximally tolerable doses compared with the observation group in t

129 fficult to reach this threshold with patient-tolerable doses of current DNMT inhibitors (DNMTIs).

130 ue concentrations of rapamycin at clinically tolerable doses.

131 e substantial therapeutic benefit using well-tolerable dosing regimens.

132 remarkably low doses, far below the maximum tolerable drug doses.

133 0.05, which has been proposed as the maximum tolerable effect to keep the ecosystem intact.

134 umab plus reduced-dose ipilimumab might be a tolerable, efficacious treatment option for patients wit

135 In this trial we demonstrated a maximum tolerable energy dose of 300 J/cm(2) to a spot on the lo

136 X chromosome formation, then the X is not a tolerable environment for genes with very high maximal n

137 Here, we have validated a tolerable European Medicines Agency-approved (U.S.

138 ial barriers to wider adoption of this safe, tolerable, evidence-based, and cost-effective prediabete

139 ready moderate amounts of CHOL increased the tolerable FE content in membranes by an order of magnitu

140 in, and pemetrexed could be an effective and tolerable first-line treatment option for patients with

141 tural motifs, respectively, were found to be tolerable for biological activities and beneficial with

142 The reaction conditions are tolerable for dialkyl-, aryl(hetaryl) alkyl-, and cycloa

143 nt with chlorambucil alone, while also being tolerable for patients who have few treatment options.

144 ission rates and standard duty cycles may be tolerable for some applications.

145 k emollient creams, rendering their eruption tolerable for the duration of treatment.

146 ich interventions are the most effective and tolerable for treating usual-type vulvar intraepithelial

147 imb of the internal capsule is effective and tolerable for treatment-refractory OCD in the long term

148 al film (10-35 mg) were administered until a tolerable full on response was achieved.

149 creased toxicity in vivo and no benefit of a tolerable GEMCAP combination was identified in the allog

150 dose was escalated until patients developed tolerable grade 2 rash or until the maximum allowed dose

151 in commensals is that they evoke a small but tolerable host immune response in order to have the host

152 EPIT, on the other hand, has proven safe and tolerable; however, the adequacy of its desensitization

153 s, we investigated whether a physiologically tolerable hypercapnic stimulus ( approximately 25 mm Hg

154 be valuable to the effective design of more tolerable immunosuppression regimens.

155 clude that ezetimibe is both efficacious and tolerable in cardiac transplant recipients taking cyclos

156 venous administration of PEG-asparaginase is tolerable in children with ALL, and potentially therapeu

157 Lenalidomide was tolerable in children with CNS tumors at doses of 116 mg

158 In mouse models, such doses are not tolerable in continuous administration, but they are tol

159 Sapacitabine seems active and tolerable in elderly patients with AML.

160 th 5 + 2 induction chemotherapy was safe and tolerable in fit older patients with AML.

161 error-prone than Pols II or V, which may be tolerable in its synthesis of short RNAs that serve as p

162 relapsed and refractory multiple myeloma and tolerable in most patients.

163 t hypercaloric enteral nutrition is safe and tolerable in patients with amyotrophic lateral sclerosis

164 hese data suggest bosutinib is effective and tolerable in patients with chronic phase imatinib-resist

165 rtezomib-dexamethasone appears effective and tolerable in patients with relapsed or relapsed and refr

166 Given fewer agents are both active and tolerable in patients with squamous cell carcinoma compa

167 ch14.18 in combination with IL-2 was tolerable in the early post-HDC/SCR period.

168 BIVV009 was found to be safe and tolerable in this elderly population, with only mild to

169 tumors and that metformin is safe to use and tolerable in this population.

170 onstrate that complete ablation of K9 is not tolerable in vivo and that K9 is required for terminal d

171 560 represents an exception as it is largely tolerable in vivo despite displaying only a small select

172 the absence of C2GnT and C4GnT activities is tolerable in vivo, core 2 O glycosylation exerts a signi

173 over PS2 subclass of gamma-secretases and is tolerable in wild-type mice but causes dose-dependent No

174 entions are not required, that is, are there tolerable infectious risks of transfusion?

175 The most efficacious and tolerable initial empirical treatment has not been defin

176 However, higher percentages of tolerable intake levels are observed when calculating ri

177 uptake is low, but new highly effective and tolerable interferon-free direct-acting antiviral (DAA)

178 ely inhibits HDAC6 while retaining a low and tolerable level of class I HDAC inhibition.

179 concentrations well below the maximum human tolerable level.

180 hence are subject to regulations of maximum tolerable levels in food.

181 nimize the contribution of photoswitching to tolerable levels in future FRAP experiments.

182 e that resulting translation errors occur at tolerable levels.

183 ons while limiting systemic drug exposure to tolerable levels.

184 , and lead (<0,56-99 ug L(-1)) was above the tolerable limit for drinking water of 10 mug L(-1) in 73

185 5 mg L(-1), respectively, and lower than the tolerable limit for ingested food.

186 ions of 3-MCPD, exceeding Malaysia's maximum tolerable limit of 0.02 mg kg(-1), were found in chicken

187 nd Cr concentrations higher than the maximum tolerable limit specified in Brazilian legislation.

188 The maximum tolerable limits by European Regulation No.

189 1mmol.L(-1), which is in accordance with the tolerable limits for coffee.

190 ers Association tests revealed values within tolerable limits for uniformity, for recovery coefficien

191 ry to normal organs were low and well within tolerable limits.

192 us supplements and doses under the set upper tolerable limits.

193 bevacizumab 5 mg/kg every 2 weeks may not be tolerable long term, and alternate sorafenib dosing sche

194 If correlations can be ignored with tolerable losses of information, the readout of neural s

195 ic inflammatory response can be destructive, tolerable low doses of LPS render the brain transiently

196 tation and are intended to manage dying in a tolerable manner based on what the decision maker believ

197 domains of error rates: negligible (yeast), tolerable (metazoan), and high (some plants), with the h

198 Wireless pH-metry is a safe and tolerable method when investigating children for GERD.

199 inment strategy aims to maintain the maximum tolerable number of pathogens, exploiting competitive su

200 erior to timolol BID and was associated with tolerable ocular AEs.

201 he AP-WP regimen is an equally effective and tolerable option for the adjuvant treatment of patients

202 e-daily dose regimens that the patient found tolerable, or placebo.

203 molecular rationale for the use of 2ME2 as a tolerable oral immunomodulatory agent for the treatment

204 On a scale of 0 (intolerable) to 10 (very tolerable) patients rated DPDT as 9.5 and AWLPDT as 9 (P

205 IONIS-APO(a)-LRx is a novel, tolerable, potent therapy to reduce Lp(a) concentrations

206 onuclide-labeled anti-PD-L1 antibody yielded tolerable projected marrow doses, further supporting its

207 he critical normal organ receiving a maximum tolerable radiation dose.

208 kidney) with short (1 second) exposures and tolerable radiation doses that will permit future in viv

209 tes investigated were found to be within the tolerable range, the preliminary probabilistic estimatio

210 ining its signaling within a physiologically tolerable range.

211 we develop a mathematical model to estimate tolerable rates of homing-resistant allele generation to

212 o achieve meaningful population suppression, tolerable rates of resistance allele generation are orde

213 perior to standard AC (DFS and OS) and was a tolerable regimen in both older and younger patients.

214 pite activity, BV plus bendamustine is not a tolerable regimen in these patients.

215 s cheap copper catalyst down to industrially tolerable residues, and some biomedical and cosmetic app

216 y the 2015 to 2017 ZIKV pandemic, a level of tolerable risk has yet to be defined in such a way that

217 GEMOX-B showed antitumour activity with tolerable safety in patients with advanced BTCs.

218 atumumab has shown substantial efficacy with tolerable safety in relapsed or refractory multiple myel

219 st-line nivolumab monotherapy demonstrated a tolerable safety profile and durable responses in first-

220 , first-line nivolumab plus ipilimumab had a tolerable safety profile and showed encouraging clinical

221 , first-line nivolumab plus ipilimumab had a tolerable safety profile and showed encouraging clinical

222 tuximab talirine demonstrates activity and a tolerable safety profile as a single agent in patients w

223 gnificantly reduced seizure frequency with a tolerable safety profile compared with placebo in patien

224 aningful response rate with a manageable and tolerable safety profile in patients with locally advanc

225 759 at a dose of 200 mg twice daily showed a tolerable safety profile in patients with NSCLC and CNS

226 T-VEC with ipilimumab had a tolerable safety profile, and the combination appeared t

227 hemotherapy plus trastuzumab while showing a tolerable safety profile.

228 long-term effects on overall survival, with tolerable safety, for treatment naive and previously tre

229 ata offer the least biased results at a well-tolerable scan duration and should thus be pursued whene

230 ith and without the threat of a painful, but tolerable, shock.

231 induced differentiation of cancer cells with tolerable side effects.

232 red to 68.4% (microscopic diagnosis), with a tolerable specificity of 66.2% for the decision support

233 nterparts in stretchability (130% versus 30% tolerable strain) and maintains high sensitivity (minimu

234 cytes exposed to Ketoprofen are subjected to tolerable stress events, conversely Diclofenac expositio

235 surfaceome for overexpressed molecules with tolerable systemic expression.

236 vastatin and pravastatin seem safer and more tolerable than other statins.

237 melanoma, with a safety profile that is more tolerable than that of ipilimumab.

238 e treatments, may prove more efficacious and tolerable than the available arsenal of treatments.

239 0 dosages of 3 ug/kg every 2 weeks were more tolerable than twice-weekly dosages used in the phase I

240 Despite attempts to develop tolerable therapeutics for management of AMR, none, to d

241 l effects on the disease, more effective and tolerable therapies are needed.

242 ve the way for more targeted, effective, and tolerable therapies for children with systemic vasculiti

243 The artificial ruggedness decreases to tolerable thresholds for cutoffs larger than the critica

244 hat the elevation of proteasomal activity is tolerable to cells and may be beneficial to prevent the

245 tional constraints limit the available sites tolerable to escape mutations.

246 3 disrupts this circuit and makes cells more tolerable to stresses, as its gain-of-function mechanism

247 se adaptive responses might render most mice tolerable to the EGCG treatment.

248 with impressive durations of response and a tolerable toxicity profile.

249 in durable engraftment of donor stem cells, tolerable toxicity, and acceptable rates of relapse risk

250 drug doses and schedules investigated, with tolerable toxicity.

251 tin has an encouraging efficacy profile with tolerable toxicity.

252 essions of MLL-AF9-driven AML in vivo with a tolerable toxicity.

253 ition of LDHA with FX11 is an achievable and tolerable treatment for LDHA-dependent tumors.

254 trastuzumab emtansine as an efficacious and tolerable treatment in this patient population.

255 that, in this non-curative setting, maximum tolerable treatment must necessarily be used first-line.

256 nutuzumab has a manageable toxicity, being a tolerable treatment option for most patients.

257 In an era of highly efficacious and highly tolerable treatment, such an approach will benefit not j

258 7% (89.6%, 91.8%) consumed more than the IOM Tolerable Upper Intake Level (2300 mg).

259 use of high dosages of FASs that exceed the Tolerable Upper Intake Level (UL) (>/=1000 mug/d) on chi

260 of these sources to usual intakes above the tolerable upper intake level (UL) (1000 microg/d) and to

261 The prevalence of adults who exceeded the tolerable upper intake level (UL) for calcium, zinc, iro

262 ge Requirement (EAR) for folate or above the Tolerable Upper Intake Level (UL) for FA.

263 ntly to usual intakes above the age-specific tolerable upper intake level (UL) for folic acid and to

264 In 1998 a Tolerable Upper Intake Level (UL) for folic acid was est

265 Currently, the tolerable upper intake level (UL) for leucine is unknown

266 3%) of dietary supplement users exceeded the Tolerable Upper Intake Level (UL) for total folic acid (

267 of women (85%) had sodium intakes above the Tolerable Upper Intake Level (UL).

268 1 in 2 had sodium intakes that exceeded the Tolerable Upper Intake Level (UL); >/=16% and 41% of the

269 cts of daily vitamin D doses at or above the tolerable upper intake level for 12 months or greater, y

270 Intakes greater than the Tolerable Upper Intake Level greatly increased the odds

271 whey protein production and up to 70% of the tolerable upper intake level was found, thus revealing t

272 for those aged > or =50 y, and 5% exceed the Tolerable Upper Intake Level.

273 for cancer death (above vs. at or below the Tolerable Upper Intake Level: multivariable-adjusted rat

274 h no individual exceeding the United Kingdom Tolerable Upper Intake Level; the 2.5th percentile of th

275 Conclusion: Calcium intake within tolerable upper intake levels (2000 to 2500 mg/d) is not

276 The usual sodium intake above the Tolerable Upper Intake Levels (ULs), potassium intakes a

277 th Recommended Dietary Allowances (RDAs) and Tolerable Upper Intake Levels.

278 h calcium intake-that is, beyond recommended tolerable upper intake levels.

279 ther these data support the development of a tolerable upper intake limit for NR based on human data.

280 ood and supplements that does not exceed the tolerable upper level of intake (defined by the National

281 The current tolerable upper level of zinc recommended by the Institu

282 hese results support the need to establish a tolerable upper limit for DHA intake particularly in the

283 DNA vaccine field and provide a novel, more tolerable vaccine with broad immunogenicity to avian inf

284 to any critical normal organ to its maximum tolerable value.

285 own farmland, may exceed the toxicologically tolerable values allowed, and therefore long-term consum

286 rmed 45-min DR (-15% slope) at their maximal tolerable velocity.

287 220 mL [183-257 mL]; P = 0.006) and maximum tolerable volume in 9 of 13 (PRE: mean 350 mL [323-377]

288 Thus considering the Provisional Tolerable Weekly Intake (PTWI) of Hg, Pb and Cd the leve

289 n this work would not exceed the provisional tolerable weekly intake (PTWI).

290 compared calculated values with provisional tolerable weekly intake (PTWI).

291 n Food Safety Authority's (EFSA) provisional tolerable weekly intakes for PFOS and PFOA.

292 of vemurafenib and cobimetinib was safe and tolerable when administered at the respective maximum to

293 bition of DNA-PKcs activity is effective and tolerable when combined with localized DNA-damaging ther

294 agweed AIT of 12 Amb a 1-U was effective and tolerable with a safety profile that permitted daily sel

295 Alisertib 60 mg/m(2) per dose for 7 days is tolerable with a standard irinotecan and temozolomide ba

296 AMG 386 combined with weekly paclitaxel was tolerable, with a manageable and distinct toxicity profi

297 he combination of erlotinib and dasatinib is tolerable, with adverse effects consistent with the two

298 schedules at 120 mg once a day but none was tolerable, with DLTs of thrombocytopenia, gastrointestin

299 hase 2 dose of 2 mg trametinib once a day is tolerable, with manageable side-effects.

300 Both regimens were tolerable, with modest toxicity increase with sorafenib.